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Protein

Probable peptide chain release factor C12orf65, mitochondrial

Gene

C12orf65

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion. May help rescuing stalled mitoribosomes during translation (By similarity).By similarity

Miscellaneous

Knockdown of C12orf65 in Hela cells results in increased ROS production and apoptosis, leading to inhibition of cell proliferation.1 Publication

Caution

In contrast to other members of the family, lacks the regions that come into close contact with the mRNA in the ribosomal A-site and determine the STOP codon specificity, suggesting a loss of codon specificity for translation release factor activity.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable peptide chain release factor C12orf65, mitochondrial
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:My030
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000130921.7

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26784 C12orf65

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613541 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H3J6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Combined oxidative phosphorylation deficiency 7 (COXPD7)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA mitochondrial disease resulting in encephalomyopathy. Clinical manifestations include psychomotor delay and regression, ataxia, optic atrophy, nystagmus and muscle atrophy and weakness.
See also OMIM:613559
Spastic paraplegia 55, autosomal recessive (SPG55)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. Complicated forms are recognized by additional variable features including spastic quadriparesis, seizures, dementia, amyotrophy, extrapyramidal disturbance, cerebral or cerebellar atrophy, optic atrophy, and peripheral neuropathy, as well as by extra neurological manifestations.
See also OMIM:615035

Keywords - Diseasei

Hereditary spastic paraplegia, Neurodegeneration, Primary mitochondrial disease

Organism-specific databases

DisGeNET

More...
DisGeNETi
91574

MalaCards human disease database

More...
MalaCardsi
C12orf65
MIMi613559 phenotype
615035 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000130921

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
320375 Autosomal recessive spastic paraplegia type 55
254930 Combined oxidative phosphorylation defect type 7

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162377963

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
C12orf65

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74733574

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 35MitochondrionSequence analysisAdd BLAST35
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000031183536 – 166Probable peptide chain release factor C12orf65, mitochondrialAdd BLAST131

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9H3J6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H3J6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H3J6

PeptideAtlas

More...
PeptideAtlasi
Q9H3J6

PRoteomics IDEntifications database

More...
PRIDEi
Q9H3J6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
80723
80724 [Q9H3J6-2]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q9H3J6-1 [Q9H3J6-1]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1629

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H3J6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H3J6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000130921 Expressed in 202 organ(s), highest expression level in thymus

CleanEx database of gene expression profiles

More...
CleanExi
HS_C12orf65

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9H3J6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H3J6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA038194
HPA057595

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124847, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q9H3J6, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000253233

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9H3J6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9H3J6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni57 – 121GGQ domainBy similarityAdd BLAST65

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili127 – 160Sequence analysisAdd BLAST34

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The GGQ domain may interact with the peptidyltransferase center (PTC) of the large ribosomal subunit to trigger peptidyl-tRNA hydrolysis.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2726 Eukaryota
COG0216 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000012759

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000217812

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG094928

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H3J6

Identification of Orthologs from Complete Genome Data

More...
OMAi
WESSKNV

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0YON

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H3J6

TreeFam database of animal gene trees

More...
TreeFami
TF323274

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000352 Pep_chain_release_fac_I_II

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00472 RF-1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H3J6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSTVGLFHFP TPLTRICPAP WGLRLWEKLT LLSPGIAVTP VQMAGKKDYP
60 70 80 90 100
ALLSLDENEL EEQFVKGHGP GGQATNKTSN CVVLKHIPSG IVVKCHQTRS
110 120 130 140 150
VDQNRKLARK ILQEKVDVFY NGENSPVHKE KREAAKKKQE RKKRAKETLE
160
KKKLLKELWE SSKKVH
Length:166
Mass (Da):18,828
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCB9B74E0CC7E920C
GO
Isoform 2 (identifier: Q9H3J6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     95-119: CHQTRSVDQNRKLARKILQEKVDVF → VDHRRPLRGEAPPKGSTASRDFSQV
     120-166: Missing.

Show »
Length:119
Mass (Da):12,923
Checksum:i6D372CA39B233171
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H4X5F5H4X5_HUMAN
Probable peptide chain release fact...
C12orf65
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GWJ6F5GWJ6_HUMAN
Probable peptide chain release fact...
C12orf65
96Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H5V8F5H5V8_HUMAN
Probable peptide chain release fact...
C12orf65
36Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_037325134A → T. Corresponds to variant dbSNP:rs1045496Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02960295 – 119CHQTR…KVDVF → VDHRRPLRGEAPPKGSTASR DFSQV in isoform 2. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_029603120 – 166Missing in isoform 2. 1 PublicationAdd BLAST47

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF061733 mRNA Translation: AAG43144.1
AK095982 mRNA Translation: BAC04665.1
CH471054 Genomic DNA Translation: EAW98395.1
CH471054 Genomic DNA Translation: EAW98396.1
BC018145 mRNA Translation: AAH18145.1
BC020885 mRNA Translation: AAH20885.1
BC062329 mRNA Translation: AAH62329.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9244.1 [Q9H3J6-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001137377.1, NM_001143905.2 [Q9H3J6-1]
NP_001181924.1, NM_001194995.1 [Q9H3J6-1]
NP_689482.1, NM_152269.4 [Q9H3J6-1]
XP_005253687.1, XM_005253630.4 [Q9H3J6-1]
XP_011537282.1, XM_011538980.2 [Q9H3J6-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.319128

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000253233; ENSP00000253233; ENSG00000130921 [Q9H3J6-1]
ENST00000366329; ENSP00000390647; ENSG00000130921 [Q9H3J6-1]
ENST00000429587; ENSP00000391513; ENSG00000130921 [Q9H3J6-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
91574

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:91574

UCSC genome browser

More...
UCSCi
uc001uen.4 human [Q9H3J6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061733 mRNA Translation: AAG43144.1
AK095982 mRNA Translation: BAC04665.1
CH471054 Genomic DNA Translation: EAW98395.1
CH471054 Genomic DNA Translation: EAW98396.1
BC018145 mRNA Translation: AAH18145.1
BC020885 mRNA Translation: AAH20885.1
BC062329 mRNA Translation: AAH62329.1
CCDSiCCDS9244.1 [Q9H3J6-1]
RefSeqiNP_001137377.1, NM_001143905.2 [Q9H3J6-1]
NP_001181924.1, NM_001194995.1 [Q9H3J6-1]
NP_689482.1, NM_152269.4 [Q9H3J6-1]
XP_005253687.1, XM_005253630.4 [Q9H3J6-1]
XP_011537282.1, XM_011538980.2 [Q9H3J6-1]
UniGeneiHs.319128

3D structure databases

ProteinModelPortaliQ9H3J6
SMRiQ9H3J6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124847, 3 interactors
IntActiQ9H3J6, 1 interactor
STRINGi9606.ENSP00000253233

PTM databases

GlyConnecti1629
iPTMnetiQ9H3J6
PhosphoSitePlusiQ9H3J6

Polymorphism and mutation databases

BioMutaiC12orf65
DMDMi74733574

Proteomic databases

EPDiQ9H3J6
MaxQBiQ9H3J6
PaxDbiQ9H3J6
PeptideAtlasiQ9H3J6
PRIDEiQ9H3J6
ProteomicsDBi80723
80724 [Q9H3J6-2]
TopDownProteomicsiQ9H3J6-1 [Q9H3J6-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
91574
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000253233; ENSP00000253233; ENSG00000130921 [Q9H3J6-1]
ENST00000366329; ENSP00000390647; ENSG00000130921 [Q9H3J6-1]
ENST00000429587; ENSP00000391513; ENSG00000130921 [Q9H3J6-1]
GeneIDi91574
KEGGihsa:91574
UCSCiuc001uen.4 human [Q9H3J6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
91574
DisGeNETi91574
EuPathDBiHostDB:ENSG00000130921.7

GeneCards: human genes, protein and diseases

More...
GeneCardsi
C12orf65
HGNCiHGNC:26784 C12orf65
HPAiHPA038194
HPA057595
MalaCardsiC12orf65
MIMi613541 gene
613559 phenotype
615035 phenotype
neXtProtiNX_Q9H3J6
OpenTargetsiENSG00000130921
Orphaneti320375 Autosomal recessive spastic paraplegia type 55
254930 Combined oxidative phosphorylation defect type 7
PharmGKBiPA162377963

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2726 Eukaryota
COG0216 LUCA
GeneTreeiENSGT00390000012759
HOGENOMiHOG000217812
HOVERGENiHBG094928
InParanoidiQ9H3J6
OMAiWESSKNV
OrthoDBiEOG091G0YON
PhylomeDBiQ9H3J6
TreeFamiTF323274

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
C12orf65 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
91574

Protein Ontology

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PROi
PR:Q9H3J6

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000130921 Expressed in 202 organ(s), highest expression level in thymus
CleanExiHS_C12orf65
ExpressionAtlasiQ9H3J6 baseline and differential
GenevisibleiQ9H3J6 HS

Family and domain databases

InterProiView protein in InterPro
IPR000352 Pep_chain_release_fac_I_II
PfamiView protein in Pfam
PF00472 RF-1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCL065_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H3J6
Secondary accession number(s): Q8WUC6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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