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Entry version 157 (17 Jun 2020)
Sequence version 1 (01 Mar 2001)
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Protein

tRNA dimethylallyltransferase

Gene

TRIT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i6A).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri395 – 425Matrin-typeAdd BLAST31

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processtRNA processing
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.5.1.75 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6782315 tRNA modification in the nucleus and cytosol
R-HSA-6787450 tRNA modification in the mitochondrion

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
tRNA dimethylallyltransferase (EC:2.5.1.751 Publication)
Alternative name(s):
Isopentenyl-diphosphate:tRNA isopentenyltransferase
Short name:
IPP transferase
Short name:
IPPT
hGRO1
tRNA isopentenyltransferase 1
Short name:
IPTase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRIT1
Synonyms:IPT, MOD5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000043514.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20286 TRIT1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617840 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H3H1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Combined oxidative phosphorylation deficiency 35 (COXPD35)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder caused by defective mitochondrial metabolism and deficiencies of mitochondrial respiratory enzyme complexes. Clinical manifestations include global developmental delay, intellectual disability, microcephaly, and early-onset seizures.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0807458 – 467Missing in COXPD35. 1 PublicationAdd BLAST460
Natural variantiVAR_080746283I → S in COXPD35; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs199622789EnsemblClinVar.1
Natural variantiVAR_080747286K → E in COXPD35; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1060505019EnsemblClinVar.1
Natural variantiVAR_080748323R → Q in COXPD35; reduced tRNA dimethylallyltransferase activity. 1 PublicationCorresponds to variant dbSNP:rs1047420796EnsemblClinVar.1
Natural variantiVAR_080749402 – 467Missing in COXPD35; unknown pathological significance. 1 PublicationAdd BLAST66
Natural variantiVAR_080750419H → P in COXPD35; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs566435653EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Primary mitochondrial disease

Organism-specific databases

DisGeNET

More...
DisGeNETi
54802

MalaCards human disease database

More...
MalaCardsi
TRIT1
MIMi617873 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000043514

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134943037

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9H3H1 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TRIT1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
56405066

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 47MitochondrionSequence analysisAdd BLAST47
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001902348 – 467tRNA dimethylallyltransferaseAdd BLAST420

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei443PhosphoserineCombined sources1
Modified residuei455PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9H3H1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9H3H1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9H3H1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H3H1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H3H1

PeptideAtlas

More...
PeptideAtlasi
Q9H3H1

PRoteomics IDEntifications database

More...
PRIDEi
Q9H3H1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
61872
80709 [Q9H3H1-1]
80710 [Q9H3H1-2]
80711 [Q9H3H1-3]
80712 [Q9H3H1-4]
80713 [Q9H3H1-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H3H1

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
Q9H3H1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H3H1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000043514 Expressed in oviduct epithelium and 222 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9H3H1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9H3H1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000043514 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei122Interaction with substrate tRNABy similarity1
Sitei206Interaction with substrate tRNABy similarity1

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
120161, 4 interactors

Protein interaction database and analysis system

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IntActi
Q9H3H1, 6 interactors

Molecular INTeraction database

More...
MINTi
Q9H3H1

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000321810

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9H3H1 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9H3H1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni32 – 37Substrate bindingBy similarity6
Regioni55 – 58Interaction with substrate tRNABy similarity4
Regioni183 – 187Interaction with substrate tRNABy similarity5
Regioni233 – 255Interaction with isopentenylpyrophosphate transferaseBy similarityAdd BLAST23
Regioni281 – 283Interaction with substrate tRNABy similarity3
Regioni313 – 331Interaction with substrate tRNABy similarityAdd BLAST19
Regioni323 – 330Interaction with substrate tRNABy similarity8

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the IPP transferase family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri395 – 425Matrin-typeAdd BLAST31

Keywords - Domaini

Transit peptide, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1384 Eukaryota
COG0324 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015214

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_032616_2_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H3H1

KEGG Orthology (KO)

More...
KOi
K00791

Identification of Orthologs from Complete Genome Data

More...
OMAi
PFTVTHF

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H3H1

TreeFam database of animal gene trees

More...
TreeFami
TF315069

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_00185 IPP_trans, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039657 Dimethylallyltransferase
IPR030666 IPP_transferase_euk
IPR018022 IPT
IPR003604 Matrin/U1-like-C_Znf_C2H2
IPR027417 P-loop_NTPase
IPR022755 Znf_C2H2_jaz
IPR036236 Znf_C2H2_sf

The PANTHER Classification System

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PANTHERi
PTHR11088 PTHR11088, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01715 IPPT, 1 hit
PF12171 zf-C2H2_jaz, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF039110 IPP_transferase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00451 ZnF_U1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit
SSF57667 SSF57667, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00174 miaA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H3H1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASVAAARAV PVGSGLRGLQ RTLPLVVILG ATGTGKSTLA LQLGQRLGGE
60 70 80 90 100
IVSADSMQVY EGLDIITNKV SAQEQRICRH HMISFVDPLV TNYTVVDFRN
110 120 130 140 150
RATALIEDIF ARDKIPIVVG GTNYYIESLL WKVLVNTKPQ EMGTEKVIDR
160 170 180 190 200
KVELEKEDGL VLHKRLSQVD PEMAAKLHPH DKRKVARSLQ VFEETGISHS
210 220 230 240 250
EFLHRQHTEE GGGPLGGPLK FSNPCILWLH ADQAVLDERL DKRVDDMLAA
260 270 280 290 300
GLLEELRDFH RRYNQKNVSE NSQDYQHGIF QSIGFKEFHE YLITEGKCTL
310 320 330 340 350
ETSNQLLKKG IEALKQVTKR YARKQNRWVK NRFLSRPGPI VPPVYGLEVS
360 370 380 390 400
DVSKWEESVL EPALEIVQSF IQGHKPTATP IKMPYNEAEN KRSYHLCDLC
410 420 430 440 450
DRIIIGDREW AAHIKSKSHL NQLKKRRRLD SDAVNTIESQ SVSPDHNKEP
460
KEKGSPGQND QELKCSV
Length:467
Mass (Da):52,725
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i634469919D7F56A5
GO
Isoform 2 (identifier: Q9H3H1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-141: Missing.

Show »
Length:326
Mass (Da):37,435
Checksum:iEAB3F0F9664B7ACE
GO
Isoform 3 (identifier: Q9H3H1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-141: Missing.
     235-236: Missing.

Show »
Length:324
Mass (Da):37,223
Checksum:i1E6835D7C09126A9
GO
Isoform 4 (identifier: Q9H3H1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     311-336: Missing.

Show »
Length:441
Mass (Da):49,453
Checksum:i28DB69A67BD6C4B8
GO
Isoform 5 (identifier: Q9H3H1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     59-138: Missing.
     235-236: Missing.

Show »
Length:385
Mass (Da):43,305
Checksum:iD1282514B2CDCF8A
GO
Isoform 6 (identifier: Q9H3H1-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-5: MASVA → MFRKI
     6-309: Missing.

Show »
Length:163
Mass (Da):18,758
Checksum:iF66F2BFD015B21F5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3T7B4Q3T7B4_HUMAN
tRNA dimethylallyltransferase
TRIT1
85Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R2Z0S4R2Z0_HUMAN
tRNA dimethylallyltransferase
TRIT1
349Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DK89B4DK89_HUMAN
cDNA FLJ60623, highly similar to tR...
TRIT1
143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R2X1S4R2X1_HUMAN
tRNA dimethylallyltransferase
TRIT1
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R3U8S4R3U8_HUMAN
tRNA dimethylallyltransferase
TRIT1
170Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R3C5S4R3C5_HUMAN
tRNA dimethylallyltransferase
TRIT1
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R3F4S4R3F4_HUMAN
tRNA dimethylallyltransferase
TRIT1
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ITK2A0A3B3ITK2_HUMAN
tRNA dimethylallyltransferase
TRIT1
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti303S → G in CAG33507 (Ref. 5) Curated1
Sequence conflicti446H → Y in AAL14107 (PubMed:11560893).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0807458 – 467Missing in COXPD35. 1 PublicationAdd BLAST460
Natural variantiVAR_020486202F → L1 PublicationCorresponds to variant dbSNP:rs3738671Ensembl.1
Natural variantiVAR_080746283I → S in COXPD35; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs199622789EnsemblClinVar.1
Natural variantiVAR_080747286K → E in COXPD35; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1060505019EnsemblClinVar.1
Natural variantiVAR_080748323R → Q in COXPD35; reduced tRNA dimethylallyltransferase activity. 1 PublicationCorresponds to variant dbSNP:rs1047420796EnsemblClinVar.1
Natural variantiVAR_080749402 – 467Missing in COXPD35; unknown pathological significance. 1 PublicationAdd BLAST66
Natural variantiVAR_080750419H → P in COXPD35; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs566435653EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0107191 – 141Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST141
Alternative sequenceiVSP_0537461 – 5MASVA → MFRKI in isoform 6. 1 Publication5
Alternative sequenceiVSP_0537476 – 309Missing in isoform 6. 1 PublicationAdd BLAST304
Alternative sequenceiVSP_01241559 – 138Missing in isoform 5. 1 PublicationAdd BLAST80
Alternative sequenceiVSP_010720235 – 236Missing in isoform 3 and isoform 5. 2 Publications2
Alternative sequenceiVSP_010721311 – 336Missing in isoform 4. 1 PublicationAdd BLAST26

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF074918 Transcribed RNA Translation: AAG31324.1
AY702944 mRNA Translation: AAW63405.1
AY702945 mRNA Translation: AAW63406.1
AY303390 mRNA Translation: AAP60111.1
AK000068 mRNA Translation: BAA90923.1
CR457226 mRNA Translation: CAG33507.1
AL033527 Genomic DNA No translation available.
BC010741 mRNA Translation: AAH10741.2
BC107569 mRNA Translation: AAI07570.1
BC128155 mRNA Translation: AAI28156.1
AY052768 mRNA Translation: AAL14107.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS30681.1 [Q9H3H1-1]
CCDS81302.1 [Q9H3H1-5]
CCDS81303.1 [Q9H3H1-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001299620.1, NM_001312691.1 [Q9H3H1-4]
NP_001299621.1, NM_001312692.1 [Q9H3H1-5]
NP_060116.2, NM_017646.5 [Q9H3H1-1]
XP_006710769.1, XM_006710706.1 [Q9H3H1-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000316891; ENSP00000321810; ENSG00000043514 [Q9H3H1-1]
ENST00000372818; ENSP00000361905; ENSG00000043514 [Q9H3H1-4]
ENST00000441669; ENSP00000388333; ENSG00000043514 [Q9H3H1-5]
ENST00000537440; ENSP00000437700; ENSG00000043514 [Q9H3H1-6]

Database of genes from NCBI RefSeq genomes

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GeneIDi
54802

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:54802

UCSC genome browser

More...
UCSCi
uc001cem.5 human [Q9H3H1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF074918 Transcribed RNA Translation: AAG31324.1
AY702944 mRNA Translation: AAW63405.1
AY702945 mRNA Translation: AAW63406.1
AY303390 mRNA Translation: AAP60111.1
AK000068 mRNA Translation: BAA90923.1
CR457226 mRNA Translation: CAG33507.1
AL033527 Genomic DNA No translation available.
BC010741 mRNA Translation: AAH10741.2
BC107569 mRNA Translation: AAI07570.1
BC128155 mRNA Translation: AAI28156.1
AY052768 mRNA Translation: AAL14107.1
CCDSiCCDS30681.1 [Q9H3H1-1]
CCDS81302.1 [Q9H3H1-5]
CCDS81303.1 [Q9H3H1-4]
RefSeqiNP_001299620.1, NM_001312691.1 [Q9H3H1-4]
NP_001299621.1, NM_001312692.1 [Q9H3H1-5]
NP_060116.2, NM_017646.5 [Q9H3H1-1]
XP_006710769.1, XM_006710706.1 [Q9H3H1-2]

3D structure databases

SMRiQ9H3H1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120161, 4 interactors
IntActiQ9H3H1, 6 interactors
MINTiQ9H3H1
STRINGi9606.ENSP00000321810

PTM databases

iPTMnetiQ9H3H1
MetOSiteiQ9H3H1
PhosphoSitePlusiQ9H3H1

Polymorphism and mutation databases

BioMutaiTRIT1
DMDMi56405066

Proteomic databases

EPDiQ9H3H1
jPOSTiQ9H3H1
MassIVEiQ9H3H1
MaxQBiQ9H3H1
PaxDbiQ9H3H1
PeptideAtlasiQ9H3H1
PRIDEiQ9H3H1
ProteomicsDBi61872
80709 [Q9H3H1-1]
80710 [Q9H3H1-2]
80711 [Q9H3H1-3]
80712 [Q9H3H1-4]
80713 [Q9H3H1-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
17887 132 antibodies

The DNASU plasmid repository

More...
DNASUi
54802

Genome annotation databases

EnsembliENST00000316891; ENSP00000321810; ENSG00000043514 [Q9H3H1-1]
ENST00000372818; ENSP00000361905; ENSG00000043514 [Q9H3H1-4]
ENST00000441669; ENSP00000388333; ENSG00000043514 [Q9H3H1-5]
ENST00000537440; ENSP00000437700; ENSG00000043514 [Q9H3H1-6]
GeneIDi54802
KEGGihsa:54802
UCSCiuc001cem.5 human [Q9H3H1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54802
DisGeNETi54802
EuPathDBiHostDB:ENSG00000043514.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TRIT1
HGNCiHGNC:20286 TRIT1
HPAiENSG00000043514 Low tissue specificity
MalaCardsiTRIT1
MIMi617840 gene
617873 phenotype
neXtProtiNX_Q9H3H1
OpenTargetsiENSG00000043514
PharmGKBiPA134943037

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1384 Eukaryota
COG0324 LUCA
GeneTreeiENSGT00390000015214
HOGENOMiCLU_032616_2_2_1
InParanoidiQ9H3H1
KOiK00791
OMAiPFTVTHF
PhylomeDBiQ9H3H1
TreeFamiTF315069

Enzyme and pathway databases

BRENDAi2.5.1.75 2681
ReactomeiR-HSA-6782315 tRNA modification in the nucleus and cytosol
R-HSA-6787450 tRNA modification in the mitochondrion

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
54802 160 hits in 787 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TRIT1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TRIT1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
54802
PharosiQ9H3H1 Tbio

Protein Ontology

More...
PROi
PR:Q9H3H1
RNActiQ9H3H1 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000043514 Expressed in oviduct epithelium and 222 other tissues
ExpressionAtlasiQ9H3H1 baseline and differential
GenevisibleiQ9H3H1 HS

Family and domain databases

HAMAPiMF_00185 IPP_trans, 1 hit
InterProiView protein in InterPro
IPR039657 Dimethylallyltransferase
IPR030666 IPP_transferase_euk
IPR018022 IPT
IPR003604 Matrin/U1-like-C_Znf_C2H2
IPR027417 P-loop_NTPase
IPR022755 Znf_C2H2_jaz
IPR036236 Znf_C2H2_sf
PANTHERiPTHR11088 PTHR11088, 1 hit
PfamiView protein in Pfam
PF01715 IPPT, 1 hit
PF12171 zf-C2H2_jaz, 1 hit
PIRSFiPIRSF039110 IPP_transferase, 1 hit
SMARTiView protein in SMART
SM00451 ZnF_U1, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF57667 SSF57667, 1 hit
TIGRFAMsiTIGR00174 miaA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMOD5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H3H1
Secondary accession number(s): A1A4X7
, Q3T7B5, Q5QPK5, Q5QPK6, Q6IAC9, Q96FJ3, Q96L45, Q9NXT7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: March 1, 2001
Last modified: June 17, 2020
This is version 157 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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