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Protein

Probable serine carboxypeptidase CPVL

Gene

CPVL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei204PROSITE-ProRule annotation1
Active sitei388PROSITE-ProRule annotation1
Active sitei448PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • serine-type carboxypeptidase activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Protease

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

More...
ESTHERi
human-CPVL Carboxypeptidase_S10

MEROPS protease database

More...
MEROPSi
S10.003

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable serine carboxypeptidase CPVL (EC:3.4.16.-)
Alternative name(s):
Carboxypeptidase, vitellogenic-like
Vitellogenic carboxypeptidase-like protein
Short name:
VCP-like protein
Short name:
hVLP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CPVL
Synonyms:VLP
ORF Names:PSEC0124, UNQ197/PRO223
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000106066.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14399 CPVL

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609780 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H3G5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
54504

Open Targets

More...
OpenTargetsi
ENSG00000106066

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26850

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CPVL

Domain mapping of disease mutations (DMDM)

More...
DMDMi
67476930

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000004281? – 476Probable serine carboxypeptidase CPVL
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000000428023 – ?Sequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi81N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi132N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi307N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi346N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein, Zymogen

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9H3G5

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9H3G5

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9H3G5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H3G5

PeptideAtlas

More...
PeptideAtlasi
Q9H3G5

PRoteomics IDEntifications database

More...
PRIDEi
Q9H3G5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
80708

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1630

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H3G5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H3G5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in macrophages but not in other leukocytes. Abundantly expressed in heart and kidney. Also expressed in spleen, leukocytes, and placenta.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000106066 Expressed in 209 organ(s), highest expression level in leukocyte

CleanEx database of gene expression profiles

More...
CleanExi
HS_CPVL

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9H3G5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H3G5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB003697
HPA045715
HPA056466

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120000, 57 interactors

Protein interaction database and analysis system

More...
IntActi
Q9H3G5, 26 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000265394

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9H3G5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9H3G5

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1282 Eukaryota
COG2939 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000159498

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000252949

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG010805

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9H3G5

KEGG Orthology (KO)

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KOi
K09645

Identification of Orthologs from Complete Genome Data

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OMAi
TWSKTHN

Database of Orthologous Groups

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OrthoDBi
625787at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H3G5

TreeFam database of animal gene trees

More...
TreeFami
TF354323

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.1820, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR029058 AB_hydrolase
IPR001563 Peptidase_S10
IPR018202 Ser_caboxypep_ser_AS

The PANTHER Classification System

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PANTHERi
PTHR11802 PTHR11802, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00450 Peptidase_S10, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00724 CRBOXYPTASEC

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53474 SSF53474, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00131 CARBOXYPEPT_SER_SER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

Q9H3G5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVGAMWKVIV SLVLLMPGPC DGLFRSLYRS VSMPPKGDSG QPLFLTPYIE
60 70 80 90 100
AGKIQKGREL SLVGPFPGLN MKSYAGFLTV NKTYNSNLFF WFFPAQIQPE
110 120 130 140 150
DAPVVLWLQG GPGGSSMFGL FVEHGPYVVT SNMTLRDRDF PWTTTLSMLY
160 170 180 190 200
IDNPVGTGFS FTDDTHGYAV NEDDVARDLY SALIQFFQIF PEYKNNDFYV
210 220 230 240 250
TGESYAGKYV PAIAHLIHSL NPVREVKINL NGIAIGDGYS DPESIIGGYA
260 270 280 290 300
EFLYQIGLLD EKQKKYFQKQ CHECIEHIRK QNWFEAFEIL DKLLDGDLTS
310 320 330 340 350
DPSYFQNVTG CSNYYNFLRC TEPEDQLYYV KFLSLPEVRQ AIHVGNQTFN
360 370 380 390 400
DGTIVEKYLR EDTVQSVKPW LTEIMNNYKV LIYNGQLDII VAAALTERSL
410 420 430 440 450
MGMDWKGSQE YKKAEKKVWK IFKSDSEVAG YIRQAGDFHQ VIIRGGGHIL
460 470
PYDQPLRAFD MINRFIYGKG WDPYVG
Length:476
Mass (Da):54,164
Last modified:June 7, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i33AA4A7360BF01E1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JLV0C9JLV0_HUMAN
Carboxypeptidase
CPVL
244Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J6L4C9J6L4_HUMAN
Carboxypeptidase
CPVL
100Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JI22C9JI22_HUMAN
Carboxypeptidase
CPVL
141Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C218H7C218_HUMAN
Probable serine carboxypeptidase CP...
CPVL
141Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C0X5H7C0X5_HUMAN
Probable serine carboxypeptidase CP...
CPVL
180Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JZ94C9JZ94_HUMAN
Probable serine carboxypeptidase CP...
CPVL
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JVI2C9JVI2_HUMAN
Probable serine carboxypeptidase CP...
CPVL
43Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti284F → L in AAG37991 (PubMed:11401439).Curated1
Sequence conflicti284F → L in AAG14348 (Ref. 2) Curated1
Sequence conflicti287F → L in BAC11618 (PubMed:16303743).Curated1
Sequence conflicti422F → L in AAG14348 (Ref. 2) Curated1
Sequence conflicti438F → S in AAG14348 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04868111S → L. Corresponds to variant dbSNP:rs36074676Ensembl.1
Natural variantiVAR_04868225R → H1 PublicationCorresponds to variant dbSNP:rs34219043Ensembl.1
Natural variantiVAR_048683398R → H2 PublicationsCorresponds to variant dbSNP:rs1052200Ensembl.1
Natural variantiVAR_022612435A → V2 PublicationsCorresponds to variant dbSNP:rs7313Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF106704 mRNA Translation: AAG37991.2
AF282617 mRNA Translation: AAG14348.1
AY358549 mRNA Translation: AAQ88913.1
AK075433 mRNA Translation: BAC11618.1
CH236948 Genomic DNA Translation: EAL24207.1
CH471073 Genomic DNA Translation: EAW93914.1
BC016838 mRNA Translation: AAH16838.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5419.1

NCBI Reference Sequences

More...
RefSeqi
NP_001334981.1, NM_001348052.1
NP_001334983.1, NM_001348054.1
NP_061902.2, NM_019029.3
NP_112601.3, NM_031311.4
XP_011513739.1, XM_011515437.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.233389

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000265394; ENSP00000265394; ENSG00000106066
ENST00000396276; ENSP00000379572; ENSG00000106066
ENST00000409850; ENSP00000387164; ENSG00000106066

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54504

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54504

UCSC genome browser

More...
UCSCi
uc003szv.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF106704 mRNA Translation: AAG37991.2
AF282617 mRNA Translation: AAG14348.1
AY358549 mRNA Translation: AAQ88913.1
AK075433 mRNA Translation: BAC11618.1
CH236948 Genomic DNA Translation: EAL24207.1
CH471073 Genomic DNA Translation: EAW93914.1
BC016838 mRNA Translation: AAH16838.1
CCDSiCCDS5419.1
RefSeqiNP_001334981.1, NM_001348052.1
NP_001334983.1, NM_001348054.1
NP_061902.2, NM_019029.3
NP_112601.3, NM_031311.4
XP_011513739.1, XM_011515437.1
UniGeneiHs.233389

3D structure databases

ProteinModelPortaliQ9H3G5
SMRiQ9H3G5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120000, 57 interactors
IntActiQ9H3G5, 26 interactors
STRINGi9606.ENSP00000265394

Protein family/group databases

ESTHERihuman-CPVL Carboxypeptidase_S10
MEROPSiS10.003

PTM databases

GlyConnecti1630
iPTMnetiQ9H3G5
PhosphoSitePlusiQ9H3G5

Polymorphism and mutation databases

BioMutaiCPVL
DMDMi67476930

Proteomic databases

EPDiQ9H3G5
jPOSTiQ9H3G5
MaxQBiQ9H3G5
PaxDbiQ9H3G5
PeptideAtlasiQ9H3G5
PRIDEiQ9H3G5
ProteomicsDBi80708

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
54504
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265394; ENSP00000265394; ENSG00000106066
ENST00000396276; ENSP00000379572; ENSG00000106066
ENST00000409850; ENSP00000387164; ENSG00000106066
GeneIDi54504
KEGGihsa:54504
UCSCiuc003szv.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
54504
DisGeNETi54504
EuPathDBiHostDB:ENSG00000106066.13

GeneCards: human genes, protein and diseases

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GeneCardsi
CPVL
HGNCiHGNC:14399 CPVL
HPAiCAB003697
HPA045715
HPA056466
MIMi609780 gene
neXtProtiNX_Q9H3G5
OpenTargetsiENSG00000106066
PharmGKBiPA26850

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1282 Eukaryota
COG2939 LUCA
GeneTreeiENSGT00940000159498
HOGENOMiHOG000252949
HOVERGENiHBG010805
InParanoidiQ9H3G5
KOiK09645
OMAiTWSKTHN
OrthoDBi625787at2759
PhylomeDBiQ9H3G5
TreeFamiTF354323

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CPVL human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CPVL

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
54504

Protein Ontology

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PROi
PR:Q9H3G5

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000106066 Expressed in 209 organ(s), highest expression level in leukocyte
CleanExiHS_CPVL
ExpressionAtlasiQ9H3G5 baseline and differential
GenevisibleiQ9H3G5 HS

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001563 Peptidase_S10
IPR018202 Ser_caboxypep_ser_AS
PANTHERiPTHR11802 PTHR11802, 1 hit
PfamiView protein in Pfam
PF00450 Peptidase_S10, 1 hit
PRINTSiPR00724 CRBOXYPTASEC
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00131 CARBOXYPEPT_SER_SER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCPVL_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H3G5
Secondary accession number(s): A4D1A4
, Q6UX20, Q8NBL7, Q96AR7, Q9HB41
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: June 7, 2005
Last modified: January 16, 2019
This is version 152 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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