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Protein

Probable serine carboxypeptidase CPVL

Gene

CPVL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei204PROSITE-ProRule annotation1
Active sitei388PROSITE-ProRule annotation1
Active sitei448PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Protease

Protein family/group databases

ESTHERihuman-CPVL Carboxypeptidase_S10
MEROPSiS10.003

Names & Taxonomyi

Protein namesi
Recommended name:
Probable serine carboxypeptidase CPVL (EC:3.4.16.-)
Alternative name(s):
Carboxypeptidase, vitellogenic-like
Vitellogenic carboxypeptidase-like protein
Short name:
VCP-like protein
Short name:
hVLP
Gene namesi
Name:CPVL
Synonyms:VLP
ORF Names:PSEC0124, UNQ197/PRO223
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000106066.13
HGNCiHGNC:14399 CPVL
MIMi609780 gene
neXtProtiNX_Q9H3G5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi54504
OpenTargetsiENSG00000106066
PharmGKBiPA26850

Polymorphism and mutation databases

BioMutaiCPVL
DMDMi67476930

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000004281? – 476Probable serine carboxypeptidase CPVL
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000000428023 – ?Sequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi81N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi132N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi307N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi346N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein, Zymogen

Proteomic databases

EPDiQ9H3G5
MaxQBiQ9H3G5
PaxDbiQ9H3G5
PeptideAtlasiQ9H3G5
PRIDEiQ9H3G5
ProteomicsDBi80708

PTM databases

GlyConnecti1630
iPTMnetiQ9H3G5
PhosphoSitePlusiQ9H3G5

Expressioni

Tissue specificityi

Expressed in macrophages but not in other leukocytes. Abundantly expressed in heart and kidney. Also expressed in spleen, leukocytes, and placenta.

Gene expression databases

BgeeiENSG00000106066 Expressed in 209 organ(s), highest expression level in leukocyte
CleanExiHS_CPVL
ExpressionAtlasiQ9H3G5 baseline and differential
GenevisibleiQ9H3G5 HS

Organism-specific databases

HPAiCAB003697
HPA045715
HPA056466

Interactioni

Protein-protein interaction databases

BioGridi120000, 51 interactors
IntActiQ9H3G5, 25 interactors
STRINGi9606.ENSP00000265394

Structurei

3D structure databases

ProteinModelPortaliQ9H3G5
SMRiQ9H3G5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1282 Eukaryota
COG2939 LUCA
GeneTreeiENSGT00880000137977
HOGENOMiHOG000252949
HOVERGENiHBG010805
InParanoidiQ9H3G5
KOiK09645
OMAiMDNALPR
OrthoDBiEOG091G08SS
PhylomeDBiQ9H3G5
TreeFamiTF354323

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001563 Peptidase_S10
IPR018202 Ser_caboxypep_ser_AS
PANTHERiPTHR11802 PTHR11802, 1 hit
PfamiView protein in Pfam
PF00450 Peptidase_S10, 1 hit
PRINTSiPR00724 CRBOXYPTASEC
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00131 CARBOXYPEPT_SER_SER, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

Q9H3G5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVGAMWKVIV SLVLLMPGPC DGLFRSLYRS VSMPPKGDSG QPLFLTPYIE
60 70 80 90 100
AGKIQKGREL SLVGPFPGLN MKSYAGFLTV NKTYNSNLFF WFFPAQIQPE
110 120 130 140 150
DAPVVLWLQG GPGGSSMFGL FVEHGPYVVT SNMTLRDRDF PWTTTLSMLY
160 170 180 190 200
IDNPVGTGFS FTDDTHGYAV NEDDVARDLY SALIQFFQIF PEYKNNDFYV
210 220 230 240 250
TGESYAGKYV PAIAHLIHSL NPVREVKINL NGIAIGDGYS DPESIIGGYA
260 270 280 290 300
EFLYQIGLLD EKQKKYFQKQ CHECIEHIRK QNWFEAFEIL DKLLDGDLTS
310 320 330 340 350
DPSYFQNVTG CSNYYNFLRC TEPEDQLYYV KFLSLPEVRQ AIHVGNQTFN
360 370 380 390 400
DGTIVEKYLR EDTVQSVKPW LTEIMNNYKV LIYNGQLDII VAAALTERSL
410 420 430 440 450
MGMDWKGSQE YKKAEKKVWK IFKSDSEVAG YIRQAGDFHQ VIIRGGGHIL
460 470
PYDQPLRAFD MINRFIYGKG WDPYVG
Length:476
Mass (Da):54,164
Last modified:June 7, 2005 - v2
Checksum:i33AA4A7360BF01E1
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JLV0C9JLV0_HUMAN
Carboxypeptidase
CPVL
244Annotation score:
C9J6L4C9J6L4_HUMAN
Carboxypeptidase
CPVL
100Annotation score:
C9JI22C9JI22_HUMAN
Carboxypeptidase
CPVL
141Annotation score:
H7C218H7C218_HUMAN
Probable serine carboxypeptidase CP...
CPVL
141Annotation score:
H7C0X5H7C0X5_HUMAN
Probable serine carboxypeptidase CP...
CPVL
180Annotation score:
C9JZ94C9JZ94_HUMAN
Probable serine carboxypeptidase CP...
CPVL
52Annotation score:
C9JVI2C9JVI2_HUMAN
Probable serine carboxypeptidase CP...
CPVL
43Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti284F → L in AAG37991 (PubMed:11401439).Curated1
Sequence conflicti284F → L in AAG14348 (Ref. 2) Curated1
Sequence conflicti287F → L in BAC11618 (PubMed:16303743).Curated1
Sequence conflicti422F → L in AAG14348 (Ref. 2) Curated1
Sequence conflicti438F → S in AAG14348 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04868111S → L. Corresponds to variant dbSNP:rs36074676Ensembl.1
Natural variantiVAR_04868225R → H1 PublicationCorresponds to variant dbSNP:rs34219043Ensembl.1
Natural variantiVAR_048683398R → H2 PublicationsCorresponds to variant dbSNP:rs1052200Ensembl.1
Natural variantiVAR_022612435A → V2 PublicationsCorresponds to variant dbSNP:rs7313Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF106704 mRNA Translation: AAG37991.2
AF282617 mRNA Translation: AAG14348.1
AY358549 mRNA Translation: AAQ88913.1
AK075433 mRNA Translation: BAC11618.1
CH236948 Genomic DNA Translation: EAL24207.1
CH471073 Genomic DNA Translation: EAW93914.1
BC016838 mRNA Translation: AAH16838.1
CCDSiCCDS5419.1
RefSeqiNP_001334981.1, NM_001348052.1
NP_001334983.1, NM_001348054.1
NP_061902.2, NM_019029.3
NP_112601.3, NM_031311.4
XP_011513739.1, XM_011515437.1
UniGeneiHs.233389

Genome annotation databases

EnsembliENST00000265394; ENSP00000265394; ENSG00000106066
ENST00000396276; ENSP00000379572; ENSG00000106066
ENST00000409850; ENSP00000387164; ENSG00000106066
GeneIDi54504
KEGGihsa:54504
UCSCiuc003szv.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF106704 mRNA Translation: AAG37991.2
AF282617 mRNA Translation: AAG14348.1
AY358549 mRNA Translation: AAQ88913.1
AK075433 mRNA Translation: BAC11618.1
CH236948 Genomic DNA Translation: EAL24207.1
CH471073 Genomic DNA Translation: EAW93914.1
BC016838 mRNA Translation: AAH16838.1
CCDSiCCDS5419.1
RefSeqiNP_001334981.1, NM_001348052.1
NP_001334983.1, NM_001348054.1
NP_061902.2, NM_019029.3
NP_112601.3, NM_031311.4
XP_011513739.1, XM_011515437.1
UniGeneiHs.233389

3D structure databases

ProteinModelPortaliQ9H3G5
SMRiQ9H3G5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120000, 51 interactors
IntActiQ9H3G5, 25 interactors
STRINGi9606.ENSP00000265394

Protein family/group databases

ESTHERihuman-CPVL Carboxypeptidase_S10
MEROPSiS10.003

PTM databases

GlyConnecti1630
iPTMnetiQ9H3G5
PhosphoSitePlusiQ9H3G5

Polymorphism and mutation databases

BioMutaiCPVL
DMDMi67476930

Proteomic databases

EPDiQ9H3G5
MaxQBiQ9H3G5
PaxDbiQ9H3G5
PeptideAtlasiQ9H3G5
PRIDEiQ9H3G5
ProteomicsDBi80708

Protocols and materials databases

DNASUi54504
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265394; ENSP00000265394; ENSG00000106066
ENST00000396276; ENSP00000379572; ENSG00000106066
ENST00000409850; ENSP00000387164; ENSG00000106066
GeneIDi54504
KEGGihsa:54504
UCSCiuc003szv.4 human

Organism-specific databases

CTDi54504
DisGeNETi54504
EuPathDBiHostDB:ENSG00000106066.13
GeneCardsiCPVL
HGNCiHGNC:14399 CPVL
HPAiCAB003697
HPA045715
HPA056466
MIMi609780 gene
neXtProtiNX_Q9H3G5
OpenTargetsiENSG00000106066
PharmGKBiPA26850
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1282 Eukaryota
COG2939 LUCA
GeneTreeiENSGT00880000137977
HOGENOMiHOG000252949
HOVERGENiHBG010805
InParanoidiQ9H3G5
KOiK09645
OMAiMDNALPR
OrthoDBiEOG091G08SS
PhylomeDBiQ9H3G5
TreeFamiTF354323

Miscellaneous databases

ChiTaRSiCPVL human
GeneWikiiCPVL
GenomeRNAii54504
PROiPR:Q9H3G5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000106066 Expressed in 209 organ(s), highest expression level in leukocyte
CleanExiHS_CPVL
ExpressionAtlasiQ9H3G5 baseline and differential
GenevisibleiQ9H3G5 HS

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001563 Peptidase_S10
IPR018202 Ser_caboxypep_ser_AS
PANTHERiPTHR11802 PTHR11802, 1 hit
PfamiView protein in Pfam
PF00450 Peptidase_S10, 1 hit
PRINTSiPR00724 CRBOXYPTASEC
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00131 CARBOXYPEPT_SER_SER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCPVL_HUMAN
AccessioniPrimary (citable) accession number: Q9H3G5
Secondary accession number(s): A4D1A4
, Q6UX20, Q8NBL7, Q96AR7, Q9HB41
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: June 7, 2005
Last modified: October 10, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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