Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

Gene

KCTD10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(BACURD3) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

  • Notch binding Source: MGI

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 31 Publication
Short name:
hBACURD31 Publication
Alternative name(s):
BTB/POZ domain-containing protein KCTD10
Potassium channel tetramerization domain-containing protein 10
Gene namesi
Name:KCTD10
Synonyms:ULR061
ORF Names:MSTP028
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000110906.12
HGNCiHGNC:23236 KCTD10
MIMi613421 gene
neXtProtiNX_Q9H3F6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi83892
OpenTargetsiENSG00000110906
PharmGKBiPA134938409

Polymorphism and mutation databases

BioMutaiKCTD10
DMDMi74733570

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002474211 – 313BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3Add BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei23PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9H3F6
MaxQBiQ9H3F6
PaxDbiQ9H3F6
PeptideAtlasiQ9H3F6
PRIDEiQ9H3F6
ProteomicsDBi80705
80706 [Q9H3F6-2]
80707 [Q9H3F6-3]

PTM databases

iPTMnetiQ9H3F6
PhosphoSitePlusiQ9H3F6

Expressioni

Gene expression databases

BgeeiENSG00000110906 Expressed in 202 organ(s), highest expression level in thoracic aorta
CleanExiHS_KCTD10
ExpressionAtlasiQ9H3F6 baseline and differential
GenevisibleiQ9H3F6 HS

Organism-specific databases

HPAiHPA014273

Interactioni

Subunit structurei

Homotetramer; forms a two-fold symmetric tetramer in solution (PubMed:28963344). Interacts with CUL3; interaction is direct and forms a 5:5 heterodecamer (PubMed:28963344). Component of the BCR(BACURD3) E3 ubiquitin ligase complex, at least composed of CUL3, KCTD10/BACURD3 and RBX1 (By similarity). Interacts with DNA polymerase delta subunit 2/POLD2 (By similarity). Interacts with PCNA (PubMed:19125419).By similarity2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi123803, 86 interactors
IntActiQ9H3F6, 26 interactors
STRINGi9606.ENSP00000228495

Structurei

Secondary structure

1313
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9H3F6
SMRiQ9H3F6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 100BTBPROSITE-ProRule annotationAdd BLAST69

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi239 – 245PCNA-bindingBy similarity7

Sequence similaritiesi

Belongs to the BACURD family.Curated

Phylogenomic databases

eggNOGiKOG2716 Eukaryota
ENOG410XQYZ LUCA
GeneTreeiENSGT00920000149007
HOGENOMiHOG000294088
HOVERGENiHBG052219
InParanoidiQ9H3F6
KOiK15074
OMAiQGLADEC
OrthoDBiEOG091G0L1Y
PhylomeDBiQ9H3F6
TreeFamiTF315649

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H3F6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEEMSGESVV SSAVPAAATR TTSFKGTSPS SKYVKLNVGG ALYYTTMQTL
60 70 80 90 100
TKQDTMLKAM FSGRMEVLTD SEGWILIDRC GKHFGTILNY LRDGAVPLPE
110 120 130 140 150
SRREIEELLA EAKYYLVQGL VEECQAALQN KDTYEPFCKV PVITSSKEEQ
160 170 180 190 200
KLIATSNKPA VKLLYNRSNN KYSYTSNSDD NMLKNIELFD KLSLRFNGRV
210 220 230 240 250
LFIKDVIGDE ICCWSFYGQG RKIAEVCCTS IVYATEKKQT KVEFPEARIY
260 270 280 290 300
EETLNILLYE AQDGRGPDNA LLEATGGAAG RSHHLDEDEE RERIERVRRI
310
HIKRPDDRAH LHQ
Length:313
Mass (Da):35,432
Last modified:March 1, 2001 - v1
Checksum:i199AF07A30D5BCA6
GO
Isoform 2 (identifier: Q9H3F6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     176-198: Missing.

Note: No experimental confirmation available.
Show »
Length:290
Mass (Da):32,779
Checksum:i44691C6FBB800C1D
GO
Isoform 3 (identifier: Q9H3F6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-158: Missing.
     159-175: PAVKLLYNRSNNKYSYT → MMAVFTSLWSPYQMLFC

Note: No experimental confirmation available.
Show »
Length:155
Mass (Da):17,985
Checksum:i1CD49234B8678D7C
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5GWA4F5GWA4_HUMAN
BTB/POZ domain-containing adapter f...
KCTD10
287Annotation score:
B3KVY5B3KVY5_HUMAN
BTB/POZ domain-containing adapter f...
KCTD10 hCG_40324
132Annotation score:
F5H268F5H268_HUMAN
BTB/POZ domain-containing adapter f...
KCTD10
121Annotation score:
F5GWK6F5GWK6_HUMAN
BTB/POZ domain-containing adapter f...
KCTD10
120Annotation score:
F5H497F5H497_HUMAN
BTB/POZ domain-containing adapter f...
KCTD10
175Annotation score:
F5H6V0F5H6V0_HUMAN
BTB/POZ domain-containing adapter f...
KCTD10
170Annotation score:
F8W8I7F8W8I7_HUMAN
BTB/POZ domain-containing adapter f...
KCTD10
77Annotation score:
F5GY15F5GY15_HUMAN
BTB/POZ domain-containing adapter f...
KCTD10
104Annotation score:
S4R3L9S4R3L9_HUMAN
BTB/POZ domain-containing adapter f...
KCTD10
64Annotation score:
S4R3Y7S4R3Y7_HUMAN
BTB/POZ domain-containing adapter f...
KCTD10
37Annotation score:

Sequence cautioni

The sequence BAB55188 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAD92595 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1M → V in BAB55188 (PubMed:14702039).Curated1
Sequence conflicti68L → P in AAT09002 (Ref. 3) Curated1
Sequence conflicti170N → T in BAD96268 (Ref. 6) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0199781 – 158Missing in isoform 3. 1 PublicationAdd BLAST158
Alternative sequenceiVSP_019979159 – 175PAVKL…KYSYT → MMAVFTSLWSPYQMLFC in isoform 3. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_019980176 – 198Missing in isoform 2. 1 PublicationAdd BLAST23

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY205299 mRNA Translation: AAO47716.1
AF113208 mRNA Translation: AAG39279.1
AY597809 mRNA Translation: AAT09002.1
AK027543 mRNA Translation: BAB55188.1 Different initiation.
AB209358 mRNA Translation: BAD92595.1 Different initiation.
AK222548 mRNA Translation: BAD96268.1
AC007570 Genomic DNA No translation available.
BC040062 mRNA Translation: AAH40062.1
CCDSiCCDS9128.1 [Q9H3F6-1]
RefSeqiNP_001304324.1, NM_001317395.1
NP_001304328.1, NM_001317399.1 [Q9H3F6-2]
NP_114160.1, NM_031954.4 [Q9H3F6-1]
UniGeneiHs.524731

Genome annotation databases

EnsembliENST00000228495; ENSP00000228495; ENSG00000110906 [Q9H3F6-1]
GeneIDi83892
KEGGihsa:83892
UCSCiuc001toi.2 human [Q9H3F6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY205299 mRNA Translation: AAO47716.1
AF113208 mRNA Translation: AAG39279.1
AY597809 mRNA Translation: AAT09002.1
AK027543 mRNA Translation: BAB55188.1 Different initiation.
AB209358 mRNA Translation: BAD92595.1 Different initiation.
AK222548 mRNA Translation: BAD96268.1
AC007570 Genomic DNA No translation available.
BC040062 mRNA Translation: AAH40062.1
CCDSiCCDS9128.1 [Q9H3F6-1]
RefSeqiNP_001304324.1, NM_001317395.1
NP_001304328.1, NM_001317399.1 [Q9H3F6-2]
NP_114160.1, NM_031954.4 [Q9H3F6-1]
UniGeneiHs.524731

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5FTAX-ray2.64A/B/C/D26-135[»]
ProteinModelPortaliQ9H3F6
SMRiQ9H3F6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123803, 86 interactors
IntActiQ9H3F6, 26 interactors
STRINGi9606.ENSP00000228495

PTM databases

iPTMnetiQ9H3F6
PhosphoSitePlusiQ9H3F6

Polymorphism and mutation databases

BioMutaiKCTD10
DMDMi74733570

Proteomic databases

EPDiQ9H3F6
MaxQBiQ9H3F6
PaxDbiQ9H3F6
PeptideAtlasiQ9H3F6
PRIDEiQ9H3F6
ProteomicsDBi80705
80706 [Q9H3F6-2]
80707 [Q9H3F6-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000228495; ENSP00000228495; ENSG00000110906 [Q9H3F6-1]
GeneIDi83892
KEGGihsa:83892
UCSCiuc001toi.2 human [Q9H3F6-1]

Organism-specific databases

CTDi83892
DisGeNETi83892
EuPathDBiHostDB:ENSG00000110906.12
GeneCardsiKCTD10
HGNCiHGNC:23236 KCTD10
HPAiHPA014273
MIMi613421 gene
neXtProtiNX_Q9H3F6
OpenTargetsiENSG00000110906
PharmGKBiPA134938409
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2716 Eukaryota
ENOG410XQYZ LUCA
GeneTreeiENSGT00920000149007
HOGENOMiHOG000294088
HOVERGENiHBG052219
InParanoidiQ9H3F6
KOiK15074
OMAiQGLADEC
OrthoDBiEOG091G0L1Y
PhylomeDBiQ9H3F6
TreeFamiTF315649

Enzyme and pathway databases

UniPathwayi
UPA00143

Miscellaneous databases

ChiTaRSiKCTD10 human
GenomeRNAii83892
PROiPR:Q9H3F6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000110906 Expressed in 202 organ(s), highest expression level in thoracic aorta
CleanExiHS_KCTD10
ExpressionAtlasiQ9H3F6 baseline and differential
GenevisibleiQ9H3F6 HS

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBACD3_HUMAN
AccessioniPrimary (citable) accession number: Q9H3F6
Secondary accession number(s): Q53HN2
, Q59FV1, Q6PL47, Q96SU0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again