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Protein

Sorting nexin-25

Gene

SNX25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in several stages of intracellular trafficking.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-25
Gene namesi
Name:SNX25
ORF Names:MSTP043
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000109762.15
HGNCiHGNC:21883 SNX25
neXtProtiNX_Q9H3E2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi83891
OpenTargetsiENSG00000109762
PharmGKBiPA134988505

Polymorphism and mutation databases

BioMutaiSNX25
DMDMi212276473

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002138751 – 840Sorting nexin-25Add BLAST840

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei665PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H3E2
MaxQBiQ9H3E2
PaxDbiQ9H3E2
PeptideAtlasiQ9H3E2
PRIDEiQ9H3E2
ProteomicsDBi80704

PTM databases

iPTMnetiQ9H3E2
PhosphoSitePlusiQ9H3E2

Expressioni

Gene expression databases

BgeeiENSG00000109762 Expressed in 195 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_SNX25
ExpressionAtlasiQ9H3E2 baseline and differential
GenevisibleiQ9H3E2 HS

Organism-specific databases

HPAiHPA036928

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi123802, 6 interactors
IntActiQ9H3E2, 1 interactor
STRINGi9606.ENSP00000264694

Structurei

3D structure databases

ProteinModelPortaliQ9H3E2
SMRiQ9H3E2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 164PXAPROSITE-ProRule annotationAdd BLAST164
Domaini287 – 401RGSPROSITE-ProRule annotationAdd BLAST115
Domaini508 – 628PXPROSITE-ProRule annotationAdd BLAST121

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili434 – 499Sequence analysisAdd BLAST66

Sequence similaritiesi

Belongs to the sorting nexin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2101 Eukaryota
ENOG410XQM8 LUCA
GeneTreeiENSGT00800000124081
HOGENOMiHOG000047059
HOVERGENiHBG066560
InParanoidiQ9H3E2
KOiK17887
OMAiYTYAPSY
OrthoDBiEOG091G049K
PhylomeDBiQ9H3E2
TreeFamiTF324055

Family and domain databases

CDDicd06878 PX_SNX25, 1 hit
Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR001683 Phox
IPR003114 Phox_assoc
IPR036871 PX_dom_sf
IPR016137 RGS
IPR036305 RGS_sf
IPR034905 SNX25
IPR037899 SNX25_PX
IPR013937 Sorting_nexin_C
PANTHERiPTHR22775:SF29 PTHR22775:SF29, 1 hit
PfamiView protein in Pfam
PF08628 Nexin_C, 1 hit
PF00787 PX, 1 hit
PF02194 PXA, 1 hit
PF00615 RGS, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SM00313 PXA, 1 hit
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit
PS51207 PXA, 1 hit
PS50132 RGS, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H3E2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDKALKEVFD YSYRDYILSW YGNLSRDEGQ LYHLLLEDFW EIARQLHHRL
60 70 80 90 100
SHVDVVKVVC NDVVRTLLTH FCDLKAANAR HEEQPRPFVL HACLRNSDDE
110 120 130 140 150
VRFLQTCSRV LVFCLLPSKD VQSLSLRIML AEILTTKVLK PVVELLSNPD
160 170 180 190 200
YINQMLLAQL AYREQMNEHH KRAYTYAPSY EDFIKLINSN SDVEFLKQLR
210 220 230 240 250
YQIVVEIIQA TTISSFPQLK RHKGKETAAM KADLLRARNM KRYINQLTVA
260 270 280 290 300
KKQCEKRIRI LGGPAYDQQE DGALDEGEGP QSQKILQFED ILANTFYREH
310 320 330 340 350
FGMYMERMDK RALISFWESV EHLKNANKNE IPQLVGEIYQ NFFVESKEIS
360 370 380 390 400
VEKSLYKEIQ QCLVGNKGIE VFYKIQEDVY ETLKDRYYPS FIVSDLYEKL
410 420 430 440 450
LIKEEEKHAS QMISNKDEMG PRDEAGEEAV DDGTNQINEQ ASFAVNKLRE
460 470 480 490 500
LNEKLEYKRQ ALNSIQNAPK PDKKIVSKLK DEIILIEKER TDLQLHMART
510 520 530 540 550
DWWCENLGMW KASITSGEVT EENGEQLPCY FVMVSLQEVG GVETKNWTVP
560 570 580 590 600
RRLSEFQNLH RKLSECVPSL KKVQLPSLSK LPFKSIDQKF MEKSKNQLNK
610 620 630 640 650
FLQNLLSDER LCQSEALYAF LSPSPDYLKV IDVQGKKNSF SLSSFLERLP
660 670 680 690 700
RDFFSHQEEE TEEDSDLSDY GDDVDGRKDA LAEPCFMLIG EIFELRGMFK
710 720 730 740 750
WVRRTLIALV QVTFGRTINK QIRDTVSWIF SEQMLVYYIN IFRDAFWPNG
760 770 780 790 800
KLAPPTTIRS KEQSQETKQR AQQKLLENIP DMLQSLVGQQ NARHGIIKIF
810 820 830 840
NALQETRANK HLLYALMELL LIELCPELRV HLDQLKAGQV
Length:840
Mass (Da):97,945
Last modified:November 4, 2008 - v2
Checksum:iD75682A660DEF124
GO
Isoform 2 (identifier: Q9H3E2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-229: Missing.
     604-658: Missing.

Note: No experimental confirmation available.
Show »
Length:556
Mass (Da):64,759
Checksum:iC9676ACAC559E122
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y9R5H0Y9R5_HUMAN
Sorting nexin-25
SNX25
142Annotation score:

Sequence cautioni

The sequence AAG39294 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047057318E → K. Corresponds to variant dbSNP:rs35700132Ensembl.1
Natural variantiVAR_047058586I → V. Corresponds to variant dbSNP:rs3756275Ensembl.1
Natural variantiVAR_047059725T → I. Corresponds to variant dbSNP:rs34120554Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0571561 – 229Missing in isoform 2. 1 PublicationAdd BLAST229
Alternative sequenceiVSP_057157604 – 658Missing in isoform 2. 1 PublicationAdd BLAST55

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY601647 mRNA Translation: AAT98627.1
BC029868 mRNA Translation: AAH29868.2
AF113223 mRNA Translation: AAG39294.1 Different initiation.
AY044656 mRNA Translation: AAK98770.1
CCDSiCCDS34116.1 [Q9H3E2-1]
RefSeqiNP_001304710.1, NM_001317781.1 [Q9H3E2-1]
UniGeneiHs.369091

Genome annotation databases

EnsembliENST00000264694; ENSP00000264694; ENSG00000109762 [Q9H3E2-1]
ENST00000504273; ENSP00000426255; ENSG00000109762 [Q9H3E2-1]
ENST00000618785; ENSP00000483653; ENSG00000109762 [Q9H3E2-2]
GeneIDi83891
KEGGihsa:83891
UCSCiuc003ixh.4 human [Q9H3E2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY601647 mRNA Translation: AAT98627.1
BC029868 mRNA Translation: AAH29868.2
AF113223 mRNA Translation: AAG39294.1 Different initiation.
AY044656 mRNA Translation: AAK98770.1
CCDSiCCDS34116.1 [Q9H3E2-1]
RefSeqiNP_001304710.1, NM_001317781.1 [Q9H3E2-1]
UniGeneiHs.369091

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5WOENMR-A506-628[»]
ProteinModelPortaliQ9H3E2
SMRiQ9H3E2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123802, 6 interactors
IntActiQ9H3E2, 1 interactor
STRINGi9606.ENSP00000264694

PTM databases

iPTMnetiQ9H3E2
PhosphoSitePlusiQ9H3E2

Polymorphism and mutation databases

BioMutaiSNX25
DMDMi212276473

Proteomic databases

EPDiQ9H3E2
MaxQBiQ9H3E2
PaxDbiQ9H3E2
PeptideAtlasiQ9H3E2
PRIDEiQ9H3E2
ProteomicsDBi80704

Protocols and materials databases

DNASUi83891
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264694; ENSP00000264694; ENSG00000109762 [Q9H3E2-1]
ENST00000504273; ENSP00000426255; ENSG00000109762 [Q9H3E2-1]
ENST00000618785; ENSP00000483653; ENSG00000109762 [Q9H3E2-2]
GeneIDi83891
KEGGihsa:83891
UCSCiuc003ixh.4 human [Q9H3E2-1]

Organism-specific databases

CTDi83891
DisGeNETi83891
EuPathDBiHostDB:ENSG00000109762.15
GeneCardsiSNX25
HGNCiHGNC:21883 SNX25
HPAiHPA036928
neXtProtiNX_Q9H3E2
OpenTargetsiENSG00000109762
PharmGKBiPA134988505
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2101 Eukaryota
ENOG410XQM8 LUCA
GeneTreeiENSGT00800000124081
HOGENOMiHOG000047059
HOVERGENiHBG066560
InParanoidiQ9H3E2
KOiK17887
OMAiYTYAPSY
OrthoDBiEOG091G049K
PhylomeDBiQ9H3E2
TreeFamiTF324055

Miscellaneous databases

ChiTaRSiSNX25 human
GenomeRNAii83891
PROiPR:Q9H3E2

Gene expression databases

BgeeiENSG00000109762 Expressed in 195 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_SNX25
ExpressionAtlasiQ9H3E2 baseline and differential
GenevisibleiQ9H3E2 HS

Family and domain databases

CDDicd06878 PX_SNX25, 1 hit
Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR001683 Phox
IPR003114 Phox_assoc
IPR036871 PX_dom_sf
IPR016137 RGS
IPR036305 RGS_sf
IPR034905 SNX25
IPR037899 SNX25_PX
IPR013937 Sorting_nexin_C
PANTHERiPTHR22775:SF29 PTHR22775:SF29, 1 hit
PfamiView protein in Pfam
PF08628 Nexin_C, 1 hit
PF00787 PX, 1 hit
PF02194 PXA, 1 hit
PF00615 RGS, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SM00313 PXA, 1 hit
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit
PS51207 PXA, 1 hit
PS50132 RGS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSNX25_HUMAN
AccessioniPrimary (citable) accession number: Q9H3E2
Secondary accession number(s): Q3ZT30, Q8N6K3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: November 4, 2008
Last modified: October 10, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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