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Protein

Sorting nexin-25

Gene

SNX25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in several stages of intracellular trafficking.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sorting nexin-25
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SNX25
ORF Names:MSTP043
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000109762.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21883 SNX25

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H3E2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
83891

Open Targets

More...
OpenTargetsi
ENSG00000109762

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134988505

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SNX25

Domain mapping of disease mutations (DMDM)

More...
DMDMi
212276473

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002138751 – 840Sorting nexin-25Add BLAST840

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei665PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9H3E2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H3E2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H3E2

PeptideAtlas

More...
PeptideAtlasi
Q9H3E2

PRoteomics IDEntifications database

More...
PRIDEi
Q9H3E2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
80704

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H3E2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H3E2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000109762 Expressed in 195 organ(s), highest expression level in pigmented layer of retina

CleanEx database of gene expression profiles

More...
CleanExi
HS_SNX25

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9H3E2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H3E2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA036928

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123802, 6 interactors

Protein interaction database and analysis system

More...
IntActi
Q9H3E2, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000264694

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1840
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9H3E2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9H3E2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 164PXAPROSITE-ProRule annotationAdd BLAST164
Domaini287 – 401RGSPROSITE-ProRule annotationAdd BLAST115
Domaini508 – 628PXPROSITE-ProRule annotationAdd BLAST121

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili434 – 499Sequence analysisAdd BLAST66

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sorting nexin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2101 Eukaryota
ENOG410XQM8 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153489

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000047059

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG066560

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H3E2

KEGG Orthology (KO)

More...
KOi
K17887

Identification of Orthologs from Complete Genome Data

More...
OMAi
LSEDFWE

Database of Orthologous Groups

More...
OrthoDBi
EOG091G049K

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H3E2

TreeFam database of animal gene trees

More...
TreeFami
TF324055

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06878 PX_SNX25, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1520.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001683 Phox
IPR003114 Phox_assoc
IPR036871 PX_dom_sf
IPR016137 RGS
IPR036305 RGS_sf
IPR034905 SNX25
IPR037899 SNX25_PX
IPR013937 Sorting_nexin_C

The PANTHER Classification System

More...
PANTHERi
PTHR22775:SF29 PTHR22775:SF29, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08628 Nexin_C, 1 hit
PF00787 PX, 1 hit
PF02194 PXA, 1 hit
PF00615 RGS, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00312 PX, 1 hit
SM00313 PXA, 1 hit
SM00315 RGS, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48097 SSF48097, 1 hit
SSF64268 SSF64268, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50195 PX, 1 hit
PS51207 PXA, 1 hit
PS50132 RGS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H3E2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDKALKEVFD YSYRDYILSW YGNLSRDEGQ LYHLLLEDFW EIARQLHHRL
60 70 80 90 100
SHVDVVKVVC NDVVRTLLTH FCDLKAANAR HEEQPRPFVL HACLRNSDDE
110 120 130 140 150
VRFLQTCSRV LVFCLLPSKD VQSLSLRIML AEILTTKVLK PVVELLSNPD
160 170 180 190 200
YINQMLLAQL AYREQMNEHH KRAYTYAPSY EDFIKLINSN SDVEFLKQLR
210 220 230 240 250
YQIVVEIIQA TTISSFPQLK RHKGKETAAM KADLLRARNM KRYINQLTVA
260 270 280 290 300
KKQCEKRIRI LGGPAYDQQE DGALDEGEGP QSQKILQFED ILANTFYREH
310 320 330 340 350
FGMYMERMDK RALISFWESV EHLKNANKNE IPQLVGEIYQ NFFVESKEIS
360 370 380 390 400
VEKSLYKEIQ QCLVGNKGIE VFYKIQEDVY ETLKDRYYPS FIVSDLYEKL
410 420 430 440 450
LIKEEEKHAS QMISNKDEMG PRDEAGEEAV DDGTNQINEQ ASFAVNKLRE
460 470 480 490 500
LNEKLEYKRQ ALNSIQNAPK PDKKIVSKLK DEIILIEKER TDLQLHMART
510 520 530 540 550
DWWCENLGMW KASITSGEVT EENGEQLPCY FVMVSLQEVG GVETKNWTVP
560 570 580 590 600
RRLSEFQNLH RKLSECVPSL KKVQLPSLSK LPFKSIDQKF MEKSKNQLNK
610 620 630 640 650
FLQNLLSDER LCQSEALYAF LSPSPDYLKV IDVQGKKNSF SLSSFLERLP
660 670 680 690 700
RDFFSHQEEE TEEDSDLSDY GDDVDGRKDA LAEPCFMLIG EIFELRGMFK
710 720 730 740 750
WVRRTLIALV QVTFGRTINK QIRDTVSWIF SEQMLVYYIN IFRDAFWPNG
760 770 780 790 800
KLAPPTTIRS KEQSQETKQR AQQKLLENIP DMLQSLVGQQ NARHGIIKIF
810 820 830 840
NALQETRANK HLLYALMELL LIELCPELRV HLDQLKAGQV
Length:840
Mass (Da):97,945
Last modified:November 4, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD75682A660DEF124
GO
Isoform 2 (identifier: Q9H3E2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-229: Missing.
     604-658: Missing.

Note: No experimental confirmation available.
Show »
Length:556
Mass (Da):64,759
Checksum:iC9676ACAC559E122
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y9R5H0Y9R5_HUMAN
Sorting nexin-25
SNX25
142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG39294 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_047057318E → K. Corresponds to variant dbSNP:rs35700132Ensembl.1
Natural variantiVAR_047058586I → V. Corresponds to variant dbSNP:rs3756275Ensembl.1
Natural variantiVAR_047059725T → I. Corresponds to variant dbSNP:rs34120554Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0571561 – 229Missing in isoform 2. 1 PublicationAdd BLAST229
Alternative sequenceiVSP_057157604 – 658Missing in isoform 2. 1 PublicationAdd BLAST55

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY601647 mRNA Translation: AAT98627.1
BC029868 mRNA Translation: AAH29868.2
AF113223 mRNA Translation: AAG39294.1 Different initiation.
AY044656 mRNA Translation: AAK98770.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34116.1 [Q9H3E2-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001304710.1, NM_001317781.1 [Q9H3E2-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.369091

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000264694; ENSP00000264694; ENSG00000109762 [Q9H3E2-1]
ENST00000504273; ENSP00000426255; ENSG00000109762 [Q9H3E2-1]
ENST00000618785; ENSP00000483653; ENSG00000109762 [Q9H3E2-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
83891

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:83891

UCSC genome browser

More...
UCSCi
uc003ixh.4 human [Q9H3E2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY601647 mRNA Translation: AAT98627.1
BC029868 mRNA Translation: AAH29868.2
AF113223 mRNA Translation: AAG39294.1 Different initiation.
AY044656 mRNA Translation: AAK98770.1
CCDSiCCDS34116.1 [Q9H3E2-1]
RefSeqiNP_001304710.1, NM_001317781.1 [Q9H3E2-1]
UniGeneiHs.369091

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5WOENMR-A506-628[»]
ProteinModelPortaliQ9H3E2
SMRiQ9H3E2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123802, 6 interactors
IntActiQ9H3E2, 1 interactor
STRINGi9606.ENSP00000264694

PTM databases

iPTMnetiQ9H3E2
PhosphoSitePlusiQ9H3E2

Polymorphism and mutation databases

BioMutaiSNX25
DMDMi212276473

Proteomic databases

EPDiQ9H3E2
MaxQBiQ9H3E2
PaxDbiQ9H3E2
PeptideAtlasiQ9H3E2
PRIDEiQ9H3E2
ProteomicsDBi80704

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
83891
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264694; ENSP00000264694; ENSG00000109762 [Q9H3E2-1]
ENST00000504273; ENSP00000426255; ENSG00000109762 [Q9H3E2-1]
ENST00000618785; ENSP00000483653; ENSG00000109762 [Q9H3E2-2]
GeneIDi83891
KEGGihsa:83891
UCSCiuc003ixh.4 human [Q9H3E2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
83891
DisGeNETi83891
EuPathDBiHostDB:ENSG00000109762.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SNX25
HGNCiHGNC:21883 SNX25
HPAiHPA036928
neXtProtiNX_Q9H3E2
OpenTargetsiENSG00000109762
PharmGKBiPA134988505

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2101 Eukaryota
ENOG410XQM8 LUCA
GeneTreeiENSGT00940000153489
HOGENOMiHOG000047059
HOVERGENiHBG066560
InParanoidiQ9H3E2
KOiK17887
OMAiLSEDFWE
OrthoDBiEOG091G049K
PhylomeDBiQ9H3E2
TreeFamiTF324055

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SNX25 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
83891

Protein Ontology

More...
PROi
PR:Q9H3E2

Gene expression databases

BgeeiENSG00000109762 Expressed in 195 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_SNX25
ExpressionAtlasiQ9H3E2 baseline and differential
GenevisibleiQ9H3E2 HS

Family and domain databases

CDDicd06878 PX_SNX25, 1 hit
Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR001683 Phox
IPR003114 Phox_assoc
IPR036871 PX_dom_sf
IPR016137 RGS
IPR036305 RGS_sf
IPR034905 SNX25
IPR037899 SNX25_PX
IPR013937 Sorting_nexin_C
PANTHERiPTHR22775:SF29 PTHR22775:SF29, 1 hit
PfamiView protein in Pfam
PF08628 Nexin_C, 1 hit
PF00787 PX, 1 hit
PF02194 PXA, 1 hit
PF00615 RGS, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SM00313 PXA, 1 hit
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit
PS51207 PXA, 1 hit
PS50132 RGS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSNX25_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H3E2
Secondary accession number(s): Q3ZT30, Q8N6K3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: November 4, 2008
Last modified: December 5, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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