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Entry version 202 (12 Aug 2020)
Sequence version 1 (01 Mar 2001)
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Protein

Tumor protein 63

Gene

TP63

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter.7 Publications

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi244ZincBy similarity1
Metal bindingi247ZincBy similarity1
Metal bindingi308ZincBy similarity1
Metal bindingi312ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi170 – 362Add BLAST193

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processApoptosis, Notch signaling pathway, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q9H3D4

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-139915, Activation of PUMA and translocation to mitochondria
R-HSA-5628897, TP53 Regulates Metabolic Genes
R-HSA-6803204, TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
R-HSA-6803205, TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
R-HSA-6803207, TP53 Regulates Transcription of Caspase Activators and Caspases
R-HSA-6803211, TP53 Regulates Transcription of Death Receptors and Ligands
R-HSA-6804759, Regulation of TP53 Activity through Association with Co-factors

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
Q9H3D4

SIGNOR Signaling Network Open Resource

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SIGNORi
Q9H3D4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tumor protein 63
Short name:
p63
Alternative name(s):
Chronic ulcerative stomatitis protein
Short name:
CUSP
Keratinocyte transcription factor KET
Transformation-related protein 63
Short name:
TP63
Tumor protein p73-like
Short name:
p73L
p40
p51
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TP63
Synonyms:KET, P63, P73H, P73L, TP73L
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000073282.12

Human Gene Nomenclature Database

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HGNCi
HGNC:15979, TP63

Online Mendelian Inheritance in Man (OMIM)

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MIMi
603273, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q9H3D4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Acro-dermato-ungual-lacrimal-tooth syndrome (ADULT syndrome)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of ectodermal dysplasia. Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. ADULT syndrome involves ectrodactyly, syndactyly, finger- and toenail dysplasia, hypoplastic breasts and nipples, intensive freckling, lacrimal duct atresia, frontal alopecia, primary hypodontia and loss of permanent teeth. ADULT syndrome differs significantly from EEC3 syndrome by the absence of facial clefting. Inheritance is autosomal dominant.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_020875337R → Q in ADULT syndrome; confers novel transcription activation capacity on isoform 6. 1 PublicationCorresponds to variant dbSNP:rs113993967EnsemblClinVar.1
Isoform 2 (identifier: Q9H3D4-2)
Natural variantiVAR_0829246N → H in ADULT syndrome. Curated1
Isoform 4 (identifier: Q9H3D4-4)
Natural variantiVAR_0829256N → H in ADULT syndrome. Curated1
Isoform 6 (identifier: Q9H3D4-6)
Natural variantiVAR_0829266N → H in ADULT syndrome. Curated1
Isoform 8 (identifier: Q9H3D4-8)
Natural variantiVAR_0829276N → H in ADULT syndrome. Curated1
Isoform 10 (identifier: Q9H3D4-10)
Natural variantiVAR_0829286N → H in ADULT syndrome. Curated1
Isoform 12 (identifier: Q9H3D4-12)
Natural variantiVAR_0829296N → H in ADULT syndrome. Curated1
Ankyloblepharon-ectodermal defects-cleft lip/palate (AEC)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant condition characterized by congenital ectodermal dysplasia with coarse, wiry, sparse hair, dystrophic nails, slight hypohidrosis, scalp infections, ankyloblepharon filiform adnatum, maxillary hypoplasia, hypodontia and cleft lip/palate.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020879553L → F in AEC. 1 PublicationCorresponds to variant dbSNP:rs121908842EnsemblClinVar.1
Natural variantiVAR_020881561C → G in AEC. 1 PublicationCorresponds to variant dbSNP:rs121908843EnsemblClinVar.1
Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. It is an autosomal dominant syndrome characterized by ectrodactyly of hands and feet, ectodermal dysplasia and facial clefting.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020870243R → Q in EEC3. 2 PublicationsCorresponds to variant dbSNP:rs121908836EnsemblClinVar.1
Natural variantiVAR_020871243R → W in EEC3. 2 PublicationsCorresponds to variant dbSNP:rs121908835EnsemblClinVar.1
Natural variantiVAR_032738266R → Q in EEC3. 1 PublicationCorresponds to variant dbSNP:rs121908849EnsemblClinVar.1
Natural variantiVAR_032739308C → Y in EEC3. 1 Publication1
Natural variantiVAR_032740311S → N in EEC3. 1 Publication1
Natural variantiVAR_032741318R → C in EEC3. 1 PublicationCorresponds to variant dbSNP:rs1205536026Ensembl.1
Natural variantiVAR_020873318R → H in EEC3 and RHS; does not decrease the transcriptional activity of the isoform 5 on a TP53 reporter system but disrupts the dominant-negative activity of isoform 2 and isoform 5 on the transcriptional activity of TP53. 3 PublicationsCorresponds to variant dbSNP:rs121908840EnsemblClinVar.1
Natural variantiVAR_032742318R → Q in EEC3. 1 Publication1
Natural variantiVAR_020874319R → C in EEC3. 2 PublicationsCorresponds to variant dbSNP:rs121908839EnsemblClinVar.1
Natural variantiVAR_032743319R → H in EEC3 and SHFM4. 1 PublicationCorresponds to variant dbSNP:rs886039442EnsemblClinVar.1
Natural variantiVAR_032744319R → S in EEC3. 1 Publication1
Natural variantiVAR_020876343R → Q in EEC3. 2 PublicationsCorresponds to variant dbSNP:rs121908841EnsemblClinVar.1
Natural variantiVAR_032745343R → W in EEC3. 1 PublicationCorresponds to variant dbSNP:rs886041251EnsemblClinVar.1
Natural variantiVAR_020877345C → R in EEC3; abolishes transcription activation. 2 PublicationsCorresponds to variant dbSNP:rs121908837EnsemblClinVar.1
Natural variantiVAR_032746347C → S in EEC3. 1 Publication1
Natural variantiVAR_032747348P → S in EEC3. 1 Publication1
Natural variantiVAR_020878351D → G in EEC3. 1 PublicationCorresponds to variant dbSNP:rs121908844EnsemblClinVar.1
Natural variantiVAR_032748351D → H in EEC3. 1 Publication1
Split-hand/foot malformation 4 (SHFM4)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA limb malformation involving the central rays of the autopod and presenting with syndactyly, median clefts of the hands and feet, and aplasia and/or hypoplasia of the phalanges, metacarpals, and metatarsals. Some patients have been found to have mental retardation, ectodermal and craniofacial findings, and orofacial clefting.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032736193T → TP in SHFM4. 1 Publication1
Natural variantiVAR_032737232K → E in SHFM4. 1 Publication1
Natural variantiVAR_020869233K → E in SHFM4. 1 PublicationCorresponds to variant dbSNP:rs121908838EnsemblClinVar.1
Natural variantiVAR_032743319R → H in EEC3 and SHFM4. 1 PublicationCorresponds to variant dbSNP:rs886039442EnsemblClinVar.1
Limb-mammary syndrome (LMS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionCharacterized by ectrodactyly, cleft palate and mammary-gland abnormalities.
Related information in OMIM
Defects in TP63 are a cause of cervical, colon, head and neck, lung and ovarian cancers.
Rapp-Hodgkin syndrome (RHS)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. Characterized by the combination of anhidrotic ectodermal dysplasia, cleft lip, and cleft palate. The clinical syndrome is comprised of a characteristic facies (narrow nose and small mouth), wiry, slow-growing, and uncombable hair, sparse eyelashes and eyebrows, obstructed lacrimal puncta/epiphora, bilateral stenosis of external auditory canals, microsomia, hypodontia, cone-shaped incisors, enamel hypoplasia, dystrophic nails, and cleft lip/cleft palate. RHS inheritance is autosomal dominant.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020873318R → H in EEC3 and RHS; does not decrease the transcriptional activity of the isoform 5 on a TP53 reporter system but disrupts the dominant-negative activity of isoform 2 and isoform 5 on the transcriptional activity of TP53. 3 PublicationsCorresponds to variant dbSNP:rs121908840EnsemblClinVar.1
Natural variantiVAR_035128549I → T in RHS. 1 PublicationCorresponds to variant dbSNP:rs121908845EnsemblClinVar.1
Natural variantiVAR_035129580S → P in RHS. 1 PublicationCorresponds to variant dbSNP:rs121908846EnsemblClinVar.1
Orofacial cleft 8 (OFC8)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035127352R → G in OFC8. 1 PublicationCorresponds to variant dbSNP:rs121908847EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi55F → A: Abrogates transcriptional activity and interaction with transactivation inhibition domain; when associated with A-59 and A-62. 1 Publication1
Mutagenesisi59W → A: Abrogates transcriptional activity and interaction with transactivation inhibition domain; when associated with A-55 and A-62. 1 Publication1
Mutagenesisi62L → A: Abrogates transcriptional activity and interaction with transactivation inhibition domain; when associated with A-55 and A-59. 1 Publication1
Mutagenesisi543Y → F: Abolishes ubiquitination. 1 Publication1

Keywords - Diseasei

Disease mutation, Ectodermal dysplasia

Organism-specific databases

DisGeNET

More...
DisGeNETi
8626

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
TP63

MalaCards human disease database

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MalaCardsi
TP63
MIMi103285, phenotype
106260, phenotype
129400, phenotype
603543, phenotype
604292, phenotype
605289, phenotype
618149, phenotype

Open Targets

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OpenTargetsi
ENSG00000073282

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
978, ADULT syndrome
1071, Ankyloblepharon-ectodermal defects-cleft lip/palate syndrome
93930, Bladder exstrophy
141291, Cleft lip and alveolus
199306, Cleft lip/palate
1896, EEC syndrome
199302, Isolated cleft lip
2440, Isolated split hand-split foot malformation
69085, Limb-mammary syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA162406776

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q9H3D4, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
TP63

Domain mapping of disease mutations (DMDM)

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DMDMi
57013009

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001857291 – 680Tumor protein 63Add BLAST680

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki676Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

May be sumoylated.By similarity
Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein.1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9H3D4

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9H3D4

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9H3D4

PeptideAtlas

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PeptideAtlasi
Q9H3D4

PRoteomics IDEntifications database

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PRIDEi
Q9H3D4

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
80692 [Q9H3D4-1]
80693 [Q9H3D4-10]
80694 [Q9H3D4-11]
80695 [Q9H3D4-12]
80696 [Q9H3D4-2]
80697 [Q9H3D4-3]
80698 [Q9H3D4-4]
80699 [Q9H3D4-5]
80700 [Q9H3D4-6]
80701 [Q9H3D4-7]
80702 [Q9H3D4-8]
80703 [Q9H3D4-9]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9H3D4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9H3D4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed, notably in heart, kidney, placenta, prostate, skeletal muscle, testis and thymus, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast, eye and prostate express high levels of DeltaN-type isoforms. Isoform 10 is predominantly expressed in skin squamous cell carcinomas, but not in normal skin tissues.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000073282, Expressed in skin of abdomen and 157 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9H3D4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9H3D4, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000073282, Tissue enhanced (skeletal muscle, skin)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity. Isoforms Alpha and Gamma interact with HIPK2.

Interacts with SSRP1, leading to stimulate coactivator activity. Isoform 1 and isoform 2 interact with WWP1.

Interacts with PDS5A. Isoform 5 (via activation domain) interacts with NOC2L.

7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

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GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
114181, 279 interactors

Database of interacting proteins

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DIPi
DIP-29588N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q9H3D4

Protein interaction database and analysis system

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IntActi
Q9H3D4, 84 interactors

Molecular INTeraction database

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MINTi
Q9H3D4

STRING: functional protein association networks

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STRINGi
9606.ENSP00000264731

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q9H3D4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1680
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9H3D4

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q9H3D4

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini541 – 607SAMAdd BLAST67

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 107Transcription activationAdd BLAST107
Regioni352 – 388Interaction with HIPK21 PublicationAdd BLAST37
Regioni394 – 443OligomerizationAdd BLAST50
Regioni610 – 680Transactivation inhibitionAdd BLAST71

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi437 – 444Poly-Gln8

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The transactivation inhibitory domain (TID) can interact with, and inhibit the activity of the N-terminal transcriptional activation domain of TA*-type isoforms.2 Publications

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the p53 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502QQ48, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00950000183153

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_019621_1_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9H3D4

KEGG Orthology (KO)

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KOi
K10149

Identification of Orthologs from Complete Genome Data

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OMAi
ELSDPMW

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9H3D4

TreeFam database of animal gene trees

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TreeFami
TF106101

Family and domain databases

Conserved Domains Database

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CDDi
cd08367, P53, 1 hit
cd09572, SAM_tumor-p63, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.150.50, 1 hit
2.60.40.720, 1 hit
4.10.170.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR008967, p53-like_TF_DNA-bd
IPR012346, p53/RUNT-type_TF_DNA-bd_sf
IPR011615, p53_DNA-bd
IPR036674, p53_tetramer_sf
IPR010991, p53_tetrameristn
IPR002117, p53_tumour_suppressor
IPR001660, SAM
IPR013761, SAM/pointed_sf
IPR032645, Tp63
IPR037611, Tumor-p63_SAM

The PANTHER Classification System

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PANTHERi
PTHR11447, PTHR11447, 1 hit
PTHR11447:SF8, PTHR11447:SF8, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00870, P53, 1 hit
PF07710, P53_tetramer, 1 hit
PF07647, SAM_2, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00386, P53SUPPRESSR

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00454, SAM, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47719, SSF47719, 1 hit
SSF47769, SSF47769, 1 hit
SSF49417, SSF49417, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00348, P53, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (12+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 12 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

This entry has 12 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H3D4-1) [UniParc]FASTAAdd to basket
Also known as: TA*-alpha, TAp63alpha, P51B

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNFETSRCAT LQYCPDPYIQ RFVETPAHFS WKESYYRSTM SQSTQTNEFL
60 70 80 90 100
SPEVFQHIWD FLEQPICSVQ PIDLNFVDEP SEDGATNKIE ISMDCIRMQD
110 120 130 140 150
SDLSDPMWPQ YTNLGLLNSM DQQIQNGSSS TSPYNTDHAQ NSVTAPSPYA
160 170 180 190 200
QPSSTFDALS PSPAIPSNTD YPGPHSFDVS FQQSSTAKSA TWTYSTELKK
210 220 230 240 250
LYCQIAKTCP IQIKVMTPPP QGAVIRAMPV YKKAEHVTEV VKRCPNHELS
260 270 280 290 300
REFNEGQIAP PSHLIRVEGN SHAQYVEDPI TGRQSVLVPY EPPQVGTEFT
310 320 330 340 350
TVLYNFMCNS SCVGGMNRRP ILIIVTLETR DGQVLGRRCF EARICACPGR
360 370 380 390 400
DRKADEDSIR KQQVSDSTKN GDGTKRPFRQ NTHGIQMTSI KKRRSPDDEL
410 420 430 440 450
LYLPVRGRET YEMLLKIKES LELMQYLPQH TIETYRQQQQ QQHQHLLQKQ
460 470 480 490 500
TSIQSPSSYG NSSPPLNKMN SMNKLPSVSQ LINPQQRNAL TPTTIPDGMG
510 520 530 540 550
ANIPMMGTHM PMAGDMNGLS PTQALPPPLS MPSTSHCTPP PPYPTDCSIV
560 570 580 590 600
SFLARLGCSS CLDYFTTQGL TTIYQIEHYS MDDLASLKIP EQFRHAIWKG
610 620 630 640 650
ILDHRQLHEF SSPSHLLRTP SSASTVSVGS SETRGERVID AVRFTLRQTI
660 670 680
SFPPRDEWND FNFDMDARRN KQQRIKEEGE
Note: Produced by alternative promoter usage.
Length:680
Mass (Da):76,785
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF66ECD45E87D9799
GO
Isoform 2 (identifier: Q9H3D4-2) [UniParc]FASTAAdd to basket
Also known as: DeltaN-alpha, DeltaNp63 alpha, P51delNalpha

The sequence of this isoform differs from the canonical sequence as follows:
     1-108: MNFETSRCAT...QDSDLSDPMW → MLYLENNAQTQFSE

Note: Produced by alternative promoter usage.Curated
Show »
Length:586
Mass (Da):65,756
Checksum:i2E2F92ABF1AF8629
GO
Isoform 3 (identifier: Q9H3D4-3) [UniParc]FASTAAdd to basket
Also known as: TA*-beta, TAp63beta

The sequence of this isoform differs from the canonical sequence as follows:
     551-680: SFLARLGCSS...KQQRIKEEGE → RIWQV

Note: Produced by alternative splicing of isoform 1.Curated
Show »
Length:555
Mass (Da):62,433
Checksum:iE22874BE7DBABCBE
GO
Isoform 4 (identifier: Q9H3D4-4) [UniParc]FASTAAdd to basket
Also known as: DeltaN-beta, DeltaNp63 beta, P51delNbeta

The sequence of this isoform differs from the canonical sequence as follows:
     1-108: MNFETSRCAT...QDSDLSDPMW → MLYLENNAQTQFSE
     551-680: SFLARLGCSS...KQQRIKEEGE → RIWQV

Note: Produced by alternative splicing of isoform 2.Curated
Show »
Length:461
Mass (Da):51,404
Checksum:i68B63547A46C1B05
GO
Isoform 5 (identifier: Q9H3D4-5) [UniParc]FASTAAdd to basket
Also known as: TA*-gamma, TAp63gamma, P51A

The sequence of this isoform differs from the canonical sequence as follows:
     450-680: QTSIQSPSSY...KQQRIKEEGE → HLLSACFRNE...SKPPNRSVYP

Note: Produced by alternative splicing of isoform 1.Curated
Show »
Length:487
Mass (Da):55,688
Checksum:i86CC865BDF2643DD
GO
Isoform 6 (identifier: Q9H3D4-6) [UniParc]FASTAAdd to basket
Also known as: DeltaN-gamma, DeltaNp63gamma, P51delNgamma

The sequence of this isoform differs from the canonical sequence as follows:
     1-108: MNFETSRCAT...QDSDLSDPMW → MLYLENNAQTQFSE
     450-680: QTSIQSPSSY...KQQRIKEEGE → HLLSACFRNE...SKPPNRSVYP

Note: Produced by alternative splicing of isoform 2.Curated
Show »
Length:393
Mass (Da):44,658
Checksum:iC6689B83FD701610
GO
Isoform 7 (identifier: Q9H3D4-7) [UniParc]FASTAAdd to basket
Also known as: TA*-delta, TAp63delta, P51delta

The sequence of this isoform differs from the canonical sequence as follows:
     503-680: IPMMGTHMPM...KQQRIKEEGE → RSGKSENP

Note: Produced by alternative splicing of isoform 1.Curated
Show »
Length:510
Mass (Da):57,619
Checksum:i3539D81485635FF0
GO
Isoform 8 (identifier: Q9H3D4-8) [UniParc]FASTAAdd to basket
Also known as: DeltaN-delta

The sequence of this isoform differs from the canonical sequence as follows:
     1-108: MNFETSRCAT...QDSDLSDPMW → MLYLENNAQTQFSE
     503-680: IPMMGTHMPM...KQQRIKEEGE → RSGKSENP

Note: Produced by alternative splicing of isoform 2.Curated
Show »
Length:416
Mass (Da):46,589
Checksum:iA5974A14B25E3118
GO
Isoform 9 (identifier: Q9H3D4-9) [UniParc]FASTAAdd to basket
Also known as: TA*-epsilon

The sequence of this isoform differs from the canonical sequence as follows:
     109-193: Missing.

Note: Produced by alternative splicing of isoform 1.Curated
Show »
Length:595
Mass (Da):67,779
Checksum:iF07014CB9FEF1FF2
GO
Isoform 10 (identifier: Q9H3D4-10) [UniParc]FASTAAdd to basket
Also known as: DeltaN-epsilon, DeltaNp73L

The sequence of this isoform differs from the canonical sequence as follows:
     1-108: MNFETSRCAT...QDSDLSDPMW → MLYLENNAQTQFSE
     109-193: Missing.

Note: Produced by alternative splicing of isoform 2.Curated
Show »
Length:501
Mass (Da):56,750
Checksum:i31E1BEA3CA305B88
GO
Isoform 11 (identifier: Q9H3D4-11) [UniParc]FASTAAdd to basket
Also known as: P63 delta

The sequence of this isoform differs from the canonical sequence as follows:
     373-377: GTKRP → A

Note: Produced by alternative splicing of isoform 1.Curated
Show »
Length:676
Mass (Da):76,317
Checksum:iEB0E2C9E93C6D34A
GO
Isoform 12 (identifier: Q9H3D4-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-108: MNFETSRCAT...QDSDLSDPMW → MLYLENNAQTQFSE
     373-377: GTKRP → A

Note: Produced by alternative splicing of isoform 2.Curated
Show »
Length:582
Mass (Da):65,288
Checksum:iA2DC3D2E13B6B531
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JW72C9JW72_HUMAN
Tumor protein 63
TP63
183Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF43486 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAF43487 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAF43488 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAF43489 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAF61624 differs from that shown. Reason: Frameshift.Curated
The sequence BAA32592 differs from that shown. Reason: Frameshift.Curated
The sequence BAA32593 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti125Q → R in BAA32433 (PubMed:9703973).Curated1
Sequence conflicti154S → P in BAA32433 (PubMed:9703973).Curated1
Sequence conflicti177F → S in BAA32433 (PubMed:9703973).Curated1
Sequence conflicti378F → S in AAC24830 (PubMed:9662346).Curated1
Sequence conflicti536H → Q in CAA76562 (PubMed:9799841).Curated1
Sequence conflicti551S → G in BAA32593 (PubMed:9662378).Curated1
Sequence conflicti551S → G in AAF43487 (PubMed:10935472).Curated1
Sequence conflicti551S → G in AAF43491 (PubMed:10935472).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035126129S → L1 PublicationCorresponds to variant dbSNP:rs193287780Ensembl.1
Natural variantiVAR_020866184S → L in head and neck cancer. 1 Publication1
Natural variantiVAR_020867187A → P in lung carcinoma; somatic mutation. 1 Publication1
Natural variantiVAR_032736193T → TP in SHFM4. 1 Publication1
Natural variantiVAR_020868204Q → L in cervical cancer. 1 Publication1
Natural variantiVAR_032737232K → E in SHFM4. 1 Publication1
Natural variantiVAR_020869233K → E in SHFM4. 1 PublicationCorresponds to variant dbSNP:rs121908838EnsemblClinVar.1
Natural variantiVAR_020870243R → Q in EEC3. 2 PublicationsCorresponds to variant dbSNP:rs121908836EnsemblClinVar.1
Natural variantiVAR_020871243R → W in EEC3. 2 PublicationsCorresponds to variant dbSNP:rs121908835EnsemblClinVar.1
Natural variantiVAR_032738266R → Q in EEC3. 1 PublicationCorresponds to variant dbSNP:rs121908849EnsemblClinVar.1
Natural variantiVAR_020872279P → H in colon cancer. 1 Publication1
Natural variantiVAR_032739308C → Y in EEC3. 1 Publication1
Natural variantiVAR_032740311S → N in EEC3. 1 Publication1
Natural variantiVAR_032741318R → C in EEC3. 1 PublicationCorresponds to variant dbSNP:rs1205536026Ensembl.1
Natural variantiVAR_020873318R → H in EEC3 and RHS; does not decrease the transcriptional activity of the isoform 5 on a TP53 reporter system but disrupts the dominant-negative activity of isoform 2 and isoform 5 on the transcriptional activity of TP53. 3 PublicationsCorresponds to variant dbSNP:rs121908840EnsemblClinVar.1
Natural variantiVAR_032742318R → Q in EEC3. 1 Publication1
Natural variantiVAR_020874319R → C in EEC3. 2 PublicationsCorresponds to variant dbSNP:rs121908839EnsemblClinVar.1
Natural variantiVAR_032743319R → H in EEC3 and SHFM4. 1 PublicationCorresponds to variant dbSNP:rs886039442EnsemblClinVar.1
Natural variantiVAR_032744319R → S in EEC3. 1 Publication1
Natural variantiVAR_020875337R → Q in ADULT syndrome; confers novel transcription activation capacity on isoform 6. 1 PublicationCorresponds to variant dbSNP:rs113993967EnsemblClinVar.1
Natural variantiVAR_020876343R → Q in EEC3. 2 PublicationsCorresponds to variant dbSNP:rs121908841EnsemblClinVar.1
Natural variantiVAR_032745343R → W in EEC3. 1 PublicationCorresponds to variant dbSNP:rs886041251EnsemblClinVar.1
Natural variantiVAR_020877345C → R in EEC3; abolishes transcription activation. 2 PublicationsCorresponds to variant dbSNP:rs121908837EnsemblClinVar.1
Natural variantiVAR_032746347C → S in EEC3. 1 Publication1
Natural variantiVAR_032747348P → S in EEC3. 1 Publication1
Natural variantiVAR_020878351D → G in EEC3. 1 PublicationCorresponds to variant dbSNP:rs121908844EnsemblClinVar.1
Natural variantiVAR_032748351D → H in EEC3. 1 Publication1
Natural variantiVAR_035127352R → G in OFC8. 1 PublicationCorresponds to variant dbSNP:rs121908847EnsemblClinVar.1
Natural variantiVAR_035128549I → T in RHS. 1 PublicationCorresponds to variant dbSNP:rs121908845EnsemblClinVar.1
Natural variantiVAR_020879553L → F in AEC. 1 PublicationCorresponds to variant dbSNP:rs121908842EnsemblClinVar.1
Natural variantiVAR_020880560S → A in ovarian cancer. 1 Publication1
Natural variantiVAR_020881561C → G in AEC. 1 PublicationCorresponds to variant dbSNP:rs121908843EnsemblClinVar.1
Natural variantiVAR_035129580S → P in RHS. 1 PublicationCorresponds to variant dbSNP:rs121908846EnsemblClinVar.1
Natural variantiVAR_035130603D → H1 PublicationCorresponds to variant dbSNP:rs767906723Ensembl.1
Isoform 2 (identifier: Q9H3D4-2)
Natural variantiVAR_0829246N → H in ADULT syndrome. Curated1
Isoform 4 (identifier: Q9H3D4-4)
Natural variantiVAR_0829256N → H in ADULT syndrome. Curated1
Isoform 6 (identifier: Q9H3D4-6)
Natural variantiVAR_0829266N → H in ADULT syndrome. Curated1
Isoform 8 (identifier: Q9H3D4-8)
Natural variantiVAR_0829276N → H in ADULT syndrome. Curated1
Isoform 10 (identifier: Q9H3D4-10)
Natural variantiVAR_0829286N → H in ADULT syndrome. Curated1
Isoform 12 (identifier: Q9H3D4-12)
Natural variantiVAR_0829296N → H in ADULT syndrome. Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0124651 – 108MNFET…SDPMW → MLYLENNAQTQFSE in isoform 2, isoform 4, isoform 6, isoform 8, isoform 10 and isoform 12. 4 PublicationsAdd BLAST108
Alternative sequenceiVSP_012466109 – 193Missing in isoform 9 and isoform 10. 1 PublicationAdd BLAST85
Alternative sequenceiVSP_012467373 – 377GTKRP → A in isoform 11 and isoform 12. 1 Publication5
Alternative sequenceiVSP_012468450 – 680QTSIQ…KEEGE → HLLSACFRNELVEPRRETPK QSDVFFRHSKPPNRSVYP in isoform 5 and isoform 6. 2 PublicationsAdd BLAST231
Alternative sequenceiVSP_012469503 – 680IPMMG…KEEGE → RSGKSENP in isoform 7 and isoform 8. 1 PublicationAdd BLAST178
Alternative sequenceiVSP_012470551 – 680SFLAR…KEEGE → RIWQV in isoform 3 and isoform 4. 1 PublicationAdd BLAST130

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB010153 mRNA Translation: BAA32433.1
Y16961 mRNA Translation: CAA76562.1
AF075428 mRNA Translation: AAC62633.1
AF075429 mRNA Translation: AAC62634.1
AF075430 mRNA Translation: AAC62635.1
AF075431 mRNA Translation: AAC62636.1
AF075432 mRNA Translation: AAC62637.1
AF075433 mRNA Translation: AAC62638.1
AF124539 AF124538 Genomic DNA Translation: AAG45607.1
AF124539 AF124537 Genomic DNA Translation: AAG45608.1
AF124540 AF124535 Genomic DNA Translation: AAG45609.1
AF124539 AF124538 Genomic DNA Translation: AAG45610.1
AF124539 AF124537 Genomic DNA Translation: AAG45611.1
AF124540 AF124530 Genomic DNA Translation: AAG45612.1
AB016072 mRNA Translation: BAA32592.1 Frameshift.
AB016073 mRNA Translation: BAA32593.1 Frameshift.
AF091627 mRNA Translation: AAC43038.1
AF116770 AF116765 Genomic DNA Translation: AAF43486.1 Different initiation.
AF116769 AF116768 Genomic DNA Translation: AAF43487.1 Different initiation.
AF116769 AF116760 Genomic DNA Translation: AAF43488.1 Different initiation.
AF116769 AF116766 Genomic DNA Translation: AAF43489.1 Different initiation.
AF116770 AF116759 Genomic DNA Translation: AAF43490.1
AF116769 AF116761 Genomic DNA Translation: AAF43491.1
AF116769 AF116762 Genomic DNA Translation: AAF43492.1
AF116769 AF116762 Genomic DNA Translation: AAF43493.1
AF116771 mRNA Translation: AAF61624.1 Frameshift.
AB042841 mRNA Translation: BAB20591.1
BC039815 mRNA Translation: AAH39815.1
AF061512 mRNA Translation: AAC24830.1
AY342152, AY341145 Genomic DNA Translation: AAQ63448.1
AY339663 Genomic DNA Translation: AAQ63449.1
AY341143, AY339664, AY341142 Genomic DNA Translation: AAQ63450.1
AY341143, AY341142 Genomic DNA Translation: AAQ63451.1
AY341144 Genomic DNA Translation: AAQ63452.1
AY342153 Genomic DNA Translation: AAQ63453.1
AY342154 Genomic DNA Translation: AAQ63454.1
AJ315499 mRNA Translation: CAC48053.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3293.1 [Q9H3D4-1]
CCDS46976.1 [Q9H3D4-3]
CCDS46977.1 [Q9H3D4-5]
CCDS46978.1 [Q9H3D4-2]
CCDS46979.1 [Q9H3D4-4]
CCDS46980.1 [Q9H3D4-6]
CCDS82887.1 [Q9H3D4-11]
CCDS87179.1 [Q9H3D4-7]
CCDS87180.1 [Q9H3D4-8]
CCDS87181.1 [Q9H3D4-10]

NCBI Reference Sequences

More...
RefSeqi
NP_001108450.1, NM_001114978.1 [Q9H3D4-3]
NP_001108451.1, NM_001114979.1 [Q9H3D4-5]
NP_001108452.1, NM_001114980.1 [Q9H3D4-2]
NP_001108453.1, NM_001114981.1 [Q9H3D4-4]
NP_001108454.1, NM_001114982.1 [Q9H3D4-6]
NP_001316073.1, NM_001329144.1 [Q9H3D4-7]
NP_001316074.1, NM_001329145.1 [Q9H3D4-8]
NP_001316075.1, NM_001329146.1 [Q9H3D4-10]
NP_001316077.1, NM_001329148.1 [Q9H3D4-11]
NP_003713.3, NM_003722.4 [Q9H3D4-1]
XP_016862876.1, XM_017007387.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000264731; ENSP00000264731; ENSG00000073282 [Q9H3D4-1]
ENST00000320472; ENSP00000317510; ENSG00000073282 [Q9H3D4-7]
ENST00000354600; ENSP00000346614; ENSG00000073282 [Q9H3D4-2]
ENST00000392460; ENSP00000376253; ENSG00000073282 [Q9H3D4-3]
ENST00000392461; ENSP00000376254; ENSG00000073282 [Q9H3D4-8]
ENST00000392463; ENSP00000376256; ENSG00000073282 [Q9H3D4-4]
ENST00000418709; ENSP00000407144; ENSG00000073282 [Q9H3D4-5]
ENST00000437221; ENSP00000392488; ENSG00000073282 [Q9H3D4-6]
ENST00000440651; ENSP00000394337; ENSG00000073282 [Q9H3D4-11]
ENST00000449992; ENSP00000387839; ENSG00000073282 [Q9H3D4-10]
ENST00000456148; ENSP00000389485; ENSG00000073282 [Q9H3D4-12]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8626

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8626

UCSC genome browser

More...
UCSCi
uc003frx.3, human [Q9H3D4-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010153 mRNA Translation: BAA32433.1
Y16961 mRNA Translation: CAA76562.1
AF075428 mRNA Translation: AAC62633.1
AF075429 mRNA Translation: AAC62634.1
AF075430 mRNA Translation: AAC62635.1
AF075431 mRNA Translation: AAC62636.1
AF075432 mRNA Translation: AAC62637.1
AF075433 mRNA Translation: AAC62638.1
AF124539 AF124538 Genomic DNA Translation: AAG45607.1
AF124539 AF124537 Genomic DNA Translation: AAG45608.1
AF124540 AF124535 Genomic DNA Translation: AAG45609.1
AF124539 AF124538 Genomic DNA Translation: AAG45610.1
AF124539 AF124537 Genomic DNA Translation: AAG45611.1
AF124540 AF124530 Genomic DNA Translation: AAG45612.1
AB016072 mRNA Translation: BAA32592.1 Frameshift.
AB016073 mRNA Translation: BAA32593.1 Frameshift.
AF091627 mRNA Translation: AAC43038.1
AF116770 AF116765 Genomic DNA Translation: AAF43486.1 Different initiation.
AF116769 AF116768 Genomic DNA Translation: AAF43487.1 Different initiation.
AF116769 AF116760 Genomic DNA Translation: AAF43488.1 Different initiation.
AF116769 AF116766 Genomic DNA Translation: AAF43489.1 Different initiation.
AF116770 AF116759 Genomic DNA Translation: AAF43490.1
AF116769 AF116761 Genomic DNA Translation: AAF43491.1
AF116769 AF116762 Genomic DNA Translation: AAF43492.1
AF116769 AF116762 Genomic DNA Translation: AAF43493.1
AF116771 mRNA Translation: AAF61624.1 Frameshift.
AB042841 mRNA Translation: BAB20591.1
BC039815 mRNA Translation: AAH39815.1
AF061512 mRNA Translation: AAC24830.1
AY342152, AY341145 Genomic DNA Translation: AAQ63448.1
AY339663 Genomic DNA Translation: AAQ63449.1
AY341143, AY339664, AY341142 Genomic DNA Translation: AAQ63450.1
AY341143, AY341142 Genomic DNA Translation: AAQ63451.1
AY341144 Genomic DNA Translation: AAQ63452.1
AY342153 Genomic DNA Translation: AAQ63453.1
AY342154 Genomic DNA Translation: AAQ63454.1
AJ315499 mRNA Translation: CAC48053.1
CCDSiCCDS3293.1 [Q9H3D4-1]
CCDS46976.1 [Q9H3D4-3]
CCDS46977.1 [Q9H3D4-5]
CCDS46978.1 [Q9H3D4-2]
CCDS46979.1 [Q9H3D4-4]
CCDS46980.1 [Q9H3D4-6]
CCDS82887.1 [Q9H3D4-11]
CCDS87179.1 [Q9H3D4-7]
CCDS87180.1 [Q9H3D4-8]
CCDS87181.1 [Q9H3D4-10]
RefSeqiNP_001108450.1, NM_001114978.1 [Q9H3D4-3]
NP_001108451.1, NM_001114979.1 [Q9H3D4-5]
NP_001108452.1, NM_001114980.1 [Q9H3D4-2]
NP_001108453.1, NM_001114981.1 [Q9H3D4-4]
NP_001108454.1, NM_001114982.1 [Q9H3D4-6]
NP_001316073.1, NM_001329144.1 [Q9H3D4-7]
NP_001316074.1, NM_001329145.1 [Q9H3D4-8]
NP_001316075.1, NM_001329146.1 [Q9H3D4-10]
NP_001316077.1, NM_001329148.1 [Q9H3D4-11]
NP_003713.3, NM_003722.4 [Q9H3D4-1]
XP_016862876.1, XM_017007387.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RG6NMR-A540-614[»]
2NB1NMR-A/C397-455[»]
2RMNNMR-A153-388[»]
2Y9TNMR-A543-622[»]
2Y9UX-ray1.60A545-611[»]
3QYMX-ray3.20A/B/C/D/E/F/G/H166-362[»]
3QYNX-ray2.50A/B/C/D166-362[»]
3US0X-ray2.50A/B/C/D166-362[»]
3US1X-ray2.80A/D166-362[»]
3US2X-ray4.20A/B/C/D/G/H/I/J166-362[»]
3ZY0X-ray1.90A/B/C/D398-427[»]
3ZY1X-ray2.15A398-441[»]
4A9ZX-ray2.29A/B/C/D397-455[»]
6FGNNMR-A47-73[»]
6RU6X-ray2.05C618-630[»]
6RU7X-ray2.08C/D618-633[»]
6RU8X-ray1.92E/F/G/H621-632[»]
SMRiQ9H3D4
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114181, 279 interactors
DIPiDIP-29588N
ELMiQ9H3D4
IntActiQ9H3D4, 84 interactors
MINTiQ9H3D4
STRINGi9606.ENSP00000264731

PTM databases

iPTMnetiQ9H3D4
PhosphoSitePlusiQ9H3D4

Polymorphism and mutation databases

BioMutaiTP63
DMDMi57013009

Proteomic databases

MassIVEiQ9H3D4
MaxQBiQ9H3D4
PaxDbiQ9H3D4
PeptideAtlasiQ9H3D4
PRIDEiQ9H3D4
ProteomicsDBi80692 [Q9H3D4-1]
80693 [Q9H3D4-10]
80694 [Q9H3D4-11]
80695 [Q9H3D4-12]
80696 [Q9H3D4-2]
80697 [Q9H3D4-3]
80698 [Q9H3D4-4]
80699 [Q9H3D4-5]
80700 [Q9H3D4-6]
80701 [Q9H3D4-7]
80702 [Q9H3D4-8]
80703 [Q9H3D4-9]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
1750, 987 antibodies

The DNASU plasmid repository

More...
DNASUi
8626

Genome annotation databases

EnsembliENST00000264731; ENSP00000264731; ENSG00000073282 [Q9H3D4-1]
ENST00000320472; ENSP00000317510; ENSG00000073282 [Q9H3D4-7]
ENST00000354600; ENSP00000346614; ENSG00000073282 [Q9H3D4-2]
ENST00000392460; ENSP00000376253; ENSG00000073282 [Q9H3D4-3]
ENST00000392461; ENSP00000376254; ENSG00000073282 [Q9H3D4-8]
ENST00000392463; ENSP00000376256; ENSG00000073282 [Q9H3D4-4]
ENST00000418709; ENSP00000407144; ENSG00000073282 [Q9H3D4-5]
ENST00000437221; ENSP00000392488; ENSG00000073282 [Q9H3D4-6]
ENST00000440651; ENSP00000394337; ENSG00000073282 [Q9H3D4-11]
ENST00000449992; ENSP00000387839; ENSG00000073282 [Q9H3D4-10]
ENST00000456148; ENSP00000389485; ENSG00000073282 [Q9H3D4-12]
GeneIDi8626
KEGGihsa:8626
UCSCiuc003frx.3, human [Q9H3D4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8626
DisGeNETi8626
EuPathDBiHostDB:ENSG00000073282.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TP63
GeneReviewsiTP63
HGNCiHGNC:15979, TP63
HPAiENSG00000073282, Tissue enhanced (skeletal muscle, skin)
MalaCardsiTP63
MIMi103285, phenotype
106260, phenotype
129400, phenotype
603273, gene
603543, phenotype
604292, phenotype
605289, phenotype
618149, phenotype
neXtProtiNX_Q9H3D4
OpenTargetsiENSG00000073282
Orphaneti978, ADULT syndrome
1071, Ankyloblepharon-ectodermal defects-cleft lip/palate syndrome
93930, Bladder exstrophy
141291, Cleft lip and alveolus
199306, Cleft lip/palate
1896, EEC syndrome
199302, Isolated cleft lip
2440, Isolated split hand-split foot malformation
69085, Limb-mammary syndrome
PharmGKBiPA162406776

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QQ48, Eukaryota
GeneTreeiENSGT00950000183153
HOGENOMiCLU_019621_1_0_1
InParanoidiQ9H3D4
KOiK10149
OMAiELSDPMW
PhylomeDBiQ9H3D4
TreeFamiTF106101

Enzyme and pathway databases

PathwayCommonsiQ9H3D4
ReactomeiR-HSA-139915, Activation of PUMA and translocation to mitochondria
R-HSA-5628897, TP53 Regulates Metabolic Genes
R-HSA-6803204, TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
R-HSA-6803205, TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
R-HSA-6803207, TP53 Regulates Transcription of Caspase Activators and Caspases
R-HSA-6803211, TP53 Regulates Transcription of Death Receptors and Ligands
R-HSA-6804759, Regulation of TP53 Activity through Association with Co-factors
SignaLinkiQ9H3D4
SIGNORiQ9H3D4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
8626, 41 hits in 897 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TP63, human
EvolutionaryTraceiQ9H3D4

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TP63

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8626
PharosiQ9H3D4, Tbio

Protein Ontology

More...
PROi
PR:Q9H3D4
RNActiQ9H3D4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000073282, Expressed in skin of abdomen and 157 other tissues
ExpressionAtlasiQ9H3D4, baseline and differential
GenevisibleiQ9H3D4, HS

Family and domain databases

CDDicd08367, P53, 1 hit
cd09572, SAM_tumor-p63, 1 hit
Gene3Di1.10.150.50, 1 hit
2.60.40.720, 1 hit
4.10.170.10, 1 hit
InterProiView protein in InterPro
IPR008967, p53-like_TF_DNA-bd
IPR012346, p53/RUNT-type_TF_DNA-bd_sf
IPR011615, p53_DNA-bd
IPR036674, p53_tetramer_sf
IPR010991, p53_tetrameristn
IPR002117, p53_tumour_suppressor
IPR001660, SAM
IPR013761, SAM/pointed_sf
IPR032645, Tp63
IPR037611, Tumor-p63_SAM
PANTHERiPTHR11447, PTHR11447, 1 hit
PTHR11447:SF8, PTHR11447:SF8, 1 hit
PfamiView protein in Pfam
PF00870, P53, 1 hit
PF07710, P53_tetramer, 1 hit
PF07647, SAM_2, 1 hit
PRINTSiPR00386, P53SUPPRESSR
SMARTiView protein in SMART
SM00454, SAM, 1 hit
SUPFAMiSSF47719, SSF47719, 1 hit
SSF47769, SSF47769, 1 hit
SSF49417, SSF49417, 1 hit
PROSITEiView protein in PROSITE
PS00348, P53, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiP63_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H3D4
Secondary accession number(s): O75080
, O75195, O75922, O76078, Q6VEG2, Q6VEG3, Q6VEG4, Q6VFJ1, Q6VFJ2, Q6VFJ3, Q6VH20, Q7LDI3, Q7LDI4, Q7LDI5, Q96KR0, Q9H3D2, Q9H3D3, Q9H3P8, Q9NPH7, Q9P1B4, Q9P1B5, Q9P1B6, Q9P1B7, Q9UBV9, Q9UE10, Q9UP26, Q9UP27, Q9UP28, Q9UP74
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: March 1, 2001
Last modified: August 12, 2020
This is version 202 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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