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Protein

Gametogenetin-binding protein 2

Gene

GGNBP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in spermatogenesis.

Miscellaneous

Strongly down-regulated in 40% of primary laryngeal carcinoma and in 6 of 10 various cancer cell lines.

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Gametogenetin-binding protein 2
Alternative name(s):
Laryngeal carcinoma-related protein 1
Protein ZNF403
Gene namesi
Name:GGNBP2
Synonyms:LCRG1, LZK1, ZNF403
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000278311.4
HGNCiHGNC:19357 GGNBP2
MIMi612275 gene
neXtProtiNX_Q9H3C7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle

Pathology & Biotechi

Organism-specific databases

DisGeNETi79893
OpenTargetsiENSG00000278311
PharmGKBiPA162389409

Polymorphism and mutation databases

DMDMi74718217

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002393481 – 697Gametogenetin-binding protein 2Add BLAST697

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei360PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H3C7
MaxQBiQ9H3C7
PaxDbiQ9H3C7
PeptideAtlasiQ9H3C7
PRIDEiQ9H3C7
ProteomicsDBi80689
80690 [Q9H3C7-2]
80691 [Q9H3C7-3]

PTM databases

iPTMnetiQ9H3C7
PhosphoSitePlusiQ9H3C7

Expressioni

Tissue specificityi

Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed more abundantly in heart, pancreas and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000278311 Expressed in 228 organ(s), highest expression level in sperm
CleanExiHS_GGNBP2
ExpressionAtlasiQ9H3C7 baseline and differential
GenevisibleiQ9H3C7 HS

Organism-specific databases

HPAiHPA018914
HPA073392

Interactioni

Subunit structurei

Interacts with GGN.By similarity

Protein-protein interaction databases

BioGridi122977, 5 interactors
STRINGi9606.ENSP00000307617

Structurei

3D structure databases

ProteinModelPortaliQ9H3C7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IEAD Eukaryota
ENOG410XRSX LUCA
GeneTreeiENSGT00390000009552
HOGENOMiHOG000264258
HOVERGENiHBG082524
InParanoidiQ9H3C7
OMAiRGCWMDV
OrthoDBiEOG091G033L
PhylomeDBiQ9H3C7
TreeFamiTF323487

Family and domain databases

InterProiView protein in InterPro
IPR026073 GGNBP2
PANTHERiPTHR13601 PTHR13601, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H3C7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARLVAVCRD GEEEFPFERR QIPLYIDDTL TMVMEFPDNV LNLDGHQNNG
60 70 80 90 100
AQLKQFIQRH GMLKQQDLSI AMVVTSREVL SALSQLVPCV GCRRSVERLF
110 120 130 140 150
SQLVESGNPA LEPLTVGPKG VLSVTRSCMT DAKKLYTLFY VHGSKLNDMI
160 170 180 190 200
DAIPKSKKNK RCQLHSLDTH KPKPLGGCWM DVWELMSQEC RDEVVLIDSS
210 220 230 240 250
CLLETLETYL RKHRFCTDCK NKVLRAYNIL IGELDCSKEK GYCAALYEGL
260 270 280 290 300
RCCPHERHIH VCCETDFIAH LLGRAEPEFA GGRRERHAKT IDIAQEEVLT
310 320 330 340 350
CLGIHLYERL HRIWQKLRAE EQTWQMLFYL GVDALRKSFE MTVEKVQGIS
360 370 380 390 400
RLEQLCEEFS EEERVRELKQ EKKRQKRKNR RKNKCVCDIP TPLQTADEKE
410 420 430 440 450
VSQEKETDFI ENSSCKACGS TEDGNTCVEV IVTNENTSCT CPSSGNLLGS
460 470 480 490 500
PKIKKGLSPH CNGSDCGYSS SMEGSETGSR EGSDVACTEG ICNHDEHGDD
510 520 530 540 550
SCVHHCEDKE DDGDSCVECW ANSEENDTKG KNKKKKKKSK ILKCDEHIQK
560 570 580 590 600
LGSCITDPGN RETSGNTMHT VFHRDKTKDT HPESCCSSEK GGQPLPWFEH
610 620 630 640 650
RKNVPQFAEP TETLFGPDSG KGAKSLVELL DESECTSDEE IFISQDEIQS
660 670 680 690
FMANNQSFYS NREQYRQHLK EKFNKYCRLN DHKRPICSGW LTTAGAN
Length:697
Mass (Da):79,086
Last modified:March 1, 2001 - v1
Checksum:iFA57264D37BF7E5D
GO
Isoform 2 (identifier: Q9H3C7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     283-288: RRERHA → YEYVIC
     289-697: Missing.

Show »
Length:288
Mass (Da):32,735
Checksum:i7925D6A6FE796730
GO
Isoform 3 (identifier: Q9H3C7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     457-457: L → K
     458-697: Missing.

Note: No experimental confirmation available.
Show »
Length:457
Mass (Da):52,253
Checksum:i0FCC22CAD00378D1
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X1D7A0A087X1D7_HUMAN
Gametogenetin-binding protein 2
GGNBP2
158Annotation score:
A0A087X1N0A0A087X1N0_HUMAN
Gametogenetin-binding protein 2
GGNBP2
133Annotation score:
A0A087X0E5A0A087X0E5_HUMAN
Gametogenetin-binding protein 2
GGNBP2
68Annotation score:

Sequence cautioni

The sequence BAB15031 differs from that shown. Reason: Frameshift at position 387.Curated
The sequence BAB15397 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAC18878 differs from that shown. Reason: Frameshift at position 433.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti415C → Y in BAB15031 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_019175283 – 288RRERHA → YEYVIC in isoform 2. 1 Publication6
Alternative sequenceiVSP_019176289 – 697Missing in isoform 2. 1 PublicationAdd BLAST409
Alternative sequenceiVSP_019177457L → K in isoform 3. 1 Publication1
Alternative sequenceiVSP_019178458 – 697Missing in isoform 3. 1 PublicationAdd BLAST240

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF268387 mRNA Translation: AAK38614.1
AF126964 mRNA Translation: AAG43247.1
AK024883 mRNA Translation: BAB15031.1 Frameshift.
AK026214 mRNA Translation: BAB15397.1 Different initiation.
CH471199 Genomic DNA Translation: EAW57566.1
BC137491 mRNA Translation: AAI37492.1
AJ404670 mRNA Translation: CAC18878.1 Frameshift.
CCDSiCCDS11314.1 [Q9H3C7-1]
RefSeqiNP_079111.1, NM_024835.4 [Q9H3C7-1]
UniGeneiHs.514116

Genome annotation databases

EnsembliENST00000613102; ENSP00000478220; ENSG00000278311 [Q9H3C7-1]
ENST00000621686; ENSP00000478954; ENSG00000275099 [Q9H3C7-1]
GeneIDi79893
KEGGihsa:79893
UCSCiuc002hnb.4 human [Q9H3C7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF268387 mRNA Translation: AAK38614.1
AF126964 mRNA Translation: AAG43247.1
AK024883 mRNA Translation: BAB15031.1 Frameshift.
AK026214 mRNA Translation: BAB15397.1 Different initiation.
CH471199 Genomic DNA Translation: EAW57566.1
BC137491 mRNA Translation: AAI37492.1
AJ404670 mRNA Translation: CAC18878.1 Frameshift.
CCDSiCCDS11314.1 [Q9H3C7-1]
RefSeqiNP_079111.1, NM_024835.4 [Q9H3C7-1]
UniGeneiHs.514116

3D structure databases

ProteinModelPortaliQ9H3C7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122977, 5 interactors
STRINGi9606.ENSP00000307617

PTM databases

iPTMnetiQ9H3C7
PhosphoSitePlusiQ9H3C7

Polymorphism and mutation databases

DMDMi74718217

Proteomic databases

EPDiQ9H3C7
MaxQBiQ9H3C7
PaxDbiQ9H3C7
PeptideAtlasiQ9H3C7
PRIDEiQ9H3C7
ProteomicsDBi80689
80690 [Q9H3C7-2]
80691 [Q9H3C7-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000613102; ENSP00000478220; ENSG00000278311 [Q9H3C7-1]
ENST00000621686; ENSP00000478954; ENSG00000275099 [Q9H3C7-1]
GeneIDi79893
KEGGihsa:79893
UCSCiuc002hnb.4 human [Q9H3C7-1]

Organism-specific databases

CTDi79893
DisGeNETi79893
EuPathDBiHostDB:ENSG00000278311.4
GeneCardsiGGNBP2
HGNCiHGNC:19357 GGNBP2
HPAiHPA018914
HPA073392
MIMi612275 gene
neXtProtiNX_Q9H3C7
OpenTargetsiENSG00000278311
PharmGKBiPA162389409
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEAD Eukaryota
ENOG410XRSX LUCA
GeneTreeiENSGT00390000009552
HOGENOMiHOG000264258
HOVERGENiHBG082524
InParanoidiQ9H3C7
OMAiRGCWMDV
OrthoDBiEOG091G033L
PhylomeDBiQ9H3C7
TreeFamiTF323487

Miscellaneous databases

ChiTaRSiGGNBP2 human
GenomeRNAii79893
PROiPR:Q9H3C7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000278311 Expressed in 228 organ(s), highest expression level in sperm
CleanExiHS_GGNBP2
ExpressionAtlasiQ9H3C7 baseline and differential
GenevisibleiQ9H3C7 HS

Family and domain databases

InterProiView protein in InterPro
IPR026073 GGNBP2
PANTHERiPTHR13601 PTHR13601, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGGNB2_HUMAN
AccessioniPrimary (citable) accession number: Q9H3C7
Secondary accession number(s): B2RPK7
, Q96T90, Q9GZR8, Q9H767
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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