Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Polyadenylate-binding protein 3

Gene

PABPC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Binds poly(A) with a slightly lower affinity as compared to PABPC1.

GO - Molecular functioni

  • mRNA 3'-UTR binding Source: GO_Central
  • poly(A) binding Source: UniProtKB
  • poly(U) RNA binding Source: GO_Central
  • RNA binding Source: GO_Central

GO - Biological processi

  • mRNA metabolic process Source: UniProtKB

Keywordsi

Molecular functionRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyadenylate-binding protein 3
Short name:
PABP-3
Short name:
Poly(A)-binding protein 3
Alternative name(s):
Testis-specific poly(A)-binding protein
Gene namesi
Name:PABPC3
Synonyms:PABP3, PABPL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000151846.8
HGNCiHGNC:8556 PABPC3
MIMi604680 gene
neXtProtiNX_Q9H361

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000151846
PharmGKBiPA32882

Polymorphism and mutation databases

BioMutaiPABPC3
DMDMi28201852

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000817021 – 631Polyadenylate-binding protein 3Add BLAST631

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei140PhosphotyrosineBy similarity1
Modified residuei315PhosphoserineBy similarity1
Modified residuei361N6,N6-dimethyllysine; alternateBy similarity1
Cross-linki361Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei364PhosphotyrosineBy similarity1
Modified residuei426Omega-N-methylarginineBy similarity1
Modified residuei430Omega-N-methylarginineBy similarity1
Modified residuei449Omega-N-methylarginineBy similarity1
Modified residuei501Dimethylated arginineBy similarity1
Modified residuei513Omega-N-methylarginineBy similarity1

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9H361
MaxQBiQ9H361
PaxDbiQ9H361
PeptideAtlasiQ9H361
PRIDEiQ9H361
ProteomicsDBi80679

PTM databases

iPTMnetiQ9H361
PhosphoSitePlusiQ9H361
SwissPalmiQ9H361

Expressioni

Tissue specificityi

Testis specific.1 Publication

Gene expression databases

BgeeiENSG00000151846 Expressed in 193 organ(s), highest expression level in parotid gland
CleanExiHS_PABPC3
ExpressionAtlasiQ9H361 baseline and differential
GenevisibleiQ9H361 HS

Organism-specific databases

HPAiHPA045423
HPA067156

Interactioni

Protein-protein interaction databases

BioGridi111079, 27 interactors
IntActiQ9H361, 8 interactors
MINTiQ9H361
STRINGi9606.ENSP00000281589

Structurei

Secondary structure

1631
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9H361
SMRiQ9H361
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H361

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 89RRM 1PROSITE-ProRule annotationAdd BLAST79
Domaini99 – 175RRM 2PROSITE-ProRule annotationAdd BLAST77
Domaini191 – 268RRM 3PROSITE-ProRule annotationAdd BLAST78
Domaini294 – 370RRM 4PROSITE-ProRule annotationAdd BLAST77
Domaini537 – 614PABCPROSITE-ProRule annotationAdd BLAST78

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0123 Eukaryota
ENOG410XR5X LUCA
GeneTreeiENSGT00760000118913
HOGENOMiHOG000217922
HOVERGENiHBG002295
InParanoidiQ9H361
KOiK13126
OMAiLRIMWSQ
OrthoDBiEOG091G03ZE
PhylomeDBiQ9H361
TreeFamiTF300458

Family and domain databases

Gene3Di3.30.70.330, 4 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR036053 PABP-dom
IPR006515 PABP_1234
IPR002004 PABP_HYD
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR003954 RRM_dom_euk
PfamiView protein in Pfam
PF00658 PABP, 1 hit
PF00076 RRM_1, 4 hits
SMARTiView protein in SMART
SM00517 PolyA, 1 hit
SM00360 RRM, 4 hits
SM00361 RRM_1, 3 hits
SUPFAMiSSF54928 SSF54928, 2 hits
SSF63570 SSF63570, 1 hit
TIGRFAMsiTIGR01628 PABP-1234, 1 hit
PROSITEiView protein in PROSITE
PS51309 PABC, 1 hit
PS50102 RRM, 4 hits

Sequencei

Sequence statusi: Complete.

Q9H361-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNPSTPSYPT ASLYVGDLHP DVTEAMLYEK FSPAGPILSI RICRDLITSG
60 70 80 90 100
SSNYAYVNFQ HTKDAEHALD TMNFDVIKGK PVRIMWSQRD PSLRKSGVGN
110 120 130 140 150
IFVKNLDKSI NNKALYDTVS AFGNILSCNV VCDENGSKGY GFVHFETHEA
160 170 180 190 200
AERAIKKMNG MLLNGRKVFV GQFKSRKERE AELGARAKEF PNVYIKNFGE
210 220 230 240 250
DMDDERLKDL FGKFGPALSV KVMTDESGKS KGFGFVSFER HEDAQKAVDE
260 270 280 290 300
MNGKELNGKQ IYVGRAQKKV ERQTELKRTF EQMKQDRITR YQVVNLYVKN
310 320 330 340 350
LDDGIDDERL RKAFSPFGTI TSAKVMMEGG RSKGFGFVCF SSPEEATKAV
360 370 380 390 400
TEMNGRIVAT KPLYVALAQR KEERQAYLTN EYMQRMASVR AVPNQRAPPS
410 420 430 440 450
GYFMTAVPQT QNHAAYYPPS QIARLRPSPR WTAQGARPHP FQNKPSAIRP
460 470 480 490 500
GAPRVPFSTM RPASSQVPRV MSTQRVANTS TQTVGPRPAA AAAAAATPAV
510 520 530 540 550
RTVPRYKYAA GVRNPQQHRN AQPQVTMQQL AVHVQGQETL TASRLASAPP
560 570 580 590 600
QKQKQMLGER LFPLIQAMHP TLAGKITGML LEIDNSELLY MLESPESLRS
610 620 630
KVDEAVAVLQ AHQAKEATQK AVNSATGVPT V
Length:631
Mass (Da):70,031
Last modified:February 1, 2003 - v2
Checksum:i2F8C5BF6F508AAEF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti221 – 222KV → EL in CAB66834 (PubMed:11230166).Curated2
Sequence conflicti492A → R in AAG38953 (PubMed:11328870).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132026 mRNA Translation: AAG38953.1
AL136900 mRNA Translation: CAB66834.2
BC027617 mRNA Translation: AAH27617.1
CCDSiCCDS9311.1
RefSeqiNP_112241.2, NM_030979.2
UniGeneiHs.458280

Genome annotation databases

EnsembliENST00000281589; ENSP00000281589; ENSG00000151846
GeneIDi5042
KEGGihsa:5042
UCSCiuc001upy.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132026 mRNA Translation: AAG38953.1
AL136900 mRNA Translation: CAB66834.2
BC027617 mRNA Translation: AAH27617.1
CCDSiCCDS9311.1
RefSeqiNP_112241.2, NM_030979.2
UniGeneiHs.458280

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D9PNMR-A286-375[»]
4IVEX-ray2.30A/B/C/D535-631[»]
ProteinModelPortaliQ9H361
SMRiQ9H361
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111079, 27 interactors
IntActiQ9H361, 8 interactors
MINTiQ9H361
STRINGi9606.ENSP00000281589

PTM databases

iPTMnetiQ9H361
PhosphoSitePlusiQ9H361
SwissPalmiQ9H361

Polymorphism and mutation databases

BioMutaiPABPC3
DMDMi28201852

Proteomic databases

EPDiQ9H361
MaxQBiQ9H361
PaxDbiQ9H361
PeptideAtlasiQ9H361
PRIDEiQ9H361
ProteomicsDBi80679

Protocols and materials databases

DNASUi5042
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000281589; ENSP00000281589; ENSG00000151846
GeneIDi5042
KEGGihsa:5042
UCSCiuc001upy.4 human

Organism-specific databases

CTDi5042
EuPathDBiHostDB:ENSG00000151846.8
GeneCardsiPABPC3
HGNCiHGNC:8556 PABPC3
HPAiHPA045423
HPA067156
MIMi604680 gene
neXtProtiNX_Q9H361
OpenTargetsiENSG00000151846
PharmGKBiPA32882
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0123 Eukaryota
ENOG410XR5X LUCA
GeneTreeiENSGT00760000118913
HOGENOMiHOG000217922
HOVERGENiHBG002295
InParanoidiQ9H361
KOiK13126
OMAiLRIMWSQ
OrthoDBiEOG091G03ZE
PhylomeDBiQ9H361
TreeFamiTF300458

Miscellaneous databases

EvolutionaryTraceiQ9H361
GeneWikiiPABPC3
GenomeRNAii5042
PROiPR:Q9H361
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000151846 Expressed in 193 organ(s), highest expression level in parotid gland
CleanExiHS_PABPC3
ExpressionAtlasiQ9H361 baseline and differential
GenevisibleiQ9H361 HS

Family and domain databases

Gene3Di3.30.70.330, 4 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR036053 PABP-dom
IPR006515 PABP_1234
IPR002004 PABP_HYD
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR003954 RRM_dom_euk
PfamiView protein in Pfam
PF00658 PABP, 1 hit
PF00076 RRM_1, 4 hits
SMARTiView protein in SMART
SM00517 PolyA, 1 hit
SM00360 RRM, 4 hits
SM00361 RRM_1, 3 hits
SUPFAMiSSF54928 SSF54928, 2 hits
SSF63570 SSF63570, 1 hit
TIGRFAMsiTIGR01628 PABP-1234, 1 hit
PROSITEiView protein in PROSITE
PS51309 PABC, 1 hit
PS50102 RRM, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPABP3_HUMAN
AccessioniPrimary (citable) accession number: Q9H361
Secondary accession number(s): Q8NHV0, Q9H086
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: February 1, 2003
Last modified: November 7, 2018
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again