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Entry version 131 (11 Dec 2019)
Sequence version 1 (01 Mar 2001)
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Protein

Cysteine-rich secretory protein LCCL domain-containing 1

Gene

CRISPLD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cysteine-rich secretory protein LCCL domain-containing 1
Alternative name(s):
CocoaCrisp
Cysteine-rich secretory protein 10
Short name:
CRISP-10
LCCL domain-containing cysteine-rich secretory protein 1
Trypsin inhibitor Hl
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CRISPLD1
Synonyms:CRISP10, LCRISP1
ORF Names:UNQ342/PRO541
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000121005.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18206 CRISPLD1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H336

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000121005

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142672076

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9H336 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CRISPLD1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74733568

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000024814624 – 500Cysteine-rich secretory protein LCCL domain-containing 1Add BLAST477

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi295 ↔ 313PROSITE-ProRule annotation
Disulfide bondi317 ↔ 337PROSITE-ProRule annotation
Disulfide bondi396 ↔ 418PROSITE-ProRule annotation
Disulfide bondi422 ↔ 445PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9H336

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9H336

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H336

PeptideAtlas

More...
PeptideAtlasi
Q9H336

PRoteomics IDEntifications database

More...
PRIDEi
Q9H336

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
6999
80668 [Q9H336-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H336

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H336

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000121005 Expressed in 159 organ(s), highest expression level in pigmented layer of retina

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9H336 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H336 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA024725

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123725, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000262207

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9H336 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9H336

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini66 – 206SCPAdd BLAST141
Domaini289 – 384LCCL 1PROSITE-ProRule annotationAdd BLAST96
Domaini390 – 492LCCL 2PROSITE-ProRule annotationAdd BLAST103

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CRISP family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3017 Eukaryota
COG2340 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156473

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000294224

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H336

Identification of Orthologs from Complete Genome Data

More...
OMAi
QAITCET

Database of Orthologous Groups

More...
OrthoDBi
1528782at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H336

TreeFam database of animal gene trees

More...
TreeFami
TF316148

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.170.130.20, 2 hits
3.40.33.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018244 Allrgn_V5/Tpx1_CS
IPR014044 CAP_domain
IPR035940 CAP_sf
IPR001283 CRISP-related
IPR004043 LCCL
IPR036609 LCCL_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10334 PTHR10334, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00188 CAP, 1 hit
PF03815 LCCL, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00837 V5TPXLIKE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00603 LCCL, 2 hits
SM00198 SCP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55797 SSF55797, 1 hit
SSF69848 SSF69848, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01010 CRISP_2, 1 hit
PS50820 LCCL, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H336-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKCTAREWLR VTTVLFMARA IPAMVVPNAT LLEKLLEKYM DEDGEWWIAK
60 70 80 90 100
QRGKRAITDN DMQSILDLHN KLRSQVYPTA SNMEYMTWDV ELERSAESWA
110 120 130 140 150
ESCLWEHGPA SLLPSIGQNL GAHWGRYRPP TFHVQSWYDE VKDFSYPYEH
160 170 180 190 200
ECNPYCPFRC SGPVCTHYTQ VVWATSNRIG CAINLCHNMN IWGQIWPKAV
210 220 230 240 250
YLVCNYSPKG NWWGHAPYKH GRPCSACPPS FGGGCRENLC YKEGSDRYYP
260 270 280 290 300
PREEETNEIE RQQSQVHDTH VRTRSDDSSR NEVISAQQMS QIVSCEVRLR
310 320 330 340 350
DQCKGTTCNR YECPAGCLDS KAKVIGSVHY EMQSSICRAA IHYGIIDNDG
360 370 380 390 400
GWVDITRQGR KHYFIKSNRN GIQTIGKYQS ANSFTVSKVT VQAVTCETTV
410 420 430 440 450
EQLCPFHKPA SHCPRVYCPR NCMQANPHYA RVIGTRVYSD LSSICRAAVH
460 470 480 490 500
AGVVRNHGGY VDVMPVDKRK TYIASFQNGI FSESLQNPPG GKAFRVFAVV
Length:500
Mass (Da):56,888
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i203B1DC4DDA003CB
GO
Isoform 2 (identifier: Q9H336-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MKCTAREWLRVTTVLFMARAIPA → MNMNATHIVHSGVLALYVHIIHR
     24-209: Missing.

Show »
Length:314
Mass (Da):35,172
Checksum:i6492A86B51890971
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7Z8V9B7Z8V9_HUMAN
Cysteine-rich secretory protein LCC...
CRISPLD1
312Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RJS4E5RJS4_HUMAN
Cysteine-rich secretory protein LCC...
CRISPLD1
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_027255286A → S. Corresponds to variant dbSNP:rs1945Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0552811 – 23MKCTA…RAIPA → MNMNATHIVHSGVLALYVHI IHR in isoform 2. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_05528224 – 209Missing in isoform 2. 1 PublicationAdd BLAST186

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF142573 mRNA Translation: AAG43287.1
AF329197 mRNA Translation: AAK16495.1
AY358564 mRNA Translation: AAQ88927.1
AK304350 mRNA Translation: BAH14165.1
AK314048 mRNA Translation: BAG36757.1
AL834301 mRNA Translation: CAH56361.1
AC100782 Genomic DNA No translation available.
AC102801 Genomic DNA No translation available.
CH471068 Genomic DNA Translation: EAW87038.1
BC020514 mRNA Translation: AAH20514.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6219.1 [Q9H336-1]
CCDS69497.1 [Q9H336-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001273706.1, NM_001286777.1 [Q9H336-2]
NP_113649.1, NM_031461.5 [Q9H336-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000262207; ENSP00000262207; ENSG00000121005 [Q9H336-1]
ENST00000517786; ENSP00000429746; ENSG00000121005 [Q9H336-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
83690

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:83690

UCSC genome browser

More...
UCSCi
uc003yan.5 human [Q9H336-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF142573 mRNA Translation: AAG43287.1
AF329197 mRNA Translation: AAK16495.1
AY358564 mRNA Translation: AAQ88927.1
AK304350 mRNA Translation: BAH14165.1
AK314048 mRNA Translation: BAG36757.1
AL834301 mRNA Translation: CAH56361.1
AC100782 Genomic DNA No translation available.
AC102801 Genomic DNA No translation available.
CH471068 Genomic DNA Translation: EAW87038.1
BC020514 mRNA Translation: AAH20514.1
CCDSiCCDS6219.1 [Q9H336-1]
CCDS69497.1 [Q9H336-2]
RefSeqiNP_001273706.1, NM_001286777.1 [Q9H336-2]
NP_113649.1, NM_031461.5 [Q9H336-1]

3D structure databases

SMRiQ9H336
ModBaseiSearch...

Protein-protein interaction databases

BioGridi123725, 1 interactor
STRINGi9606.ENSP00000262207

PTM databases

iPTMnetiQ9H336
PhosphoSitePlusiQ9H336

Polymorphism and mutation databases

BioMutaiCRISPLD1
DMDMi74733568

Proteomic databases

EPDiQ9H336
MassIVEiQ9H336
PaxDbiQ9H336
PeptideAtlasiQ9H336
PRIDEiQ9H336
ProteomicsDBi6999
80668 [Q9H336-1]

Genome annotation databases

EnsembliENST00000262207; ENSP00000262207; ENSG00000121005 [Q9H336-1]
ENST00000517786; ENSP00000429746; ENSG00000121005 [Q9H336-2]
GeneIDi83690
KEGGihsa:83690
UCSCiuc003yan.5 human [Q9H336-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
83690
EuPathDBiHostDB:ENSG00000121005.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CRISPLD1
HGNCiHGNC:18206 CRISPLD1
HPAiHPA024725
neXtProtiNX_Q9H336
OpenTargetsiENSG00000121005
PharmGKBiPA142672076

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3017 Eukaryota
COG2340 LUCA
GeneTreeiENSGT00940000156473
HOGENOMiHOG000294224
InParanoidiQ9H336
OMAiQAITCET
OrthoDBi1528782at2759
PhylomeDBiQ9H336
TreeFamiTF316148

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
83690
PharosiQ9H336 Tbio

Protein Ontology

More...
PROi
PR:Q9H336
RNActiQ9H336 protein

Gene expression databases

BgeeiENSG00000121005 Expressed in 159 organ(s), highest expression level in pigmented layer of retina
ExpressionAtlasiQ9H336 baseline and differential
GenevisibleiQ9H336 HS

Family and domain databases

Gene3Di2.170.130.20, 2 hits
3.40.33.10, 1 hit
InterProiView protein in InterPro
IPR018244 Allrgn_V5/Tpx1_CS
IPR014044 CAP_domain
IPR035940 CAP_sf
IPR001283 CRISP-related
IPR004043 LCCL
IPR036609 LCCL_sf
PANTHERiPTHR10334 PTHR10334, 1 hit
PfamiView protein in Pfam
PF00188 CAP, 1 hit
PF03815 LCCL, 2 hits
PRINTSiPR00837 V5TPXLIKE
SMARTiView protein in SMART
SM00603 LCCL, 2 hits
SM00198 SCP, 1 hit
SUPFAMiSSF55797 SSF55797, 1 hit
SSF69848 SSF69848, 2 hits
PROSITEiView protein in PROSITE
PS01010 CRISP_2, 1 hit
PS50820 LCCL, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCRLD1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H336
Secondary accession number(s): B2RA60, B7Z929
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: March 1, 2001
Last modified: December 11, 2019
This is version 131 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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