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Entry version 182 (08 May 2019)
Sequence version 1 (01 Mar 2001)
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Protein

Forkhead box protein P1

Gene

FOXP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional repressor (PubMed:18347093, PubMed:26647308). Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal chord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18 (By similarity). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis (PubMed:25267198). Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor (PubMed:15286807, PubMed:18799727, PubMed:18347093). Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B (PubMed:24023716). Can negatively regulate androgen receptor signaling (PubMed:18640093).By similarity2 Publications6 Publications
Isoform 8: Involved in transcriptional regulation in embryonic stem cells (ESCs). Stimulates expression of transcription factors that are required for pluripotency and decreases expression of differentiation-associated genes. Has distinct DNA-binding specifities as compared to the canonical form and preferentially binds DNA with the sequence 5'-CGATACAA-3' (or closely related sequences) (PubMed:21924763). Promotes ESC self-renewal and pluripotency (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri306 – 331C2H2-typeAdd BLAST26
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi465 – 555Fork-headPROSITE-ProRule annotationAdd BLAST91

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-452723 Transcriptional regulation of pluripotent stem cells

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9H334

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9H334

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Forkhead box protein P1
Alternative name(s):
Mac-1-regulated forkhead1 Publication
Short name:
MFH1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FOXP1
ORF Names:HSPC215
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3823 FOXP1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
605515 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H334

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving FOXP1 is found in acute lymphoblastic leukemia. Translocation t(9;3)(p13;p14.1) with PAX5.
Mental retardation with language impairment and autistic features (MRLIAF)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA developmental disorder characterized by mild to moderate mental retardation, language impairment, and autistic features. Patients show global delay, delayed walking, severely delayed speech development, and behavioral abnormalities, including irritability, hyperactivity, aggression, and stereotypical rigid behaviors.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_075247465R → G in MRLIAF; nuclear and cytoplasmic aggregation; loss of transcriptional repression activity; loss of ability to self-associate; loss of interaction with FOXP2. 1 PublicationCorresponds to variant dbSNP:rs869025202EnsemblClinVar.1
Natural variantiVAR_075248514R → C in MRLIAF; nuclear and cytoplasmic aggregation; loss of transcriptional repression activity; loss of ability to self-associate; loss of interaction with FOXP2. 1 PublicationCorresponds to variant dbSNP:rs869025203EnsemblClinVar.1
Natural variantiVAR_075249534W → R in MRLIAF; nuclear and cytoplasmic aggregation; loss of transcriptional repression activity; loss of ability to self-associate; loss of interaction with FOXP2. 1 PublicationCorresponds to variant dbSNP:rs587777855EnsemblClinVar.1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei59 – 60Breakpoint for translocation to form PAX5-FOXP12

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

DisGeNET

More...
DisGeNETi
27086

MalaCards human disease database

More...
MalaCardsi
FOXP1
MIMi613670 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000114861

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
391372 Intellectual disability-severe speech delay-mild dysmorphism syndrome
52417 MALT lymphoma
99860 Precursor B-cell acute lymphoblastic leukemia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28241

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FOXP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
14548062

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000918771 – 677Forkhead box protein P1Add BLAST677

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei83PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki287Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki372Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki377Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki442Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei653PhosphothreonineCombined sources1
Modified residuei658PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9H334

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9H334

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9H334

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9H334

PeptideAtlas

More...
PeptideAtlasi
Q9H334

PRoteomics IDEntifications database

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PRIDEi
Q9H334

ProteomicsDB human proteome resource

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ProteomicsDBi
80663
80665 [Q9H334-3]
80666 [Q9H334-4]
80667 [Q9H334-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H334

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H334

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 8 is specifically expressed in embryonic stem cells.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By androgen in an isoform-specific manner; expression of isoform 4 is greatly induced.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000114861 Expressed in 212 organ(s), highest expression level in forebrain

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9H334 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9H334 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB011501
HPA003876

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms homodimers and heterodimers with FOXP2 and FOXP4 (PubMed:25027557). Dimerization is required for DNA-binding. Self-associates (PubMed:26647308). Interacts with CTBP1 (By similarity). Interacts with NCOR2 and AR (PubMed:18347093, PubMed:18640093). Interacts with FOXP2 (PubMed:26647308).By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
117989, 47 interactors

Database of interacting proteins

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DIPi
DIP-36585N

Protein interaction database and analysis system

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IntActi
Q9H334, 41 interactors

Molecular INTeraction database

More...
MINTi
Q9H334

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000484803

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1677
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9H334

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni348 – 369Leucine-zipperAdd BLAST22
Regioni382 – 386CTBP1-bindingBy similarity5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi55 – 230Gln-richAdd BLAST176

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The leucine-zipper is required for dimerization and transcriptional repression.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri306 – 331C2H2-typeAdd BLAST26

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4385 Eukaryota
COG5025 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000159892

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000092089

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9H334

KEGG Orthology (KO)

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KOi
K09409

Identification of Orthologs from Complete Genome Data

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OMAi
TSHAYCT

Database of Orthologous Groups

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OrthoDBi
836427at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9H334

TreeFam database of animal gene trees

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TreeFami
TF326978

Family and domain databases

Conserved Domains Database

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CDDi
cd00059 FH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001766 Fork_head_dom
IPR032354 FOXP-CC
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00250 Forkhead, 1 hit
PF16159 FOXP-CC, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00053 FORKHEAD

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00339 FH, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF46785 SSF46785, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 7 described isoforms and 27 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H334-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMQESGTETK SNGSAIQNGS GGSNHLLECG GLREGRSNGE TPAVDIGAAD
60 70 80 90 100
LAHAQQQQQQ ALQVARQLLL QQQQQQQVSG LKSPKRNDKQ PALQVPVSVA
110 120 130 140 150
MMTPQVITPQ QMQQILQQQV LSPQQLQVLL QQQQALMLQQ QQLQEFYKKQ
160 170 180 190 200
QEQLQLQLLQ QQHAGKQPKE QQQVATQQLA FQQQLLQMQQ LQQQHLLSLQ
210 220 230 240 250
RQGLLTIQPG QPALPLQPLA QGMIPTELQQ LWKEVTSAHT AEETTGNNHS
260 270 280 290 300
SLDLTTTCVS SSAPSKTSLI MNPHASTNGQ LSVHTPKRES LSHEEHPHSH
310 320 330 340 350
PLYGHGVCKW PGCEAVCEDF QSFLKHLNSE HALDDRSTAQ CRVQMQVVQQ
360 370 380 390 400
LELQLAKDKE RLQAMMTHLH VKSTEPKAAP QPLNLVSSVT LSKSASEASP
410 420 430 440 450
QSLPHTPTTP TAPLTPVTQG PSVITTTSMH TVGPIRRRYS DKYNVPISSA
460 470 480 490 500
DIAQNQEFYK NAEVRPPFTY ASLIRQAILE SPEKQLTLNE IYNWFTRMFA
510 520 530 540 550
YFRRNAATWK NAVRHNLSLH KCFVRVENVK GAVWTVDEVE FQKRRPQKIS
560 570 580 590 600
GNPSLIKNMQ SSHAYCTPLN AALQASMAEN SIPLYTTASM GNPTLGNLAS
610 620 630 640 650
AIREELNGAM EHTNSNESDS SPGRSPMQAV HPVHVKEEPL DPEEAEGPLS
660 670
LVTTANHSPD FDHDRDYEDE PVNEDME
Length:677
Mass (Da):75,317
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAEE92D47BB20964B
GO
Isoform 3 (identifier: Q9H334-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: MMQESGTETK...LAHAQQQQQQ → MFQCVFSSSV...APFAKLFIFS
     95-170: Missing.

Note: Incomplete sequence.
Show »
Length:603
Mass (Da):67,415
Checksum:i3B9156608207614E
GO
Isoform 4 (identifier: Q9H334-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: MMQESGTETK...LAHAQQQQQQ → MFQCVFSSSV...APFAKLFIFS

Note: Incomplete sequence. No experimental confirmation available.
Show »
Length:679
Mass (Da):76,314
Checksum:i003F5DFCAEC01AB8
GO
Isoform 5 (identifier: Q9H334-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     61-114: ALQVARQLLL...QVITPQQMQQ → WHLINHQPSR...PVCQPNPSPF
     115-677: Missing.

Show »
Length:114
Mass (Da):12,256
Checksum:iA1CC32BD8BBC4EA5
GO
Isoform 6 (identifier: Q9H334-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     95-170: Missing.

Show »
Length:601
Mass (Da):66,417
Checksum:i599FC834381D194C
GO
Isoform 7 (identifier: Q9H334-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     450-450: Missing.

Note: No experimental confirmation available. May be due to competing acceptor splice site.
Show »
Length:676
Mass (Da):75,246
Checksum:iF70967CCDB289929
GO
Isoform 8 (identifier: Q9H334-8) [UniParc]FASTAAdd to basket
Also known as: FOXP1-ES

The sequence of this isoform differs from the canonical sequence as follows:
     511-551: NAVRHNLSLH...QKRRPQKISG → GAIRTNLSLH...DENFDELVAH

Show »
Length:693
Mass (Da):77,363
Checksum:i1177D1149A03373C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 27 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4J2F3A0A0B4J2F3_HUMAN
Forkhead box protein P1
FOXP1
576Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J0F0C9J0F0_HUMAN
Forkhead box protein P1
FOXP1
612Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G5E965G5E965_HUMAN
Forkhead box P1, isoform CRA_f
FOXP1 hCG_1778483
566Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IS20A0A3B3IS20_HUMAN
Forkhead box protein P1
FOXP1
678Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IT66A0A3B3IT66_HUMAN
Forkhead box protein P1
FOXP1
577Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IRS5A0A3B3IRS5_HUMAN
Forkhead box P1, isoform CRA_g
FOXP1 hCG_1778483
675Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IST0A0A3B3IST0_HUMAN
Forkhead box protein P1
FOXP1
676Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IRW5A0A3B3IRW5_HUMAN
Forkhead box protein P1
FOXP1
576Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IUB6A0A3B3IUB6_HUMAN
Forkhead box protein P1
FOXP1
672Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IST6A0A3B3IST6_HUMAN
Forkhead box protein P1
FOXP1
628Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF36135 differs from that shown. Reason: Frameshift at positions 531 and 545.Curated
The sequence AAG47634 differs from that shown. Aberrant splicing.Curated
The sequence ABI33105 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB55005 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti138L → P in BAG53682 (PubMed:14702039).Curated1
Sequence conflicti173Q → R in BAB55005 (PubMed:14702039).Curated1
Sequence conflicti205L → V in BAB55005 (PubMed:14702039).Curated1
Sequence conflicti210 – 212GQP → ARA in AAK69408 (PubMed:11751404).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0650675S → P1 PublicationCorresponds to variant dbSNP:rs762898505EnsemblClinVar.1
Natural variantiVAR_065068101M → V1 PublicationCorresponds to variant dbSNP:rs564508875EnsemblClinVar.1
Natural variantiVAR_075246107I → T Polymorphism; does not affect nuclear localization; no loss of transcriptional repression activity; no loss of ability to self-associate; no loss of interaction with FOXP2. 2 Publications1
Natural variantiVAR_065069215P → A Polymorphism; does not affect nuclear localization; no loss of transcriptional repression activity; no loss of ability to self-associate; no loss of interaction with FOXP2. 4 PublicationsCorresponds to variant dbSNP:rs146606219EnsemblClinVar.1
Natural variantiVAR_065070261S → P1 Publication1
Natural variantiVAR_065071390T → S1 PublicationCorresponds to variant dbSNP:rs761840006Ensembl.1
Natural variantiVAR_065072445V → M1 PublicationCorresponds to variant dbSNP:rs147756430Ensembl.1
Natural variantiVAR_075247465R → G in MRLIAF; nuclear and cytoplasmic aggregation; loss of transcriptional repression activity; loss of ability to self-associate; loss of interaction with FOXP2. 1 PublicationCorresponds to variant dbSNP:rs869025202EnsemblClinVar.1
Natural variantiVAR_075248514R → C in MRLIAF; nuclear and cytoplasmic aggregation; loss of transcriptional repression activity; loss of ability to self-associate; loss of interaction with FOXP2. 1 PublicationCorresponds to variant dbSNP:rs869025203EnsemblClinVar.1
Natural variantiVAR_075249534W → R in MRLIAF; nuclear and cytoplasmic aggregation; loss of transcriptional repression activity; loss of ability to self-associate; loss of interaction with FOXP2. 1 PublicationCorresponds to variant dbSNP:rs587777855EnsemblClinVar.1
Natural variantiVAR_065073570N → S Polymorphism; does not affect nuclear localization; no loss of transcriptional repression activity; no loss of ability to self-associate; no loss of interaction with FOXP2. 3 PublicationsCorresponds to variant dbSNP:rs140161845EnsemblClinVar.1
Natural variantiVAR_065074597N → T Polymorphism; does not affect nuclear localization; no loss of transcriptional repression activity; no loss of ability to self-associate; no loss of interaction with FOXP2. 2 Publications1
Natural variantiVAR_065075613T → N1 PublicationCorresponds to variant dbSNP:rs1318614471Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0015551 – 60MMQES…QQQQQ → MFQCVFSSSVLQPHSTSCLF KHLFYHSATPASQKQPEPIY SKKTEIQRQTVRAPFAKLFI FS in isoform 3 and isoform 4. 1 PublicationAdd BLAST60
Alternative sequenceiVSP_04346261 – 114ALQVA…QQMQQ → WHLINHQPSRSPSSWLKRLI SSPWELEVLQVPLWGAVAET KMSGPVCQPNPSPF in isoform 5. 2 PublicationsAdd BLAST54
Alternative sequenceiVSP_00155695 – 170Missing in isoform 3 and isoform 6. 1 PublicationAdd BLAST76
Alternative sequenceiVSP_043463115 – 677Missing in isoform 5. 2 PublicationsAdd BLAST563
Alternative sequenceiVSP_046930450Missing in isoform 7. 2 Publications1
Alternative sequenceiVSP_057341511 – 551NAVRH…QKISG → GAIRTNLSLHKCFIRVEDEF GSFWTVDDEEFKRGRHIQRG RPRKYCPDENFDELVAH in isoform 8. 1 PublicationAdd BLAST41

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF146696 mRNA Translation: AAG47632.1
AF146697 mRNA Translation: AAG47633.1
AF146698 mRNA Translation: AAG47634.1 Sequence problems.
AF275309 mRNA Translation: AAK69408.1
BT006643 mRNA Translation: AAP35289.1
AK092383 mRNA Translation: BAC03875.1
AK122710 mRNA Translation: BAG53682.1
AC097632 Genomic DNA No translation available.
AC097634 Genomic DNA No translation available.
AC103586 Genomic DNA No translation available.
AC104442 Genomic DNA No translation available.
AC104645 Genomic DNA No translation available.
AC138058 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW65494.1
CH471055 Genomic DNA Translation: EAW65499.1
BC005055 mRNA Translation: AAH05055.1
BC054815 mRNA Translation: AAH54815.1
BC071893 mRNA Translation: AAH71893.1
BC080521 mRNA Translation: AAH80521.1
DQ845346 mRNA Translation: ABI33105.1 Different initiation.
AK027264 mRNA Translation: BAB55005.1 Different initiation.
AF151049 mRNA Translation: AAF36135.1 Frameshift.
BQ017072 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2914.1 [Q9H334-1]
CCDS33785.1 [Q9H334-5]
CCDS58837.1 [Q9H334-4]
CCDS58838.1 [Q9H334-6]
CCDS58839.1 [Q9H334-7]
CCDS74964.1 [Q9H334-8]

NCBI Reference Sequences

More...
RefSeqi
NP_001012523.1, NM_001012505.1 [Q9H334-5]
NP_001231737.1, NM_001244808.1 [Q9H334-7]
NP_001231739.1, NM_001244810.1 [Q9H334-8]
NP_001231741.1, NM_001244812.1 [Q9H334-6]
NP_001231743.1, NM_001244814.1 [Q9H334-1]
NP_001231744.1, NM_001244815.1 [Q9H334-4]
NP_001231745.1, NM_001244816.1 [Q9H334-1]
NP_116071.2, NM_032682.5 [Q9H334-1]
XP_006713165.1, XM_006713102.2 [Q9H334-1]
XP_006713166.1, XM_006713103.2 [Q9H334-1]
XP_006713167.1, XM_006713104.2 [Q9H334-1]
XP_011531886.1, XM_011533584.2
XP_011531887.1, XM_011533585.2 [Q9H334-1]
XP_016861654.1, XM_017006165.1 [Q9H334-1]
XP_016861655.1, XM_017006166.1
XP_016861657.1, XM_017006168.1 [Q9H334-5]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000318779; ENSP00000318721; ENSG00000114861 [Q9H334-5]
ENST00000318789; ENSP00000318902; ENSG00000114861 [Q9H334-1]
ENST00000475937; ENSP00000419393; ENSG00000114861 [Q9H334-1]
ENST00000484350; ENSP00000417857; ENSG00000114861 [Q9H334-6]
ENST00000493089; ENSP00000418524; ENSG00000114861 [Q9H334-7]
ENST00000498215; ENSP00000418102; ENSG00000114861 [Q9H334-1]
ENST00000615603; ENSP00000484803; ENSG00000114861 [Q9H334-8]
ENST00000622151; ENSP00000477918; ENSG00000114861 [Q9H334-5]
ENST00000648107; ENSP00000497914; ENSG00000114861 [Q9H334-5]
ENST00000648380; ENSP00000497344; ENSG00000114861 [Q9H334-1]
ENST00000648426; ENSP00000498110; ENSG00000114861 [Q9H334-8]
ENST00000648662; ENSP00000496873; ENSG00000114861 [Q9H334-5]
ENST00000648718; ENSP00000496810; ENSG00000114861 [Q9H334-7]
ENST00000649528; ENSP00000497369; ENSG00000114861 [Q9H334-1]
ENST00000649631; ENSP00000496990; ENSG00000114861 [Q9H334-1]
ENST00000649695; ENSP00000496841; ENSG00000114861 [Q9H334-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
27086

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:27086

UCSC genome browser

More...
UCSCi
uc003dol.4 human [Q9H334-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF146696 mRNA Translation: AAG47632.1
AF146697 mRNA Translation: AAG47633.1
AF146698 mRNA Translation: AAG47634.1 Sequence problems.
AF275309 mRNA Translation: AAK69408.1
BT006643 mRNA Translation: AAP35289.1
AK092383 mRNA Translation: BAC03875.1
AK122710 mRNA Translation: BAG53682.1
AC097632 Genomic DNA No translation available.
AC097634 Genomic DNA No translation available.
AC103586 Genomic DNA No translation available.
AC104442 Genomic DNA No translation available.
AC104645 Genomic DNA No translation available.
AC138058 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW65494.1
CH471055 Genomic DNA Translation: EAW65499.1
BC005055 mRNA Translation: AAH05055.1
BC054815 mRNA Translation: AAH54815.1
BC071893 mRNA Translation: AAH71893.1
BC080521 mRNA Translation: AAH80521.1
DQ845346 mRNA Translation: ABI33105.1 Different initiation.
AK027264 mRNA Translation: BAB55005.1 Different initiation.
AF151049 mRNA Translation: AAF36135.1 Frameshift.
BQ017072 mRNA No translation available.
CCDSiCCDS2914.1 [Q9H334-1]
CCDS33785.1 [Q9H334-5]
CCDS58837.1 [Q9H334-4]
CCDS58838.1 [Q9H334-6]
CCDS58839.1 [Q9H334-7]
CCDS74964.1 [Q9H334-8]
RefSeqiNP_001012523.1, NM_001012505.1 [Q9H334-5]
NP_001231737.1, NM_001244808.1 [Q9H334-7]
NP_001231739.1, NM_001244810.1 [Q9H334-8]
NP_001231741.1, NM_001244812.1 [Q9H334-6]
NP_001231743.1, NM_001244814.1 [Q9H334-1]
NP_001231744.1, NM_001244815.1 [Q9H334-4]
NP_001231745.1, NM_001244816.1 [Q9H334-1]
NP_116071.2, NM_032682.5 [Q9H334-1]
XP_006713165.1, XM_006713102.2 [Q9H334-1]
XP_006713166.1, XM_006713103.2 [Q9H334-1]
XP_006713167.1, XM_006713104.2 [Q9H334-1]
XP_011531886.1, XM_011533584.2
XP_011531887.1, XM_011533585.2 [Q9H334-1]
XP_016861654.1, XM_017006165.1 [Q9H334-1]
XP_016861655.1, XM_017006166.1
XP_016861657.1, XM_017006168.1 [Q9H334-5]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KIUNMR-A462-548[»]
SMRiQ9H334
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117989, 47 interactors
DIPiDIP-36585N
IntActiQ9H334, 41 interactors
MINTiQ9H334
STRINGi9606.ENSP00000484803

PTM databases

iPTMnetiQ9H334
PhosphoSitePlusiQ9H334

Polymorphism and mutation databases

BioMutaiFOXP1
DMDMi14548062

Proteomic databases

EPDiQ9H334
jPOSTiQ9H334
MaxQBiQ9H334
PaxDbiQ9H334
PeptideAtlasiQ9H334
PRIDEiQ9H334
ProteomicsDBi80663
80665 [Q9H334-3]
80666 [Q9H334-4]
80667 [Q9H334-5]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
27086
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318779; ENSP00000318721; ENSG00000114861 [Q9H334-5]
ENST00000318789; ENSP00000318902; ENSG00000114861 [Q9H334-1]
ENST00000475937; ENSP00000419393; ENSG00000114861 [Q9H334-1]
ENST00000484350; ENSP00000417857; ENSG00000114861 [Q9H334-6]
ENST00000493089; ENSP00000418524; ENSG00000114861 [Q9H334-7]
ENST00000498215; ENSP00000418102; ENSG00000114861 [Q9H334-1]
ENST00000615603; ENSP00000484803; ENSG00000114861 [Q9H334-8]
ENST00000622151; ENSP00000477918; ENSG00000114861 [Q9H334-5]
ENST00000648107; ENSP00000497914; ENSG00000114861 [Q9H334-5]
ENST00000648380; ENSP00000497344; ENSG00000114861 [Q9H334-1]
ENST00000648426; ENSP00000498110; ENSG00000114861 [Q9H334-8]
ENST00000648662; ENSP00000496873; ENSG00000114861 [Q9H334-5]
ENST00000648718; ENSP00000496810; ENSG00000114861 [Q9H334-7]
ENST00000649528; ENSP00000497369; ENSG00000114861 [Q9H334-1]
ENST00000649631; ENSP00000496990; ENSG00000114861 [Q9H334-1]
ENST00000649695; ENSP00000496841; ENSG00000114861 [Q9H334-4]
GeneIDi27086
KEGGihsa:27086
UCSCiuc003dol.4 human [Q9H334-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
27086
DisGeNETi27086

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FOXP1
HGNCiHGNC:3823 FOXP1
HPAiCAB011501
HPA003876
MalaCardsiFOXP1
MIMi605515 gene
613670 phenotype
neXtProtiNX_Q9H334
OpenTargetsiENSG00000114861
Orphaneti391372 Intellectual disability-severe speech delay-mild dysmorphism syndrome
52417 MALT lymphoma
99860 Precursor B-cell acute lymphoblastic leukemia
PharmGKBiPA28241

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4385 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00940000159892
HOGENOMiHOG000092089
InParanoidiQ9H334
KOiK09409
OMAiTSHAYCT
OrthoDBi836427at2759
PhylomeDBiQ9H334
TreeFamiTF326978

Enzyme and pathway databases

ReactomeiR-HSA-452723 Transcriptional regulation of pluripotent stem cells
SignaLinkiQ9H334
SIGNORiQ9H334

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FOXP1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
FOXP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
27086

Protein Ontology

More...
PROi
PR:Q9H334

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000114861 Expressed in 212 organ(s), highest expression level in forebrain
ExpressionAtlasiQ9H334 baseline and differential
GenevisibleiQ9H334 HS

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR032354 FOXP-CC
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PF16159 FOXP-CC, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFOXP1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H334
Secondary accession number(s): A3QVP8
, B3KV70, G5E9V8, Q8NAN6, Q9BSG9, Q9H332, Q9H333, Q9P0R1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 1, 2001
Last modified: May 8, 2019
This is version 182 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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