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Protein

Forkhead box protein P1

Gene

FOXP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor (PubMed:18347093, PubMed:26647308). Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal chord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18 (By similarity). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis (PubMed:25267198). Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor (PubMed:15286807, PubMed:18799727, PubMed:18347093). Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B (PubMed:24023716). Can negatively regulate androgen receptor signaling (PubMed:18640093).By similarity2 Publications6 Publications
Isoform 8: Involved in transcriptional regulation in embryonic stem cells (ESCs). Stimulates expression of transcription factors that are required for pluripotency and decreases expression of differentiation-associated genes. Has distinct DNA-binding specifities as compared to the canonical form and preferentially binds DNA with the sequence 5'-CGATACAA-3' (or closely related sequences) (PubMed:21924763). Promotes ESC self-renewal and pluripotency (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri306 – 331C2H2-typeAdd BLAST26
DNA bindingi465 – 555Fork-headPROSITE-ProRule annotationAdd BLAST91

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-452723 Transcriptional regulation of pluripotent stem cells
SignaLinkiQ9H334
SIGNORiQ9H334

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein P1
Alternative name(s):
Mac-1-regulated forkhead1 Publication
Short name:
MFH1 Publication
Gene namesi
Name:FOXP1
ORF Names:HSPC215
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000114861.18
HGNCiHGNC:3823 FOXP1
MIMi605515 gene
neXtProtiNX_Q9H334

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving FOXP1 is found in acute lymphoblastic leukemia. Translocation t(9;3)(p13;p14.1) with PAX5.
Mental retardation with language impairment and autistic features (MRLIAF)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA developmental disorder characterized by mild to moderate mental retardation, language impairment, and autistic features. Patients show global delay, delayed walking, severely delayed speech development, and behavioral abnormalities, including irritability, hyperactivity, aggression, and stereotypical rigid behaviors.
See also OMIM:613670
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_075247465R → G in MRLIAF; nuclear and cytoplasmic aggregation; loss of transcriptional repression activity; loss of ability to self-associate; loss of interaction with FOXP2. 1 PublicationCorresponds to variant dbSNP:rs869025202EnsemblClinVar.1
Natural variantiVAR_075248514R → C in MRLIAF; nuclear and cytoplasmic aggregation; loss of transcriptional repression activity; loss of ability to self-associate; loss of interaction with FOXP2. 1 PublicationCorresponds to variant dbSNP:rs869025203EnsemblClinVar.1
Natural variantiVAR_075249534W → R in MRLIAF; nuclear and cytoplasmic aggregation; loss of transcriptional repression activity; loss of ability to self-associate; loss of interaction with FOXP2. 1 PublicationCorresponds to variant dbSNP:rs587777855EnsemblClinVar.1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei59 – 60Breakpoint for translocation to form PAX5-FOXP12

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

DisGeNETi27086
MalaCardsiFOXP1
MIMi613670 phenotype
OpenTargetsiENSG00000114861
Orphaneti391372 Intellectual disability-severe speech delay-mild dysmorphism syndrome
52417 MALT lymphoma
99860 Precursor B-cell acute lymphoblastic leukemia
PharmGKBiPA28241

Polymorphism and mutation databases

BioMutaiFOXP1
DMDMi14548062

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000918771 – 677Forkhead box protein P1Add BLAST677

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei83PhosphoserineCombined sources1
Cross-linki287Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki372Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki377Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki442Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei653PhosphothreonineCombined sources1
Modified residuei658PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9H334
MaxQBiQ9H334
PaxDbiQ9H334
PeptideAtlasiQ9H334
PRIDEiQ9H334
ProteomicsDBi80663
80665 [Q9H334-3]
80666 [Q9H334-4]
80667 [Q9H334-5]

PTM databases

iPTMnetiQ9H334
PhosphoSitePlusiQ9H334

Expressioni

Tissue specificityi

Isoform 8 is specifically expressed in embryonic stem cells.1 Publication

Inductioni

By androgen in an isoform-specific manner; expression of isoform 4 is greatly induced.1 Publication

Gene expression databases

BgeeiENSG00000114861 Expressed in 212 organ(s), highest expression level in forebrain
CleanExiHS_FOXP1
ExpressionAtlasiQ9H334 baseline and differential
GenevisibleiQ9H334 HS

Organism-specific databases

HPAiCAB011501
HPA003876

Interactioni

Subunit structurei

Forms homodimers and heterodimers with FOXP2 and FOXP4 (PubMed:25027557). Dimerization is required for DNA-binding. Self-associates (PubMed:26647308). Interacts with CTBP1 (By similarity). Interacts with NCOR2 and AR (PubMed:18347093, PubMed:18640093). Interacts with FOXP2 (PubMed:26647308).By similarity4 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117989, 44 interactors
DIPiDIP-36585N
IntActiQ9H334, 41 interactors
MINTiQ9H334
STRINGi9606.ENSP00000318902

Structurei

Secondary structure

1677
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9H334
SMRiQ9H334
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni348 – 369Leucine-zipperAdd BLAST22
Regioni382 – 386CTBP1-bindingBy similarity5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi55 – 230Gln-richAdd BLAST176

Domaini

The leucine-zipper is required for dimerization and transcriptional repression.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri306 – 331C2H2-typeAdd BLAST26

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG4385 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00920000148947
HOGENOMiHOG000092089
HOVERGENiHBG051657
InParanoidiQ9H334
KOiK09409
PhylomeDBiQ9H334
TreeFamiTF326978

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR032354 FOXP-CC
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PF16159 FOXP-CC, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit

Sequences (7+)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 7 described isoforms and 8 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q9H334-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMQESGTETK SNGSAIQNGS GGSNHLLECG GLREGRSNGE TPAVDIGAAD
60 70 80 90 100
LAHAQQQQQQ ALQVARQLLL QQQQQQQVSG LKSPKRNDKQ PALQVPVSVA
110 120 130 140 150
MMTPQVITPQ QMQQILQQQV LSPQQLQVLL QQQQALMLQQ QQLQEFYKKQ
160 170 180 190 200
QEQLQLQLLQ QQHAGKQPKE QQQVATQQLA FQQQLLQMQQ LQQQHLLSLQ
210 220 230 240 250
RQGLLTIQPG QPALPLQPLA QGMIPTELQQ LWKEVTSAHT AEETTGNNHS
260 270 280 290 300
SLDLTTTCVS SSAPSKTSLI MNPHASTNGQ LSVHTPKRES LSHEEHPHSH
310 320 330 340 350
PLYGHGVCKW PGCEAVCEDF QSFLKHLNSE HALDDRSTAQ CRVQMQVVQQ
360 370 380 390 400
LELQLAKDKE RLQAMMTHLH VKSTEPKAAP QPLNLVSSVT LSKSASEASP
410 420 430 440 450
QSLPHTPTTP TAPLTPVTQG PSVITTTSMH TVGPIRRRYS DKYNVPISSA
460 470 480 490 500
DIAQNQEFYK NAEVRPPFTY ASLIRQAILE SPEKQLTLNE IYNWFTRMFA
510 520 530 540 550
YFRRNAATWK NAVRHNLSLH KCFVRVENVK GAVWTVDEVE FQKRRPQKIS
560 570 580 590 600
GNPSLIKNMQ SSHAYCTPLN AALQASMAEN SIPLYTTASM GNPTLGNLAS
610 620 630 640 650
AIREELNGAM EHTNSNESDS SPGRSPMQAV HPVHVKEEPL DPEEAEGPLS
660 670
LVTTANHSPD FDHDRDYEDE PVNEDME
Length:677
Mass (Da):75,317
Last modified:March 1, 2001 - v1
Checksum:iAEE92D47BB20964B
GO
Isoform 3 (identifier: Q9H334-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: MMQESGTETK...LAHAQQQQQQ → MFQCVFSSSV...APFAKLFIFS
     95-170: Missing.

Note: Incomplete sequence.
Show »
Length:603
Mass (Da):67,415
Checksum:i3B9156608207614E
GO
Isoform 4 (identifier: Q9H334-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: MMQESGTETK...LAHAQQQQQQ → MFQCVFSSSV...APFAKLFIFS

Note: Incomplete sequence. No experimental confirmation available.
Show »
Length:679
Mass (Da):76,314
Checksum:i003F5DFCAEC01AB8
GO
Isoform 5 (identifier: Q9H334-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     61-114: ALQVARQLLL...QVITPQQMQQ → WHLINHQPSR...PVCQPNPSPF
     115-677: Missing.

Show »
Length:114
Mass (Da):12,256
Checksum:iA1CC32BD8BBC4EA5
GO
Isoform 6 (identifier: Q9H334-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     95-170: Missing.

Show »
Length:601
Mass (Da):66,417
Checksum:i599FC834381D194C
GO
Isoform 7 (identifier: Q9H334-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     450-450: Missing.

Note: No experimental confirmation available. May be due to competing acceptor splice site.
Show »
Length:676
Mass (Da):75,246
Checksum:iF70967CCDB289929
GO
Isoform 8 (identifier: Q9H334-8) [UniParc]FASTAAdd to basket
Also known as: FOXP1-ES

The sequence of this isoform differs from the canonical sequence as follows:
     511-551: NAVRHNLSLH...QKRRPQKISG → GAIRTNLSLH...DENFDELVAH

Show »
Length:693
Mass (Da):77,363
Checksum:i1177D1149A03373C
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4J2F3A0A0B4J2F3_HUMAN
Forkhead box protein P1
FOXP1
577Annotation score:
C9J0F0C9J0F0_HUMAN
Forkhead box protein P1
FOXP1
613Annotation score:
G5E965G5E965_HUMAN
Forkhead box P1, isoform CRA_f
FOXP1 hCG_1778483
566Annotation score:
H0Y882H0Y882_HUMAN
Forkhead box protein P1
FOXP1
573Annotation score:
C9J5T4C9J5T4_HUMAN
Forkhead box protein P1
FOXP1
224Annotation score:
C9IYY1C9IYY1_HUMAN
Forkhead box protein P1
FOXP1
123Annotation score:
A0A087X2G3A0A087X2G3_HUMAN
Forkhead box protein P1
FOXP1
203Annotation score:
A0A087WVT2A0A087WVT2_HUMAN
Forkhead box protein P1
FOXP1
117Annotation score:

Sequence cautioni

The sequence AAF36135 differs from that shown. Reason: Frameshift at positions 531 and 545.Curated
The sequence AAG47634 differs from that shown. Aberrant splicing.Curated
The sequence ABI33105 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB55005 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti138L → P in BAG53682 (PubMed:14702039).Curated1
Sequence conflicti173Q → R in BAB55005 (PubMed:14702039).Curated1
Sequence conflicti205L → V in BAB55005 (PubMed:14702039).Curated1
Sequence conflicti210 – 212GQP → ARA in AAK69408 (PubMed:11751404).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0650675S → P1 PublicationCorresponds to variant dbSNP:rs762898505EnsemblClinVar.1
Natural variantiVAR_065068101M → V1 PublicationCorresponds to variant dbSNP:rs564508875EnsemblClinVar.1
Natural variantiVAR_075246107I → T Polymorphism; does not affect nuclear localization; no loss of transcriptional repression activity; no loss of ability to self-associate; no loss of interaction with FOXP2. 1 Publication1
Natural variantiVAR_065069215P → A Polymorphism; does not affect nuclear localization; no loss of transcriptional repression activity; no loss of ability to self-associate; no loss of interaction with FOXP2. 4 PublicationsCorresponds to variant dbSNP:rs146606219EnsemblClinVar.1
Natural variantiVAR_065070261S → P1 Publication1
Natural variantiVAR_065071390T → S1 PublicationCorresponds to variant dbSNP:rs761840006Ensembl.1
Natural variantiVAR_065072445V → M1 PublicationCorresponds to variant dbSNP:rs147756430Ensembl.1
Natural variantiVAR_075247465R → G in MRLIAF; nuclear and cytoplasmic aggregation; loss of transcriptional repression activity; loss of ability to self-associate; loss of interaction with FOXP2. 1 PublicationCorresponds to variant dbSNP:rs869025202EnsemblClinVar.1
Natural variantiVAR_075248514R → C in MRLIAF; nuclear and cytoplasmic aggregation; loss of transcriptional repression activity; loss of ability to self-associate; loss of interaction with FOXP2. 1 PublicationCorresponds to variant dbSNP:rs869025203EnsemblClinVar.1
Natural variantiVAR_075249534W → R in MRLIAF; nuclear and cytoplasmic aggregation; loss of transcriptional repression activity; loss of ability to self-associate; loss of interaction with FOXP2. 1 PublicationCorresponds to variant dbSNP:rs587777855EnsemblClinVar.1
Natural variantiVAR_065073570N → S Polymorphism; does not affect nuclear localization; no loss of transcriptional repression activity; no loss of ability to self-associate; no loss of interaction with FOXP2. 3 PublicationsCorresponds to variant dbSNP:rs140161845EnsemblClinVar.1
Natural variantiVAR_065074597N → T Polymorphism; does not affect nuclear localization; no loss of transcriptional repression activity; no loss of ability to self-associate; no loss of interaction with FOXP2. 2 Publications1
Natural variantiVAR_065075613T → N1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0015551 – 60MMQES…QQQQQ → MFQCVFSSSVLQPHSTSCLF KHLFYHSATPASQKQPEPIY SKKTEIQRQTVRAPFAKLFI FS in isoform 3 and isoform 4. 1 PublicationAdd BLAST60
Alternative sequenceiVSP_04346261 – 114ALQVA…QQMQQ → WHLINHQPSRSPSSWLKRLI SSPWELEVLQVPLWGAVAET KMSGPVCQPNPSPF in isoform 5. 2 PublicationsAdd BLAST54
Alternative sequenceiVSP_00155695 – 170Missing in isoform 3 and isoform 6. 1 PublicationAdd BLAST76
Alternative sequenceiVSP_043463115 – 677Missing in isoform 5. 2 PublicationsAdd BLAST563
Alternative sequenceiVSP_046930450Missing in isoform 7. 2 Publications1
Alternative sequenceiVSP_057341511 – 551NAVRH…QKISG → GAIRTNLSLHKCFIRVEDEF GSFWTVDDEEFKRGRHIQRG RPRKYCPDENFDELVAH in isoform 8. 1 PublicationAdd BLAST41

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF146696 mRNA Translation: AAG47632.1
AF146697 mRNA Translation: AAG47633.1
AF146698 mRNA Translation: AAG47634.1 Sequence problems.
AF275309 mRNA Translation: AAK69408.1
BT006643 mRNA Translation: AAP35289.1
AK092383 mRNA Translation: BAC03875.1
AK122710 mRNA Translation: BAG53682.1
AC097632 Genomic DNA No translation available.
AC097634 Genomic DNA No translation available.
AC103586 Genomic DNA No translation available.
AC104442 Genomic DNA No translation available.
AC104645 Genomic DNA No translation available.
AC138058 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW65494.1
CH471055 Genomic DNA Translation: EAW65499.1
BC005055 mRNA Translation: AAH05055.1
BC054815 mRNA Translation: AAH54815.1
BC071893 mRNA Translation: AAH71893.1
BC080521 mRNA Translation: AAH80521.1
DQ845346 mRNA Translation: ABI33105.1 Different initiation.
AK027264 mRNA Translation: BAB55005.1 Different initiation.
AF151049 mRNA Translation: AAF36135.1 Frameshift.
BQ017072 mRNA No translation available.
CCDSiCCDS2914.1 [Q9H334-1]
CCDS33785.1 [Q9H334-5]
CCDS58837.1 [Q9H334-4]
CCDS58838.1 [Q9H334-6]
CCDS58839.1 [Q9H334-7]
CCDS74964.1 [Q9H334-8]
RefSeqiNP_001012523.1, NM_001012505.1 [Q9H334-5]
NP_001231737.1, NM_001244808.1 [Q9H334-7]
NP_001231739.1, NM_001244810.1 [Q9H334-8]
NP_001231741.1, NM_001244812.1 [Q9H334-6]
NP_001231743.1, NM_001244814.1 [Q9H334-1]
NP_001231744.1, NM_001244815.1 [Q9H334-4]
NP_001231745.1, NM_001244816.1 [Q9H334-1]
NP_116071.2, NM_032682.5 [Q9H334-1]
XP_006713165.1, XM_006713102.2 [Q9H334-1]
XP_006713166.1, XM_006713103.2 [Q9H334-1]
XP_006713167.1, XM_006713104.2 [Q9H334-1]
XP_011531886.1, XM_011533584.2
XP_011531887.1, XM_011533585.2 [Q9H334-1]
XP_016861654.1, XM_017006165.1 [Q9H334-1]
XP_016861655.1, XM_017006166.1
XP_016861657.1, XM_017006168.1 [Q9H334-5]
UniGeneiHs.59368

Genome annotation databases

EnsembliENST00000318779; ENSP00000318721; ENSG00000114861 [Q9H334-5]
ENST00000318789; ENSP00000318902; ENSG00000114861 [Q9H334-1]
ENST00000475937; ENSP00000419393; ENSG00000114861 [Q9H334-1]
ENST00000484350; ENSP00000417857; ENSG00000114861 [Q9H334-6]
ENST00000491238; ENSP00000420736; ENSG00000114861 [Q9H334-4]
ENST00000493089; ENSP00000418524; ENSG00000114861 [Q9H334-7]
ENST00000498215; ENSP00000418102; ENSG00000114861 [Q9H334-1]
ENST00000615603; ENSP00000484803; ENSG00000114861 [Q9H334-8]
ENST00000622151; ENSP00000477918; ENSG00000114861 [Q9H334-5]
GeneIDi27086
KEGGihsa:27086
UCSCiuc003dol.4 human [Q9H334-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF146696 mRNA Translation: AAG47632.1
AF146697 mRNA Translation: AAG47633.1
AF146698 mRNA Translation: AAG47634.1 Sequence problems.
AF275309 mRNA Translation: AAK69408.1
BT006643 mRNA Translation: AAP35289.1
AK092383 mRNA Translation: BAC03875.1
AK122710 mRNA Translation: BAG53682.1
AC097632 Genomic DNA No translation available.
AC097634 Genomic DNA No translation available.
AC103586 Genomic DNA No translation available.
AC104442 Genomic DNA No translation available.
AC104645 Genomic DNA No translation available.
AC138058 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW65494.1
CH471055 Genomic DNA Translation: EAW65499.1
BC005055 mRNA Translation: AAH05055.1
BC054815 mRNA Translation: AAH54815.1
BC071893 mRNA Translation: AAH71893.1
BC080521 mRNA Translation: AAH80521.1
DQ845346 mRNA Translation: ABI33105.1 Different initiation.
AK027264 mRNA Translation: BAB55005.1 Different initiation.
AF151049 mRNA Translation: AAF36135.1 Frameshift.
BQ017072 mRNA No translation available.
CCDSiCCDS2914.1 [Q9H334-1]
CCDS33785.1 [Q9H334-5]
CCDS58837.1 [Q9H334-4]
CCDS58838.1 [Q9H334-6]
CCDS58839.1 [Q9H334-7]
CCDS74964.1 [Q9H334-8]
RefSeqiNP_001012523.1, NM_001012505.1 [Q9H334-5]
NP_001231737.1, NM_001244808.1 [Q9H334-7]
NP_001231739.1, NM_001244810.1 [Q9H334-8]
NP_001231741.1, NM_001244812.1 [Q9H334-6]
NP_001231743.1, NM_001244814.1 [Q9H334-1]
NP_001231744.1, NM_001244815.1 [Q9H334-4]
NP_001231745.1, NM_001244816.1 [Q9H334-1]
NP_116071.2, NM_032682.5 [Q9H334-1]
XP_006713165.1, XM_006713102.2 [Q9H334-1]
XP_006713166.1, XM_006713103.2 [Q9H334-1]
XP_006713167.1, XM_006713104.2 [Q9H334-1]
XP_011531886.1, XM_011533584.2
XP_011531887.1, XM_011533585.2 [Q9H334-1]
XP_016861654.1, XM_017006165.1 [Q9H334-1]
XP_016861655.1, XM_017006166.1
XP_016861657.1, XM_017006168.1 [Q9H334-5]
UniGeneiHs.59368

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KIUNMR-A462-548[»]
ProteinModelPortaliQ9H334
SMRiQ9H334
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117989, 44 interactors
DIPiDIP-36585N
IntActiQ9H334, 41 interactors
MINTiQ9H334
STRINGi9606.ENSP00000318902

PTM databases

iPTMnetiQ9H334
PhosphoSitePlusiQ9H334

Polymorphism and mutation databases

BioMutaiFOXP1
DMDMi14548062

Proteomic databases

EPDiQ9H334
MaxQBiQ9H334
PaxDbiQ9H334
PeptideAtlasiQ9H334
PRIDEiQ9H334
ProteomicsDBi80663
80665 [Q9H334-3]
80666 [Q9H334-4]
80667 [Q9H334-5]

Protocols and materials databases

DNASUi27086
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318779; ENSP00000318721; ENSG00000114861 [Q9H334-5]
ENST00000318789; ENSP00000318902; ENSG00000114861 [Q9H334-1]
ENST00000475937; ENSP00000419393; ENSG00000114861 [Q9H334-1]
ENST00000484350; ENSP00000417857; ENSG00000114861 [Q9H334-6]
ENST00000491238; ENSP00000420736; ENSG00000114861 [Q9H334-4]
ENST00000493089; ENSP00000418524; ENSG00000114861 [Q9H334-7]
ENST00000498215; ENSP00000418102; ENSG00000114861 [Q9H334-1]
ENST00000615603; ENSP00000484803; ENSG00000114861 [Q9H334-8]
ENST00000622151; ENSP00000477918; ENSG00000114861 [Q9H334-5]
GeneIDi27086
KEGGihsa:27086
UCSCiuc003dol.4 human [Q9H334-1]

Organism-specific databases

CTDi27086
DisGeNETi27086
EuPathDBiHostDB:ENSG00000114861.18
GeneCardsiFOXP1
HGNCiHGNC:3823 FOXP1
HPAiCAB011501
HPA003876
MalaCardsiFOXP1
MIMi605515 gene
613670 phenotype
neXtProtiNX_Q9H334
OpenTargetsiENSG00000114861
Orphaneti391372 Intellectual disability-severe speech delay-mild dysmorphism syndrome
52417 MALT lymphoma
99860 Precursor B-cell acute lymphoblastic leukemia
PharmGKBiPA28241
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4385 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00920000148947
HOGENOMiHOG000092089
HOVERGENiHBG051657
InParanoidiQ9H334
KOiK09409
PhylomeDBiQ9H334
TreeFamiTF326978

Enzyme and pathway databases

ReactomeiR-HSA-452723 Transcriptional regulation of pluripotent stem cells
SignaLinkiQ9H334
SIGNORiQ9H334

Miscellaneous databases

ChiTaRSiFOXP1 human
GeneWikiiFOXP1
GenomeRNAii27086
PROiPR:Q9H334
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000114861 Expressed in 212 organ(s), highest expression level in forebrain
CleanExiHS_FOXP1
ExpressionAtlasiQ9H334 baseline and differential
GenevisibleiQ9H334 HS

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR032354 FOXP-CC
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PF16159 FOXP-CC, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFOXP1_HUMAN
AccessioniPrimary (citable) accession number: Q9H334
Secondary accession number(s): A3QVP8
, B3KV70, G5E9V8, Q8NAN6, Q9BSG9, Q9H332, Q9H333, Q9P0R1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 1, 2001
Last modified: September 12, 2018
This is version 175 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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