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Entry version 127 (16 Oct 2019)
Sequence version 3 (28 Mar 2018)
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Protein

Transmembrane protein 245

Gene

TMEM245

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protein 245
Alternative name(s):
Protein CG-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM245
Synonyms:C9orf5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1363 TMEM245

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H330

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Transmembranei148 – 168HelicalSequence analysisAdd BLAST21
Transmembranei185 – 205HelicalSequence analysisAdd BLAST21
Transmembranei219 – 239HelicalSequence analysisAdd BLAST21
Transmembranei241 – 261HelicalSequence analysisAdd BLAST21
Transmembranei354 – 374HelicalSequence analysisAdd BLAST21
Transmembranei377 – 397HelicalSequence analysisAdd BLAST21
Transmembranei460 – 480HelicalSequence analysisAdd BLAST21
Transmembranei626 – 646HelicalSequence analysisAdd BLAST21
Transmembranei650 – 670HelicalSequence analysisAdd BLAST21
Transmembranei732 – 752HelicalSequence analysisAdd BLAST21
Transmembranei776 – 796HelicalSequence analysisAdd BLAST21
Transmembranei815 – 835HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23731

Open Targets

More...
OpenTargetsi
ENSG00000106771

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25980

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9H330

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TMEM245

Domain mapping of disease mutations (DMDM)

More...
DMDMi
71152403

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000896702 – 879Transmembrane protein 245Add BLAST878

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei12PhosphoserineBy similarity1
Modified residuei16PhosphoserineBy similarity1
Modified residuei36PhosphothreonineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi210N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei324PhosphoserineCombined sources1
Modified residuei327PhosphoserineCombined sources1
Modified residuei330PhosphoserineBy similarity1
Modified residuei332PhosphoserineCombined sources1
Modified residuei334PhosphothreonineCombined sources1
Glycosylationi500N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi551N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi575N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei877PhosphoserineCombined sources1
Isoform 2 (identifier: Q9H330-2)
Modified residuei877Phosphoserine1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9H330

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9H330

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9H330

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H330

PeptideAtlas

More...
PeptideAtlasi
Q9H330

PRoteomics IDEntifications database

More...
PRIDEi
Q9H330

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
80660 [Q9H330-2]
80661 [Q9H330-3]
80662 [Q9H330-4]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1853

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H330

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H330

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9H330

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000106771 Expressed in 216 organ(s), highest expression level in cardiac muscle of right atrium

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9H330 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H330 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA023892

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117237, 17 interactors

Protein interaction database and analysis system

More...
IntActi
Q9H330, 13 interactors

Molecular INTeraction database

More...
MINTi
Q9H330

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000363714

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2365 Eukaryota
ENOG410XRXR LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000001667

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000049264

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H330

Identification of Orthologs from Complete Genome Data

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OMAi
FFWKPEN

Database of Orthologous Groups

More...
OrthoDBi
228524at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H330

TreeFam database of animal gene trees

More...
TreeFami
TF315224

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR002549 AI-2E-like

The PANTHER Classification System

More...
PANTHERi
PTHR21716 PTHR21716, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01594 AI-2E_transport, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 2 (identifier: Q9H330-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADGGGPKDA PSLRSSPGPA PRVPRAVGPS GGGGETPRTA ALALRFDKPI
60 70 80 90 100
KQAFYNTGAV LFVCLCCGAA VLVYFILEAF LRPLLWAVLC GTFLHPFKSS
110 120 130 140 150
LTRLGRHWLQ RLHRAHTPIV LAALLLPLCF VDYGVEALGE QALRRRRLLL
160 170 180 190 200
LLGAGGPLLY GLYCLGSYLG VQVLLVHAAT LICRGLDYFS SLWIWTLVVG
210 220 230 240 250
YVLTVSFKWN ASTERYLRAV SIPVWIILLF HLASLAGSWR IPVFLVIVFL
260 270 280 290 300
MSVGTLYEKQ NGKESSGAEL PGQVISMAAS TLANLAISIT GYESSSEDQP
310 320 330 340 350
STQPAEAVDR GESAPTLSTS PSPSSPSPTS PSPTLGRRRP EIGTFLRKKK
360 370 380 390 400
TSDIYFVSLV WAIVVMQIWL NLWIVQLLPV PIAVWILKKL VIHFGVVDFL
410 420 430 440 450
EKRYHVWWGI IESFLKERQG ALAPWPIVGL GKFLLKVDSK LWHWLNKKMI
460 470 480 490 500
IWLEKMLDKI ISIFIIFLLV IGTLLLALLL TAKVHQESVH MIEVTSNLIN
510 520 530 540 550
ETLANHPEWA NWLPEAQVVQ RALNSAANNV YQYGREWITH KLHKILGDKV
560 570 580 590 600
NNTAVIEKQV LELWDRLYHS WFVKNVTHSG RHKGQKLHVS RQNSWLGDIL
610 620 630 640 650
DWQDIVSFVH ENIETFLSIL ESLWIVMSRN VSLLFTTVTT LLTILFYSGT
660 670 680 690 700
ALLNFVLSLI IFLTTLFYLL SSSDEYYKPV KWVISLTPLS QPGPSSNIIG
710 720 730 740 750
QSVEEAIRGV FDASLKMAGF YGLYTWLTHT MFGINIVFIP SALAAILGAV
760 770 780 790 800
PFLGTYWAAV PAVLDLWLTQ GLGCKAILLL IFHLLPTYFV DTAIYSDISG
810 820 830 840 850
GGHPYLTGLA VAGGAYYLGL EGAIIGPILL CILVVASNIY SAMLVSPTNS
860 870
VPTPNQTPWP AQPQRTFRDI SEDLKSSVG
Length:879
Mass (Da):97,357
Last modified:March 28, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAD26DE952B1D94AE
GO
Isoform 3 (identifier: Q9H330-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-448: Missing.

Note: No experimental confirmation available.
Show »
Length:431
Mass (Da):48,042
Checksum:i341EA2D18CE658DE
GO
Isoform 4 (identifier: Q9H330-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     440-447: Missing.
     511-511: N → K
     512-879: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:503
Mass (Da):55,433
Checksum:i810DA48BC071FE0E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WBJ7F8WBJ7_HUMAN
Transmembrane protein 245
TMEM245
253Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C0G1H7C0G1_HUMAN
Transmembrane protein 245
TMEM245
472Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG43365 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti785L → V in BAG61779 (PubMed:14702039).Curated1
Sequence conflicti855N → I in BAD18785 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0596049D → E1 PublicationCorresponds to variant dbSNP:rs12001627Ensembl.1
Natural variantiVAR_056815314A → T. Corresponds to variant dbSNP:rs2271877Ensembl.1
Natural variantiVAR_056816787T → A. Corresponds to variant dbSNP:rs3750455Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0146801 – 448Missing in isoform 3. 1 PublicationAdd BLAST448
Alternative sequenceiVSP_059402440 – 447Missing in isoform 4. 1 Publication8
Alternative sequenceiVSP_059403511N → K in isoform 4. 1 Publication1
Alternative sequenceiVSP_059404512 – 879Missing in isoform 4. 1 PublicationAdd BLAST368

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF153415 mRNA Translation: AAG43365.1 Frameshift.
AK299952 mRNA Translation: BAG61779.1
AK172815 mRNA Translation: BAD18785.1
AL669894 Genomic DNA No translation available.
AL358815 Genomic DNA No translation available.
AL354797 Genomic DNA No translation available.
BC014248 mRNA Translation: AAH14248.2
AL833960 mRNA Translation: CAD38810.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43858.1 [Q9H330-2]

NCBI Reference Sequences

More...
RefSeqi
NP_114401.2, NM_032012.3 [Q9H330-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000374586; ENSP00000363714; ENSG00000106771 [Q9H330-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23731

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23731

UCSC genome browser

More...
UCSCi
uc004bdt.5 human [Q9H330-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF153415 mRNA Translation: AAG43365.1 Frameshift.
AK299952 mRNA Translation: BAG61779.1
AK172815 mRNA Translation: BAD18785.1
AL669894 Genomic DNA No translation available.
AL358815 Genomic DNA No translation available.
AL354797 Genomic DNA No translation available.
BC014248 mRNA Translation: AAH14248.2
AL833960 mRNA Translation: CAD38810.1
CCDSiCCDS43858.1 [Q9H330-2]
RefSeqiNP_114401.2, NM_032012.3 [Q9H330-2]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi117237, 17 interactors
IntActiQ9H330, 13 interactors
MINTiQ9H330
STRINGi9606.ENSP00000363714

PTM databases

GlyConnecti1853
iPTMnetiQ9H330
PhosphoSitePlusiQ9H330
SwissPalmiQ9H330

Polymorphism and mutation databases

BioMutaiTMEM245
DMDMi71152403

Proteomic databases

EPDiQ9H330
jPOSTiQ9H330
MassIVEiQ9H330
PaxDbiQ9H330
PeptideAtlasiQ9H330
PRIDEiQ9H330
ProteomicsDBi80660 [Q9H330-2]
80661 [Q9H330-3]
80662 [Q9H330-4]

Genome annotation databases

EnsembliENST00000374586; ENSP00000363714; ENSG00000106771 [Q9H330-2]
GeneIDi23731
KEGGihsa:23731
UCSCiuc004bdt.5 human [Q9H330-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23731
DisGeNETi23731

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TMEM245
HGNCiHGNC:1363 TMEM245
HPAiHPA023892
neXtProtiNX_Q9H330
OpenTargetsiENSG00000106771
PharmGKBiPA25980

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2365 Eukaryota
ENOG410XRXR LUCA
GeneTreeiENSGT00390000001667
HOGENOMiHOG000049264
InParanoidiQ9H330
OMAiFFWKPEN
OrthoDBi228524at2759
PhylomeDBiQ9H330
TreeFamiTF315224

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TMEM245 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23731
PharosiQ9H330

Protein Ontology

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PROi
PR:Q9H330

Gene expression databases

BgeeiENSG00000106771 Expressed in 216 organ(s), highest expression level in cardiac muscle of right atrium
ExpressionAtlasiQ9H330 baseline and differential
GenevisibleiQ9H330 HS

Family and domain databases

InterProiView protein in InterPro
IPR002549 AI-2E-like
PANTHERiPTHR21716 PTHR21716, 1 hit
PfamiView protein in Pfam
PF01594 AI-2E_transport, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTM245_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H330
Secondary accession number(s): B4DSW7
, Q5JTQ5, Q5SS43, Q6ZME3, Q8NDJ5, Q96CG6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: March 28, 2018
Last modified: October 16, 2019
This is version 127 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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