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Protein

Band 4.1-like protein 4B

Gene

EPB41L4B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Up-regulates the activity of the Rho guanine nucleotide exchange factor ARHGEF18 (By similarity). Involved in the regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950). Promotes cellular adhesion, migration and motility in vitro and may play a role in wound healing (PubMed:23664528). May have a role in mediating cytoskeletal changes associated with steroid-induced cell differentiation (PubMed:14521927).By similarity3 Publications

GO - Molecular functioni

  • cytoskeletal protein binding Source: InterPro
  • structural constituent of cytoskeleton Source: ProtInc

GO - Biological processi

  • actomyosin structure organization Source: MGI
  • positive regulation of cell adhesion Source: UniProtKB
  • positive regulation of gene expression Source: UniProtKB
  • positive regulation of keratinocyte migration Source: UniProtKB
  • wound healing Source: UniProtKB

Enzyme and pathway databases

SIGNORiQ9H329

Names & Taxonomyi

Protein namesi
Recommended name:
Band 4.1-like protein 4B
Alternative name(s):
FERM-containing protein CG1
Protein EHM2
Gene namesi
Name:EPB41L4B
Synonyms:EHM2, LULU21 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000095203.14
HGNCiHGNC:19818 EPB41L4B
MIMi610340 gene
neXtProtiNX_Q9H329

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Tight junction

Pathology & Biotechi

Organism-specific databases

DisGeNETi54566
OpenTargetsiENSG00000095203
PharmGKBiPA134986250

Polymorphism and mutation databases

BioMutaiEPB41L4B
DMDMi209572611

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002194041 – 900Band 4.1-like protein 4BAdd BLAST900

Post-translational modificationi

May be negatively regulated by phosphorylation.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H329
MaxQBiQ9H329
PaxDbiQ9H329
PeptideAtlasiQ9H329
PRIDEiQ9H329
ProteomicsDBi80657
80658 [Q9H329-2]

PTM databases

iPTMnetiQ9H329
PhosphoSitePlusiQ9H329

Expressioni

Tissue specificityi

Expressed at higher levels in acute wounds than chronic wounds with increased expression in healing wounds, especially at the leading wound edge (PubMed:23664528). Isoform 1 is highly expressed in brain. Isoform 2 is highly expressed in testis with lower levels in prostate and breast (PubMed:14521927).2 Publications

Inductioni

By the androgen dihydrotestosterone (DHT).1 Publication

Gene expression databases

BgeeiENSG00000095203 Expressed in 185 organ(s), highest expression level in colon
CleanExiHS_EPB41L4B
GenevisibleiQ9H329 HS

Organism-specific databases

HPAiHPA042862

Interactioni

Subunit structurei

Interacts (via FERM domain) with ARHGEF18 (via C-terminus); the interaction activates ARHGEF18.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi120044, 19 interactors
IntActiQ9H329, 12 interactors
STRINGi9606.ENSP00000363694

Structurei

3D structure databases

ProteinModelPortaliQ9H329
SMRiQ9H329
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini85 – 369FERMPROSITE-ProRule annotationAdd BLAST285

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi504 – 517His-richAdd BLAST14

Phylogenomic databases

eggNOGiENOG410IQ5Y Eukaryota
ENOG410YG1S LUCA
GeneTreeiENSGT00760000118823
HOGENOMiHOG000231632
HOVERGENiHBG051434
InParanoidiQ9H329
KOiK21111
OMAiDPNVRSP
OrthoDBiEOG091G032O
PhylomeDBiQ9H329
TreeFamiTF319780

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
Gene3Di1.20.80.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR030698 Band4.1-like4B
IPR019749 Band_41_domain
IPR000798 Ez/rad/moesin-like
IPR014847 FERM-adjacent
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR019747 FERM_CS
IPR000299 FERM_domain
IPR018979 FERM_N
IPR018980 FERM_PH-like_C
IPR011993 PH-like_dom_sf
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR23280:SF18 PTHR23280:SF18, 1 hit
PfamiView protein in Pfam
PF08736 FA, 1 hit
PF09380 FERM_C, 1 hit
PF00373 FERM_M, 1 hit
PF09379 FERM_N, 1 hit
PRINTSiPR00935 BAND41
PR00661 ERMFAMILY
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM01195 FA, 1 hit
SM01196 FERM_C, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS00661 FERM_2, 1 hit
PS50057 FERM_3, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9H329-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLRFLRRTFG RRSMQRYARG AAGRGAAGLG DERDGGPRGG PAAAASSSAL
60 70 80 90 100
PAAPGGSVFP AGGGPLLTGG AAVHISAAGA AKATLYCRVF LLDGTEVSVD
110 120 130 140 150
LPKHAKGQDL FDQIVYHLDL VETDYFGLQF LDSAQVAHWL DHAKPIKKQM
160 170 180 190 200
KIGPAYALHF RVKYYSSEPN NLREEFTRYL FVLQLRHDIL SGKLKCPYET
210 220 230 240 250
AVELAALCLQ AELGECELPE HTPELVSEFR FIPNQTEAME FDIFQRWKEC
260 270 280 290 300
RGKSPAQAEL SYLNKAKWLE MYGVDMHVVR GRDGCEYSLG LTPTGILIFE
310 320 330 340 350
GANKIGLFFW PKITKMDFKK SKLTLVVVED DDQGREQEHT FVFRLDSART
360 370 380 390 400
CKHLWKCAVE HHAFFRLRTP GNSKSNRSDF IRLGSRFRFS GRTEYQATHG
410 420 430 440 450
SRLRRTSTFE RKPSKRYPSR RHSTFKASNP VIAAQLCSKT NPEVHNYQPQ
460 470 480 490 500
YHPNIHPSQP RWHPHSPNVS YPLPSPVLSS SDRLPFGIEE NGGTPFLTAA
510 520 530 540 550
SGRHHHQHQH QHQHQHHSNY SLSLTLENKE GPLRSPNSSS KSLTKLSPGT
560 570 580 590 600
PALFSEAAAH LKKLELETVK AAGPWPPLHI NINKAEEKKV SEKTLQTPLL
610 620 630 640 650
PSPVADHVKC NILKAQLENA SRVNIQGGKE ESPFVNINKK SSLQDASVRS
660 670 680 690 700
PIPIRVETAQ PAVEKPEIKP PRVRKLTRQY SFDEDDLPPD LAEAVGVTTS
710 720 730 740 750
TTTNTTTAAT QVSVPLPSPK VQNVSSPHKS EGKGLLSPGA KSPSDRGGAF
760 770 780 790 800
TLEPGDLLMD FTEATPLAEP ASNPHCAHSR CSPPLSLPMK EETTGVCMYP
810 820 830 840 850
PIKTRLIKTF PVDTMNPFPD TFTTGPQFTA DFRDSKLQCC PGPTSPLIPA
860 870 880 890 900
ATLRPLTETV STVQTIYTTR KPVSLAASAE TLRQELEREK MMKRLLMTEL
Length:900
Mass (Da):99,712
Last modified:October 14, 2008 - v2
Checksum:i9A4BD658DBE65BDE
GO
Isoform 2 (identifier: Q9H329-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     470-518: SYPLPSPVLS...QHQHQHQHHS → RPSFQDDRSH...MYRDKLMTAL
     519-900: Missing.

Show »
Length:518
Mass (Da):58,566
Checksum:i7CF6295CD2BE4E21
GO

Sequence cautioni

The sequence AAG43366 differs from that shown. Reason: Frameshift at positions 19, 35 and 870.Curated
The sequence AAG43368 differs from that shown. Reason: Frameshift at positions 19 and 35.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti73V → M in BAA96079 (PubMed:10783258).Curated1
Sequence conflicti899E → R in AAG43366 (PubMed:10603000).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048356816N → T1 PublicationCorresponds to variant dbSNP:rs3750450Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_007202470 – 518SYPLP…HQHHS → RPSFQDDRSHWKASASGDDS HFDYVHDQNQKNLGGMQSMM YRDKLMTAL in isoform 2. 2 PublicationsAdd BLAST49
Alternative sequenceiVSP_007203519 – 900Missing in isoform 2. 2 PublicationsAdd BLAST382

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF153416 mRNA Translation: AAG43366.1 Frameshift.
AF153418 mRNA Translation: AAG43368.1 Frameshift.
AB032179 mRNA Translation: BAA96079.2
AL359963 Genomic DNA No translation available.
AL358815 Genomic DNA No translation available.
CCDSiCCDS43859.1 [Q9H329-1]
CCDS43860.1 [Q9H329-2]
RefSeqiNP_060894.2, NM_018424.3 [Q9H329-2]
NP_061987.3, NM_019114.4 [Q9H329-1]
UniGeneiHs.591901

Genome annotation databases

EnsembliENST00000374557; ENSP00000363685; ENSG00000095203 [Q9H329-2]
ENST00000374566; ENSP00000363694; ENSG00000095203 [Q9H329-1]
GeneIDi54566
KEGGihsa:54566
UCSCiuc004bdz.3 human [Q9H329-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF153416 mRNA Translation: AAG43366.1 Frameshift.
AF153418 mRNA Translation: AAG43368.1 Frameshift.
AB032179 mRNA Translation: BAA96079.2
AL359963 Genomic DNA No translation available.
AL358815 Genomic DNA No translation available.
CCDSiCCDS43859.1 [Q9H329-1]
CCDS43860.1 [Q9H329-2]
RefSeqiNP_060894.2, NM_018424.3 [Q9H329-2]
NP_061987.3, NM_019114.4 [Q9H329-1]
UniGeneiHs.591901

3D structure databases

ProteinModelPortaliQ9H329
SMRiQ9H329
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120044, 19 interactors
IntActiQ9H329, 12 interactors
STRINGi9606.ENSP00000363694

PTM databases

iPTMnetiQ9H329
PhosphoSitePlusiQ9H329

Polymorphism and mutation databases

BioMutaiEPB41L4B
DMDMi209572611

Proteomic databases

EPDiQ9H329
MaxQBiQ9H329
PaxDbiQ9H329
PeptideAtlasiQ9H329
PRIDEiQ9H329
ProteomicsDBi80657
80658 [Q9H329-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374557; ENSP00000363685; ENSG00000095203 [Q9H329-2]
ENST00000374566; ENSP00000363694; ENSG00000095203 [Q9H329-1]
GeneIDi54566
KEGGihsa:54566
UCSCiuc004bdz.3 human [Q9H329-1]

Organism-specific databases

CTDi54566
DisGeNETi54566
EuPathDBiHostDB:ENSG00000095203.14
GeneCardsiEPB41L4B
HGNCiHGNC:19818 EPB41L4B
HPAiHPA042862
MIMi610340 gene
neXtProtiNX_Q9H329
OpenTargetsiENSG00000095203
PharmGKBiPA134986250
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQ5Y Eukaryota
ENOG410YG1S LUCA
GeneTreeiENSGT00760000118823
HOGENOMiHOG000231632
HOVERGENiHBG051434
InParanoidiQ9H329
KOiK21111
OMAiDPNVRSP
OrthoDBiEOG091G032O
PhylomeDBiQ9H329
TreeFamiTF319780

Enzyme and pathway databases

SIGNORiQ9H329

Miscellaneous databases

ChiTaRSiEPB41L4B human
GenomeRNAii54566
PROiPR:Q9H329
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000095203 Expressed in 185 organ(s), highest expression level in colon
CleanExiHS_EPB41L4B
GenevisibleiQ9H329 HS

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
Gene3Di1.20.80.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR030698 Band4.1-like4B
IPR019749 Band_41_domain
IPR000798 Ez/rad/moesin-like
IPR014847 FERM-adjacent
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR019747 FERM_CS
IPR000299 FERM_domain
IPR018979 FERM_N
IPR018980 FERM_PH-like_C
IPR011993 PH-like_dom_sf
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR23280:SF18 PTHR23280:SF18, 1 hit
PfamiView protein in Pfam
PF08736 FA, 1 hit
PF09380 FERM_C, 1 hit
PF00373 FERM_M, 1 hit
PF09379 FERM_N, 1 hit
PRINTSiPR00935 BAND41
PR00661 ERMFAMILY
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM01195 FA, 1 hit
SM01196 FERM_C, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS00661 FERM_2, 1 hit
PS50057 FERM_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE41LB_HUMAN
AccessioniPrimary (citable) accession number: Q9H329
Secondary accession number(s): Q5T4G5
, Q5T4G6, Q9H328, Q9P2V3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: October 14, 2008
Last modified: November 7, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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