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Entry version 155 (02 Dec 2020)
Sequence version 2 (14 Oct 2008)
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Protein

Band 4.1-like protein 4B

Gene

EPB41L4B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Up-regulates the activity of the Rho guanine nucleotide exchange factor ARHGEF18 (By similarity). Involved in the regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950). Promotes cellular adhesion, migration and motility in vitro and may play a role in wound healing (PubMed:23664528). May have a role in mediating cytoskeletal changes associated with steroid-induced cell differentiation (PubMed:14521927).By similarity3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9H329

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9H329

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Band 4.1-like protein 4B
Alternative name(s):
Erythrocyte membrane protein band 4.1-like 4BImported
FERM-containing protein CG1
Protein EHM2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EPB41L4BImported
Synonyms:EHM2Imported, LULU21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...
EuPathDBi
HostDB:ENSG00000095203.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19818, EPB41L4B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610340, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H329

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cytoplasm, Tight junction

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
54566

Open Targets

More...
OpenTargetsi
ENSG00000095203

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134986250

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9H329, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
EPB41L4B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
209572611

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002194041 – 900Band 4.1-like protein 4BAdd BLAST900

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

May be negatively regulated by phosphorylation.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9H329

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9H329

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9H329

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H329

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H329

PeptideAtlas

More...
PeptideAtlasi
Q9H329

PRoteomics IDEntifications database

More...
PRIDEi
Q9H329

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
80657 [Q9H329-1]
80658 [Q9H329-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H329

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H329

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at higher levels in acute wounds than chronic wounds with increased expression in healing wounds, especially at the leading wound edge (PubMed:23664528). Isoform 1 is highly expressed in brain. Isoform 2 is highly expressed in testis with lower levels in prostate and breast (PubMed:14521927).2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By the androgen dihydrotestosterone (DHT).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000095203, Expressed in colon and 193 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H329, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000095203, Tissue enhanced (liver, pancreas)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via FERM domain) with ARHGEF18 (via C-terminus); the interaction activates ARHGEF18.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
120044, 24 interactors

Protein interaction database and analysis system

More...
IntActi
Q9H329, 16 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000363694

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9H329, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9H329

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini85 – 369FERMPROSITE-ProRule annotationAdd BLAST285

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi504 – 517His-richAdd BLAST14

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3530, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158331

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003623_5_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H329

Identification of Orthologs from Complete Genome Data

More...
OMAi
IYTPEAC

Database of Orthologous Groups

More...
OrthoDBi
241659at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H329

TreeFam database of animal gene trees

More...
TreeFami
TF319780

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14473, FERM_B-lobe, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.80.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030698, Band4.1-like4B
IPR019749, Band_41_domain
IPR000798, Ez/rad/moesin-like
IPR014847, FERM-adjacent
IPR014352, FERM/acyl-CoA-bd_prot_sf
IPR035963, FERM_2
IPR019748, FERM_central
IPR019747, FERM_CS
IPR000299, FERM_domain
IPR018979, FERM_N
IPR018980, FERM_PH-like_C
IPR011993, PH-like_dom_sf
IPR029071, Ubiquitin-like_domsf

The PANTHER Classification System

More...
PANTHERi
PTHR23280:SF18, PTHR23280:SF18, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08736, FA, 1 hit
PF09380, FERM_C, 1 hit
PF00373, FERM_M, 1 hit
PF09379, FERM_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00935, BAND41
PR00661, ERMFAMILY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00295, B41, 1 hit
SM01195, FA, 1 hit
SM01196, FERM_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47031, SSF47031, 1 hit
SSF54236, SSF54236, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00661, FERM_2, 1 hit
PS50057, FERM_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9H329-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLRFLRRTFG RRSMQRYARG AAGRGAAGLG DERDGGPRGG PAAAASSSAL
60 70 80 90 100
PAAPGGSVFP AGGGPLLTGG AAVHISAAGA AKATLYCRVF LLDGTEVSVD
110 120 130 140 150
LPKHAKGQDL FDQIVYHLDL VETDYFGLQF LDSAQVAHWL DHAKPIKKQM
160 170 180 190 200
KIGPAYALHF RVKYYSSEPN NLREEFTRYL FVLQLRHDIL SGKLKCPYET
210 220 230 240 250
AVELAALCLQ AELGECELPE HTPELVSEFR FIPNQTEAME FDIFQRWKEC
260 270 280 290 300
RGKSPAQAEL SYLNKAKWLE MYGVDMHVVR GRDGCEYSLG LTPTGILIFE
310 320 330 340 350
GANKIGLFFW PKITKMDFKK SKLTLVVVED DDQGREQEHT FVFRLDSART
360 370 380 390 400
CKHLWKCAVE HHAFFRLRTP GNSKSNRSDF IRLGSRFRFS GRTEYQATHG
410 420 430 440 450
SRLRRTSTFE RKPSKRYPSR RHSTFKASNP VIAAQLCSKT NPEVHNYQPQ
460 470 480 490 500
YHPNIHPSQP RWHPHSPNVS YPLPSPVLSS SDRLPFGIEE NGGTPFLTAA
510 520 530 540 550
SGRHHHQHQH QHQHQHHSNY SLSLTLENKE GPLRSPNSSS KSLTKLSPGT
560 570 580 590 600
PALFSEAAAH LKKLELETVK AAGPWPPLHI NINKAEEKKV SEKTLQTPLL
610 620 630 640 650
PSPVADHVKC NILKAQLENA SRVNIQGGKE ESPFVNINKK SSLQDASVRS
660 670 680 690 700
PIPIRVETAQ PAVEKPEIKP PRVRKLTRQY SFDEDDLPPD LAEAVGVTTS
710 720 730 740 750
TTTNTTTAAT QVSVPLPSPK VQNVSSPHKS EGKGLLSPGA KSPSDRGGAF
760 770 780 790 800
TLEPGDLLMD FTEATPLAEP ASNPHCAHSR CSPPLSLPMK EETTGVCMYP
810 820 830 840 850
PIKTRLIKTF PVDTMNPFPD TFTTGPQFTA DFRDSKLQCC PGPTSPLIPA
860 870 880 890 900
ATLRPLTETV STVQTIYTTR KPVSLAASAE TLRQELEREK MMKRLLMTEL
Length:900
Mass (Da):99,712
Last modified:October 14, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9A4BD658DBE65BDE
GO
Isoform 2 (identifier: Q9H329-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     470-518: SYPLPSPVLS...QHQHQHQHHS → RPSFQDDRSH...MYRDKLMTAL
     519-900: Missing.

Show »
Length:518
Mass (Da):58,566
Checksum:i7CF6295CD2BE4E21
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG43366 differs from that shown. Reason: Frameshift.Curated
The sequence AAG43368 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti73V → M in BAA96079 (PubMed:10783258).Curated1
Sequence conflicti899E → R in AAG43366 (PubMed:10603000).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048356816N → T1 PublicationCorresponds to variant dbSNP:rs3750450Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_007202470 – 518SYPLP…HQHHS → RPSFQDDRSHWKASASGDDS HFDYVHDQNQKNLGGMQSMM YRDKLMTAL in isoform 2. 2 PublicationsAdd BLAST49
Alternative sequenceiVSP_007203519 – 900Missing in isoform 2. 2 PublicationsAdd BLAST382

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF153416 mRNA Translation: AAG43366.1 Frameshift.
AF153418 mRNA Translation: AAG43368.1 Frameshift.
AB032179 mRNA Translation: BAA96079.2
AL359963 Genomic DNA No translation available.
AL358815 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43859.1 [Q9H329-1]
CCDS43860.1 [Q9H329-2]

NCBI Reference Sequences

More...
RefSeqi
NP_060894.2, NM_018424.3 [Q9H329-2]
NP_061987.3, NM_019114.4 [Q9H329-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000374557; ENSP00000363685; ENSG00000095203 [Q9H329-2]
ENST00000374566; ENSP00000363694; ENSG00000095203 [Q9H329-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
54566

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54566

UCSC genome browser

More...
UCSCi
uc004bdz.3, human [Q9H329-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF153416 mRNA Translation: AAG43366.1 Frameshift.
AF153418 mRNA Translation: AAG43368.1 Frameshift.
AB032179 mRNA Translation: BAA96079.2
AL359963 Genomic DNA No translation available.
AL358815 Genomic DNA No translation available.
CCDSiCCDS43859.1 [Q9H329-1]
CCDS43860.1 [Q9H329-2]
RefSeqiNP_060894.2, NM_018424.3 [Q9H329-2]
NP_061987.3, NM_019114.4 [Q9H329-1]

3D structure databases

SMRiQ9H329
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120044, 24 interactors
IntActiQ9H329, 16 interactors
STRINGi9606.ENSP00000363694

PTM databases

iPTMnetiQ9H329
PhosphoSitePlusiQ9H329

Polymorphism and mutation databases

BioMutaiEPB41L4B
DMDMi209572611

Proteomic databases

EPDiQ9H329
jPOSTiQ9H329
MassIVEiQ9H329
MaxQBiQ9H329
PaxDbiQ9H329
PeptideAtlasiQ9H329
PRIDEiQ9H329
ProteomicsDBi80657 [Q9H329-1]
80658 [Q9H329-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
29426, 81 antibodies

Genome annotation databases

EnsembliENST00000374557; ENSP00000363685; ENSG00000095203 [Q9H329-2]
ENST00000374566; ENSP00000363694; ENSG00000095203 [Q9H329-1]
GeneIDi54566
KEGGihsa:54566
UCSCiuc004bdz.3, human [Q9H329-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
54566
DisGeNETi54566
EuPathDBiHostDB:ENSG00000095203.14

GeneCards: human genes, protein and diseases

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GeneCardsi
EPB41L4B
HGNCiHGNC:19818, EPB41L4B
HPAiENSG00000095203, Tissue enhanced (liver, pancreas)
MIMi610340, gene
neXtProtiNX_Q9H329
OpenTargetsiENSG00000095203
PharmGKBiPA134986250

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3530, Eukaryota
GeneTreeiENSGT00940000158331
HOGENOMiCLU_003623_5_0_1
InParanoidiQ9H329
OMAiIYTPEAC
OrthoDBi241659at2759
PhylomeDBiQ9H329
TreeFamiTF319780

Enzyme and pathway databases

PathwayCommonsiQ9H329
SIGNORiQ9H329

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
54566, 1 hit in 841 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
EPB41L4B, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
54566
PharosiQ9H329, Tbio

Protein Ontology

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PROi
PR:Q9H329
RNActiQ9H329, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000095203, Expressed in colon and 193 other tissues
GenevisibleiQ9H329, HS

Family and domain databases

CDDicd14473, FERM_B-lobe, 1 hit
Gene3Di1.20.80.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR030698, Band4.1-like4B
IPR019749, Band_41_domain
IPR000798, Ez/rad/moesin-like
IPR014847, FERM-adjacent
IPR014352, FERM/acyl-CoA-bd_prot_sf
IPR035963, FERM_2
IPR019748, FERM_central
IPR019747, FERM_CS
IPR000299, FERM_domain
IPR018979, FERM_N
IPR018980, FERM_PH-like_C
IPR011993, PH-like_dom_sf
IPR029071, Ubiquitin-like_domsf
PANTHERiPTHR23280:SF18, PTHR23280:SF18, 1 hit
PfamiView protein in Pfam
PF08736, FA, 1 hit
PF09380, FERM_C, 1 hit
PF00373, FERM_M, 1 hit
PF09379, FERM_N, 1 hit
PRINTSiPR00935, BAND41
PR00661, ERMFAMILY
SMARTiView protein in SMART
SM00295, B41, 1 hit
SM01195, FA, 1 hit
SM01196, FERM_C, 1 hit
SUPFAMiSSF47031, SSF47031, 1 hit
SSF54236, SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS00661, FERM_2, 1 hit
PS50057, FERM_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE41LB_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H329
Secondary accession number(s): Q5T4G5
, Q5T4G6, Q9H328, Q9P2V3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: October 14, 2008
Last modified: December 2, 2020
This is version 155 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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