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Entry version 160 (13 Feb 2019)
Sequence version 2 (12 Jun 2007)
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Protein

A disintegrin and metalloproteinase with thrombospondin motifs 10

Gene

ADAMTS10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Metalloprotease that participate in microfibrils assembly. Microfibrils are extracellular matrix components occurring independently or along with elastin in the formation of elastic tissues.1 Publication

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi392Zinc; catalyticBy similarity1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei393PROSITE-ProRule annotation1
Metal bindingi396Zinc; catalyticBy similarity1
Metal bindingi402Zinc; catalyticBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5083635 Defective B3GALTL causes Peters-plus syndrome (PpS)
R-HSA-5173214 O-glycosylation of TSR domain-containing proteins

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M12.235

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
A disintegrin and metalloproteinase with thrombospondin motifs 10 (EC:3.4.24.-)
Short name:
ADAM-TS 10
Short name:
ADAM-TS10
Short name:
ADAMTS-10
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000142303.13

Human Gene Nomenclature Database

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HGNCi
HGNC:13201 ADAMTS10

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608990 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H324

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Weill-Marchesani syndrome 1 (WMS1)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare connective tissue disorder characterized by short stature, brachydactyly, joint stiffness, and eye abnormalities including microspherophakia, ectopia lentis, severe myopia and glaucoma.
See also OMIM:277600
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05443925A → T in WMS1; shows consistent and significantly diminished protein secretion. 1 Publication1

Keywords - Diseasei

Disease mutation, Dwarfism

Organism-specific databases

DisGeNET

More...
DisGeNETi
81794

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
ADAMTS10

MalaCards human disease database

More...
MalaCardsi
ADAMTS10
MIMi277600 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000142303

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
3449 Weill-Marchesani syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24537

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ADAMTS10

Domain mapping of disease mutations (DMDM)

More...
DMDMi
148887344

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000002918426 – 233By similarityAdd BLAST208
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000029185234 – 1103A disintegrin and metalloproteinase with thrombospondin motifs 10Add BLAST870

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi90N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi222N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi315 ↔ 376By similarity
Glycosylationi323N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi351 ↔ 358By similarity
Disulfide bondi370 ↔ 452By similarity
Disulfide bondi409 ↔ 436By similarity
Disulfide bondi479 ↔ 501By similarity
Disulfide bondi490 ↔ 508By similarity
Disulfide bondi496 ↔ 531By similarity
Disulfide bondi521 ↔ 536By similarity
Disulfide bondi559 ↔ 596By similarity
Disulfide bondi563 ↔ 601By similarity
Disulfide bondi574 ↔ 586By similarity
Glycosylationi740N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi795N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi892N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X2-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9H324

PeptideAtlas

More...
PeptideAtlasi
Q9H324

PRoteomics IDEntifications database

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PRIDEi
Q9H324

ProteomicsDB human proteome resource

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ProteomicsDBi
80656

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H324

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H324

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed in adult tissues.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000142303 Expressed in 204 organ(s), highest expression level in islet of Langerhans

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9H324 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9H324 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA040223

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with FBN1; this interaction promotes microfibrils assembly.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123586, 7 interactors

Protein interaction database and analysis system

More...
IntActi
Q9H324, 9 interactors

Molecular INTeraction database

More...
MINTi
Q9H324

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000270328

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9H324

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9H324

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini239 – 457Peptidase M12BPROSITE-ProRule annotationAdd BLAST219
Domaini460 – 546DisintegrinAdd BLAST87
Domaini547 – 602TSP type-1 1PROSITE-ProRule annotationAdd BLAST56
Domaini825 – 883TSP type-1 2PROSITE-ProRule annotationAdd BLAST59
Domaini884 – 945TSP type-1 3PROSITE-ProRule annotationAdd BLAST62
Domaini947 – 1001TSP type-1 4PROSITE-ProRule annotationAdd BLAST55
Domaini1003 – 1058TSP type-1 5PROSITE-ProRule annotationAdd BLAST56
Domaini1065 – 1103PLACPROSITE-ProRule annotationAdd BLAST39

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni706 – 828SpacerAdd BLAST123

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi58 – 61Poly-Pro4
Compositional biasi568 – 571Poly-Ser4
Compositional biasi604 – 705Cys-richAdd BLAST102

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.By similarity

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3538 Eukaryota
ENOG410XPKZ LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158404

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000004800

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG004315

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9H324

KEGG Orthology (KO)

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KOi
K08625

Database of Orthologous Groups

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OrthoDBi
125522at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9H324

TreeFam database of animal gene trees

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TreeFami
TF313537

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.20.100.10, 5 hits
3.40.390.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR010294 ADAM_spacer1
IPR013273 ADAMTS/ADAMTS-like
IPR024079 MetalloPept_cat_dom_sf
IPR001590 Peptidase_M12B
IPR002870 Peptidase_M12B_N
IPR010909 PLAC
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05986 ADAM_spacer1, 1 hit
PF01562 Pep_M12B_propep, 1 hit
PF08686 PLAC, 1 hit
PF01421 Reprolysin, 1 hit
PF00090 TSP_1, 5 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01857 ADAMTSFAMILY

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00209 TSP1, 5 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF82895 SSF82895, 5 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50215 ADAM_MEPRO, 1 hit
PS50900 PLAC, 1 hit
PS50092 TSP1, 5 hits
PS00142 ZINC_PROTEASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H324-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPACQILRW ALALGLGLMF EVTHAFRSQD EFLSSLESYE IAFPTRVDHN
60 70 80 90 100
GALLAFSPPP PRRQRRGTGA TAESRLFYKV ASPSTHFLLN LTRSSRLLAG
110 120 130 140 150
HVSVEYWTRE GLAWQRAARP HCLYAGHLQG QASTSHVAIS TCGGLHGLIV
160 170 180 190 200
ADEEEYLIEP LHGGPKGSRS PEESGPHVVY KRSSLRHPHL DTACGVRDEK
210 220 230 240 250
PWKGRPWWLR TLKPPPARPL GNETERGQPG LKRSVSRERY VETLVVADKM
260 270 280 290 300
MVAYHGRRDV EQYVLAIMNI VAKLFQDSSL GSTVNILVTR LILLTEDQPT
310 320 330 340 350
LEITHHAGKS LDSFCKWQKS IVNHSGHGNA IPENGVANHD TAVLITRYDI
360 370 380 390 400
CIYKNKPCGT LGLAPVGGMC ERERSCSVNE DIGLATAFTI AHEIGHTFGM
410 420 430 440 450
NHDGVGNSCG ARGQDPAKLM AAHITMKTNP FVWSSCSRDY ITSFLDSGLG
460 470 480 490 500
LCLNNRPPRQ DFVYPTVAPG QAYDADEQCR FQHGVKSRQC KYGEVCSELW
510 520 530 540 550
CLSKSNRCIT NSIPAAEGTL CQTHTIDKGW CYKRVCVPFG SRPEGVDGAW
560 570 580 590 600
GPWTPWGDCS RTCGGGVSSS SRHCDSPRPT IGGKYCLGER RRHRSCNTDD
610 620 630 640 650
CPPGSQDFRE VQCSEFDSIP FRGKFYKWKT YRGGGVKACS LTCLAEGFNF
660 670 680 690 700
YTERAAAVVD GTPCRPDTVD ICVSGECKHV GCDRVLGSDL REDKCRVCGG
710 720 730 740 750
DGSACETIEG VFSPASPGAG YEDVVWIPKG SVHIFIQDLN LSLSHLALKG
760 770 780 790 800
DQESLLLEGL PGTPQPHRLP LAGTTFQLRQ GPDQVQSLEA LGPINASLIV
810 820 830 840 850
MVLARTELPA LRYRFNAPIA RDSLPPYSWH YAPWTKCSAQ CAGGSQVQAV
860 870 880 890 900
ECRNQLDSSA VAPHYCSAHS KLPKRQRACN TEPCPPDWVV GNWSLCSRSC
910 920 930 940 950
DAGVRSRSVV CQRRVSAAEE KALDDSACPQ PRPPVLEACH GPTCPPEWAA
960 970 980 990 1000
LDWSECTPSC GPGLRHRVVL CKSADHRATL PPAHCSPAAK PPATMRCNLR
1010 1020 1030 1040 1050
RCPPARWVAG EWGECSAQCG VGQRQRSVRC TSHTGQASHE CTEALRPPTT
1060 1070 1080 1090 1100
QQCEAKCDSP TPGDGPEECK DVNKVAYCPL VLKFQFCSRA YFRQMCCKTC

HGH
Length:1,103
Mass (Da):120,874
Last modified:June 12, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD7558271C303A87C
GO
Isoform 2 (identifier: Q9H324-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-637: MAPACQILRW...WKTYRGGGVK → MGPTSVLRAG...NSTSGKRTGE

Note: No experimental confirmation available. Gene prediction based on partial mRNA and EST data.
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Length:590
Mass (Da):62,530
Checksum:i346AE6537FB016C6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MQW6A0A0A0MQW6_HUMAN
A disintegrin and metalloproteinase...
ADAMTS10
1,103Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QY36M0QY36_HUMAN
A disintegrin and metalloproteinase...
ADAMTS10
289Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QY12M0QY12_HUMAN
A disintegrin and metalloproteinase...
ADAMTS10
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti385 – 386AT → PQ in AAG35563 (PubMed:15355968).Curated2
Sequence conflicti437S → N in AAG35563 (PubMed:15355968).Curated1
Sequence conflicti643C → S in AAG35563 (PubMed:15355968).Curated1
Sequence conflicti1101H → Q in AAG35563 (PubMed:15355968).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05443925A → T in WMS1; shows consistent and significantly diminished protein secretion. 1 Publication1
Natural variantiVAR_054440119R → Q. Corresponds to variant dbSNP:rs3814291EnsemblClinVar.1
Natural variantiVAR_054441134T → S1 PublicationCorresponds to variant dbSNP:rs7255721Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0547071 – 637MAPAC…GGGVK → MGPTSVLRAGLTPSCLPPPS GATNGSVSPLGRAQRVWTEP GGRGLHGATAAGPVAAACPL LAVTATAPGQPSGASTVWVR EGGTAPATRMTVPLAPRTSE KCSVLNLTASLSVGNSTSGK RTGE in isoform 2. CuratedAdd BLAST637

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AC092315 Genomic DNA No translation available.
AC130469 Genomic DNA No translation available.
AF163762 mRNA Translation: AAG35563.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS12206.1 [Q9H324-1]
CCDS62529.1 [Q9H324-2]

NCBI Reference Sequences

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RefSeqi
NP_001269281.1, NM_001282352.1 [Q9H324-2]
NP_112219.3, NM_030957.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.657508

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000595838; ENSP00000470501; ENSG00000142303 [Q9H324-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
81794

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:81794

UCSC genome browser

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UCSCi
uc002mki.3 human [Q9H324-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC092315 Genomic DNA No translation available.
AC130469 Genomic DNA No translation available.
AF163762 mRNA Translation: AAG35563.1
CCDSiCCDS12206.1 [Q9H324-1]
CCDS62529.1 [Q9H324-2]
RefSeqiNP_001269281.1, NM_001282352.1 [Q9H324-2]
NP_112219.3, NM_030957.3
UniGeneiHs.657508

3D structure databases

ProteinModelPortaliQ9H324
SMRiQ9H324
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123586, 7 interactors
IntActiQ9H324, 9 interactors
MINTiQ9H324
STRINGi9606.ENSP00000270328

Protein family/group databases

MEROPSiM12.235

PTM databases

iPTMnetiQ9H324
PhosphoSitePlusiQ9H324

Polymorphism and mutation databases

BioMutaiADAMTS10
DMDMi148887344

Proteomic databases

PaxDbiQ9H324
PeptideAtlasiQ9H324
PRIDEiQ9H324
ProteomicsDBi80656

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000595838; ENSP00000470501; ENSG00000142303 [Q9H324-2]
GeneIDi81794
KEGGihsa:81794
UCSCiuc002mki.3 human [Q9H324-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
81794
DisGeNETi81794
EuPathDBiHostDB:ENSG00000142303.13

GeneCards: human genes, protein and diseases

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GeneCardsi
ADAMTS10
GeneReviewsiADAMTS10
HGNCiHGNC:13201 ADAMTS10
HPAiHPA040223
MalaCardsiADAMTS10
MIMi277600 phenotype
608990 gene
neXtProtiNX_Q9H324
OpenTargetsiENSG00000142303
Orphaneti3449 Weill-Marchesani syndrome
PharmGKBiPA24537

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3538 Eukaryota
ENOG410XPKZ LUCA
GeneTreeiENSGT00940000158404
HOGENOMiHOG000004800
HOVERGENiHBG004315
InParanoidiQ9H324
KOiK08625
OrthoDBi125522at2759
PhylomeDBiQ9H324
TreeFamiTF313537

Enzyme and pathway databases

ReactomeiR-HSA-5083635 Defective B3GALTL causes Peters-plus syndrome (PpS)
R-HSA-5173214 O-glycosylation of TSR domain-containing proteins

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ADAMTS10 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ADAMTS10

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
81794

Protein Ontology

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PROi
PR:Q9H324

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000142303 Expressed in 204 organ(s), highest expression level in islet of Langerhans
ExpressionAtlasiQ9H324 baseline and differential
GenevisibleiQ9H324 HS

Family and domain databases

Gene3Di2.20.100.10, 5 hits
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR010294 ADAM_spacer1
IPR013273 ADAMTS/ADAMTS-like
IPR024079 MetalloPept_cat_dom_sf
IPR001590 Peptidase_M12B
IPR002870 Peptidase_M12B_N
IPR010909 PLAC
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
PfamiView protein in Pfam
PF05986 ADAM_spacer1, 1 hit
PF01562 Pep_M12B_propep, 1 hit
PF08686 PLAC, 1 hit
PF01421 Reprolysin, 1 hit
PF00090 TSP_1, 5 hits
PRINTSiPR01857 ADAMTSFAMILY
SMARTiView protein in SMART
SM00209 TSP1, 5 hits
SUPFAMiSSF82895 SSF82895, 5 hits
PROSITEiView protein in PROSITE
PS50215 ADAM_MEPRO, 1 hit
PS50900 PLAC, 1 hit
PS50092 TSP1, 5 hits
PS00142 ZINC_PROTEASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATS10_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H324
Secondary accession number(s): M0QZE4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: June 12, 2007
Last modified: February 13, 2019
This is version 160 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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