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Protein

Variable charge X-linked protein 1

Gene

VCX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May mediate a process in spermatogenesis or may play a role in sex ratio distortion.

GO - Molecular functioni

  • chromatin binding Source: UniProtKB

GO - Biological processi

  • brain development Source: GO_Central
  • chromatin organization Source: UniProtKB
  • ribosome assembly Source: UniProtKB
  • spermatogenesis Source: ProtInc

Names & Taxonomyi

Protein namesi
Recommended name:
Variable charge X-linked protein 1
Alternative name(s):
Variable charge protein on X with ten repeats
Short name:
VCX-10r
Variably charged protein X-B1
Short name:
VCX-B1
Gene namesi
Name:VCX
Synonyms:VCX1, VCX10R, VCXB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000182583.12
HGNCiHGNC:12667 VCX
MIMi300229 gene
neXtProtiNX_Q9H320

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi26609
OpenTargetsiENSG00000182583
PharmGKBiPA37290

Polymorphism and mutation databases

BioMutaiVCX
DMDMi17368950

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001846591 – 206Variable charge X-linked protein 1Add BLAST206

Proteomic databases

PaxDbiQ9H320
PeptideAtlasiQ9H320
PRIDEiQ9H320
ProteomicsDBi80653

PTM databases

iPTMnetiQ9H320
PhosphoSitePlusiQ9H320

Expressioni

Tissue specificityi

Expressed exclusively in testis.

Gene expression databases

BgeeiENSG00000182583
CleanExiHS_VCX
ExpressionAtlasiQ9H320 baseline and differential
GenevisibleiQ9H320 HS

Organism-specific databases

HPAiHPA044996
HPA049357

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000370447

Structurei

3D structure databases

ProteinModelPortaliQ9H320
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati104 – 113110
Repeati114 – 123210
Repeati124 – 133310
Repeati134 – 143410
Repeati144 – 153510
Repeati154 – 163610
Repeati164 – 173710
Repeati174 – 183810
Repeati184 – 193910
Repeati194 – 2031010

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni104 – 20310 X 10 AA tandem repeats of L-S-Q-E-S-[EQ]-V-E-E-PAdd BLAST100

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi83 – 206Glu-richAdd BLAST124

Sequence similaritiesi

Belongs to the VCX/VCY family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410J6ZU Eukaryota
ENOG4111QYX LUCA
GeneTreeiENSGT00440000034745
HOGENOMiHOG000074166
InParanoidiQ9H320
OMAiDETQMED

Family and domain databases

InterProiView protein in InterPro
IPR026653 VCX/VCY1
PANTHERiPTHR15251:SF2 PTHR15251:SF2, 2 hits
PfamiView protein in Pfam
PF15231 VCX_VCY, 4 hits

Sequencei

Sequence statusi: Complete.

Q9H320-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPKPRASGP PAKATEAGKR KSSSQPSPSD PKKKTTKVAK KGKAVRRGRR
60 70 80 90 100
GKKGAATKMA AVTAPEAESA PAAPGPSDQP SQELPQHELP PEEPVSEGTQ
110 120 130 140 150
HDPLSQEAEL EEPLSQESEV EEPLSQESQV EEPLSQESEV EEPLSQESQV
160 170 180 190 200
EEPLSQESEV EEPLSQESQV EEPLSQESEM EEPLSQESQV EEPPSQESEM

EELPSV
Length:206
Mass (Da):22,289
Last modified:March 1, 2001 - v1
Checksum:i070880B5587C2BB0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15 – 17TEA → KET in AAH98123 (PubMed:15489334).Curated3
Sequence conflicti108A → S in AAH98123 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07043170A → G2 PublicationsCorresponds to variant dbSNP:rs6639946Ensembl.1
Natural variantiVAR_070432194P → L1 PublicationCorresponds to variant dbSNP:rs78342118Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF167081 mRNA Translation: AAG41767.1
AF159129 mRNA Translation: AAF28174.1
BC098123 mRNA Translation: AAH98123.1
BC126903 mRNA Translation: AAI26904.1
CCDSiCCDS14128.1
RefSeqiNP_038480.2, NM_013452.2
UniGeneiHs.278906
Hs.567503

Genome annotation databases

EnsembliENST00000381059; ENSP00000370447; ENSG00000182583
GeneIDi26609
KEGGihsa:26609
UCSCiuc004crz.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiVCX1_HUMAN
AccessioniPrimary (citable) accession number: Q9H320
Secondary accession number(s): A0JNS5, Q4V774, Q9P0H3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: March 1, 2001
Last modified: June 20, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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