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Entry version 157 (16 Oct 2019)
Sequence version 5 (28 Mar 2018)
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Protein

Pinin

Gene

PNN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Component of the PSAP complex which binds RNA in a sequence-independent manner and is proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. Involved in the establishment and maintenance of epithelia cell-cell adhesion. Potential tumor suppressor for renal cell carcinoma.5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: ProtInc
  • mRNA splicing, via spliceosome Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processmRNA processing, mRNA splicing, Transcription, Transcription regulation

Protein family/group databases

MoonProt database of moonlighting proteins

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MoonProti
Q9H307

Transport Classification Database

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TCDBi
3.A.18.1.1 the nuclear mrna exporter (mrna-e) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pinin
Alternative name(s):
140 kDa nuclear and cell adhesion-related phosphoprotein
Desmosome-associated protein
Domain-rich serine protein
Short name:
DRS protein
Short name:
DRSP
Melanoma metastasis clone A protein
Nuclear protein SDK3
SR-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PNN
Synonyms:DRS, MEMA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:9162 PNN

Online Mendelian Inheritance in Man (OMIM)

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MIMi
603154 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H307

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Nucleus, Spliceosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi8L → P: Abolishes interaction with KRT18. 1 Publication1
Mutagenesisi19L → P: Abolishes interaction with KRT18. 1 Publication1
Mutagenesisi502 – 503PE → AA: Abolishes interaction with CTBP1 and shows moderate relief of CTBP1-mediated repression. 1 Publication2

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNET

More...
DisGeNETi
5411

Open Targets

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OpenTargetsi
ENSG00000100941

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA33484

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9H307

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
PNN

Domain mapping of disease mutations (DMDM)

More...
DMDMi
73921750

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001902422 – 717PininAdd BLAST716

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei48PhosphoserineCombined sources1
Modified residuei54Omega-N-methylarginineBy similarity1
Modified residuei58PhosphoserineCombined sources1
Modified residuei66PhosphoserineCombined sources1
Modified residuei96PhosphoserineCombined sources1
Modified residuei100PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki109Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei114PhosphoserineCombined sources1
Modified residuei115PhosphoserineCombined sources1
Cross-linki121Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei124PhosphothreonineCombined sources1
Cross-linki137Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki155Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki157Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki157Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki228Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei238N6-acetyllysine; alternateCombined sources1
Modified residuei238N6-succinyllysine; alternateBy similarity1
Cross-linki280Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki304Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki311Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei347PhosphoserineCombined sources1
Cross-linki359Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki365Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei375PhosphoserineCombined sources1
Modified residuei381PhosphoserineCombined sources1
Modified residuei443PhosphoserineBy similarity1
Modified residuei450PhosphoserineCombined sources1
Cross-linki528Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki536Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei552PhosphoserineCombined sources1
Cross-linki553Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei658PhosphoserineCombined sources1
Modified residuei692PhosphoserineCombined sources1
Modified residuei695PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9H307

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9H307

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9H307

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9H307

PeptideAtlas

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PeptideAtlasi
Q9H307

PRoteomics IDEntifications database

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PRIDEi
Q9H307

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9H307

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9H307

SwissPalm database of S-palmitoylation events

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SwissPalmi
Q9H307

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, epidermis, esophagus, brain and smooth and skeletal muscle. Expressed strongly in melanoma metastasis lesions and advanced primary tumors.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000100941 Expressed in 231 organ(s), highest expression level in tendon of biceps brachii

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9H307 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9H307 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA001378

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Found in a mRNA splicing-dependent exon junction complex (EJC).

Found in a complex with SR proteins.

Found in a mRNP complex with RNPS1.

Component of the PSAP complex consisting of RNPS1, SAP18 and PNN.

Interacts with PNISR, CTBP1, CTBP2, KRT8, KRT18, KRT19, PS1D/PNO40, PPIG, RNPS1, SFRS4 and SRRM2. Identified in the spliceosome C complex.

10 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
111412, 143 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q9H307

Database of interacting proteins

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DIPi
DIP-32950N

Protein interaction database and analysis system

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IntActi
Q9H307, 104 interactors

Molecular INTeraction database

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MINTi
Q9H307

STRING: functional protein association networks

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STRINGi
9606.ENSP00000216832

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9H307

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 284Necessary for interaction with RNPS1Add BLAST283
Regioni2 – 167Necessary for mediating alternative 5' splicingAdd BLAST166
Regioni2 – 98Necessary for interactions with KRT8, KRT18 and KRT19Add BLAST97
Regioni221 – 284Sufficient for PSAP complex assemblyAdd BLAST64
Regioni606 – 717Necessary for interaction with PPIG1 PublicationAdd BLAST112

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili2 – 32Sequence analysisAdd BLAST31
Coiled coili163 – 234Sequence analysisAdd BLAST72
Coiled coili287 – 379Sequence analysisAdd BLAST93
Coiled coili446 – 467Sequence analysisAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi172 – 471Glu-richAdd BLAST300
Compositional biasi469 – 520Gln-richAdd BLAST52
Compositional biasi552 – 704Ser-richAdd BLAST153
Compositional biasi632 – 717Arg-richAdd BLAST86

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the pinin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3756 Eukaryota
ENOG4110W63 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00730000111160

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9H307

KEGG Orthology (KO)

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KOi
K13114

Identification of Orthologs from Complete Genome Data

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OMAi
QVIQEQG

Database of Orthologous Groups

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OrthoDBi
881609at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9H307

TreeFam database of animal gene trees

More...
TreeFami
TF331859

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039853 Pinin
IPR006786 Pinin_SDK_MemA
IPR006787 Pinin_SDK_N

The PANTHER Classification System

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PANTHERi
PTHR12707 PTHR12707, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF04696 Pinin_SDK_memA, 1 hit
PF04697 Pinin_SDK_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9H307-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVAVRTLQE QLEKAKESLK NVDENIRKLT GRDPNDVRPI QARLLALSGP
60 70 80 90 100
GGGRGRGSLL LRRGFSDSGG GPPAKQRDLE GAVSRLGGER RTRRESRQES
110 120 130 140 150
DPEDDDVKKP ALQSSVVATS KERTRRDLIQ DQNMDEKGKQ RNRRIFGLLM
160 170 180 190 200
GTLQKFKQES TVATERQKRR QEIEQKLEVQ AEEERKQVEN ERRELFEERR
210 220 230 240 250
AKQTELRLLE QKVELAQLQE EWNEHNAKII KYIRTKTKPH LFYIPGRMCP
260 270 280 290 300
ATQKLIEESQ RKMNALFEGR RIEFAEQINK MEARPRRQSM KEKEHQVVRN
310 320 330 340 350
EEQKAEQEEG KVAQREEELE ETGNQHNDVE IEEAGEEEEK EIAIVHSDAE
360 370 380 390 400
KEQEEEEQKQ EMEVKMEEET EVRESEKQQD SQPEEVMDVL EMVENVKHVI
410 420 430 440 450
ADQEVMETNR VESVEPSENE ASKELEPEME FEIEPDKECK TLSPGKENVS
460 470 480 490 500
ALDMEKESEE KEEKESEPQP EPVAQPQPQS QPQLQLQSQS QPVLQSQPPS
510 520 530 540 550
QPEDLSLAVL QPTPQVTQEQ GHLLPERKDF PVESVKLTEV PVEPVLTVHP
560 570 580 590 600
ESKSKTKTRS RSRGRARNKT SKSRSRSSSS SSSSSSSTSS SSGSSSSSGS
610 620 630 640 650
SSSRSSSSSS SSTSGSSSRD SSSSTSSSSE SRSRSRGRGH NRDRKHRRSV
660 670 680 690 700
DRKRRDTSGL ERSHKSSKGG SSRDTKGSKD KNSRSDRKRS ISESSRSGKR
710
SSRSERDRKS DRKDKRR
Length:717
Mass (Da):81,628
Last modified:March 28, 2018 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1F24D3F12E053C8F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V579G3V579_HUMAN
Pinin
PNN
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V5F0G3V5F0_HUMAN
Pinin
PNN
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA70874 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti69Missing in AAB48304 (PubMed:8922384).Curated1
Sequence conflicti168K → N in AAB48304 (PubMed:8922384).Curated1
Sequence conflicti268E → D in AAB48304 (PubMed:8922384).Curated1
Sequence conflicti303Q → H in AAB48304 (PubMed:8922384).Curated1
Sequence conflicti320E → V in AAB48304 (PubMed:8922384).Curated1
Sequence conflicti343A → G in AAB48304 (PubMed:8922384).Curated1
Sequence conflicti402 – 403DQ → EE in AAG33941 (PubMed:10645008).Curated2
Sequence conflicti441T → S in BAG64240 (PubMed:14702039).Curated1
Sequence conflicti441T → S in CAA70874 (PubMed:10095061).Curated1
Sequence conflicti459E → D in AAB48304 (PubMed:8922384).Curated1
Sequence conflicti478P → A in AAB48304 (PubMed:8922384).Curated1
Sequence conflicti491 – 492QP → EPQPQLQPEPAQPQLQSQPQ LQLQSQCHA AA sequence (PubMed:8922384).Curated2
Sequence conflicti497Q → H in AAB48304 (PubMed:8922384).Curated1
Sequence conflicti520Q → H in AAB48304 (PubMed:8922384).Curated1
Sequence conflicti523L → F in AAB48304 (PubMed:8922384).Curated1
Sequence conflicti541P → T AA sequence (PubMed:8922384).Curated1
Sequence conflicti543E → D in AAB48304 (PubMed:8922384).Curated1
Sequence conflicti547T → I AA sequence (PubMed:8922384).Curated1
Sequence conflicti550P → S AA sequence (PubMed:8922384).Curated1
Sequence conflicti551E → D AA sequence (PubMed:8922384).Curated1
Sequence conflicti553 – 557KSKTK → ESETN in AAB48304 (PubMed:8922384).Curated5
Sequence conflicti566A → T in AAB48304 (PubMed:8922384).Curated1
Sequence conflicti569 – 571KTS → RTT in AAB48304 (PubMed:8922384).Curated3
Sequence conflicti618S → G in AAF17209 (PubMed:10931946).Curated1
Sequence conflicti618S → G in CAA71377 (PubMed:9447706).Curated1
Sequence conflicti623S → SST in CAA70874 (PubMed:10095061).Curated1
Sequence conflicti664H → P in AAG33941 (PubMed:10645008).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_023368671S → G2 PublicationsCorresponds to variant dbSNP:rs13021Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U77718 mRNA Translation: AAB48304.1
AF195139 Genomic DNA Translation: AAG33941.1
AF112222 mRNA Translation: AAF17209.1
AK223612 mRNA Translation: BAD97332.1
BC062602 mRNA Translation: AAH62602.1
Y09703 mRNA Translation: CAA70874.1 Frameshift.
Y10351 mRNA Translation: CAA71377.1
AK303136 mRNA Translation: BAG64240.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9671.1

NCBI Reference Sequences

More...
RefSeqi
NP_002678.2, NM_002687.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000216832; ENSP00000216832; ENSG00000100941

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5411

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5411

UCSC genome browser

More...
UCSCi
uc001wuw.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77718 mRNA Translation: AAB48304.1
AF195139 Genomic DNA Translation: AAG33941.1
AF112222 mRNA Translation: AAF17209.1
AK223612 mRNA Translation: BAD97332.1
BC062602 mRNA Translation: AAH62602.1
Y09703 mRNA Translation: CAA70874.1 Frameshift.
Y10351 mRNA Translation: CAA71377.1
AK303136 mRNA Translation: BAG64240.1
CCDSiCCDS9671.1
RefSeqiNP_002678.2, NM_002687.3

3D structure databases

SMRiQ9H307
ModBaseiSearch...

Protein-protein interaction databases

BioGridi111412, 143 interactors
CORUMiQ9H307
DIPiDIP-32950N
IntActiQ9H307, 104 interactors
MINTiQ9H307
STRINGi9606.ENSP00000216832

Protein family/group databases

MoonProtiQ9H307
TCDBi3.A.18.1.1 the nuclear mrna exporter (mrna-e) family

PTM databases

iPTMnetiQ9H307
PhosphoSitePlusiQ9H307
SwissPalmiQ9H307

Polymorphism and mutation databases

BioMutaiPNN
DMDMi73921750

Proteomic databases

EPDiQ9H307
jPOSTiQ9H307
MassIVEiQ9H307
PaxDbiQ9H307
PeptideAtlasiQ9H307
PRIDEiQ9H307

Genome annotation databases

EnsembliENST00000216832; ENSP00000216832; ENSG00000100941
GeneIDi5411
KEGGihsa:5411
UCSCiuc001wuw.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5411
DisGeNETi5411

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PNN
HGNCiHGNC:9162 PNN
HPAiHPA001378
MIMi603154 gene
neXtProtiNX_Q9H307
OpenTargetsiENSG00000100941
PharmGKBiPA33484

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3756 Eukaryota
ENOG4110W63 LUCA
GeneTreeiENSGT00730000111160
InParanoidiQ9H307
KOiK13114
OMAiQVIQEQG
OrthoDBi881609at2759
PhylomeDBiQ9H307
TreeFamiTF331859

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PNN human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Pinin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5411
PharosiQ9H307

Protein Ontology

More...
PROi
PR:Q9H307

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000100941 Expressed in 231 organ(s), highest expression level in tendon of biceps brachii
ExpressionAtlasiQ9H307 baseline and differential
GenevisibleiQ9H307 HS

Family and domain databases

InterProiView protein in InterPro
IPR039853 Pinin
IPR006786 Pinin_SDK_MemA
IPR006787 Pinin_SDK_N
PANTHERiPTHR12707 PTHR12707, 1 hit
PfamiView protein in Pfam
PF04696 Pinin_SDK_memA, 1 hit
PF04697 Pinin_SDK_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPININ_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H307
Secondary accession number(s): B4DZX8
, O60899, Q53EM7, Q6P5X4, Q7KYL1, Q99738, Q9UHZ9, Q9UQR9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: March 28, 2018
Last modified: October 16, 2019
This is version 157 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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