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Entry version 159 (12 Aug 2020)
Sequence version 2 (18 May 2010)
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Protein

Solute carrier organic anion transporter family member 5A1

Gene

SLCO5A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9H2Y9

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I01.972

Transport Classification Database

More...
TCDBi
2.A.60.1.16, the organo anion transporter (oat) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 5A1
Alternative name(s):
Organic anion transporter polypeptide-related protein 4
Short name:
OATP-RP4
Short name:
OATPRP4
Solute carrier family 21 member 15
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLCO5A1
Synonyms:OATP5A1, SLC21A15
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000137571.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19046, SLCO5A1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613543, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H2Y9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 128CytoplasmicSequence analysisAdd BLAST128
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei129 – 149Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini150 – 168ExtracellularSequence analysisAdd BLAST19
Transmembranei169 – 189Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini190 – 195CytoplasmicSequence analysis6
Transmembranei196 – 220Helical; Name=3Sequence analysisAdd BLAST25
Topological domaini221 – 260ExtracellularSequence analysisAdd BLAST40
Transmembranei261 – 290Helical; Name=4Sequence analysisAdd BLAST30
Topological domaini291 – 309CytoplasmicSequence analysisAdd BLAST19
Transmembranei310 – 329Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini330 – 344ExtracellularSequence analysisAdd BLAST15
Transmembranei345 – 369Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini370 – 427CytoplasmicSequence analysisAdd BLAST58
Transmembranei428 – 449Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini450 – 469ExtracellularSequence analysisAdd BLAST20
Transmembranei470 – 493Helical; Name=8Sequence analysisAdd BLAST24
Topological domaini494 – 497CytoplasmicSequence analysis4
Transmembranei498 – 521Helical; Name=9Sequence analysisAdd BLAST24
Topological domaini522 – 651ExtracellularSequence analysisAdd BLAST130
Transmembranei652 – 674Helical; Name=10Sequence analysisAdd BLAST23
Topological domaini675 – 683CytoplasmicSequence analysis9
Transmembranei684 – 709Helical; Name=11Sequence analysisAdd BLAST26
Topological domaini710 – 742ExtracellularSequence analysisAdd BLAST33
Transmembranei743 – 760Helical; Name=12Sequence analysisAdd BLAST18
Topological domaini761 – 808CytoplasmicSequence analysisAdd BLAST48

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
81796

Open Targets

More...
OpenTargetsi
ENSG00000137571

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134948571

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9H2Y9, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLCO5A1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296452911

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001910701 – 848Solute carrier organic anion transporter family member 5A1Add BLAST848

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi228N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi241N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi469N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi550N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi555 ↔ 581PROSITE-ProRule annotation
Disulfide bondi559 ↔ 570PROSITE-ProRule annotation
Disulfide bondi561 ↔ 585PROSITE-ProRule annotation
Glycosylationi590N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi597N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi730N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H2Y9

PeptideAtlas

More...
PeptideAtlasi
Q9H2Y9

PRoteomics IDEntifications database

More...
PRIDEi
Q9H2Y9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
21498
32322
80635 [Q9H2Y9-1]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q9H2Y9, 7 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H2Y9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H2Y9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000137571, Expressed in quadriceps femoris and 125 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9H2Y9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H2Y9, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000137571, Tissue enhanced (heart muscle, lymphoid tissue, skeletal muscle, tongue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
123587, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q9H2Y9, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000260126

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9H2Y9, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini549 – 603Kazal-likePROSITE-ProRule annotationAdd BLAST55

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi377 – 383Poly-Lys7

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3626, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT01000000214547

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_008954_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H2Y9

KEGG Orthology (KO)

More...
KOi
K14356

Identification of Orthologs from Complete Genome Data

More...
OMAi
PFSEAIN

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H2Y9

TreeFam database of animal gene trees

More...
TreeFami
TF317540

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002350, Kazal_dom
IPR036058, Kazal_dom_sf
IPR020846, MFS_dom
IPR036259, MFS_trans_sf
IPR004156, OATP

The PANTHER Classification System

More...
PANTHERi
PTHR11388, PTHR11388, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07648, Kazal_2, 1 hit
PF03137, OATP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100895, SSF100895, 1 hit
SSF103473, SSF103473, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00805, oat, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51465, KAZAL_2, 1 hit
PS50850, MFS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H2Y9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDEGTGLQPG AGEQLEAPAT AEAVQERCEP ETLRSKSLPV LSSASCRPSL
60 70 80 90 100
SPTSGDANPA FGCVDSSGHQ ELKQGPNPLA PSPSAPSTSA GLGDCNHRVD
110 120 130 140 150
LSKTFSVSSA LAMLQERRCL YVVLTDSRCF LVCMCFLTFI QALMVSGYLS
160 170 180 190 200
SVITTIERRY SLKSSESGLL VSCFDIGNLV VVVFVSYFGG RGRRPLWLAV
210 220 230 240 250
GGLLIAFGAA LFALPHFISP PYQIQELNAS APNDGLCQGG NSTATLEPPA
260 270 280 290 300
CPKDSGGNNH WVYVALFICA QILIGMGSTP IYTLGPTYLD DNVKKENSSL
310 320 330 340 350
YLAIMYVMGA LGPAVGYLLG GLLIGFYVDP RNPVHLDQND PRFIGNWWSG
360 370 380 390 400
FLLCAIAMFL VIFPMFTFPK KLPPRHKKKK KKKFSVDAVS DDDVLKEKSN
410 420 430 440 450
NSEQADKKVS SMGFGKDVRD LPRAAVRILS NMTFLFVSLS YTAESAIVTA
460 470 480 490 500
FITFIPKFIE SQFGIPASNA SIYTGVIIVP SAGVGIVLGG YIIKKLKLGA
510 520 530 540 550
RESAKLAMIC SGVSLLCFST LFIVGCESIN LGGINIPYTT GPSLTMPHRN
560 570 580 590 600
LTGSCNVNCG CKIHEYEPVC GSDGITYFNP CLAGCVNSGN LSTGIRNYTE
610 620 630 640 650
CTCVQSRQVI TPPTVGQRSQ LRVVIVKTYL NENGYAVSGK CKRTCNTLIP
660 670 680 690 700
FLVFLFIVTF ITACAQPSAI IVTLRSVEDE ERPFALGMQF VLLRTLAYIP
710 720 730 740 750
TPIYFGAVID TTCMLWQQEC GVQGSCWEYN VTSFRFVYFG LAAGLKFVGF
760 770 780 790 800
IFIFLAWYSI KYKEDGLQRR RQREFPLSTV SERVGHPDNA RTRSCPAFST
810 820 830 840
QGEFHEETGL QKGIQCAAQT YPGPFPEAIS SSADPGLEES PAALEPPS
Length:848
Mass (Da):91,864
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF213B18FE8389596
GO
Isoform 2 (identifier: Q9H2Y9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     420-474: Missing.

Show »
Length:793
Mass (Da):85,850
Checksum:iB1031ACFCC20CCB8
GO
Isoform 3 (identifier: Q9H2Y9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     675-687: RSVEDEERPFALG → SIHSYSNLLWSSH
     688-848: Missing.

Show »
Length:687
Mass (Da):73,843
Checksum:i772B469C80E2BEEE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PPI0E9PPI0_HUMAN
Solute carrier organic anion transp...
SLCO5A1
312Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti40V → A in BAG51109 (PubMed:14702039).Curated1
Sequence conflicti264V → L in AAG42207 (Ref. 1) Curated1
Sequence conflicti457K → E in BAG51109 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02204133L → F1 PublicationCorresponds to variant dbSNP:rs3750266Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_045498420 – 474Missing in isoform 2. 1 PublicationAdd BLAST55
Alternative sequenceiVSP_045499675 – 687RSVED…PFALG → SIHSYSNLLWSSH in isoform 3. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_045500688 – 848Missing in isoform 3. 1 PublicationAdd BLAST161

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF205075 mRNA Translation: AAG42207.1
AK022760 mRNA Translation: BAG51109.1
AC024680 Genomic DNA No translation available.
AC079089 Genomic DNA No translation available.
AC091047 Genomic DNA No translation available.
CH471068 Genomic DNA Translation: EAW86957.1
CH471068 Genomic DNA Translation: EAW86958.1
BC137424 mRNA Translation: AAI37425.1
BC139755 mRNA Translation: AAI39756.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS55242.1 [Q9H2Y9-2]
CCDS55243.1 [Q9H2Y9-3]
CCDS6205.1 [Q9H2Y9-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001139480.1, NM_001146008.1 [Q9H2Y9-3]
NP_001139481.1, NM_001146009.1 [Q9H2Y9-2]
NP_112220.2, NM_030958.2 [Q9H2Y9-1]
XP_005251370.1, XM_005251313.2 [Q9H2Y9-2]
XP_016869372.1, XM_017013883.1 [Q9H2Y9-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000260126; ENSP00000260126; ENSG00000137571 [Q9H2Y9-1]
ENST00000524945; ENSP00000434422; ENSG00000137571 [Q9H2Y9-3]
ENST00000530307; ENSP00000431611; ENSG00000137571 [Q9H2Y9-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
81796

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:81796

UCSC genome browser

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UCSCi
uc003xyk.4, human [Q9H2Y9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF205075 mRNA Translation: AAG42207.1
AK022760 mRNA Translation: BAG51109.1
AC024680 Genomic DNA No translation available.
AC079089 Genomic DNA No translation available.
AC091047 Genomic DNA No translation available.
CH471068 Genomic DNA Translation: EAW86957.1
CH471068 Genomic DNA Translation: EAW86958.1
BC137424 mRNA Translation: AAI37425.1
BC139755 mRNA Translation: AAI39756.1
CCDSiCCDS55242.1 [Q9H2Y9-2]
CCDS55243.1 [Q9H2Y9-3]
CCDS6205.1 [Q9H2Y9-1]
RefSeqiNP_001139480.1, NM_001146008.1 [Q9H2Y9-3]
NP_001139481.1, NM_001146009.1 [Q9H2Y9-2]
NP_112220.2, NM_030958.2 [Q9H2Y9-1]
XP_005251370.1, XM_005251313.2 [Q9H2Y9-2]
XP_016869372.1, XM_017013883.1 [Q9H2Y9-3]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi123587, 1 interactor
IntActiQ9H2Y9, 2 interactors
STRINGi9606.ENSP00000260126

Protein family/group databases

MEROPSiI01.972
TCDBi2.A.60.1.16, the organo anion transporter (oat) family

PTM databases

GlyGeniQ9H2Y9, 7 sites
iPTMnetiQ9H2Y9
PhosphoSitePlusiQ9H2Y9

Polymorphism and mutation databases

BioMutaiSLCO5A1
DMDMi296452911

Proteomic databases

PaxDbiQ9H2Y9
PeptideAtlasiQ9H2Y9
PRIDEiQ9H2Y9
ProteomicsDBi21498
32322
80635 [Q9H2Y9-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
12199, 32 antibodies

Genome annotation databases

EnsembliENST00000260126; ENSP00000260126; ENSG00000137571 [Q9H2Y9-1]
ENST00000524945; ENSP00000434422; ENSG00000137571 [Q9H2Y9-3]
ENST00000530307; ENSP00000431611; ENSG00000137571 [Q9H2Y9-2]
GeneIDi81796
KEGGihsa:81796
UCSCiuc003xyk.4, human [Q9H2Y9-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
81796
DisGeNETi81796
EuPathDBiHostDB:ENSG00000137571.10

GeneCards: human genes, protein and diseases

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GeneCardsi
SLCO5A1
HGNCiHGNC:19046, SLCO5A1
HPAiENSG00000137571, Tissue enhanced (heart muscle, lymphoid tissue, skeletal muscle, tongue)
MIMi613543, gene
neXtProtiNX_Q9H2Y9
OpenTargetsiENSG00000137571
PharmGKBiPA134948571

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3626, Eukaryota
GeneTreeiENSGT01000000214547
HOGENOMiCLU_008954_1_1_1
InParanoidiQ9H2Y9
KOiK14356
OMAiPFSEAIN
PhylomeDBiQ9H2Y9
TreeFamiTF317540

Enzyme and pathway databases

PathwayCommonsiQ9H2Y9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
81796, 1 hit in 864 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SLCO5A1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
81796
PharosiQ9H2Y9, Tdark

Protein Ontology

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PROi
PR:Q9H2Y9
RNActiQ9H2Y9, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000137571, Expressed in quadriceps femoris and 125 other tissues
ExpressionAtlasiQ9H2Y9, baseline and differential
GenevisibleiQ9H2Y9, HS

Family and domain databases

InterProiView protein in InterPro
IPR002350, Kazal_dom
IPR036058, Kazal_dom_sf
IPR020846, MFS_dom
IPR036259, MFS_trans_sf
IPR004156, OATP
PANTHERiPTHR11388, PTHR11388, 1 hit
PfamiView protein in Pfam
PF07648, Kazal_2, 1 hit
PF03137, OATP, 1 hit
SUPFAMiSSF100895, SSF100895, 1 hit
SSF103473, SSF103473, 2 hits
TIGRFAMsiTIGR00805, oat, 1 hit
PROSITEiView protein in PROSITE
PS51465, KAZAL_2, 1 hit
PS50850, MFS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSO5A1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H2Y9
Secondary accession number(s): A4QPC2
, B2RPF7, B3KMU7, E9PKK5, G3V1C0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: May 18, 2010
Last modified: August 12, 2020
This is version 159 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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