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Protein

Zinc finger protein 106

Gene

ZNF106

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri20 – 44C2H2-type 1; atypicalAdd BLAST25
Zinc fingeri1813 – 1838C2H2-type 2; atypicalAdd BLAST26

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • RNA binding Source: UniProtKB
  • SH3 domain binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9H2Y7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 106
Short name:
Zfp-106
Alternative name(s):
Zinc finger protein 474
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF106
Synonyms:SH3BP3, ZFP106, ZNF474
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000103994.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12886 ZNF106

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H2Y7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
64397

Open Targets

More...
OpenTargetsi
ENSG00000103994

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA166048944

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF106

Domain mapping of disease mutations (DMDM)

More...
DMDMi
51702191

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000514671 – 1883Zinc finger protein 106Add BLAST1883

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki69Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki76Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki133Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki243Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki287Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki305Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki356Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki365Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki371Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki417Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei422PhosphoserineCombined sources1
Cross-linki451Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki461Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki477Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki492Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki505Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki515Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki525Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki539Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki557Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei590PhosphoserineCombined sources1
Cross-linki603Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei641PhosphoserineCombined sources1
Modified residuei661PhosphoserineCombined sources1
Cross-linki671Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki684Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki705Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki721Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki741Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki775Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki807Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei859PhosphoserineCombined sources1
Modified residuei861PhosphoserineCombined sources1
Modified residuei864PhosphoserineCombined sources1
Modified residuei893PhosphoserineCombined sources1
Cross-linki905Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki911Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei937PhosphoserineCombined sources1
Cross-linki953Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1021PhosphothreonineCombined sources1
Modified residuei1025PhosphoserineCombined sources1
Modified residuei1026PhosphoserineCombined sources1
Modified residuei1031PhosphoserineCombined sources1
Modified residuei1249PhosphoserineCombined sources1
Cross-linki1265Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1279PhosphoserineCombined sources1
Modified residuei1281PhosphoserineBy similarity1
Modified residuei1284PhosphoserineCombined sources1
Cross-linki1299Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1302PhosphoserineCombined sources1
Cross-linki1324Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1328PhosphoserineCombined sources1
Modified residuei1370PhosphoserineCombined sources1
Modified residuei1372PhosphothreonineCombined sources1
Cross-linki1380Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1392Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1395Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1454Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1468PhosphoserineCombined sources1
Cross-linki1486Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1504Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1585Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1737Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1864Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Isoform 2 (identifier: Q9H2Y7-2)
Cross-linki6Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki37Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by FYN in vitro.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9H2Y7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H2Y7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H2Y7

PeptideAtlas

More...
PeptideAtlasi
Q9H2Y7

PRoteomics IDEntifications database

More...
PRIDEi
Q9H2Y7

ProteomicsDB human proteome resource

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ProteomicsDBi
80634

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H2Y7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H2Y7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000103994 Expressed in 239 organ(s), highest expression level in quadriceps femoris

CleanEx database of gene expression profiles

More...
CleanExi
HS_ZFP106
HS_ZNF474

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9H2Y7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H2Y7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA054267

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with KNOP1. Interacts with TARDBP and NUP107. Interacts (via N-terminus) with RBM39. Interacts with the SH3 domains of FYN and GRB2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122154, 32 interactors

Protein interaction database and analysis system

More...
IntActi
Q9H2Y7, 24 interactors

Molecular INTeraction database

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MINTi
Q9H2Y7

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000263805

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9H2Y7

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1529 – 1568WD 1Add BLAST40
Repeati1570 – 1611WD 2Add BLAST42
Repeati1654 – 1695WD 3Add BLAST42
Repeati1698 – 1737WD 4Add BLAST40
Repeati1738 – 1775WD 5Add BLAST38
Repeati1778 – 1815WD 6Add BLAST38

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri20 – 44C2H2-type 1; atypicalAdd BLAST25
Zinc fingeri1813 – 1838C2H2-type 2; atypicalAdd BLAST26

Keywords - Domaini

Repeat, WD repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157336

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG079376

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H2Y7

Identification of Orthologs from Complete Genome Data

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OMAi
DAFFTSR

Database of Orthologous Groups

More...
OrthoDBi
EOG091G00B2

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H2Y7

TreeFam database of animal gene trees

More...
TreeFami
TF105569

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00400 WD40, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 6 hits
SM00355 ZnF_C2H2, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H2Y7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPVGRIECPS SPSFPRDISH ECRVCGVTEV GLSAYAKHIS GQLHKDNVDA
60 70 80 90 100
QEREDDGKGE EEEEDYFDKE LIQLIKQRKE QSRQDEPSNS NQEINSDDRR
110 120 130 140 150
PQWRREDRIP YQDRESYSQP AWHHRGPPQR DWKWEKDGFN NTRKNSFPHS
160 170 180 190 200
LRNGGGPRGR SGWHKGVAGG SSTWFHNHSN SGGGWLSNSG AVDWNHNGTG
210 220 230 240 250
RNSSWLSEGT GGFSSWHMNN SNGNWKSSVR STNNWNYSGP GDKFQPGRNR
260 270 280 290 300
NSNCQMEDMT MLWNKKSNKS NKYSHDRYNW QRQENDKLGT VATYRGPSEG
310 320 330 340 350
FTSDKFPSEG LLDFNFEQLE SQTTKQADTA TSKVSGKNGS AAREKPRRWT
360 370 380 390 400
PYPSQKTLDL QSGLKDITGN KSEMIEKPLF DFSLITTGIQ EPQTDETRNS
410 420 430 440 450
PTQKTQKEIH TGSLNHKASS DSAASFEVVR QCPTAEKPEQ EHTPNKMPSL
460 470 480 490 500
KSPLLPCPAT KSLSQKQDPK NISKNTKTNF FSPGEHSNPS NKPTVEDNHG
510 520 530 540 550
PYISKLRSSC PHVLKGNKST FGSQKQSGDN LNDTLRKAKE VLQCHESLQN
560 570 580 590 600
PLLSTSKSTR NYAKASRNVE ESEKGSLKIE FQVHALEDES DGETSDTEKH
610 620 630 640 650
GTKIGTLGSA TTELLSGSTR TADEKEEDDR ILKTSRELST SPCNPIVRQK
660 670 680 690 700
ESELQMTSAA SPHPGLLLDL KTSLEDAQVD DSIKSHVSYE TEGFESASLD
710 720 730 740 750
AELQKSDISQ PSGPLLPELS KLGFPASLQR DLTRHISLKS KTGVHLPEPN
760 770 780 790 800
LNSARRIRNI SGHRKSETEK ESGLKPTLRQ ILNASRRNVN WEQVIQQVTK
810 820 830 840 850
KKQELGKGLP RFGIEMVPLV QNEQEALDLD GEPDLSSLEG FQWEGVSISS
860 870 880 890 900
SPGLARKRSL SESSVIMDRA PSVYSFFSEE GTGKENEPQQ MVSPSNSLRA
910 920 930 940 950
GQSQKATMHL KQEVTPRAAS LRTGERAENV ATQRRHSAQL SSDHIIPLMH
960 970 980 990 1000
LAKDLNSQER SIPPSENQNS QESNGEGNCL SSSASSALAI SSLADAATDS
1010 1020 1030 1040 1050
SCTSGAEQND GQSIRKKRRA TGDGSSPELP SLERKNKRRK IKGKKERSQV
1060 1070 1080 1090 1100
DQLLNISLRE EELSKSLQCM DNNLLQARAA LQTAYVEVQR LLMLKQQITM
1110 1120 1130 1140 1150
EMSALRTHRI QILQGLQETY EPSEHPDQVP CSLTRERRNS RSQTSIDAAL
1160 1170 1180 1190 1200
LPTPFFPLFL EPPSSHVSPS PTGASLQITT SPTFQTHGSV PAPDSSVQIK
1210 1220 1230 1240 1250
QEPMSPEQDE NVNAVPPSSA CNVSKELLEA NREISDSCPV YPVITARLSL
1260 1270 1280 1290 1300
PESTESFHEP SQELKFSVEQ RNTRNRENSP SSQSAGLSSI NKEGEEPTKG
1310 1320 1330 1340 1350
NSGSEACTSS FLRLSFASET PLEKEPHSPA DQPEQQAEST LTSAETRGSK
1360 1370 1380 1390 1400
KKKKLRKKKS LRAAHVPENS DTEQDVLTVK PVRKVKAGKL IKGGKVTTST
1410 1420 1430 1440 1450
WEDSRTGREQ ESVRDEPDSD SSLEVLEIPN PQLEVVAIDS SESGEEKPDS
1460 1470 1480 1490 1500
PSKKDIWNST EQNPLETSRS GCDEVSSTSE IGTRYKDGIP VSVAETQTVI
1510 1520 1530 1540 1550
SSIKGSKNSS EISSEPGDDD EPTEGSFEGH QAAVNAIQIF GNLLYTCSAD
1560 1570 1580 1590 1600
KTVRVYNLVS RKCIGVFEGH TSKVNCLLVT QTSGKNAALY TGSSDHTIRC
1610 1620 1630 1640 1650
YNVKSRECVE QLQLEDRVLC LHSRWRILYA GLANGTVVTF NIKNNKRLEI
1660 1670 1680 1690 1700
FECHGPRAVS CLATAQEGAR KLLVVGSYDC TISVRDARNG LLLRTLEGHS
1710 1720 1730 1740 1750
KTILCMKVVN DLVFSGSSDQ SVHAHNIHTG ELVRIYKGHN HAVTVVNILG
1760 1770 1780 1790 1800
KVMVTACLDK FVRVYELQSH DRLQVYGGHK DMIMCMTIHK SMIYTGCYDG
1810 1820 1830 1840 1850
SIQAVRLNLM QNYRCWWHGC SLIFGVVDHL KQHLLTDHTN PNFQTLKCRW
1860 1870 1880
KNCDAFFTAR KGSKQDAAGH IERHAEDDSK IDS
Length:1,883
Mass (Da):208,883
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7D1CBD6193F8888C
GO
Isoform 2 (identifier: Q9H2Y7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: MPVGRIECPS...EVGLSAYAKH → MVRERKCILC...HHRELENLKG
     39-810: Missing.

Note: No experimental confirmation available.Combined sources
Show »
Length:1,111
Mass (Da):122,869
Checksum:iAD7FA61E3235E46E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DGM5A0A0C4DGM5_HUMAN
Zinc finger protein 106 homolog (Mo...
ZNF106 ZFP106, hCG_40432
1,068Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BS99H3BS99_HUMAN
Zinc finger protein 106
ZNF106
850Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BNJ4H3BNJ4_HUMAN
Zinc finger protein 106
ZNF106
201Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BSS6H3BSS6_HUMAN
Zinc finger protein 106
ZNF106
1,906Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BRD4H3BRD4_HUMAN
Zinc finger protein 106
ZNF106
217Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BNX5H3BNX5_HUMAN
Zinc finger protein 106
ZNF106
816Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
U3KQH7U3KQH7_HUMAN
Zinc finger protein 106
ZNF106
191Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH58023 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH70244 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAB14976 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAD91134 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti475N → D in BAB71475 (PubMed:14702039).Curated1
Sequence conflicti680D → G in CAD91147 (PubMed:17974005).Curated1
Sequence conflicti757I → V in BAB71475 (PubMed:14702039).Curated1
Sequence conflicti1293E → G in CAD91142 (PubMed:17974005).Curated1
Sequence conflicti1509S → P in BAG63952 (PubMed:14702039).Curated1
Sequence conflicti1606R → L in BAB14976 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053440103W → R. Corresponds to variant dbSNP:rs12440118Ensembl.1
Natural variantiVAR_053441646I → T. Corresponds to variant dbSNP:rs12101559Ensembl.1
Natural variantiVAR_053442656M → V. Corresponds to variant dbSNP:rs34792942Ensembl.1
Natural variantiVAR_0534431162P → T. Corresponds to variant dbSNP:rs34983340Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0571201 – 38MPVGR…AYAKH → MVRERKCILCHIVYSSKKEM DEHMRSMLHHRELENLKG in isoform 2. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_05712139 – 810Missing in isoform 2. 1 PublicationAdd BLAST772

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF205632 mRNA Translation: AAG35666.1
AF209502 Genomic DNA Translation: AAL40184.1
AK024726 mRNA Translation: BAB14976.1 Different initiation.
AK057410 mRNA Translation: BAB71475.1
AK302735 mRNA Translation: BAG63952.1
AC012651 Genomic DNA No translation available.
AC018362 Genomic DNA No translation available.
BC058023 mRNA Translation: AAH58023.1 Sequence problems.
BC070244 mRNA Translation: AAH70244.1 Sequence problems.
AL832455 mRNA Translation: CAD89926.1
AL831983 mRNA Translation: CAD91134.1 Different initiation.
AL833301 mRNA Translation: CAD91142.1
AL832014 mRNA Translation: CAD91147.1
AL832352 mRNA Translation: CAD91149.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32208.1 [Q9H2Y7-1]
CCDS61603.1 [Q9H2Y7-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001271235.1, NM_001284306.1
NP_001271236.1, NM_001284307.1 [Q9H2Y7-2]
NP_071918.1, NM_022473.2 [Q9H2Y7-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.511143
Hs.735946

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000263805; ENSP00000263805; ENSG00000103994 [Q9H2Y7-1]
ENST00000565380; ENSP00000455674; ENSG00000103994 [Q9H2Y7-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
64397

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:64397

UCSC genome browser

More...
UCSCi
uc001zpv.5 human [Q9H2Y7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF205632 mRNA Translation: AAG35666.1
AF209502 Genomic DNA Translation: AAL40184.1
AK024726 mRNA Translation: BAB14976.1 Different initiation.
AK057410 mRNA Translation: BAB71475.1
AK302735 mRNA Translation: BAG63952.1
AC012651 Genomic DNA No translation available.
AC018362 Genomic DNA No translation available.
BC058023 mRNA Translation: AAH58023.1 Sequence problems.
BC070244 mRNA Translation: AAH70244.1 Sequence problems.
AL832455 mRNA Translation: CAD89926.1
AL831983 mRNA Translation: CAD91134.1 Different initiation.
AL833301 mRNA Translation: CAD91142.1
AL832014 mRNA Translation: CAD91147.1
AL832352 mRNA Translation: CAD91149.1
CCDSiCCDS32208.1 [Q9H2Y7-1]
CCDS61603.1 [Q9H2Y7-2]
RefSeqiNP_001271235.1, NM_001284306.1
NP_001271236.1, NM_001284307.1 [Q9H2Y7-2]
NP_071918.1, NM_022473.2 [Q9H2Y7-1]
UniGeneiHs.511143
Hs.735946

3D structure databases

ProteinModelPortaliQ9H2Y7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122154, 32 interactors
IntActiQ9H2Y7, 24 interactors
MINTiQ9H2Y7
STRINGi9606.ENSP00000263805

PTM databases

iPTMnetiQ9H2Y7
PhosphoSitePlusiQ9H2Y7

Polymorphism and mutation databases

BioMutaiZNF106
DMDMi51702191

Proteomic databases

EPDiQ9H2Y7
MaxQBiQ9H2Y7
PaxDbiQ9H2Y7
PeptideAtlasiQ9H2Y7
PRIDEiQ9H2Y7
ProteomicsDBi80634

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263805; ENSP00000263805; ENSG00000103994 [Q9H2Y7-1]
ENST00000565380; ENSP00000455674; ENSG00000103994 [Q9H2Y7-2]
GeneIDi64397
KEGGihsa:64397
UCSCiuc001zpv.5 human [Q9H2Y7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
64397
DisGeNETi64397
EuPathDBiHostDB:ENSG00000103994.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZNF106
HGNCiHGNC:12886 ZNF106
HPAiHPA054267
neXtProtiNX_Q9H2Y7
OpenTargetsiENSG00000103994
PharmGKBiPA166048944

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000157336
HOVERGENiHBG079376
InParanoidiQ9H2Y7
OMAiDAFFTSR
OrthoDBiEOG091G00B2
PhylomeDBiQ9H2Y7
TreeFamiTF105569

Enzyme and pathway databases

SignaLinkiQ9H2Y7

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ZNF106 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ZFP106

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
64397

Protein Ontology

More...
PROi
PR:Q9H2Y7

Gene expression databases

BgeeiENSG00000103994 Expressed in 239 organ(s), highest expression level in quadriceps femoris
CleanExiHS_ZFP106
HS_ZNF474
ExpressionAtlasiQ9H2Y7 baseline and differential
GenevisibleiQ9H2Y7 HS

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN106_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H2Y7
Secondary accession number(s): B4DZ40
, E9PE29, Q6NSD9, Q6PEK1, Q86T43, Q86T45, Q86T50, Q86T58, Q86TA9, Q96M37, Q9H7B8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: March 1, 2001
Last modified: December 5, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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