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Protein

C-type lectin domain family 4 member M

Gene

CLEC4M

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates.1 Publication
(Microbial infection) Acts as an attachment receptor for Ebolavirus.2 Publications
(Microbial infection) Acts as an attachment receptor for Hepatitis C virus.2 Publications
(Microbial infection) Acts as an attachment receptor for HIV-1.2 Publications
(Microbial infection) Acts as an attachment receptor for Human coronavirus 229E.1 Publication
(Microbial infection) Acts as an attachment receptor for Human cytomegalovirus/HHV-5.1 Publication
(Microbial infection) Acts as an attachment receptor for Influenzavirus.1 Publication
(Microbial infection) Acts as an attachment receptor for SARS coronavirus.1 Publication
(Microbial infection) Acts as an attachment receptor for West-nile virus.1 Publication
(Microbial infection) Acts as an attachment receptor for Japanese encephalitis virus.1 Publication
(Microbial infection) Acts as an attachment receptor for Marburg virus glycoprotein.1 Publication
(Microbial infection) Recognition of M.bovis by dendritic cells may occur partially via this molecule.1 Publication

Miscellaneous

In vitro, is a receptor for HIV-1 and transmits HIV-1 to permissive T-cells.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi359Calcium1
Metal bindingi361Calcium1
Metal bindingi363Calcium; via carbonyl oxygen1
Metal bindingi366Calcium1
Metal bindingi377Calcium1
Metal bindingi378Calcium1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium-dependent protein binding Source: AgBase
  • carbohydrate binding Source: UniProtKB
  • ICAM-3 receptor activity Source: UniProtKB
  • mannose binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • peptide antigen binding Source: UniProtKB
  • signaling receptor activity Source: UniProtKB
  • virion binding Source: UniProtKB
  • virus receptor activity Source: CACAO

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHost cell receptor for virus entry, Receptor
Biological processAdaptive immunity, Endocytosis, Host-virus interaction, Immunity, Innate immunity
LigandCalcium, Lectin, Mannose-binding, Metal-binding

Protein family/group databases

UniLectin database of carbohydrate-binding proteins

More...
UniLectini
Q9H2X3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
C-type lectin domain family 4 member M
Alternative name(s):
CD209 antigen-like protein 1
DC-SIGN-related protein
Short name:
DC-SIGNR
Dendritic cell-specific ICAM-3-grabbing non-integrin 2
Short name:
DC-SIGN2
Liver/lymph node-specific ICAM-3-grabbing non-integrin
Short name:
L-SIGN
CD_antigen: CD299
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CLEC4M
Synonyms:CD209L, CD209L1, CD299
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000104938.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13523 CLEC4M

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605872 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H2X3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 49CytoplasmicCuratedAdd BLAST49
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei50 – 70Helical; Signal-anchor for type II membrane proteinCuratedAdd BLAST21
Topological domaini71 – 399ExtracellularCuratedAdd BLAST329

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10332

Open Targets

More...
OpenTargetsi
ENSG00000104938

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26200

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2176858

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CLEC4M

Domain mapping of disease mutations (DMDM)

More...
DMDMi
46395990

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000466261 – 399C-type lectin domain family 4 member MAdd BLAST399

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi92N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi265 ↔ 395
Disulfide bondi268 ↔ 279
Disulfide bondi296 ↔ 389
Glycosylationi361N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi368 ↔ 381

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H2X3

PeptideAtlas

More...
PeptideAtlasi
Q9H2X3

PRoteomics IDEntifications database

More...
PRIDEi
Q9H2X3

ProteomicsDB human proteome resource

More...
ProteomicsDBi
80616
80617 [Q9H2X3-10]
80619 [Q9H2X3-2]
80620 [Q9H2X3-3]
80621 [Q9H2X3-4]
80622 [Q9H2X3-5]
80623 [Q9H2X3-6]
80624 [Q9H2X3-7]
80625 [Q9H2X3-8]
80626 [Q9H2X3-9]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H2X3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H2X3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly highly expressed in liver sinusoidal endothelial cells and in lymph node. Found in placental endothelium but not in macrophages. Expressed in type II alveolar cells and lung endothelial cells.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000104938 Expressed in 93 organ(s), highest expression level in adrenal gland

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9H2X3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H2X3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB033689
CAB033691
HPA042661

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer.2 Publications
(Microbial infection) Interacts with ebola virus glycoprotein (PubMed:12050398, PubMed:12502850).2 Publications
(Microbial infection) Interacts with hepatitis C virus E1 and E2 protein (PubMed:15371595, PubMed:16816373).2 Publications
(Microbial infection) Interacts with HIV-1 gp120 (PubMed:21277928, PubMed:12502850).2 Publications
(Microbial infection) Interacts with human coronavirus 229E spike glycoprotein.1 Publication
(Microbial infection) Interacts with human cytomegalovirus/HHV-5 gB protein.1 Publication
(Microbial infection) Interacts with influenzavirus hemagglutinin.1 Publication
(Microbial infection) Interacts with SARS coronavirus spike glycoprotein.1 Publication
(Microbial infection) Interacts with west-nile virus envelope protein E.1 Publication
(Microbial infection) Interacts with Japanese encephalitis virus E protein.1 Publication
(Microbial infection) Interacts with Marburg virus glycoprotein.1 Publication
(Microbial infection) Interacts with M.bovis LprG.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115615, 7 interactors

Protein interaction database and analysis system

More...
IntActi
Q9H2X3, 4 interactors

Molecular INTeraction database

More...
MINTi
Q9H2X3

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000316228

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1399
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9H2X3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9H2X3

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9H2X3

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati108 – 1301Add BLAST23
Repeati131 – 1532Add BLAST23
Repeati154 – 1763Add BLAST23
Repeati177 – 1994Add BLAST23
Repeati200 – 2225Add BLAST23
Repeati223 – 2456Add BLAST23
Repeati246 – 2687Add BLAST23
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini274 – 390C-type lectinPROSITE-ProRule annotationAdd BLAST117

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni108 – 2697 X approximate tandem repeatsAdd BLAST162

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi14 – 15Endocytosis signalBy similarity2

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The tandem repeat domain, also called neck domain, mediates oligomerization.

Keywords - Domaini

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4297 Eukaryota
ENOG410XPJ1 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000167383

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG050992

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H2X3

KEGG Orthology (KO)

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KOi
K06563

Identification of Orthologs from Complete Genome Data

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OMAi
RQEKIYQ

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0G9W

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H2X3

TreeFam database of animal gene trees

More...
TreeFami
TF333341

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03590 CLECT_DC-SIGN_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.100.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR033989 CD209-like_CTLD
IPR016187 CTDL_fold

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00059 Lectin_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00034 CLECT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56436 SSF56436, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (10+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 10 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist. Several splicing events may occur independently in a modular way. Deletion of the transmembrane domain encoding exon through alternative splicing produces soluble isoforms.

This entry has 10 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H2X3-1) [UniParc]FASTAAdd to basket
Also known as: mDC-SIGN2 type I

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSDSKEPRVQ QLGLLEEDPT TSGIRLFPRD FQFQQIHGHK SSTGCLGHGA
60 70 80 90 100
LVLQLLSFML LAGVLVAILV QVSKVPSSLS QEQSEQDAIY QNLTQLKAAV
110 120 130 140 150
GELSEKSKLQ EIYQELTQLK AAVGELPEKS KLQEIYQELT RLKAAVGELP
160 170 180 190 200
EKSKLQEIYQ ELTRLKAAVG ELPEKSKLQE IYQELTRLKA AVGELPEKSK
210 220 230 240 250
LQEIYQELTE LKAAVGELPE KSKLQEIYQE LTQLKAAVGE LPDQSKQQQI
260 270 280 290 300
YQELTDLKTA FERLCRHCPK DWTFFQGNCY FMSNSQRNWH DSVTACQEVR
310 320 330 340 350
AQLVVIKTAE EQNFLQLQTS RSNRFSWMGL SDLNQEGTWQ WVDGSPLSPS
360 370 380 390
FQRYWNSGEP NNSGNEDCAE FSGSGWNDNR CDVDNYWICK KPAACFRDE
Length:399
Mass (Da):45,350
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0FADC99F72AEA593
GO
Isoform 2 (identifier: Q9H2X3-2) [UniParc]FASTAAdd to basket
Also known as: mDC-SIGN2 type III, mDC-SIGN2 type IV

The sequence of this isoform differs from the canonical sequence as follows:
     262-272: ERLCRHCPKDW → GEFLHIKGPWA
     273-399: Missing.

Note: May be due to intron retention.
Show »
Length:272
Mass (Da):30,481
Checksum:iB26BE2F2DE541F5E
GO
Isoform 3 (identifier: Q9H2X3-3) [UniParc]FASTAAdd to basket
Also known as: mDC-SIGN2 type V

The sequence of this isoform differs from the canonical sequence as follows:
     313-324: NFLQLQTSRSNR → LPAVLEQWRTQQ
     325-399: Missing.

Show »
Length:324
Mass (Da):36,769
Checksum:iB22BD6E0C926649A
GO
Isoform 4 (identifier: Q9H2X3-4) [UniParc]FASTAAdd to basket
Also known as: mDC-SIGN2 type VI

The sequence of this isoform differs from the canonical sequence as follows:
     170-238: Missing.
     239-261: Missing.
     313-324: NFLQLQTSRSNR → LPAVLEQWRTQQ
     325-399: Missing.

Show »
Length:232
Mass (Da):26,283
Checksum:iB50EB1500097CB70
GO
Isoform 5 (identifier: Q9H2X3-5) [UniParc]FASTAAdd to basket
Also known as: sDC-SIGN2 type I

The sequence of this isoform differs from the canonical sequence as follows:
     44-71: GCLGHGALVLQLLSFMLLAGVLVAILVQ → VPFLLGP
     177-199: Missing.
     239-261: Missing.

Show »
Length:332
Mass (Da):37,954
Checksum:iC6FDEF92C1B073C6
GO
Isoform 6 (identifier: Q9H2X3-6) [UniParc]FASTAAdd to basket
Also known as: sDC-SIGN2 type II

The sequence of this isoform differs from the canonical sequence as follows:
     44-71: GCLGHGALVLQLLSFMLLAGVLVAILVQ → VPFLLGP
     262-272: ERLCRHCPKDW → GEFLHIKGPWA
     273-399: Missing.

Note: May be due to intron retention.
Show »
Length:251
Mass (Da):28,373
Checksum:i86F69F6CD6055D6E
GO
Isoform 7 (identifier: Q9H2X3-7) [UniParc]FASTAAdd to basket
Also known as: sDC-SIGN2 type III

The sequence of this isoform differs from the canonical sequence as follows:
     44-71: GCLGHGALVLQLLSFMLLAGVLVAILVQ → VPFLLGP
     147-261: Missing.

Show »
Length:263
Mass (Da):30,131
Checksum:i2BB0AAF2C506495E
GO
Isoform 8 (identifier: Q9H2X3-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     177-199: Missing.

Note: Non-canonical intron-exon splice junction.
Show »
Length:376
Mass (Da):42,724
Checksum:i36CB19991F23BE90
GO
Isoform 9 (identifier: Q9H2X3-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-43: Missing.
     313-324: NFLQLQTSRSNR → LPAVLEQWRTQQ
     325-399: Missing.

Show »
Length:296
Mass (Da):33,528
Checksum:i70228F848F2DE64F
GO
Isoform 10 (identifier: Q9H2X3-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-43: Missing.
     44-71: Missing.
     262-272: ERLCRHCPKDW → GEFLHIKGPWA
     273-399: Missing.

Note: May be due to intron retention.
Show »
Length:216
Mass (Da):24,408
Checksum:i45F01AD20E279619
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BXU4H7BXU4_HUMAN
C-type lectin domain family 4 membe...
CLEC4M
348Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QYX2M0QYX2_HUMAN
C-type lectin domain family 4 membe...
CLEC4M
332Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ENS9E7ENS9_HUMAN
C-type lectin domain family 4 membe...
CLEC4M
387Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZ42M0QZ42_HUMAN
C-type lectin domain family 4 membe...
CLEC4M
282Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAR04559 differs from that shown. Aberrant splicing.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti99A → T in BAB14667 (Ref. 5) Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

The number of repeats in the tandem repeat domain is shown to vary between 3 and 9 per allele thus contributing to a further variability in addition to alternative splicing. The shown 7 repeat-containing form has been shown to be the most frequent one (53.9%) in a study with 350 Caucasian individuals.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_050107164R → Q1 PublicationCorresponds to variant dbSNP:rs11465376Ensembl.1
Natural variantiVAR_050108205Y → C. Corresponds to variant dbSNP:rs479448Ensembl.1
Natural variantiVAR_050109251Y → C. Corresponds to variant dbSNP:rs479448Ensembl.1
Natural variantiVAR_021957291D → N1 PublicationCorresponds to variant dbSNP:rs2277998Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01005616 – 43Missing in isoform 9 and isoform 10. 2 PublicationsAdd BLAST28
Alternative sequenceiVSP_01005744 – 71Missing in isoform 10. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_01005844 – 71GCLGH…AILVQ → VPFLLGP in isoform 5, isoform 6 and isoform 7. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_010059147 – 261Missing in isoform 7. 1 PublicationAdd BLAST115
Alternative sequenceiVSP_010060170 – 238Missing in isoform 4. 1 PublicationAdd BLAST69
Alternative sequenceiVSP_010061177 – 199Missing in isoform 5 and isoform 8. 3 PublicationsAdd BLAST23
Alternative sequenceiVSP_010062239 – 261Missing in isoform 4 and isoform 5. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_010063262 – 272ERLCRHCPKDW → GEFLHIKGPWA in isoform 2, isoform 6 and isoform 10. 2 PublicationsAdd BLAST11
Alternative sequenceiVSP_010064273 – 399Missing in isoform 2, isoform 6 and isoform 10. 2 PublicationsAdd BLAST127
Alternative sequenceiVSP_010065313 – 324NFLQL…SRSNR → LPAVLEQWRTQQ in isoform 3, isoform 4 and isoform 9. 2 PublicationsAdd BLAST12
Alternative sequenceiVSP_010066325 – 399Missing in isoform 3, isoform 4 and isoform 9. 2 PublicationsAdd BLAST75

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB015629 mRNA Translation: BAA76496.1
AF245219 mRNA Translation: AAG13848.2
AF209481, AF209480 Genomic DNA Translation: AAG13815.2
AY042234 mRNA Translation: AAK91859.1
AY042235 mRNA Translation: AAK91860.1
AY042236 mRNA Translation: AAK91861.1
AY042237 mRNA Translation: AAK91862.1
AY042238 mRNA Translation: AAK91863.1
AY042239 mRNA Translation: AAK91864.1
AY042240 mRNA Translation: AAK91865.1
AF290887 mRNA Translation: AAK20998.1
AY343913 mRNA Translation: AAR04559.1 Sequence problems.
AK023750 mRNA Translation: BAB14667.1
AK292278 mRNA Translation: BAF84967.1
AC008812 Genomic DNA No translation available.
BC038851 mRNA Translation: AAH38851.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12187.1 [Q9H2X3-1]
CCDS59346.1 [Q9H2X3-4]
CCDS59347.1 [Q9H2X3-7]
CCDS59348.1 [Q9H2X3-9]

NCBI Reference Sequences

More...
RefSeqi
NP_001138377.1, NM_001144905.1
NP_001138378.1, NM_001144906.1 [Q9H2X3-7]
NP_001138379.1, NM_001144907.1 [Q9H2X3-5]
NP_001138380.1, NM_001144908.1 [Q9H2X3-4]
NP_001138381.1, NM_001144909.1
NP_001138382.1, NM_001144910.1 [Q9H2X3-8]
NP_001138383.1, NM_001144911.1 [Q9H2X3-9]
NP_055072.3, NM_014257.4 [Q9H2X3-1]
XP_006722678.1, XM_006722615.2 [Q9H2X3-3]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.421437

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000248228; ENSP00000248228; ENSG00000104938 [Q9H2X3-8]
ENST00000327325; ENSP00000316228; ENSG00000104938 [Q9H2X3-1]
ENST00000359059; ENSP00000351954; ENSG00000104938 [Q9H2X3-5]
ENST00000595496; ENSP00000470132; ENSG00000104938 [Q9H2X3-7]
ENST00000596363; ENSP00000471125; ENSG00000104938 [Q9H2X3-9]
ENST00000597522; ENSP00000471132; ENSG00000104938 [Q9H2X3-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
10332

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10332

UCSC genome browser

More...
UCSCi
uc002mhz.4 human [Q9H2X3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Functional Glycomics Gateway - Glycan Binding

DC-SIGNR

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015629 mRNA Translation: BAA76496.1
AF245219 mRNA Translation: AAG13848.2
AF209481, AF209480 Genomic DNA Translation: AAG13815.2
AY042234 mRNA Translation: AAK91859.1
AY042235 mRNA Translation: AAK91860.1
AY042236 mRNA Translation: AAK91861.1
AY042237 mRNA Translation: AAK91862.1
AY042238 mRNA Translation: AAK91863.1
AY042239 mRNA Translation: AAK91864.1
AY042240 mRNA Translation: AAK91865.1
AF290887 mRNA Translation: AAK20998.1
AY343913 mRNA Translation: AAR04559.1 Sequence problems.
AK023750 mRNA Translation: BAB14667.1
AK292278 mRNA Translation: BAF84967.1
AC008812 Genomic DNA No translation available.
BC038851 mRNA Translation: AAH38851.1
CCDSiCCDS12187.1 [Q9H2X3-1]
CCDS59346.1 [Q9H2X3-4]
CCDS59347.1 [Q9H2X3-7]
CCDS59348.1 [Q9H2X3-9]
RefSeqiNP_001138377.1, NM_001144905.1
NP_001138378.1, NM_001144906.1 [Q9H2X3-7]
NP_001138379.1, NM_001144907.1 [Q9H2X3-5]
NP_001138380.1, NM_001144908.1 [Q9H2X3-4]
NP_001138381.1, NM_001144909.1
NP_001138382.1, NM_001144910.1 [Q9H2X3-8]
NP_001138383.1, NM_001144911.1 [Q9H2X3-9]
NP_055072.3, NM_014257.4 [Q9H2X3-1]
XP_006722678.1, XM_006722615.2 [Q9H2X3-3]
UniGeneiHs.421437

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K9JX-ray1.90A/B262-399[»]
1SL6X-ray2.25A/B/C/D/E/F216-399[»]
1XARX-ray2.25A/B216-399[»]
1XPHX-ray1.41A250-399[»]
1Z0Ymodel-A/B/C/D85-399[»]
3JQHX-ray2.20A101-264[»]
ProteinModelPortaliQ9H2X3
SMRiQ9H2X3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115615, 7 interactors
IntActiQ9H2X3, 4 interactors
MINTiQ9H2X3
STRINGi9606.ENSP00000316228

Chemistry databases

ChEMBLiCHEMBL2176858

Protein family/group databases

UniLectiniQ9H2X3

PTM databases

iPTMnetiQ9H2X3
PhosphoSitePlusiQ9H2X3

Polymorphism and mutation databases

BioMutaiCLEC4M
DMDMi46395990

Proteomic databases

PaxDbiQ9H2X3
PeptideAtlasiQ9H2X3
PRIDEiQ9H2X3
ProteomicsDBi80616
80617 [Q9H2X3-10]
80619 [Q9H2X3-2]
80620 [Q9H2X3-3]
80621 [Q9H2X3-4]
80622 [Q9H2X3-5]
80623 [Q9H2X3-6]
80624 [Q9H2X3-7]
80625 [Q9H2X3-8]
80626 [Q9H2X3-9]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10332
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000248228; ENSP00000248228; ENSG00000104938 [Q9H2X3-8]
ENST00000327325; ENSP00000316228; ENSG00000104938 [Q9H2X3-1]
ENST00000359059; ENSP00000351954; ENSG00000104938 [Q9H2X3-5]
ENST00000595496; ENSP00000470132; ENSG00000104938 [Q9H2X3-7]
ENST00000596363; ENSP00000471125; ENSG00000104938 [Q9H2X3-9]
ENST00000597522; ENSP00000471132; ENSG00000104938 [Q9H2X3-4]
GeneIDi10332
KEGGihsa:10332
UCSCiuc002mhz.4 human [Q9H2X3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10332
DisGeNETi10332
EuPathDBiHostDB:ENSG00000104938.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CLEC4M
HGNCiHGNC:13523 CLEC4M
HPAiCAB033689
CAB033691
HPA042661
MIMi605872 gene
neXtProtiNX_Q9H2X3
OpenTargetsiENSG00000104938
PharmGKBiPA26200

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00940000167383
HOVERGENiHBG050992
InParanoidiQ9H2X3
KOiK06563
OMAiRQEKIYQ
OrthoDBiEOG091G0G9W
PhylomeDBiQ9H2X3
TreeFamiTF333341

Miscellaneous databases

EvolutionaryTraceiQ9H2X3

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CLEC4M

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10332

Protein Ontology

More...
PROi
PR:Q9H2X3

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000104938 Expressed in 93 organ(s), highest expression level in adrenal gland
ExpressionAtlasiQ9H2X3 baseline and differential
GenevisibleiQ9H2X3 HS

Family and domain databases

CDDicd03590 CLECT_DC-SIGN_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR033989 CD209-like_CTLD
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCLC4M_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H2X3
Secondary accession number(s): A6NKI4
, A8K8B3, Q69F40, Q969M4, Q96QP3, Q96QP4, Q96QP5, Q96QP6, Q9BXS3, Q9H2Q9, Q9H8F0, Q9Y2A8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2001
Last modified: December 5, 2018
This is version 174 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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