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Protein

Chordin

Gene

CHRD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cytokine binding Source: BHF-UCL
  • heparin binding Source: Ensembl
  • syndecan binding Source: Ensembl

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chordin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CHRD
ORF Names:UNQ217/PRO243
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000090539.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1949 CHRD

Online Mendelian Inheritance in Man (OMIM)

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MIMi
603475 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H2X0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
8646

Open Targets

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OpenTargetsi
ENSG00000090539

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA26482

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
CHRD

Domain mapping of disease mutations (DMDM)

More...
DMDMi
118572631

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000536427 – 955ChordinAdd BLAST929

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi217N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi351N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi365N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi434N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Cleaved by tolloid proteases; cleavage participates in dorsoventral patterning during early development.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9H2X0

PeptideAtlas

More...
PeptideAtlasi
Q9H2X0

PRoteomics IDEntifications database

More...
PRIDEi
Q9H2X0

ProteomicsDB human proteome resource

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ProteomicsDBi
80611
80612 [Q9H2X0-2]
80613 [Q9H2X0-3]
80614 [Q9H2X0-4]
80615 [Q9H2X0-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H2X0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H2X0

Miscellaneous databases

CutDB - Proteolytic event database

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PMAP-CutDBi
Q9H2X0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at the highest level in liver.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000090539 Expressed in 144 organ(s), highest expression level in right hemisphere of cerebellum

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9H2X0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9H2X0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA035827

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TWSG1 and/or BMP4.By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
114198, 24 interactors

Database of interacting proteins

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DIPi
DIP-48857N

Protein interaction database and analysis system

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IntActi
Q9H2X0, 52 interactors

Molecular INTeraction database

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MINTi
Q9H2X0

STRING: functional protein association networks

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STRINGi
9606.ENSP00000204604

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9H2X0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9H2X0

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini49 – 126VWFC 1PROSITE-ProRule annotationAdd BLAST78
Domaini168 – 277CHRD 1PROSITE-ProRule annotationAdd BLAST110
Domaini279 – 402CHRD 2PROSITE-ProRule annotationAdd BLAST124
Domaini403 – 524CHRD 3PROSITE-ProRule annotationAdd BLAST122
Domaini530 – 650CHRD 4PROSITE-ProRule annotationAdd BLAST121
Domaini703 – 763VWFC 2PROSITE-ProRule annotationAdd BLAST61
Domaini784 – 850VWFC 3PROSITE-ProRule annotationAdd BLAST67
Domaini872 – 932VWFC 4PROSITE-ProRule annotationAdd BLAST61

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the chordin family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEDE Eukaryota
ENOG410XSBA LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000161767

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG005330

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9H2X0

KEGG Orthology (KO)

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KOi
K04657

Identification of Orthologs from Complete Genome Data

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OMAi
RRVPRDY

Database of Orthologous Groups

More...
OrthoDBi
EOG091G11A0

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H2X0

TreeFam database of animal gene trees

More...
TreeFami
TF106451

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR016353 Chordin
IPR010895 CHRD
IPR001007 VWF_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07452 CHRD, 2 hits
PF00093 VWC, 3 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002496 Chordin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00754 CHRD, 4 hits
SM00214 VWC, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50933 CHRD, 4 hits
PS01208 VWFC_1, 2 hits
PS50184 VWFC_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Experimental confirmation may be lacking for some isoforms.

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H2X0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPSLPAPPAP LLLLGLLLLG SRPARGAGPE PPVLPIRSEK EPLPVRGAAG
60 70 80 90 100
CTFGGKVYAL DETWHPDLGE PFGVMRCVLC ACEAPQWGRR TRGPGRVSCK
110 120 130 140 150
NIKPECPTPA CGQPRQLPGH CCQTCPQERS SSERQPSGLS FEYPRDPEHR
160 170 180 190 200
SYSDRGEPGA EERARGDGHT DFVALLTGPR SQAVARARVS LLRSSLRFSI
210 220 230 240 250
SYRRLDRPTR IRFSDSNGSV LFEHPAAPTQ DGLVCGVWRA VPRLSLRLLR
260 270 280 290 300
AEQLHVALVT LTHPSGEVWG PLIRHRALAA ETFSAILTLE GPPQQGVGGI
310 320 330 340 350
TLLTLSDTED SLHFLLLFRG LLEPRSGGLT QVPLRLQILH QGQLLRELQA
360 370 380 390 400
NVSAQEPGFA EVLPNLTVQE MDWLVLGELQ MALEWAGRPG LRISGHIAAR
410 420 430 440 450
KSCDVLQSVL CGADALIPVQ TGAAGSASLT LLGNGSLIYQ VQVVGTSSEV
460 470 480 490 500
VAMTLETKPQ RRDQRTVLCH MAGLQPGGHT AVGICPGLGA RGAHMLLQNE
510 520 530 540 550
LFLNVGTKDF PDGELRGHVA ALPYCGHSAR HDTLPVPLAG ALVLPPVKSQ
560 570 580 590 600
AAGHAWLSLD THCHLHYEVL LAGLGGSEQG TVTAHLLGPP GTPGPRRLLK
610 620 630 640 650
GFYGSEAQGV VKDLEPELLR HLAKGMASLM ITTKGSPRGE LRGQVHIANQ
660 670 680 690 700
CEVGGLRLEA AGAEGVRALG APDTASAAPP VVPGLPALAP AKPGGPGRPR
710 720 730 740 750
DPNTCFFEGQ QRPHGARWAP NYDPLCSLCT CQRRTVICDP VVCPPPSCPH
760 770 780 790 800
PVQAPDQCCP VCPEKQDVRD LPGLPRSRDP GEGCYFDGDR SWRAAGTRWH
810 820 830 840 850
PVVPPFGLIK CAVCTCKGGT GEVHCEKVQC PRLACAQPVR VNPTDCCKQC
860 870 880 890 900
PVGSGAHPQL GDPMQADGPR GCRFAGQWFP ESQSWHPSVP PFGEMSCITC
910 920 930 940 950
RCGAGVPHCE RDDCSLPLSC GSGKESRCCS RCTAHRRPAP ETRTDPELEK

EAEGS
Length:955
Mass (Da):102,032
Last modified:November 28, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i53F9D9F39A517686
GO
Isoform 2 (identifier: Q9H2X0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     85-86: PQ → GP
     87-955: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:86
Mass (Da):8,897
Checksum:i0679D7166DF9F994
GO
Isoform 3 (identifier: Q9H2X0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     85-94: PQWGRRTRGP → TGTLRPREMK
     95-955: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:94
Mass (Da):9,913
Checksum:i74479F0AE711A2C4
GO
Isoform 4 (identifier: Q9H2X0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     328-350: GLTQVPLRLQILHQGQLLRELQA → DSTPGAATARTSGQCLSPGTRLC
     351-955: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:350
Mass (Da):37,782
Checksum:iF18D4B0ED3EB6A98
GO
Isoform 5 (identifier: Q9H2X0-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     441-480: Missing.

Show »
Length:915
Mass (Da):97,731
Checksum:i506ADC62F09ED062
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7ESX1E7ESX1_HUMAN
Chordin
CHRD
954Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti70E → Q in AAQ89285 (PubMed:12975309).Curated1
Sequence conflicti115 – 118RQLP → QVAA in AAC69835 (PubMed:9782094).Curated4
Sequence conflicti189V → A in AAC69835 (PubMed:9782094).Curated1
Sequence conflicti216S → P in AAC69835 (PubMed:9782094).Curated1
Sequence conflicti674T → P in AAC69835 (PubMed:9782094).Curated1
Sequence conflicti939Missing in AAQ89285 (PubMed:12975309).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04872794P → S. Corresponds to variant dbSNP:rs34095724Ensembl.1
Natural variantiVAR_021517630M → L2 PublicationsCorresponds to variant dbSNP:rs16858780Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00107185 – 94PQWGRRTRGP → TGTLRPREMK in isoform 3. 1 Publication10
Alternative sequenceiVSP_00106985 – 86PQ → GP in isoform 2. 1 Publication2
Alternative sequenceiVSP_00107087 – 955Missing in isoform 2. 1 PublicationAdd BLAST869
Alternative sequenceiVSP_00107295 – 955Missing in isoform 3. 1 PublicationAdd BLAST861
Alternative sequenceiVSP_001073328 – 350GLTQV…RELQA → DSTPGAATARTSGQCLSPGT RLC in isoform 4. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_001074351 – 955Missing in isoform 4. 1 PublicationAdd BLAST605
Alternative sequenceiVSP_001075441 – 480Missing in isoform 5. 1 PublicationAdd BLAST40

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF209928 mRNA Translation: AAG35767.1
AF209929 mRNA Translation: AAG35768.1
AF209930 mRNA Translation: AAG35769.1
AF283325 mRNA Translation: AAG35784.1
AY358926 mRNA Translation: AAQ89285.1
BC112345 mRNA Translation: AAI12346.1
AF076612 mRNA Translation: AAC69835.1
AF136632 Genomic DNA Translation: AAF70236.1
AF136633 Genomic DNA Translation: AAF70237.1
AF136634 Genomic DNA Translation: AAF70238.1
AF136635 Genomic DNA Translation: AAF70239.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3266.1 [Q9H2X0-1]

NCBI Reference Sequences

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RefSeqi
NP_001291401.1, NM_001304472.1
NP_001291402.1, NM_001304473.1
NP_001291403.1, NM_001304474.1
NP_003732.2, NM_003741.3 [Q9H2X0-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.166186

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000204604; ENSP00000204604; ENSG00000090539 [Q9H2X0-1]
ENST00000348986; ENSP00000334036; ENSG00000090539 [Q9H2X0-5]
ENST00000356534; ENSP00000348930; ENSG00000090539 [Q9H2X0-2]
ENST00000420973; ENSP00000392794; ENSG00000090539 [Q9H2X0-4]
ENST00000448472; ENSP00000408624; ENSG00000090539 [Q9H2X0-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
8646

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:8646

UCSC genome browser

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UCSCi
uc003fov.3 human [Q9H2X0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF209928 mRNA Translation: AAG35767.1
AF209929 mRNA Translation: AAG35768.1
AF209930 mRNA Translation: AAG35769.1
AF283325 mRNA Translation: AAG35784.1
AY358926 mRNA Translation: AAQ89285.1
BC112345 mRNA Translation: AAI12346.1
AF076612 mRNA Translation: AAC69835.1
AF136632 Genomic DNA Translation: AAF70236.1
AF136633 Genomic DNA Translation: AAF70237.1
AF136634 Genomic DNA Translation: AAF70238.1
AF136635 Genomic DNA Translation: AAF70239.1
CCDSiCCDS3266.1 [Q9H2X0-1]
RefSeqiNP_001291401.1, NM_001304472.1
NP_001291402.1, NM_001304473.1
NP_001291403.1, NM_001304474.1
NP_003732.2, NM_003741.3 [Q9H2X0-1]
UniGeneiHs.166186

3D structure databases

ProteinModelPortaliQ9H2X0
SMRiQ9H2X0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114198, 24 interactors
DIPiDIP-48857N
IntActiQ9H2X0, 52 interactors
MINTiQ9H2X0
STRINGi9606.ENSP00000204604

PTM databases

iPTMnetiQ9H2X0
PhosphoSitePlusiQ9H2X0

Polymorphism and mutation databases

BioMutaiCHRD
DMDMi118572631

Proteomic databases

PaxDbiQ9H2X0
PeptideAtlasiQ9H2X0
PRIDEiQ9H2X0
ProteomicsDBi80611
80612 [Q9H2X0-2]
80613 [Q9H2X0-3]
80614 [Q9H2X0-4]
80615 [Q9H2X0-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000204604; ENSP00000204604; ENSG00000090539 [Q9H2X0-1]
ENST00000348986; ENSP00000334036; ENSG00000090539 [Q9H2X0-5]
ENST00000356534; ENSP00000348930; ENSG00000090539 [Q9H2X0-2]
ENST00000420973; ENSP00000392794; ENSG00000090539 [Q9H2X0-4]
ENST00000448472; ENSP00000408624; ENSG00000090539 [Q9H2X0-3]
GeneIDi8646
KEGGihsa:8646
UCSCiuc003fov.3 human [Q9H2X0-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
8646
DisGeNETi8646
EuPathDBiHostDB:ENSG00000090539.15

GeneCards: human genes, protein and diseases

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GeneCardsi
CHRD

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0003911
HGNCiHGNC:1949 CHRD
HPAiHPA035827
MIMi603475 gene
neXtProtiNX_Q9H2X0
OpenTargetsiENSG00000090539
PharmGKBiPA26482

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IEDE Eukaryota
ENOG410XSBA LUCA
GeneTreeiENSGT00940000161767
HOVERGENiHBG005330
InParanoidiQ9H2X0
KOiK04657
OMAiRRVPRDY
OrthoDBiEOG091G11A0
PhylomeDBiQ9H2X0
TreeFamiTF106451

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CHRD human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
8646
PMAP-CutDBiQ9H2X0

Protein Ontology

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PROi
PR:Q9H2X0

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000090539 Expressed in 144 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasiQ9H2X0 baseline and differential
GenevisibleiQ9H2X0 HS

Family and domain databases

InterProiView protein in InterPro
IPR016353 Chordin
IPR010895 CHRD
IPR001007 VWF_dom
PfamiView protein in Pfam
PF07452 CHRD, 2 hits
PF00093 VWC, 3 hits
PIRSFiPIRSF002496 Chordin, 1 hit
SMARTiView protein in SMART
SM00754 CHRD, 4 hits
SM00214 VWC, 4 hits
PROSITEiView protein in PROSITE
PS50933 CHRD, 4 hits
PS01208 VWFC_1, 2 hits
PS50184 VWFC_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCHRD_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H2X0
Secondary accession number(s): O95254
, Q2M1I8, Q6UW83, Q9H2D3, Q9H2W8, Q9H2W9, Q9P0Z2, Q9P0Z3, Q9P0Z4, Q9P0Z5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 28, 2006
Last modified: December 5, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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