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Entry version 140 (13 Feb 2019)
Sequence version 1 (01 Mar 2001)
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Protein

Protein spinster homolog 1

Gene

SPNS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sphingolipid transporter (By similarity). May be involved in necrotic or autophagic cell death.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processLipid transport, Transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.1.49.2 the major facilitator superfamily (mfs)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein spinster homolog 1
Alternative name(s):
HSpin1
Spinster-like protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPNS1
Synonyms:SPIN1
ORF Names:PP20300
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000169682.17

Human Gene Nomenclature Database

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HGNCi
HGNC:30621 SPNS1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
612583 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q9H2V7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei50 – 70HelicalSequence analysisAdd BLAST21
Transmembranei98 – 118HelicalSequence analysisAdd BLAST21
Transmembranei127 – 147HelicalSequence analysisAdd BLAST21
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Transmembranei187 – 207HelicalSequence analysisAdd BLAST21
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
Transmembranei278 – 298HelicalSequence analysisAdd BLAST21
Transmembranei323 – 343HelicalSequence analysisAdd BLAST21
Transmembranei357 – 377HelicalSequence analysisAdd BLAST21
Transmembranei381 – 401HelicalSequence analysisAdd BLAST21
Transmembranei421 – 441HelicalSequence analysisAdd BLAST21
Transmembranei465 – 485HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
83985

Open Targets

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OpenTargetsi
ENSG00000169682

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162404561

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SPNS1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74733566

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003050392 – 528Protein spinster homolog 1Add BLAST527

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei518PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9H2V7

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9H2V7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H2V7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H2V7

PeptideAtlas

More...
PeptideAtlasi
Q9H2V7

PRoteomics IDEntifications database

More...
PRIDEi
Q9H2V7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
80600
80601 [Q9H2V7-2]
80602 [Q9H2V7-3]
80603 [Q9H2V7-4]
80604 [Q9H2V7-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H2V7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H2V7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000169682 Expressed in 91 organ(s), highest expression level in left adrenal gland

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9H2V7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9H2V7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA041995
HPA042988

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with BCL2 and BCL2L1.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
BCL2L1Q078173EBI-1386527,EBI-78035

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
123836, 9 interactors

Protein interaction database and analysis system

More...
IntActi
Q9H2V7, 26 interactors

Molecular INTeraction database

More...
MINTi
Q9H2V7

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000309945

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9H2V7

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1330 Eukaryota
COG0477 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000005976

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG055503

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9H2V7

Database of Orthologous Groups

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OrthoDBi
891881at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9H2V7

TreeFam database of animal gene trees

More...
TreeFami
TF314395

Family and domain databases

Conserved Domains Database

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CDDi
cd06174 MFS, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf

Pfam protein domain database

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Pfami
View protein in Pfam
PF07690 MFS_1, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF103473 SSF103473, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50850 MFS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H2V7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGSDTAPFL SQADDPDDGP VPGTPGLPGS TGNPKSEEPE VPDQEGLQRI
60 70 80 90 100
TGLSPGRSAL IVAVLCYINL LNYMDRFTVA GVLPDIEQFF NIGDSSSGLI
110 120 130 140 150
QTVFISSYMV LAPVFGYLGD RYNRKYLMCG GIAFWSLVTL GSSFIPGEHF
160 170 180 190 200
WLLLLTRGLV GVGEASYSTI APTLIADLFV ADQRSRMLSI FYFAIPVGSG
210 220 230 240 250
LGYIAGSKVK DMAGDWHWAL RVTPGLGVVA VLLLFLVVRE PPRGAVERHS
260 270 280 290 300
DLPPLNPTSW WADLRALARN PSFVLSSLGF TAVAFVTGSL ALWAPAFLLR
310 320 330 340 350
SRVVLGETPP CLPGDSCSSS DSLIFGLITC LTGVLGVGLG VEISRRLRHS
360 370 380 390 400
NPRADPLVCA TGLLGSAPFL FLSLACARGS IVATYIFIFI GETLLSMNWA
410 420 430 440 450
IVADILLYVV IPTRRSTAEA FQIVLSHLLG DAGSPYLIGL ISDRLRRNWP
460 470 480 490 500
PSFLSEFRAL QFSLMLCAFV GALGGAAFLG TAIFIEADRR RAQLHVQGLL
510 520
HEAGSTDDRI VVPQRGRSTR VPVASVLI
Length:528
Mass (Da):56,630
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF1B9D2EB3F9F1B48
GO
Isoform 2 (identifier: Q9H2V7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     271-322: Missing.

Show »
Length:476
Mass (Da):51,333
Checksum:i99272BB60BA81889
GO
Isoform 3 (identifier: Q9H2V7-3) [UniParc]FASTAAdd to basket
Also known as: CRA_d

The sequence of this isoform differs from the canonical sequence as follows:
     81-102: Missing.
     271-322: Missing.

Show »
Length:454
Mass (Da):49,013
Checksum:i4A393F34239B87CF
GO
Isoform 4 (identifier: Q9H2V7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: Missing.

Note: No experimental confirmation available.
Show »
Length:455
Mass (Da):49,139
Checksum:i63B25A8A61A99C30
GO
Isoform 5 (identifier: Q9H2V7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     223-528: TPGLGVVAVL...TRVPVASVLI → SLVLAWG

Note: No experimental confirmation available.
Show »
Length:229
Mass (Da):24,594
Checksum:i07FF7E3B57DF8B8A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BMF4H3BMF4_HUMAN
Protein spinster homolog 1
SPNS1 SPIN1, hCG_2002366
573Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BR82H3BR82_HUMAN
Protein spinster homolog 1
SPNS1
538Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BT44H3BT44_HUMAN
Protein spinster homolog 1
SPNS1
178Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BPQ9H3BPQ9_HUMAN
Protein spinster homolog 1
SPNS1
274Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BP14H3BP14_HUMAN
Protein spinster homolog 1
SPNS1
142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BPT8H3BPT8_HUMAN
Protein spinster homolog 1
SPNS1
179Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAQ15259 differs from that shown. Reason: Frameshift at position 97.Curated
The sequence AAQ15259 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_035157230A → P1 PublicationCorresponds to variant dbSNP:rs17855956Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0281941 – 73Missing in isoform 4. 1 PublicationAdd BLAST73
Alternative sequenceiVSP_02819581 – 102Missing in isoform 3. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_036389223 – 528TPGLG…ASVLI → SLVLAWG in isoform 5. 1 PublicationAdd BLAST306
Alternative sequenceiVSP_028196271 – 322Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST52

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF212371 mRNA Translation: AAG43830.1
AK095677 mRNA Translation: BAC04603.1
AK289787 mRNA Translation: BAF82476.1
AF370423 mRNA Translation: AAQ15259.1 Sequence problems.
AL390215 mRNA Translation: CAB99229.1
AC109460 Genomic DNA No translation available.
CH471267 Genomic DNA Translation: EAW52018.1
CH471267 Genomic DNA Translation: EAW52019.1
BC006156 mRNA Translation: AAH06156.1
BC008325 mRNA Translation: AAH08325.1
BC038961 mRNA Translation: AAH38961.1
BC047741 mRNA Translation: AAH47741.1
BC065235 mRNA Translation: AAH65235.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10646.1 [Q9H2V7-1]
CCDS45452.1 [Q9H2V7-2]
CCDS45453.1 [Q9H2V7-3]
CCDS45454.1 [Q9H2V7-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001135920.1, NM_001142448.1 [Q9H2V7-1]
NP_001135921.1, NM_001142449.1 [Q9H2V7-3]
NP_001135922.1, NM_001142450.1 [Q9H2V7-4]
NP_001135923.1, NM_001142451.1 [Q9H2V7-2]
NP_114427.1, NM_032038.2 [Q9H2V7-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.617449

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000311008; ENSP00000309945; ENSG00000169682 [Q9H2V7-1]
ENST00000323081; ENSP00000318228; ENSG00000169682 [Q9H2V7-4]
ENST00000334536; ENSP00000335494; ENSG00000169682 [Q9H2V7-2]
ENST00000352260; ENSP00000306050; ENSG00000169682 [Q9H2V7-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
83985

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:83985

UCSC genome browser

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UCSCi
uc002drx.3 human [Q9H2V7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF212371 mRNA Translation: AAG43830.1
AK095677 mRNA Translation: BAC04603.1
AK289787 mRNA Translation: BAF82476.1
AF370423 mRNA Translation: AAQ15259.1 Sequence problems.
AL390215 mRNA Translation: CAB99229.1
AC109460 Genomic DNA No translation available.
CH471267 Genomic DNA Translation: EAW52018.1
CH471267 Genomic DNA Translation: EAW52019.1
BC006156 mRNA Translation: AAH06156.1
BC008325 mRNA Translation: AAH08325.1
BC038961 mRNA Translation: AAH38961.1
BC047741 mRNA Translation: AAH47741.1
BC065235 mRNA Translation: AAH65235.1
CCDSiCCDS10646.1 [Q9H2V7-1]
CCDS45452.1 [Q9H2V7-2]
CCDS45453.1 [Q9H2V7-3]
CCDS45454.1 [Q9H2V7-4]
RefSeqiNP_001135920.1, NM_001142448.1 [Q9H2V7-1]
NP_001135921.1, NM_001142449.1 [Q9H2V7-3]
NP_001135922.1, NM_001142450.1 [Q9H2V7-4]
NP_001135923.1, NM_001142451.1 [Q9H2V7-2]
NP_114427.1, NM_032038.2 [Q9H2V7-1]
UniGeneiHs.617449

3D structure databases

ProteinModelPortaliQ9H2V7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123836, 9 interactors
IntActiQ9H2V7, 26 interactors
MINTiQ9H2V7
STRINGi9606.ENSP00000309945

Protein family/group databases

TCDBi2.A.1.49.2 the major facilitator superfamily (mfs)

PTM databases

iPTMnetiQ9H2V7
PhosphoSitePlusiQ9H2V7

Polymorphism and mutation databases

BioMutaiSPNS1
DMDMi74733566

Proteomic databases

EPDiQ9H2V7
jPOSTiQ9H2V7
MaxQBiQ9H2V7
PaxDbiQ9H2V7
PeptideAtlasiQ9H2V7
PRIDEiQ9H2V7
ProteomicsDBi80600
80601 [Q9H2V7-2]
80602 [Q9H2V7-3]
80603 [Q9H2V7-4]
80604 [Q9H2V7-5]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
83985
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311008; ENSP00000309945; ENSG00000169682 [Q9H2V7-1]
ENST00000323081; ENSP00000318228; ENSG00000169682 [Q9H2V7-4]
ENST00000334536; ENSP00000335494; ENSG00000169682 [Q9H2V7-2]
ENST00000352260; ENSP00000306050; ENSG00000169682 [Q9H2V7-3]
GeneIDi83985
KEGGihsa:83985
UCSCiuc002drx.3 human [Q9H2V7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
83985
DisGeNETi83985
EuPathDBiHostDB:ENSG00000169682.17

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SPNS1
HGNCiHGNC:30621 SPNS1
HPAiHPA041995
HPA042988
MIMi612583 gene
neXtProtiNX_Q9H2V7
OpenTargetsiENSG00000169682
PharmGKBiPA162404561

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1330 Eukaryota
COG0477 LUCA
GeneTreeiENSGT00390000005976
HOVERGENiHBG055503
InParanoidiQ9H2V7
OrthoDBi891881at2759
PhylomeDBiQ9H2V7
TreeFamiTF314395

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SPNS1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
83985

Protein Ontology

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PROi
PR:Q9H2V7

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000169682 Expressed in 91 organ(s), highest expression level in left adrenal gland
ExpressionAtlasiQ9H2V7 baseline and differential
GenevisibleiQ9H2V7 HS

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPNS1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H2V7
Secondary accession number(s): B5MDM9
, Q6P182, Q71RB5, Q7L541, Q86VU7, Q8N953, Q8TCS5, Q9BRN5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: March 1, 2001
Last modified: February 13, 2019
This is version 140 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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