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UniProtKB - Q9H2S5 (RNF39_HUMAN)

Entry version 156 (02 Dec 2020)
Sequence version 2 (21 Jun 2005)
Previous versions | rss
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Protein

RING finger protein 39

Gene

RNF39

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in prolonged long term-potentiation (LTP) maintenance.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri88 – 135RING-typePROSITE-ProRule annotationAdd BLAST48

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9H2S5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RING finger protein 39
Alternative name(s):
Protein HZFw
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RNF39
Synonyms:HZFW
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000204618.8

Human Gene Nomenclature Database

More...HGNCi		HGNC:18064, RNF39

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607524, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9H2S5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		80352

Open Targets

More...OpenTargetsi		ENSG00000204618

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134949953

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9H2S5, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RNF39

Domain mapping of disease mutations (DMDM)

More...DMDMi		68053317

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000560801 – 420RING finger protein 39Add BLAST420

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9H2S5

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9H2S5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9H2S5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9H2S5

PeptideAtlas

More...PeptideAtlasi		Q9H2S5

PRoteomics IDEntifications database

More...PRIDEi		Q9H2S5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		80584 [Q9H2S5-1]
80585 [Q9H2S5-2]
80586 [Q9H2S5-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9H2S5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9H2S5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000204618, Expressed in ectocervix and 147 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9H2S5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9H2S5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000204618, Tissue enhanced (esophagus, skin)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		123258, 8 interactors

Protein interaction database and analysis system

More...IntActi		Q9H2S5, 7 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000244360

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9H2S5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9H2S5

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini210 – 420B30.2/SPRYPROSITE-ProRule annotationAdd BLAST211

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri88 – 135RING-typePROSITE-ProRule annotationAdd BLAST48

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2177, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162641

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_013137_7_5_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9H2S5

Identification of Orthologs from Complete Genome Data

More...OMAi		GESCYAV

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9H2S5

TreeFam database of animal gene trees

More...TreeFami		TF317532

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.120.920, 1 hit
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001870, B30.2/SPRY
IPR043136, B30.2/SPRY_sf
IPR003879, Butyrophylin_SPRY
IPR013320, ConA-like_dom_sf
IPR006574, PRY
IPR003877, SPRY_dom
IPR018957, Znf_C3HC4_RING-type
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
IPR017907, Znf_RING_CS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13765, PRY, 1 hit
PF00097, zf-C3HC4, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01407, BUTYPHLNCDUF

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00589, PRY, 1 hit
SM00184, RING, 1 hit
SM00449, SPRY, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49899, SSF49899, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50188, B302_SPRY, 1 hit
PS00518, ZF_RING_1, 1 hit
PS50089, ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H2S5-1) [UniParc]FASTAAdd to basket
Also known as: HZFW1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWWRDLTRLR LWLKREAIPG EGRKAAKVNA GVGEKGIYTA SSRGGPPSAR 
        60         70         80         90        100
SKAVTVVAEG AASRSWLSMD APELGPGLVE RLEQLATCPL CGGSFEDPVL 
       110        120        130        140        150
LACEHSFCRA CLARRWGTPP ATGTEASPTA CPCCGLPCPR RSLRSNVRLA 
       160        170        180        190        200
VEVRISRELR EKLAEPGARA GRRRGGRIPT MGCLDLPGED MRKTWRRFEV 
       210        220        230        240        250
PTSKSSNSED DLPEDYPVVK KMLHRLTADL TLDPGTAHRR LLISADRRSV 
       260        270        280        290        300
QLAPPGTPAP PDGPKRFDQL PAVLGAQGFG AGRHCWEVET ADAASCRDSS 
       310        320        330        340        350
GEDADDEESH YAVGAAGESV QRKGCVRLCP AGAVWAVEGR GGRLWALTAP 
       360        370        380        390        400
EPTLLGGVEP PPRRIRVDLD WERGRVAFYD GRSLDLLYAF QAPGPLGERI 
       410        420
FPLFCTCDPR APLRIVPAES
Length:420
Mass (Da):45,525
Last modified:June 21, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCE9C7869D93016EC
GO
Isoform 2 (identifier: Q9H2S5-2) [UniParc]FASTAAdd to basket
Also known as: HZFW2

The sequence of this isoform differs from the canonical sequence as follows:
     326-391: Missing.

Show »
Length:354
Mass (Da):38,179
Checksum:i26F8CA120301D406
GO
Isoform 3 (identifier: Q9H2S5-3) [UniParc]FASTAAdd to basket
Also known as: HZFW3

The sequence of this isoform differs from the canonical sequence as follows:
     160-251: REKLAEPGAR...LISADRRSVQ → LFGGGIPHSF...NRPSPSVLVK
     252-420: Missing.

Show »
Length:251
Mass (Da):27,081
Checksum:i81BFF50746712554
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A140T8Y9A0A140T8Y9_HUMAN
RING finger protein 39
RNF39
420Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T901A0A140T901_HUMAN
RING finger protein 39
RNF39
420Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG40630 differs from that shown. Reason: Frameshift.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_022723203S → P1 PublicationCorresponds to variant dbSNP:rs2074479Ensembl.1
Natural variantiVAR_022724245A → T1 PublicationCorresponds to variant dbSNP:rs2301752Ensembl.1
Natural variantiVAR_022725268D → N2 PublicationsCorresponds to variant dbSNP:rs1057539Ensembl.1
Natural variantiVAR_022726304A → E1 PublicationCorresponds to variant dbSNP:rs2301753Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_014240160 – 251REKLA…RRSVQ → LFGGGIPHSFLGTHSHAHCR SINSNPHFRPKIMRPHLVST FPRPCSKPNPFLPSGSQNLL SPTATTVLPDFSHSNHSRPA MGNRPSPSVLVK in isoform 3. 1 PublicationAdd BLAST92
Alternative sequenceiVSP_014241252 – 420Missing in isoform 3. 1 PublicationAdd BLAST169
Alternative sequenceiVSP_014242326 – 391Missing in isoform 2. 1 PublicationAdd BLAST66

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF238315 mRNA Translation: AAG40628.1
AF238316 mRNA Translation: AAG40629.1
AF238317 mRNA Translation: AAG40630.1 Frameshift.
AL669914 Genomic DNA No translation available.
AL671859 Genomic DNA No translation available.
AL845439 Genomic DNA No translation available.
BX088647 Genomic DNA No translation available.
BX927229 Genomic DNA No translation available.
CR388205 Genomic DNA No translation available.
CR759763 Genomic DNA No translation available.
CR759960 Genomic DNA No translation available.
CR933538 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03256.1

NCBI Reference Sequences

More...RefSeqi		NP_079512.2, NM_025236.3 [Q9H2S5-1]
NP_739575.2, NM_170769.2 [Q9H2S5-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000244360; ENSP00000244360; ENSG00000204618 [Q9H2S5-1]
ENST00000376750; ENSP00000365941; ENSG00000206500
ENST00000376751; ENSP00000365942; ENSG00000204618 [Q9H2S5-2]
ENST00000417541; ENSP00000407248; ENSG00000237733
ENST00000425956; ENSP00000393560; ENSG00000227171 [Q9H2S5-1]
ENST00000432647; ENSP00000398512; ENSG00000230332 [Q9H2S5-1]
ENST00000441449; ENSP00000392508; ENSG00000236967 [Q9H2S5-2]
ENST00000442063; ENSP00000415281; ENSG00000235022 [Q9H2S5-2]
ENST00000442378; ENSP00000401131; ENSG00000227171 [Q9H2S5-2]
ENST00000449145; ENSP00000408539; ENSG00000237733
ENST00000450015; ENSP00000407291; ENSG00000236967 [Q9H2S5-1]
ENST00000451425; ENSP00000391822; ENSG00000230332 [Q9H2S5-2]
ENST00000456156; ENSP00000395696; ENSG00000235022 [Q9H2S5-1]
ENST00000457092; ENSP00000405340; ENSG00000230467 [Q9H2S5-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		80352

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:80352

UCSC genome browser

More...UCSCi		uc003npd.4, human [Q9H2S5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF238315 mRNA Translation: AAG40628.1
AF238316 mRNA Translation: AAG40629.1
AF238317 mRNA Translation: AAG40630.1 Frameshift.
AL669914 Genomic DNA No translation available.
AL671859 Genomic DNA No translation available.
AL845439 Genomic DNA No translation available.
BX088647 Genomic DNA No translation available.
BX927229 Genomic DNA No translation available.
CR388205 Genomic DNA No translation available.
CR759763 Genomic DNA No translation available.
CR759960 Genomic DNA No translation available.
CR933538 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03256.1
RefSeqiNP_079512.2, NM_025236.3 [Q9H2S5-1]
NP_739575.2, NM_170769.2 [Q9H2S5-2]

3D structure databases

SMRiQ9H2S5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi123258, 8 interactors
IntActiQ9H2S5, 7 interactors
STRINGi9606.ENSP00000244360

PTM databases

iPTMnetiQ9H2S5
PhosphoSitePlusiQ9H2S5

Polymorphism and mutation databases

BioMutaiRNF39
DMDMi68053317

Proteomic databases

EPDiQ9H2S5
jPOSTiQ9H2S5
MassIVEiQ9H2S5
PaxDbiQ9H2S5
PeptideAtlasiQ9H2S5
PRIDEiQ9H2S5
ProteomicsDBi80584 [Q9H2S5-1]
80585 [Q9H2S5-2]
80586 [Q9H2S5-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		44916, 237 antibodies

The DNASU plasmid repository

More...DNASUi		80352

Genome annotation databases

EnsembliENST00000244360; ENSP00000244360; ENSG00000204618 [Q9H2S5-1]
ENST00000376750; ENSP00000365941; ENSG00000206500
ENST00000376751; ENSP00000365942; ENSG00000204618 [Q9H2S5-2]
ENST00000417541; ENSP00000407248; ENSG00000237733
ENST00000425956; ENSP00000393560; ENSG00000227171 [Q9H2S5-1]
ENST00000432647; ENSP00000398512; ENSG00000230332 [Q9H2S5-1]
ENST00000441449; ENSP00000392508; ENSG00000236967 [Q9H2S5-2]
ENST00000442063; ENSP00000415281; ENSG00000235022 [Q9H2S5-2]
ENST00000442378; ENSP00000401131; ENSG00000227171 [Q9H2S5-2]
ENST00000449145; ENSP00000408539; ENSG00000237733
ENST00000450015; ENSP00000407291; ENSG00000236967 [Q9H2S5-1]
ENST00000451425; ENSP00000391822; ENSG00000230332 [Q9H2S5-2]
ENST00000456156; ENSP00000395696; ENSG00000235022 [Q9H2S5-1]
ENST00000457092; ENSP00000405340; ENSG00000230467 [Q9H2S5-2]
GeneIDi80352
KEGGihsa:80352
UCSCiuc003npd.4, human [Q9H2S5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		80352
DisGeNETi80352
EuPathDBiHostDB:ENSG00000204618.8

GeneCards: human genes, protein and diseases

More...GeneCardsi		RNF39
HGNCiHGNC:18064, RNF39
HPAiENSG00000204618, Tissue enhanced (esophagus, skin)
MIMi607524, gene
neXtProtiNX_Q9H2S5
OpenTargetsiENSG00000204618
PharmGKBiPA134949953

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2177, Eukaryota
GeneTreeiENSGT00940000162641
HOGENOMiCLU_013137_7_5_1
InParanoidiQ9H2S5
OMAiGESCYAV
PhylomeDBiQ9H2S5
TreeFamiTF317532

Enzyme and pathway databases

PathwayCommonsiQ9H2S5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		80352, 2 hits in 844 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RNF39, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		RNF39

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		80352
PharosiQ9H2S5, Tbio

Protein Ontology

More...PROi		PR:Q9H2S5
RNActiQ9H2S5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000204618, Expressed in ectocervix and 147 other tissues
ExpressionAtlasiQ9H2S5, baseline and differential
GenevisibleiQ9H2S5, HS

Family and domain databases

Gene3Di2.60.120.920, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001870, B30.2/SPRY
IPR043136, B30.2/SPRY_sf
IPR003879, Butyrophylin_SPRY
IPR013320, ConA-like_dom_sf
IPR006574, PRY
IPR003877, SPRY_dom
IPR018957, Znf_C3HC4_RING-type
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
IPR017907, Znf_RING_CS
PfamiView protein in Pfam
PF13765, PRY, 1 hit
PF00097, zf-C3HC4, 1 hit
PRINTSiPR01407, BUTYPHLNCDUF
SMARTiView protein in SMART
SM00589, PRY, 1 hit
SM00184, RING, 1 hit
SM00449, SPRY, 1 hit
SUPFAMiSSF49899, SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188, B302_SPRY, 1 hit
PS00518, ZF_RING_1, 1 hit
PS50089, ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRNF39_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H2S5
Secondary accession number(s): A2BEK3
, A6NCD6, B0S858, Q5SPM8, Q5SPM9, Q5SPN0, Q5SRJ9, Q5SRK1, Q5SS29, Q9H2S3, Q9H2S4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 21, 2005
Last modified: December 2, 2020
This is version 156 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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