UniProtKB - Q9H2S5 (RNF39_HUMAN)
Protein
RING finger protein 39
Gene
RNF39
Organism
Homo sapiens (Human)
Status
Functioni
May play a role in prolonged long term-potentiation (LTP) maintenance.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 88 – 135 | RING-typePROSITE-ProRule annotationAdd BLAST | 48 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- ubiquitin protein ligase activity Source: GO_Central
GO - Biological processi
- innate immune response Source: GO_Central
- protein ubiquitination Source: GO_Central
- regulation of gene expression Source: GO_Central
Keywordsi
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9H2S5 |
Names & Taxonomyi
Protein namesi | Recommended name: RING finger protein 39Alternative name(s): Protein HZFw |
Gene namesi | Name:RNF39 Synonyms:HZFW |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000204618.8 |
HGNCi | HGNC:18064, RNF39 |
MIMi | 607524, gene |
neXtProti | NX_Q9H2S5 |
Subcellular locationi
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 80352 |
OpenTargetsi | ENSG00000204618 |
PharmGKBi | PA134949953 |
Miscellaneous databases
Pharosi | Q9H2S5, Tbio |
Polymorphism and mutation databases
BioMutai | RNF39 |
DMDMi | 68053317 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000056080 | 1 – 420 | RING finger protein 39Add BLAST | 420 |
Proteomic databases
EPDi | Q9H2S5 |
jPOSTi | Q9H2S5 |
MassIVEi | Q9H2S5 |
PaxDbi | Q9H2S5 |
PeptideAtlasi | Q9H2S5 |
PRIDEi | Q9H2S5 |
ProteomicsDBi | 80584 [Q9H2S5-1] 80585 [Q9H2S5-2] 80586 [Q9H2S5-3] |
PTM databases
iPTMneti | Q9H2S5 |
PhosphoSitePlusi | Q9H2S5 |
Expressioni
Tissue specificityi
Expressed in testis.1 Publication
Gene expression databases
Bgeei | ENSG00000204618, Expressed in ectocervix and 147 other tissues |
ExpressionAtlasi | Q9H2S5, baseline and differential |
Genevisiblei | Q9H2S5, HS |
Organism-specific databases
HPAi | ENSG00000204618, Tissue enhanced (esophagus, skin) |
Interactioni
Binary interactionsi
Hide detailsQ9H2S5
Protein-protein interaction databases
BioGRIDi | 123258, 8 interactors |
IntActi | Q9H2S5, 7 interactors |
STRINGi | 9606.ENSP00000244360 |
Miscellaneous databases
RNActi | Q9H2S5, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 210 – 420 | B30.2/SPRYPROSITE-ProRule annotationAdd BLAST | 211 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 88 – 135 | RING-typePROSITE-ProRule annotationAdd BLAST | 48 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG2177, Eukaryota |
GeneTreei | ENSGT00940000162641 |
HOGENOMi | CLU_013137_7_5_1 |
InParanoidi | Q9H2S5 |
OMAi | GESCYAV |
PhylomeDBi | Q9H2S5 |
TreeFami | TF317532 |
Family and domain databases
Gene3Di | 2.60.120.920, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR001870, B30.2/SPRY IPR043136, B30.2/SPRY_sf IPR003879, Butyrophylin_SPRY IPR013320, ConA-like_dom_sf IPR006574, PRY IPR003877, SPRY_dom IPR018957, Znf_C3HC4_RING-type IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF13765, PRY, 1 hit PF00097, zf-C3HC4, 1 hit |
PRINTSi | PR01407, BUTYPHLNCDUF |
SMARTi | View protein in SMART SM00589, PRY, 1 hit SM00184, RING, 1 hit SM00449, SPRY, 1 hit |
SUPFAMi | SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS50188, B302_SPRY, 1 hit PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9H2S5-1) [UniParc]FASTAAdd to basket
Also known as: HZFW1
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MWWRDLTRLR LWLKREAIPG EGRKAAKVNA GVGEKGIYTA SSRGGPPSAR
60 70 80 90 100
SKAVTVVAEG AASRSWLSMD APELGPGLVE RLEQLATCPL CGGSFEDPVL
110 120 130 140 150
LACEHSFCRA CLARRWGTPP ATGTEASPTA CPCCGLPCPR RSLRSNVRLA
160 170 180 190 200
VEVRISRELR EKLAEPGARA GRRRGGRIPT MGCLDLPGED MRKTWRRFEV
210 220 230 240 250
PTSKSSNSED DLPEDYPVVK KMLHRLTADL TLDPGTAHRR LLISADRRSV
260 270 280 290 300
QLAPPGTPAP PDGPKRFDQL PAVLGAQGFG AGRHCWEVET ADAASCRDSS
310 320 330 340 350
GEDADDEESH YAVGAAGESV QRKGCVRLCP AGAVWAVEGR GGRLWALTAP
360 370 380 390 400
EPTLLGGVEP PPRRIRVDLD WERGRVAFYD GRSLDLLYAF QAPGPLGERI
410 420
FPLFCTCDPR APLRIVPAES
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A140T8Y9 | A0A140T8Y9_HUMAN | RING finger protein 39 | RNF39 | 420 | Annotation score: | ||
A0A140T901 | A0A140T901_HUMAN | RING finger protein 39 | RNF39 | 420 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_022723 | 203 | S → P1 PublicationCorresponds to variant dbSNP:rs2074479Ensembl. | 1 | |
Natural variantiVAR_022724 | 245 | A → T1 PublicationCorresponds to variant dbSNP:rs2301752Ensembl. | 1 | |
Natural variantiVAR_022725 | 268 | D → N2 PublicationsCorresponds to variant dbSNP:rs1057539Ensembl. | 1 | |
Natural variantiVAR_022726 | 304 | A → E1 PublicationCorresponds to variant dbSNP:rs2301753Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_014240 | 160 – 251 | REKLA…RRSVQ → LFGGGIPHSFLGTHSHAHCR SINSNPHFRPKIMRPHLVST FPRPCSKPNPFLPSGSQNLL SPTATTVLPDFSHSNHSRPA MGNRPSPSVLVK in isoform 3. 1 PublicationAdd BLAST | 92 | |
Alternative sequenceiVSP_014241 | 252 – 420 | Missing in isoform 3. 1 PublicationAdd BLAST | 169 | |
Alternative sequenceiVSP_014242 | 326 – 391 | Missing in isoform 2. 1 PublicationAdd BLAST | 66 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF238315 mRNA Translation: AAG40628.1 AF238316 mRNA Translation: AAG40629.1 AF238317 mRNA Translation: AAG40630.1 Frameshift. AL669914 Genomic DNA No translation available. AL671859 Genomic DNA No translation available. AL845439 Genomic DNA No translation available. BX088647 Genomic DNA No translation available. BX927229 Genomic DNA No translation available. CR388205 Genomic DNA No translation available. CR759763 Genomic DNA No translation available. CR759960 Genomic DNA No translation available. CR933538 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03256.1 |
RefSeqi | NP_079512.2, NM_025236.3 [Q9H2S5-1] NP_739575.2, NM_170769.2 [Q9H2S5-2] |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF238315 mRNA Translation: AAG40628.1 AF238316 mRNA Translation: AAG40629.1 AF238317 mRNA Translation: AAG40630.1 Frameshift. AL669914 Genomic DNA No translation available. AL671859 Genomic DNA No translation available. AL845439 Genomic DNA No translation available. BX088647 Genomic DNA No translation available. BX927229 Genomic DNA No translation available. CR388205 Genomic DNA No translation available. CR759763 Genomic DNA No translation available. CR759960 Genomic DNA No translation available. CR933538 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03256.1 |
RefSeqi | NP_079512.2, NM_025236.3 [Q9H2S5-1] NP_739575.2, NM_170769.2 [Q9H2S5-2] |
3D structure databases
SMRi | Q9H2S5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 123258, 8 interactors |
IntActi | Q9H2S5, 7 interactors |
STRINGi | 9606.ENSP00000244360 |
PTM databases
iPTMneti | Q9H2S5 |
PhosphoSitePlusi | Q9H2S5 |
Polymorphism and mutation databases
BioMutai | RNF39 |
DMDMi | 68053317 |
Proteomic databases
EPDi | Q9H2S5 |
jPOSTi | Q9H2S5 |
MassIVEi | Q9H2S5 |
PaxDbi | Q9H2S5 |
PeptideAtlasi | Q9H2S5 |
PRIDEi | Q9H2S5 |
ProteomicsDBi | 80584 [Q9H2S5-1] 80585 [Q9H2S5-2] 80586 [Q9H2S5-3] |
Protocols and materials databases
Antibodypediai | 44916, 237 antibodies |
DNASUi | 80352 |
Genome annotation databases
Organism-specific databases
CTDi | 80352 |
DisGeNETi | 80352 |
EuPathDBi | HostDB:ENSG00000204618.8 |
GeneCardsi | RNF39 |
HGNCi | HGNC:18064, RNF39 |
HPAi | ENSG00000204618, Tissue enhanced (esophagus, skin) |
MIMi | 607524, gene |
neXtProti | NX_Q9H2S5 |
OpenTargetsi | ENSG00000204618 |
PharmGKBi | PA134949953 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2177, Eukaryota |
GeneTreei | ENSGT00940000162641 |
HOGENOMi | CLU_013137_7_5_1 |
InParanoidi | Q9H2S5 |
OMAi | GESCYAV |
PhylomeDBi | Q9H2S5 |
TreeFami | TF317532 |
Enzyme and pathway databases
PathwayCommonsi | Q9H2S5 |
Miscellaneous databases
BioGRID-ORCSi | 80352, 2 hits in 844 CRISPR screens |
ChiTaRSi | RNF39, human |
GeneWikii | RNF39 |
GenomeRNAii | 80352 |
Pharosi | Q9H2S5, Tbio |
PROi | PR:Q9H2S5 |
RNActi | Q9H2S5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000204618, Expressed in ectocervix and 147 other tissues |
ExpressionAtlasi | Q9H2S5, baseline and differential |
Genevisiblei | Q9H2S5, HS |
Family and domain databases
Gene3Di | 2.60.120.920, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR001870, B30.2/SPRY IPR043136, B30.2/SPRY_sf IPR003879, Butyrophylin_SPRY IPR013320, ConA-like_dom_sf IPR006574, PRY IPR003877, SPRY_dom IPR018957, Znf_C3HC4_RING-type IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF13765, PRY, 1 hit PF00097, zf-C3HC4, 1 hit |
PRINTSi | PR01407, BUTYPHLNCDUF |
SMARTi | View protein in SMART SM00589, PRY, 1 hit SM00184, RING, 1 hit SM00449, SPRY, 1 hit |
SUPFAMi | SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS50188, B302_SPRY, 1 hit PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RNF39_HUMAN | |
Accessioni | Q9H2S5Primary (citable) accession number: Q9H2S5 Secondary accession number(s): A2BEK3 Q9H2S4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 21, 2005 |
Last sequence update: | June 21, 2005 | |
Last modified: | December 2, 2020 | |
This is version 156 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations