Small conductance calcium-activated potassium channel protein 2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• alpha-actinin binding Source: BHF-UCL <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Molecular coupling of a Ca2+-activated K+ channel to L-type Ca2+ channels via alpha-actinin2."
    Lu L., Zhang Q., Timofeyev V., Zhang Z., Young J.N., Shin H.S., Knowlton A.A., Chiamvimonvat N.
    Circ Res 100:112-120(2007) [PubMed] [Europe PMC] [Abstract]
• calcium-activated potassium channel activity Source: BHF-UCL <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Molecular coupling of a Ca2+-activated K+ channel to L-type Ca2+ channels via alpha-actinin2."
    Lu L., Zhang Q., Timofeyev V., Zhang Z., Young J.N., Shin H.S., Knowlton A.A., Chiamvimonvat N.
    Circ Res 100:112-120(2007) [PubMed] [Europe PMC] [Abstract]
• calmodulin binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• protein domain specific binding Source: UniProtKBInferred from physical interactionⁱ
  • "Alpha-actinin2 cytoskeletal protein is required for the functional membrane localization of a Ca2+-activated K+ channel (SK2 channel)."
    Lu L., Timofeyev V., Li N., Rafizadeh S., Singapuri A., Harris T.R., Chiamvimonvat N.
    Proc Natl Acad Sci U S A 106:18402-18407(2009) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: BHF-UCLInferred from physical interactionⁱ
  • "Molecular coupling of a Ca2+-activated K+ channel to L-type Ca2+ channels via alpha-actinin2."
    Lu L., Zhang Q., Timofeyev V., Zhang Z., Young J.N., Shin H.S., Knowlton A.A., Chiamvimonvat N.
    Circ Res 100:112-120(2007) [PubMed] [Europe PMC] [Abstract]
• small conductance calcium-activated potassium channel activity Source: BHF-UCLInferred from direct assayⁱ
  • "Functional interaction with filamin A and intracellular Ca2+ enhance the surface membrane expression of a small-conductance Ca2+-activated K+ (SK2) channel."
    Rafizadeh S., Zhang Z., Woltz R.L., Kim H.J., Myers R.E., Lu L., Tuteja D., Singapuri A., Bigdeli A.A., Harchache S.B., Knowlton A.A., Yarov-Yarovoy V., Yamoah E.N., Chiamvimonvat N.
    Proc Natl Acad Sci U S A 111:9989-9994(2014) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• ion transport Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• membrane repolarization during atrial cardiac muscle cell action potential Source: BHF-UCL <p>Inferred from Sequence or Structural Similarity<br />Used for any analysis based on sequence alignment, structure comparison, or evaluation of sequence features such as composition.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iss">GO evidence code guide</a></p> Inferred from sequence or structural similarityⁱ
  • "Ablation of a Ca2+-activated K+ channel (SK2 channel) results in action potential prolongation in atrial myocytes and atrial fibrillation."
    Li N., Timofeyev V., Tuteja D., Xu D., Lu L., Zhang Q., Zhang Z., Singapuri A., Albert T.R., Rajagopal A.V., Bond C.T., Periasamy M., Adelman J., Chiamvimonvat N.
    J Physiol 587:1087-1100(2009) [PubMed] [Europe PMC] [Abstract]
• potassium ion transmembrane transport Source: BHF-UCLInferred from direct assayⁱ
  • "Molecular coupling of a Ca2+-activated K+ channel to L-type Ca2+ channels via alpha-actinin2."
    Lu L., Zhang Q., Timofeyev V., Zhang Z., Young J.N., Shin H.S., Knowlton A.A., Chiamvimonvat N.
    Circ Res 100:112-120(2007) [PubMed] [Europe PMC] [Abstract]
  • "Functional interaction with filamin A and intracellular Ca2+ enhance the surface membrane expression of a small-conductance Ca2+-activated K+ (SK2) channel."
    Rafizadeh S., Zhang Z., Woltz R.L., Kim H.J., Myers R.E., Lu L., Tuteja D., Singapuri A., Bigdeli A.A., Harchache S.B., Knowlton A.A., Yarov-Yarovoy V., Yamoah E.N., Chiamvimonvat N.
    Proc Natl Acad Sci U S A 111:9989-9994(2014) [PubMed] [Europe PMC] [Abstract]
• potassium ion transport Source: UniProtKB <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • Ref.1

    "Ca2+-activated K+ channels in human leukemic Jurkat T cells. Molecular cloning, biochemical and functional characterization."
    Desai R., Peretz A., Idelson H., Lazarovici P., Attali B.
    J. Biol. Chem. 275:39954-39963(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
• regulation of potassium ion transmembrane transport Source: BHF-UCLInferred from direct assayⁱ
  • "Molecular coupling of a Ca2+-activated K+ channel to L-type Ca2+ channels via alpha-actinin2."
    Lu L., Zhang Q., Timofeyev V., Zhang Z., Young J.N., Shin H.S., Knowlton A.A., Chiamvimonvat N.
    Circ Res 100:112-120(2007) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

Miscellaneous databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• alpha-actinin binding Source: BHF-UCLInferred from physical interactionⁱ
  • "Molecular coupling of a Ca2+-activated K+ channel to L-type Ca2+ channels via alpha-actinin2."
    Lu L., Zhang Q., Timofeyev V., Zhang Z., Young J.N., Shin H.S., Knowlton A.A., Chiamvimonvat N.
    Circ Res 100:112-120(2007) [PubMed] [Europe PMC] [Abstract]
• calmodulin binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• protein domain specific binding Source: UniProtKBInferred from physical interactionⁱ
  • "Alpha-actinin2 cytoskeletal protein is required for the functional membrane localization of a Ca2+-activated K+ channel (SK2 channel)."
    Lu L., Timofeyev V., Li N., Rafizadeh S., Singapuri A., Harris T.R., Chiamvimonvat N.
    Proc Natl Acad Sci U S A 106:18402-18407(2009) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: BHF-UCLInferred from physical interactionⁱ
  • "Molecular coupling of a Ca2+-activated K+ channel to L-type Ca2+ channels via alpha-actinin2."
    Lu L., Zhang Q., Timofeyev V., Zhang Z., Young J.N., Shin H.S., Knowlton A.A., Chiamvimonvat N.
    Circ Res 100:112-120(2007) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Chemistry databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MSSCRYNGGV MRPLSNLSAS RRNLHEMDSE AQPLQPPASV GGGGGASSPS 
        60         70         80         90        100
AAAAAAAAVS SSAPEIVVSK PEHNNSNNLA LYGTGGGGST GGGGGGGGSG 
       110        120        130        140        150
HGSSSGTKSS KKKNQNIGYK LGHRRALFEK RKRLSDYALI FGMFGIVVMV 
       160        170        180        190        200
IETELSWGAY DKASLYSLAL KCLISLSTII LLGLIIVYHA REIQLFMVDN 
       210        220        230        240        250
GADDWRIAMT YERIFFICLE ILVCAIHPIP GNYTFTWTAR LAFSYAPSTT 
       260        270        280        290        300
TADVDIILSI PMFLRLYLIA RVMLLHSKLF TDASSRSIGA LNKINFNTRF 
       310        320        330        340        350
VMKTLMTICP GTVLLVFSIS LWIIAAWTVR ACERYHDQQD VTSNFLGAMW 
       360        370        380        390        400
LISITFLSIG YGDMVPNTYC GKGVCLLTGI MGAGCTALVV AVVARKLELT 
       410        420        430        440        450
KAEKHVHNFM MDTQLTKRVK NAAANVLRET WLIYKNTKLV KKIDHAKVRK 
       460        470        480        490        500
HQRKFLQAIH QLRSVKMEQR KLNDQANTLV DLAKTQNIMY DMISDLNERS 
       510        520        530        540        550
EDFEKRIVTL ETKLETLIGS IHALPGLISQ TIRQQQRDFI EAQMESYDKH 
       560        570 
VTYNAERSRS SSRRRRSSST APPTSSESS                        

        10         20         30         40         50
MWLISITFLS IGYGDMVPNT YCGKGVCLLT GIMGAGCTAL VVAVVARKLE 
        60         70         80         90        100
LTKAEKHVHN FMMDTQLTKR VKNAAANVLR ETWLIYKNTK LVKKIDHAKV 
       110        120        130        140        150
RKHQRKFLQA IHQLRSVKME QRKLNDQANT LVDLAKTQNI MYDMISDLNE 
       160        170        180        190        200
RSEDFEKRIV TLETKLETLI GSIHALPGLI SQTIRQQQRD FIEAQMESYD 
       210        220        230 
KHVTYNAERS RSSSRRRRSS STAPPTSSES S                     

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Human chromosome 5
   Human chromosome 5: entries, gene names and cross-references to MIM
2. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
3. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
4. SIMILARITY comments
   Index of protein domains and families