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UniProtKB - Q9H2S1 (KCNN2_HUMAN)

Entry version 175 (29 Sep 2021)
Sequence version 2 (14 Oct 2008)
Previous versions | rss
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Protein

Small conductance calcium-activated potassium channel protein 2

Gene

KCNN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Forms a voltage-independent potassium channel activated by intracellular calcium (PubMed:10991935, PubMed:9287325).

Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization.

2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by bee venom neurotoxin apamin (PubMed:10991935, PubMed:9287325). Inhibited by UCL 1684 and tetraethylammonium (TEA) (By similarity).By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding, Ion channel
Biological processIon transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9H2S1

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1296052, Ca2+ activated K+ channels
R-HSA-9667769, Acetylcholine inhibits contraction of outer hair cells

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9H2S1

Protein family/group databases

Transport Classification Database

More...TCDBi		1.A.1.16.1, the voltage-gated ion channel (vic) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Small conductance calcium-activated potassium channel protein 2
Short name:
SK2
Short name:
SKCa 2
Short name:
SKCa2
Alternative name(s):
KCa2.2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KCNN2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6291, KCNN2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605879, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9H2S1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000080709

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei138 – 158Helical; Name=Segment S1Sequence analysisAdd BLAST21
Transmembranei168 – 188Helical; Name=Segment S2Sequence analysisAdd BLAST21
Transmembranei214 – 234Helical; Name=Segment S3Sequence analysisAdd BLAST21
Transmembranei256 – 276Helical; Name=Segment S4Sequence analysisAdd BLAST21
Transmembranei305 – 325Helical; Name=Segment S5Sequence analysisAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei345 – 365Pore-forming; Name=Segment H5Sequence analysisAdd BLAST21
Transmembranei374 – 394Helical; Name=Segment S6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		3781

Open Targets

More...OpenTargetsi		ENSG00000080709

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30071

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9H2S1, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4469

Drug and drug target database

More...DrugBanki		DB01110, Miconazole
DB00721, Procaine
DB09089, Trimebutine

DrugCentral

More...DrugCentrali		Q9H2S1

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		382

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		KCNN2

Domain mapping of disease mutations (DMDM)

More...DMDMi		209572638

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001550101 – 579Small conductance calcium-activated potassium channel protein 2Add BLAST579

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei160PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9H2S1

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9H2S1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9H2S1

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9H2S1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9H2S1

PeptideAtlas

More...PeptideAtlasi		Q9H2S1

PRoteomics IDEntifications database

More...PRIDEi		Q9H2S1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		67208
80583 [Q9H2S1-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9H2S1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9H2S1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in atrial myocytes (at protein level). Widely expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000080709, Expressed in right adrenal gland and 171 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9H2S1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9H2S1, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000080709, Tissue enhanced (adrenal gland, brain, liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109982, 6 interactors

Database of interacting proteins

More...DIPi		DIP-48997N

Protein interaction database and analysis system

More...IntActi		Q9H2S1, 4 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000427120

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q9H2S1

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9H2S1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1579
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		Q9H2S1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9H2S1

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 54DisorderedSequence analysisAdd BLAST54
Regioni90 – 115DisorderedSequence analysisAdd BLAST26
Regioni412 – 488Calmodulin-bindingBy similarityAdd BLAST77
Regioni551 – 579DisorderedSequence analysisAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi100 – 115Polar residuesSequence analysisAdd BLAST16
Compositional biasi565 – 579Polar residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the potassium channel KCNN family. KCa2.2/KCNN2 subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3684, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182904

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_014617_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9H2S1

Database of Orthologous Groups

More...OrthoDBi		907751at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9H2S1

TreeFam database of animal gene trees

More...TreeFami		TF315015

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004178, CaM-bd_dom
IPR036122, CaM-bd_dom_sf
IPR015449, K_chnl_Ca-activ_SK
IPR013099, K_chnl_dom

The PANTHER Classification System

More...PANTHERi		PTHR10153, PTHR10153, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02888, CaMBD, 1 hit
PF07885, Ion_trans_2, 1 hit
PF03530, SK_channel, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01451, SKCHANNEL

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01053, CaMBD, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF81327, SSF81327, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H2S1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSCRYNGGV MRPLSNLSAS RRNLHEMDSE AQPLQPPASV GGGGGASSPS 
        60         70         80         90        100
AAAAAAAAVS SSAPEIVVSK PEHNNSNNLA LYGTGGGGST GGGGGGGGSG 
       110        120        130        140        150
HGSSSGTKSS KKKNQNIGYK LGHRRALFEK RKRLSDYALI FGMFGIVVMV 
       160        170        180        190        200
IETELSWGAY DKASLYSLAL KCLISLSTII LLGLIIVYHA REIQLFMVDN 
       210        220        230        240        250
GADDWRIAMT YERIFFICLE ILVCAIHPIP GNYTFTWTAR LAFSYAPSTT 
       260        270        280        290        300
TADVDIILSI PMFLRLYLIA RVMLLHSKLF TDASSRSIGA LNKINFNTRF 
       310        320        330        340        350
VMKTLMTICP GTVLLVFSIS LWIIAAWTVR ACERYHDQQD VTSNFLGAMW 
       360        370        380        390        400
LISITFLSIG YGDMVPNTYC GKGVCLLTGI MGAGCTALVV AVVARKLELT 
       410        420        430        440        450
KAEKHVHNFM MDTQLTKRVK NAAANVLRET WLIYKNTKLV KKIDHAKVRK 
       460        470        480        490        500
HQRKFLQAIH QLRSVKMEQR KLNDQANTLV DLAKTQNIMY DMISDLNERS 
       510        520        530        540        550
EDFEKRIVTL ETKLETLIGS IHALPGLISQ TIRQQQRDFI EAQMESYDKH 
       560        570 
VTYNAERSRS SSRRRRSSST APPTSSESS
Length:579
Mass (Da):63,760
Last modified:October 14, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2ED87FE13C106183
GO
Isoform 2 (identifier: Q9H2S1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-348: Missing.

Show »
Length:231
Mass (Da):26,341
Checksum:i89BD2ED1EAD6E54B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A669KBH3A0A669KBH3_HUMAN
Small conductance calcium-activated...
KCNN2
791Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3F2YNY5A0A3F2YNY5_HUMAN
Small conductance calcium-activated...
KCNN2
857Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YW81A0A0J9YW81_HUMAN
Small conductance calcium-activated...
KCNN2
595Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RGY7D6RGY7_HUMAN
Small conductance calcium-activated...
KCNN2
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti50S → SA in AAK84039 (Ref. 3) Curated1
Sequence conflicti52A → D in AAG16728 (PubMed:10991935).Curated1
Sequence conflicti58A → AA in AAP45946 (PubMed:13679367).Curated1
Sequence conflicti323I → T in AAK84039 (Ref. 3) Curated1
Sequence conflicti530Q → R in AAP45946 (PubMed:13679367).Curated1
Sequence conflicti530Q → R in AAK84039 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0445841 – 348Missing in isoform 2. 1 PublicationAdd BLAST348

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF239613 mRNA Translation: AAG16728.1
AY258141 mRNA Translation: AAP45946.1
AF397175 mRNA Translation: AAK84039.1
AK289948 mRNA Translation: BAF82637.1
AC025761 Genomic DNA No translation available.
AC109482 Genomic DNA No translation available.
CH471086 Genomic DNA Translation: EAW48975.1
CH471086 Genomic DNA Translation: EAW48976.1
BC015371 mRNA Translation: AAH15371.1
BC117454 mRNA Translation: AAI17455.1
BC117456 mRNA Translation: AAI17457.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS43352.1 [Q9H2S1-2]

NCBI Reference Sequences

More...RefSeqi		NP_001265133.1, NM_001278204.1 [Q9H2S1-2]
NP_067627.2, NM_021614.3
NP_740721.1, NM_170775.2 [Q9H2S1-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000264773; ENSP00000264773; ENSG00000080709 [Q9H2S1-1]
ENST00000503706; ENSP00000421439; ENSG00000080709 [Q9H2S1-2]
ENST00000610748; ENSP00000483124; ENSG00000080709 [Q9H2S1-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3781

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3781

UCSC genome browser

More...UCSCi		uc003kqo.4, human [Q9H2S1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF239613 mRNA Translation: AAG16728.1
AY258141 mRNA Translation: AAP45946.1
AF397175 mRNA Translation: AAK84039.1
AK289948 mRNA Translation: BAF82637.1
AC025761 Genomic DNA No translation available.
AC109482 Genomic DNA No translation available.
CH471086 Genomic DNA Translation: EAW48975.1
CH471086 Genomic DNA Translation: EAW48976.1
BC015371 mRNA Translation: AAH15371.1
BC117454 mRNA Translation: AAI17455.1
BC117456 mRNA Translation: AAI17457.1
CCDSiCCDS43352.1 [Q9H2S1-2]
RefSeqiNP_001265133.1, NM_001278204.1 [Q9H2S1-2]
NP_067627.2, NM_021614.3
NP_740721.1, NM_170775.2 [Q9H2S1-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5V02X-ray1.78B395-486[»]
5WBXX-ray1.90B395-486[»]
5WC5X-ray2.30B395-486[»]
6ALEX-ray2.50B394-486[»]
BMRBiQ9H2S1
SMRiQ9H2S1
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109982, 6 interactors
DIPiDIP-48997N
IntActiQ9H2S1, 4 interactors
STRINGi9606.ENSP00000427120

Chemistry databases

BindingDBiQ9H2S1
ChEMBLiCHEMBL4469
DrugBankiDB01110, Miconazole
DB00721, Procaine
DB09089, Trimebutine
DrugCentraliQ9H2S1
GuidetoPHARMACOLOGYi382

Protein family/group databases

TCDBi1.A.1.16.1, the voltage-gated ion channel (vic) superfamily

PTM databases

iPTMnetiQ9H2S1
PhosphoSitePlusiQ9H2S1

Genetic variation databases

BioMutaiKCNN2
DMDMi209572638

Proteomic databases

EPDiQ9H2S1
jPOSTiQ9H2S1
MassIVEiQ9H2S1
MaxQBiQ9H2S1
PaxDbiQ9H2S1
PeptideAtlasiQ9H2S1
PRIDEiQ9H2S1
ProteomicsDBi67208
80583 [Q9H2S1-1]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q9H2S1, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...Antibodypediai		13591, 125 antibodies

The DNASU plasmid repository

More...DNASUi		3781

Genome annotation databases

EnsembliENST00000264773; ENSP00000264773; ENSG00000080709 [Q9H2S1-1]
ENST00000503706; ENSP00000421439; ENSG00000080709 [Q9H2S1-2]
ENST00000610748; ENSP00000483124; ENSG00000080709 [Q9H2S1-2]
GeneIDi3781
KEGGihsa:3781
UCSCiuc003kqo.4, human [Q9H2S1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3781
DisGeNETi3781

GeneCards: human genes, protein and diseases

More...GeneCardsi		KCNN2
HGNCiHGNC:6291, KCNN2
HPAiENSG00000080709, Tissue enhanced (adrenal gland, brain, liver)
MIMi605879, gene
neXtProtiNX_Q9H2S1
OpenTargetsiENSG00000080709
PharmGKBiPA30071
VEuPathDBiHostDB:ENSG00000080709

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3684, Eukaryota
GeneTreeiENSGT00950000182904
HOGENOMiCLU_014617_0_1_1
InParanoidiQ9H2S1
OrthoDBi907751at2759
PhylomeDBiQ9H2S1
TreeFamiTF315015

Enzyme and pathway databases

PathwayCommonsiQ9H2S1
ReactomeiR-HSA-1296052, Ca2+ activated K+ channels
R-HSA-9667769, Acetylcholine inhibits contraction of outer hair cells
SIGNORiQ9H2S1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3781, 5 hits in 1009 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		KCNN2, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		KCNN2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3781
PharosiQ9H2S1, Tchem

Protein Ontology

More...PROi		PR:Q9H2S1
RNActiQ9H2S1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000080709, Expressed in right adrenal gland and 171 other tissues
ExpressionAtlasiQ9H2S1, baseline and differential
GenevisibleiQ9H2S1, HS

Family and domain databases

InterProiView protein in InterPro
IPR004178, CaM-bd_dom
IPR036122, CaM-bd_dom_sf
IPR015449, K_chnl_Ca-activ_SK
IPR013099, K_chnl_dom
PANTHERiPTHR10153, PTHR10153, 1 hit
PfamiView protein in Pfam
PF02888, CaMBD, 1 hit
PF07885, Ion_trans_2, 1 hit
PF03530, SK_channel, 1 hit
PRINTSiPR01451, SKCHANNEL
SMARTiView protein in SMART
SM01053, CaMBD, 1 hit
SUPFAMiSSF81327, SSF81327, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKCNN2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H2S1
Secondary accession number(s): A6NF94
, Q0VFZ4, Q6PJI0, Q6X2Y2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: October 14, 2008
Last modified: September 29, 2021
This is version 175 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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