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Protein

Kallikrein-15

Gene

KLK15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protease whose physiological substrate is not yet known.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei62Charge relay systemBy similarity1
Active sitei106Charge relay systemBy similarity1
Active sitei209Charge relay systemBy similarity1

GO - Molecular functioni

  • serine-type endopeptidase activity Source: UniProtKB
  • serine-type peptidase activity Source: ProtInc

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.081

Names & Taxonomyi

Protein namesi
Recommended name:
Kallikrein-15 (EC:3.4.21.-)
Alternative name(s):
ACO protease
Gene namesi
Name:KLK15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000174562.13
HGNCiHGNC:20453 KLK15
MIMi610601 gene
neXtProtiNX_Q9H2R5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi55554
OpenTargetsiENSG00000174562
PharmGKBiPA134977502

Polymorphism and mutation databases

DMDMi18202940

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
PropeptideiPRO_000002796017 – 21Activation peptideSequence analysis5
ChainiPRO_000002796122 – 256Kallikrein-15Add BLAST235

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi47 ↔ 63PROSITE-ProRule annotation
Disulfide bondi138 ↔ 215PROSITE-ProRule annotation
Glycosylationi171N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi180 ↔ 194PROSITE-ProRule annotation
Disulfide bondi205 ↔ 230PROSITE-ProRule annotation
Glycosylationi232N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ9H2R5
PeptideAtlasiQ9H2R5
PRIDEiQ9H2R5
ProteomicsDBi80579
80580 [Q9H2R5-2]
80581 [Q9H2R5-3]
80582 [Q9H2R5-4]

PTM databases

iPTMnetiQ9H2R5
PhosphoSitePlusiQ9H2R5

Expressioni

Tissue specificityi

Highest expression in the thyroid gland. Also expressed in the prostate, salivary, and adrenal glands and in the colon testis and kidney.1 Publication

Gene expression databases

BgeeiENSG00000174562 Expressed in 141 organ(s), highest expression level in amniotic fluid
CleanExiHS_KLK15
ExpressionAtlasiQ9H2R5 baseline and differential
GenevisibleiQ9H2R5 HS

Organism-specific databases

HPAiHPA019802

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TRIP6Q156543EBI-8645371,EBI-742327

Protein-protein interaction databases

BioGridi120715, 12 interactors
IntActiQ9H2R5, 3 interactors
MINTiQ9H2R5
STRINGi9606.ENSP00000469315

Structurei

3D structure databases

ProteinModelPortaliQ9H2R5
SMRiQ9H2R5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 254Peptidase S1PROSITE-ProRule annotationAdd BLAST233

Sequence similaritiesi

Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000118862
HOVERGENiHBG013304
InParanoidiQ9H2R5
KOiK09623
OMAiARSHRHD
OrthoDBiEOG091G0DF7
PhylomeDBiQ9H2R5
TreeFamiTF331065

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H2R5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWLLLTLSFL LASTAAQDGD KLLEGDECAP HSQPWQVALY ERGRFNCGAS
60 70 80 90 100
LISPHWVLSA AHCQSRFMRV RLGEHNLRKR DGPEQLRTTS RVIPHPRYEA
110 120 130 140 150
RSHRNDIMLL RLVQPARLNP QVRPAVLPTR CPHPGEACVV SGWGLVSHNE
160 170 180 190 200
PGTAGSPRSQ VSLPDTLHCA NISIISDTSC DKSYPGRLTN TMVCAGAEGR
210 220 230 240 250
GAESCEGDSG GPLVCGGILQ GIVSWGDVPC DNTTKPGVYT KVCHYLEWIR

ETMKRN
Length:256
Mass (Da):28,087
Last modified:March 1, 2001 - v1
Checksum:iB5EBF8D6022786B5
GO
Isoform 2 (identifier: Q9H2R5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     122-256: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:121
Mass (Da):13,907
Checksum:i43BD650A394BF369
GO
Isoform 3 (identifier: Q9H2R5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     161-161: V → G
     162-256: Missing.

Show »
Length:161
Mass (Da):17,954
Checksum:i539D5C6163B16285
GO
Isoform 4 (identifier: Q9H2R5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     122-206: Missing.

Show »
Length:171
Mass (Da):19,341
Checksum:i20CDE27B3E7B89E4
GO
Isoform 5 (identifier: Q9H2R5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     15-15: Missing.

Note: No experimental confirmation available.
Show »
Length:255
Mass (Da):28,016
Checksum:i1581B784D4A39C4F
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R0D7M0R0D7_HUMAN
Kallikrein-15
KLK15
160Annotation score:
M0QX22M0QX22_HUMAN
Kallikrein-15
KLK15
120Annotation score:
M0R2F7M0R2F7_HUMAN
Kallikrein-15
KLK15
43Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti147 – 160SHNEP…SPRSQ → PLSSP (PubMed:11054574).CuratedAdd BLAST14

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020179134P → L. Corresponds to variant dbSNP:rs3212805Ensembl.1
Natural variantiVAR_036298137A → T in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05462115Missing in isoform 5. 1 Publication1
Alternative sequenceiVSP_005405122 – 256Missing in isoform 2. CuratedAdd BLAST135
Alternative sequenceiVSP_005404122 – 206Missing in isoform 4. CuratedAdd BLAST85
Alternative sequenceiVSP_005406161V → G in isoform 3. Curated1
Alternative sequenceiVSP_005407162 – 256Missing in isoform 3. CuratedAdd BLAST95

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF242195 Genomic DNA Translation: AAG09469.1
AF242195 Genomic DNA Translation: AAG09470.1
AF242195 Genomic DNA Translation: AAG09471.1
AF242195 Genomic DNA Translation: AAG09472.1
AF243527 Genomic DNA Translation: AAG33354.1
X75363 mRNA Translation: CAA53145.1 Sequence problems.
CH471135 Genomic DNA Translation: EAW71918.1
BC069480 mRNA Translation: AAH69480.1
BC069507 mRNA Translation: AAH69507.1
BC069518 mRNA Translation: AAH69518.1
BC126137 mRNA Translation: AAI26138.1
BC144046 mRNA Translation: AAI44047.1
CCDSiCCDS12805.1 [Q9H2R5-1]
CCDS62766.1 [Q9H2R5-5]
PIRiS45356
RefSeqiNP_001264010.1, NM_001277081.1 [Q9H2R5-5]
NP_001264011.1, NM_001277082.1
NP_059979.2, NM_017509.3 [Q9H2R5-1]
XP_006723328.1, XM_006723265.3 [Q9H2R5-1]
XP_011525387.1, XM_011527085.2 [Q9H2R5-5]
XP_011525389.1, XM_011527087.2 [Q9H2R5-4]
XP_011525390.1, XM_011527088.2 [Q9H2R5-3]
XP_016882432.1, XM_017026943.1 [Q9H2R5-2]
UniGeneiHs.567535

Genome annotation databases

EnsembliENST00000326856; ENSP00000314783; ENSG00000174562 [Q9H2R5-5]
ENST00000598239; ENSP00000469315; ENSG00000174562 [Q9H2R5-1]
GeneIDi55554
KEGGihsa:55554
UCSCiuc002ptl.4 human [Q9H2R5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF242195 Genomic DNA Translation: AAG09469.1
AF242195 Genomic DNA Translation: AAG09470.1
AF242195 Genomic DNA Translation: AAG09471.1
AF242195 Genomic DNA Translation: AAG09472.1
AF243527 Genomic DNA Translation: AAG33354.1
X75363 mRNA Translation: CAA53145.1 Sequence problems.
CH471135 Genomic DNA Translation: EAW71918.1
BC069480 mRNA Translation: AAH69480.1
BC069507 mRNA Translation: AAH69507.1
BC069518 mRNA Translation: AAH69518.1
BC126137 mRNA Translation: AAI26138.1
BC144046 mRNA Translation: AAI44047.1
CCDSiCCDS12805.1 [Q9H2R5-1]
CCDS62766.1 [Q9H2R5-5]
PIRiS45356
RefSeqiNP_001264010.1, NM_001277081.1 [Q9H2R5-5]
NP_001264011.1, NM_001277082.1
NP_059979.2, NM_017509.3 [Q9H2R5-1]
XP_006723328.1, XM_006723265.3 [Q9H2R5-1]
XP_011525387.1, XM_011527085.2 [Q9H2R5-5]
XP_011525389.1, XM_011527087.2 [Q9H2R5-4]
XP_011525390.1, XM_011527088.2 [Q9H2R5-3]
XP_016882432.1, XM_017026943.1 [Q9H2R5-2]
UniGeneiHs.567535

3D structure databases

ProteinModelPortaliQ9H2R5
SMRiQ9H2R5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120715, 12 interactors
IntActiQ9H2R5, 3 interactors
MINTiQ9H2R5
STRINGi9606.ENSP00000469315

Protein family/group databases

MEROPSiS01.081

PTM databases

iPTMnetiQ9H2R5
PhosphoSitePlusiQ9H2R5

Polymorphism and mutation databases

DMDMi18202940

Proteomic databases

PaxDbiQ9H2R5
PeptideAtlasiQ9H2R5
PRIDEiQ9H2R5
ProteomicsDBi80579
80580 [Q9H2R5-2]
80581 [Q9H2R5-3]
80582 [Q9H2R5-4]

Protocols and materials databases

DNASUi55554
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326856; ENSP00000314783; ENSG00000174562 [Q9H2R5-5]
ENST00000598239; ENSP00000469315; ENSG00000174562 [Q9H2R5-1]
GeneIDi55554
KEGGihsa:55554
UCSCiuc002ptl.4 human [Q9H2R5-1]

Organism-specific databases

CTDi55554
DisGeNETi55554
EuPathDBiHostDB:ENSG00000174562.13
GeneCardsiKLK15
HGNCiHGNC:20453 KLK15
HPAiHPA019802
MIMi610601 gene
neXtProtiNX_Q9H2R5
OpenTargetsiENSG00000174562
PharmGKBiPA134977502
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000118862
HOVERGENiHBG013304
InParanoidiQ9H2R5
KOiK09623
OMAiARSHRHD
OrthoDBiEOG091G0DF7
PhylomeDBiQ9H2R5
TreeFamiTF331065

Miscellaneous databases

GeneWikiiKLK15
GenomeRNAii55554
PROiPR:Q9H2R5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000174562 Expressed in 141 organ(s), highest expression level in amniotic fluid
CleanExiHS_KLK15
ExpressionAtlasiQ9H2R5 baseline and differential
GenevisibleiQ9H2R5 HS

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKLK15_HUMAN
AccessioniPrimary (citable) accession number: Q9H2R5
Secondary accession number(s): A0AUY8
, Q15358, Q6ISI0, Q9H2R3, Q9H2R4, Q9H2R6, Q9HBG9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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