UniProtKB - Q9H2P0 (ADNP_HUMAN)
Protein
Activity-dependent neuroprotector homeobox protein
Gene
ADNP
Organism
Homo sapiens (Human)
Status
Functioni
Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation.
Miscellaneous
When isolated from the sequence, neuroprotective peptide (NAP) provides neuroprotection against the amyloid-beta peptide.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 74 – 97 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 107 – 129 | C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 165 – 188 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 221 – 244 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 447 – 469 | C2H2-type 5; atypicalPROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 489 – 510 | C2H2-type 6; atypicalPROSITE-ProRule annotationAdd BLAST | 22 | |
Zinc fingeri | 512 – 535 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 622 – 647 | C2H2-type 8; atypicalPROSITE-ProRule annotationAdd BLAST | 26 | |
Zinc fingeri | 662 – 686 | C2H2-type 9; atypicalPROSITE-ProRule annotationAdd BLAST | 25 | |
DNA bindingi | 754 – 814 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 61 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- metal ion binding Source: UniProtKB-KW
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9H2P0 |
Names & Taxonomyi
Protein namesi | Recommended name: Activity-dependent neuroprotector homeobox proteinAlternative name(s): Activity-dependent neuroprotective protein |
Gene namesi | Name:ADNP Synonyms:ADNP1, KIAA0784 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15766, ADNP |
MIMi | 611386, gene |
neXtProti | NX_Q9H2P0 |
VEuPathDBi | HostDB:ENSG00000101126.15 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nuclear chromatin Source: NTNU_SB
Other locations
- RNA polymerase II transcription regulator complex Source: ARUK-UCL
Keywords - Cellular componenti
NucleusPathology & Biotechi
Involvement in diseasei
Helsmoortel-van der Aa syndrome (HVDAS)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disorder characterized by intellectual disability, autism spectrum disorder, and dysmorphic facial features including prominent forehead, high hairline, downslanting palpebral fissures, notched eyelids, broad nasal bridge, thin upper lip, and smooth philtrum.
Related information in OMIMKeywords - Diseasei
Autism spectrum disorder, Mental retardationOrganism-specific databases
DisGeNETi | 23394 |
GeneReviewsi | ADNP |
MalaCardsi | ADNP |
MIMi | 615873, phenotype |
OpenTargetsi | ENSG00000101126 |
Orphaneti | 404448, ADNP syndrome |
PharmGKBi | PA24582 |
Miscellaneous databases
Pharosi | Q9H2P0, Tbio |
Genetic variation databases
BioMutai | ADNP |
DMDMi | 24636245 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000048807 | 1 – 1102 | Activity-dependent neuroprotector homeobox proteinAdd BLAST | 1102 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 39 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 72 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 98 | PhosphoserineCombined sources | 1 | |
Cross-linki | 144 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 155 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 203 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 231 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 266 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 274 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 278 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 279 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 311 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 335 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 348 | Asymmetric dimethylarginineBy similarity | 1 | |
Cross-linki | 367 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 408 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 409 | PhosphoserineCombined sources | 1 | |
Modified residuei | 413 | PhosphoserineCombined sources | 1 | |
Cross-linki | 427 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 600 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 606 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 608 | PhosphoserineCombined sources | 1 | |
Cross-linki | 616 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 621 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 632 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 658 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 699 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 709 | PhosphoserineCombined sources | 1 | |
Cross-linki | 716 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 728 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 731 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 736 | PhosphoserineCombined sources | 1 | |
Modified residuei | 738 | PhosphoserineBy similarity | 1 | |
Cross-linki | 745 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 805 | PhosphoserineCombined sources | 1 | |
Cross-linki | 807 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 829 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 835 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 876 | PhosphoserineCombined sources | 1 | |
Modified residuei | 878 | PhosphoserineCombined sources | 1 | |
Modified residuei | 886 | PhosphoserineBy similarity | 1 | |
Modified residuei | 889 | PhosphoserineBy similarity | 1 | |
Cross-linki | 914 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 921 | PhosphoserineCombined sources | 1 | |
Cross-linki | 930 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 935 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 953 | PhosphoserineCombined sources | 1 | |
Modified residuei | 955 | PhosphoserineCombined sources | 1 | |
Cross-linki | 1016 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 1035 | N6-acetyllysine; alternateCombined sources | 1 | |
Cross-linki | 1035 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Modified residuei | 1042 | N6-acetyllysine; alternateCombined sources | 1 | |
Cross-linki | 1042 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Modified residuei | 1071 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9H2P0 |
jPOSTi | Q9H2P0 |
MassIVEi | Q9H2P0 |
MaxQBi | Q9H2P0 |
PaxDbi | Q9H2P0 |
PeptideAtlasi | Q9H2P0 |
PRIDEi | Q9H2P0 |
ProteomicsDBi | 80571 |
PTM databases
GlyConnecti | 2014, 1 N-Linked glycan (1 site) |
GlyGeni | Q9H2P0, 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site) |
iPTMneti | Q9H2P0 |
MetOSitei | Q9H2P0 |
PhosphoSitePlusi | Q9H2P0 |
SwissPalmi | Q9H2P0 |
Expressioni
Tissue specificityi
Widely expressed. Strong expression in heart, skeletal muscle, kidney and placenta. In brain, expression is stronger in the cerebellum and cortex regions. No expression detected in the colon. Strong increase of expression in colon and breast cancer tissues.
Gene expression databases
Bgeei | ENSG00000101126, Expressed in female gonad and 250 other tissues |
ExpressionAtlasi | Q9H2P0, baseline and differential |
Genevisiblei | Q9H2P0, HS |
Organism-specific databases
HPAi | ENSG00000101126, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ9H2P0
With | #Exp. | IntAct |
---|---|---|
CBX1 [P83916] | 4 | EBI-1764854,EBI-78129 |
CBX3 [Q13185] | 4 | EBI-1764854,EBI-78176 |
CBX5 [P45973] | 3 | EBI-1764854,EBI-78219 |
Protein-protein interaction databases
BioGRIDi | 116967, 86 interactors |
DIPi | DIP-47288N |
IntActi | Q9H2P0, 45 interactors |
MINTi | Q9H2P0 |
STRINGi | 9606.ENSP00000379346 |
Miscellaneous databases
RNActi | Q9H2P0, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 354 – 361 | Neuroprotective peptide (NAP)1 Publication | 8 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 74 – 97 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 107 – 129 | C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 165 – 188 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 221 – 244 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 447 – 469 | C2H2-type 5; atypicalPROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 489 – 510 | C2H2-type 6; atypicalPROSITE-ProRule annotationAdd BLAST | 22 | |
Zinc fingeri | 512 – 535 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 622 – 647 | C2H2-type 8; atypicalPROSITE-ProRule annotationAdd BLAST | 26 | |
Zinc fingeri | 662 – 686 | C2H2-type 9; atypicalPROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Homeobox, Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | ENOG502QSYX, Eukaryota |
GeneTreei | ENSGT00530000063631 |
HOGENOMi | CLU_009119_0_0_1 |
InParanoidi | Q9H2P0 |
OMAi | VYIKHTS |
OrthoDBi | 135860at2759 |
PhylomeDBi | Q9H2P0 |
TreeFami | TF328818 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR038861, ADNP/ADNP2 IPR009057, Homeobox-like_sf IPR001356, Homeobox_dom IPR013087, Znf_C2H2_type |
PANTHERi | PTHR15740, PTHR15740, 1 hit |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 1 hit SM00355, ZnF_C2H2, 8 hits |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS50071, HOMEOBOX_2, 1 hit PS00028, ZINC_FINGER_C2H2_1, 1 hit PS50157, ZINC_FINGER_C2H2_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q9H2P0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFQLPVNNLG SLRKARKTVK KILSDIGLEY CKEHIEDFKQ FEPNDFYLKN
60 70 80 90 100
TTWEDVGLWD PSLTKNQDYR TKPFCCSACP FSSKFFSAYK SHFRNVHSED
110 120 130 140 150
FENRILLNCP YCTFNADKKT LETHIKIFHA PNASAPSSSL STFKDKNKND
160 170 180 190 200
GLKPKQADSV EQAVYYCKKC TYRDPLYEIV RKHIYREHFQ HVAAPYIAKA
210 220 230 240 250
GEKSLNGAVP LGSNAREESS IHCKRCLFMP KSYEALVQHV IEDHERIGYQ
260 270 280 290 300
VTAMIGHTNV VVPRSKPLML IAPKPQDKKS MGLPPRIGSL ASGNVRSLPS
310 320 330 340 350
QQMVNRLSIP KPNLNSTGVN MMSSVHLQQN NYGVKSVGQG YSVGQSMRLG
360 370 380 390 400
LGGNAPVSIP QQSQSVKQLL PSGNGRSYGL GSEQRSQAPA RYSLQSANAS
410 420 430 440 450
SLSSGQLKSP SLSQSQASRV LGQSSSKPAA AATGPPPGNT SSTQKWKICT
460 470 480 490 500
ICNELFPENV YSVHFEKEHK AEKVPAVANY IMKIHNFTSK CLYCNRYLPT
510 520 530 540 550
DTLLNHMLIH GLSCPYCRST FNDVEKMAAH MRMVHIDEEM GPKTDSTLSF
560 570 580 590 600
DLTLQQGSHT NIHLLVTTYN LRDAPAESVA YHAQNNPPVP PKPQPKVQEK
610 620 630 640 650
ADIPVKSSPQ AAVPYKKDVG KTLCPLCFSI LKGPISDALA HHLRERHQVI
660 670 680 690 700
QTVHPVEKKL TYKCIHCLGV YTSNMTASTI TLHLVHCRGV GKTQNGQDKT
710 720 730 740 750
NAPSRLNQSP SLAPVKRTYE QMEFPLLKKR KLDDDSDSPS FFEEKPEEPV
760 770 780 790 800
VLALDPKGHE DDSYEARKSF LTKYFNKQPY PTRREIEKLA ASLWLWKSDI
810 820 830 840 850
ASHFSNKRKK CVRDCEKYKP GVLLGFNMKE LNKVKHEMDF DAEWLFENHD
860 870 880 890 900
EKDSRVNASK TADKKLNLGK EDDSSSDSFE NLEEESNESG SPFDPVFEVE
910 920 930 940 950
PKISNDNPEE HVLKVIPEDA SESEEKLDQK EDGSKYETIH LTEEPTKLMH
960 970 980 990 1000
NASDSEVDQD DVVEWKDGAS PSESGPGSQQ VSDFEDNTCE MKPGTWSDES
1010 1020 1030 1040 1050
SQSEDARSSK PAAKKKATMQ GDREQLKWKN SSYGKVEGFW SKDQSQWKNA
1060 1070 1080 1090 1100
SENDERLSNP QIEWQNSTID SEDGEQFDNM TDGVAEPMHG SLAGVKLSSQ
QA
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A2R8Y6X0 | A0A2R8Y6X0_HUMAN | Activity-dependent neuroprotector h... | ADNP | 874 | Annotation score: | ||
A0A669KBJ7 | A0A669KBJ7_HUMAN | Activity-dependent neuroprotector h... | ADNP | 1,174 | Annotation score: | ||
A0A2R8YCL6 | A0A2R8YCL6_HUMAN | Activity-dependent neuroprotector h... | ADNP | 111 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_078696 | 1094 | G → V Found in a patient with autism; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs780706686Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF250860 mRNA Translation: AAG47651.1 AL034553 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75611.1 CH471077 Genomic DNA Translation: EAW75612.1 BC090933 mRNA Translation: AAH90933.1 AB018327 mRNA Translation: BAA34504.1 AL080163 mRNA Translation: CAB45752.1 |
CCDSi | CCDS13433.1 |
PIRi | T12546 |
RefSeqi | NP_001269460.1, NM_001282531.2 NP_001269461.1, NM_001282532.1 NP_001334440.1, NM_001347511.1 NP_056154.1, NM_015339.4 NP_852107.1, NM_181442.3 XP_011527049.1, XM_011528747.2 XP_016883247.1, XM_017027758.1 XP_016883248.1, XM_017027759.1 |
Genome annotation databases
Ensembli | ENST00000349014; ENSP00000342905; ENSG00000101126 ENST00000371602; ENSP00000360662; ENSG00000101126 ENST00000396029; ENSP00000379346; ENSG00000101126 ENST00000396032; ENSP00000379349; ENSG00000101126 ENST00000621696; ENSP00000483881; ENSG00000101126 |
GeneIDi | 23394 |
KEGGi | hsa:23394 |
UCSCi | uc002xvt.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF250860 mRNA Translation: AAG47651.1 AL034553 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75611.1 CH471077 Genomic DNA Translation: EAW75612.1 BC090933 mRNA Translation: AAH90933.1 AB018327 mRNA Translation: BAA34504.1 AL080163 mRNA Translation: CAB45752.1 |
CCDSi | CCDS13433.1 |
PIRi | T12546 |
RefSeqi | NP_001269460.1, NM_001282531.2 NP_001269461.1, NM_001282532.1 NP_001334440.1, NM_001347511.1 NP_056154.1, NM_015339.4 NP_852107.1, NM_181442.3 XP_011527049.1, XM_011528747.2 XP_016883247.1, XM_017027758.1 XP_016883248.1, XM_017027759.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 116967, 86 interactors |
DIPi | DIP-47288N |
IntActi | Q9H2P0, 45 interactors |
MINTi | Q9H2P0 |
STRINGi | 9606.ENSP00000379346 |
PTM databases
GlyConnecti | 2014, 1 N-Linked glycan (1 site) |
GlyGeni | Q9H2P0, 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site) |
iPTMneti | Q9H2P0 |
MetOSitei | Q9H2P0 |
PhosphoSitePlusi | Q9H2P0 |
SwissPalmi | Q9H2P0 |
Genetic variation databases
BioMutai | ADNP |
DMDMi | 24636245 |
Proteomic databases
EPDi | Q9H2P0 |
jPOSTi | Q9H2P0 |
MassIVEi | Q9H2P0 |
MaxQBi | Q9H2P0 |
PaxDbi | Q9H2P0 |
PeptideAtlasi | Q9H2P0 |
PRIDEi | Q9H2P0 |
ProteomicsDBi | 80571 |
Protocols and materials databases
Antibodypediai | 1423, 329 antibodies |
Genome annotation databases
Ensembli | ENST00000349014; ENSP00000342905; ENSG00000101126 ENST00000371602; ENSP00000360662; ENSG00000101126 ENST00000396029; ENSP00000379346; ENSG00000101126 ENST00000396032; ENSP00000379349; ENSG00000101126 ENST00000621696; ENSP00000483881; ENSG00000101126 |
GeneIDi | 23394 |
KEGGi | hsa:23394 |
UCSCi | uc002xvt.3, human |
Organism-specific databases
CTDi | 23394 |
DisGeNETi | 23394 |
GeneCardsi | ADNP |
GeneReviewsi | ADNP |
HGNCi | HGNC:15766, ADNP |
HPAi | ENSG00000101126, Low tissue specificity |
MalaCardsi | ADNP |
MIMi | 611386, gene 615873, phenotype |
neXtProti | NX_Q9H2P0 |
OpenTargetsi | ENSG00000101126 |
Orphaneti | 404448, ADNP syndrome |
PharmGKBi | PA24582 |
VEuPathDBi | HostDB:ENSG00000101126.15 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QSYX, Eukaryota |
GeneTreei | ENSGT00530000063631 |
HOGENOMi | CLU_009119_0_0_1 |
InParanoidi | Q9H2P0 |
OMAi | VYIKHTS |
OrthoDBi | 135860at2759 |
PhylomeDBi | Q9H2P0 |
TreeFami | TF328818 |
Enzyme and pathway databases
PathwayCommonsi | Q9H2P0 |
Miscellaneous databases
BioGRID-ORCSi | 23394, 107 hits in 899 CRISPR screens |
ChiTaRSi | ADNP, human |
GenomeRNAii | 23394 |
Pharosi | Q9H2P0, Tbio |
PROi | PR:Q9H2P0 |
RNActi | Q9H2P0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000101126, Expressed in female gonad and 250 other tissues |
ExpressionAtlasi | Q9H2P0, baseline and differential |
Genevisiblei | Q9H2P0, HS |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR038861, ADNP/ADNP2 IPR009057, Homeobox-like_sf IPR001356, Homeobox_dom IPR013087, Znf_C2H2_type |
PANTHERi | PTHR15740, PTHR15740, 1 hit |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 1 hit SM00355, ZnF_C2H2, 8 hits |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS50071, HOMEOBOX_2, 1 hit PS00028, ZINC_FINGER_C2H2_1, 1 hit PS50157, ZINC_FINGER_C2H2_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ADNP_HUMAN | |
Accessioni | Q9H2P0Primary (citable) accession number: Q9H2P0 Secondary accession number(s): E1P5Y2 Q9UG34 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 2002 |
Last sequence update: | March 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 180 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants