UniProtKB - Q9H2M2 (Q9H2M2_HUMAN)
Protein
Submitted name:
Estrogen receptor
Gene
ESR1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: InterPro
- estrogen receptor activity Source: InterPro
- steroid binding Source: InterPro
GO - Biological processi
- regulation of transcription, DNA-templated Source: InterPro
Keywordsi
Molecular function | ReceptorImported |
Names & Taxonomyi
Protein namesi | Submitted name: Estrogen receptorImportedSubmitted name: Estrogen receptor alphaImported |
Gene namesi | Name:ESR1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3467, ESR1 |
VEuPathDBi | HostDB:ENSG00000091831.21 |
Subcellular locationi
Nucleus
- nucleus Source: InterPro
Expressioni
Gene expression databases
Bgeei | ENSG00000091831, Expressed in endometrium and 168 other tissues |
ExpressionAtlasi | Q9H2M2, baseline and differential |
Family & Domainsi
Phylogenomic databases
GeneTreei | ENSGT00940000158133 |
HOGENOMi | CLU_108078_0_0_1 |
Family and domain databases
InterProi | View protein in InterPro IPR001292, Oestr_rcpt |
Pfami | View protein in Pfam PF02159, Oest_recep, 1 hit |
PRINTSi | PR00543, OESTROGENR |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
Q9H2M2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTMTLHTKAS GMALLHQIQG NELEPLNRPQ LKIPLERPLG EVYLDSSKPA
60 70 80 90 100
VYNYPEGAAY EFNAAAAANA QVYGQTGLPY GPGSEAAAFG SNGLGGFPPL
110 120 130 140 150
NSVSPSPLML LHPPPQLSPF LQPHGQQVPY YLENEPSGYT VREAGPPAFY
RT
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP03372 | ESR1_HUMAN | Estrogen receptor | ESR1 ESR, NR3A1 | 595 | Annotation score: | ||
Q9H2M1 | Q9H2M1_HUMAN | ER-alpha | ESR1 | 334 | Annotation score: | ||
H0Y4W6 | H0Y4W6_HUMAN | Estrogen receptor | ESR1 | 310 | Annotation score: | ||
Q9UE35 | Q9UE35_HUMAN | Estrogen receptor | ESR1 estrogen receptor | 115 | Annotation score: | ||
Q5T5H8 | Q5T5H8_HUMAN | Estrogen receptor | ESR1 | 84 | Annotation score: | ||
B0QYW7 | B0QYW7_HUMAN | Estrogen receptor | ESR1 | 107 | Annotation score: | ||
A0A1W2PP92 | A0A1W2PP92_HUMAN | Estrogen receptor | ESR1 | 44 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL035695 Genomic DNA No translation available. AL049821 Genomic DNA No translation available. AL356311 Genomic DNA No translation available. AL590993 Genomic DNA No translation available. KF454881 Genomic DNA No translation available. KF458326 Genomic DNA No translation available. KF458327 Genomic DNA No translation available. AF258449 mRNA Translation: AAG41358.1 |
Genome annotation databases
Ensembli | ENST00000456483; ENSP00000415934; ENSG00000091831 |
UCSCi | uc063shk.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL035695 Genomic DNA No translation available. AL049821 Genomic DNA No translation available. AL356311 Genomic DNA No translation available. AL590993 Genomic DNA No translation available. KF454881 Genomic DNA No translation available. KF458326 Genomic DNA No translation available. KF458327 Genomic DNA No translation available. AF258449 mRNA Translation: AAG41358.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q9H2M2, 1 interactor |
Protocols and materials databases
Antibodypediai | 739, 3964 antibodies |
Genome annotation databases
Ensembli | ENST00000456483; ENSP00000415934; ENSG00000091831 |
UCSCi | uc063shk.1, human |
Organism-specific databases
HGNCi | HGNC:3467, ESR1 |
OpenTargetsi | ENSG00000091831 |
VEuPathDBi | HostDB:ENSG00000091831.21 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000158133 |
HOGENOMi | CLU_108078_0_0_1 |
Miscellaneous databases
ChiTaRSi | ESR1, human |
Gene expression databases
Bgeei | ENSG00000091831, Expressed in endometrium and 168 other tissues |
ExpressionAtlasi | Q9H2M2, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR001292, Oestr_rcpt |
Pfami | View protein in Pfam PF02159, Oest_recep, 1 hit |
PRINTSi | PR00543, OESTROGENR |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q9H2M2_HUMAN | |
Accessioni | Q9H2M2Primary (citable) accession number: Q9H2M2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 1, 2001 |
Last sequence update: | March 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 95 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |