UniProtKB - Q9H2M1 (Q9H2M1_HUMAN)
Protein
ER-alpha
Gene
ESR1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- estrogen receptor activity Source: InterPro
- metal ion binding Source: UniProtKB-KW
- steroid binding Source: InterPro
- steroid hormone receptor activity Source: UniProtKB
GO - Biological processi
- regulation of transcription, DNA-templated Source: InterPro
Keywordsi
Molecular function | DNA-bindingARBA annotation, ReceptorImportedARBA annotation |
Biological process | Transcription, Transcription regulationARBA annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: ER-alphaARBA annotationAlternative name(s): Estradiol receptorARBA annotation Estrogen receptorARBA annotation Nuclear receptor subfamily 3 group A member 1ARBA annotation |
Gene namesi | Name:ESR1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3467, ESR1 |
VEuPathDBi | HostDB:ENSG00000091831.21 |
Subcellular locationi
Nucleus
- nucleus Source: UniProtKB-KW
Keywords - Cellular componenti
NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000091831, Expressed in endometrium and 168 other tissues |
ExpressionAtlasi | Q9H2M1, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 286 | NR LBDInterPro annotationAdd BLAST | 286 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 292 – 312 | DisorderedSequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 297 – 312 | PolarSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Keywords - Domaini
Zinc-fingerARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000158133 |
HOGENOMi | CLU_831438_0_0_1 |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR001292, Oestr_rcpt IPR024736, Oestrogen-typ_rcpt_final_C_dom |
Pfami | View protein in Pfam PF12743, ESR1_C, 1 hit PF00104, Hormone_recep, 1 hit PF02159, Oest_recep, 1 hit |
PRINTSi | PR00543, OESTROGENR PR00398, STRDHORMONER |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
Q9H2M1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTMTLHTKAS GMALLHQIQG NELEPLNRPQ LKIPLERPLG EVYLDSSKPA
60 70 80 90 100
VYNYPEGAAY EFNAAAAANA QVYGQTGLPY GPGSEAAAFG SNGLGGFPPL
110 120 130 140 150
NSVSPSPLML LHPPPQLSPF LQPHGQQVPY YLENEPSGYT VREAGPPAFY
160 170 180 190 200
RNQGKCVEGM VEIFDMLLAT SSRFRMMNLQ GEEFVCLKSI ILLNSGVYTF
210 220 230 240 250
LSSTLKSLEE KDHIHRVLDK ITDTLIHLMA KAGLTLQQQH QRLAQLLLIL
260 270 280 290 300
SHIRHMSNKG MEHLYSMKCK NVVPLYDLLL EMLDAHRLHA PTSRGGASVE
310 320 330
ETDQSHLATA GSTSSHSLQK YYITGEAEGF PATV
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP03372 | ESR1_HUMAN | Estrogen receptor | ESR1 ESR, NR3A1 | 595 | Annotation score: | ||
H0Y4W6 | H0Y4W6_HUMAN | Estrogen receptor | ESR1 | 310 | Annotation score: | ||
Q9UE35 | Q9UE35_HUMAN | Estrogen receptor | ESR1 estrogen receptor | 115 | Annotation score: | ||
Q5T5H8 | Q5T5H8_HUMAN | Estrogen receptor | ESR1 | 84 | Annotation score: | ||
Q9H2M2 | Q9H2M2_HUMAN | Estrogen receptor | ESR1 | 152 | Annotation score: | ||
B0QYW7 | B0QYW7_HUMAN | Estrogen receptor | ESR1 | 107 | Annotation score: | ||
A0A1W2PP92 | A0A1W2PP92_HUMAN | Estrogen receptor | ESR1 | 44 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL035695 Genomic DNA No translation available. AL049821 Genomic DNA No translation available. AL356311 Genomic DNA No translation available. AL590993 Genomic DNA No translation available. KF454881 Genomic DNA No translation available. KF458326 Genomic DNA No translation available. KF458327 Genomic DNA No translation available. AF258450 mRNA Translation: AAG41359.1 |
Genome annotation databases
Ensembli | ENST00000406599; ENSP00000384064; ENSG00000091831 |
UCSCi | uc010kir.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL035695 Genomic DNA No translation available. AL049821 Genomic DNA No translation available. AL356311 Genomic DNA No translation available. AL590993 Genomic DNA No translation available. KF454881 Genomic DNA No translation available. KF458326 Genomic DNA No translation available. KF458327 Genomic DNA No translation available. AF258450 mRNA Translation: AAG41359.1 |
3D structure databases
SMRi | Q9H2M1 |
ModBasei | Search... |
Proteomic databases
ProteomicsDBi | 80566 |
Protocols and materials databases
Antibodypediai | 739, 3964 antibodies |
Genome annotation databases
Ensembli | ENST00000406599; ENSP00000384064; ENSG00000091831 |
UCSCi | uc010kir.4, human |
Organism-specific databases
HGNCi | HGNC:3467, ESR1 |
OpenTargetsi | ENSG00000091831 |
VEuPathDBi | HostDB:ENSG00000091831.21 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000158133 |
HOGENOMi | CLU_831438_0_0_1 |
Miscellaneous databases
ChiTaRSi | ESR1, human |
Gene expression databases
Bgeei | ENSG00000091831, Expressed in endometrium and 168 other tissues |
ExpressionAtlasi | Q9H2M1, baseline and differential |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR001292, Oestr_rcpt IPR024736, Oestrogen-typ_rcpt_final_C_dom |
Pfami | View protein in Pfam PF12743, ESR1_C, 1 hit PF00104, Hormone_recep, 1 hit PF02159, Oest_recep, 1 hit |
PRINTSi | PR00543, OESTROGENR PR00398, STRDHORMONER |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q9H2M1_HUMAN | |
Accessioni | Q9H2M1Primary (citable) accession number: Q9H2M1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 1, 2001 |
Last sequence update: | March 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 143 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |