The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - Q9H2L4 (TMM60_HUMAN)
Protein
Transmembrane protein 60
Gene
TMEM60
Organism
Homo sapiens (Human)
Status
Functioni
Enzyme and pathway databases
PathwayCommonsi | Q9H2L4 |
SignaLinki | Q9H2L4 |
Protein family/group databases
TCDBi | 8.A.76.1.2, the tmem203 or pf14967 (tmem203) family |
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane protein 60 |
Gene namesi | Name:TMEM60 Synonyms:C7orf35 ORF Names:DC32 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:21754, TMEM60 |
neXtProti | NX_Q9H2L4 |
VEuPathDBi | HostDB:ENSG00000135211 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 5 – 25 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 35 – 55 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 78 – 98 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 110 – 130 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 85025 |
OpenTargetsi | ENSG00000135211 |
PharmGKBi | PA134910139 |
Miscellaneous databases
Pharosi | Q9H2L4, Tdark |
Genetic variation databases
BioMutai | TMEM60 |
DMDMi | 47605551 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000072581 | 1 – 133 | Transmembrane protein 60Add BLAST | 133 |
Proteomic databases
PaxDbi | Q9H2L4 |
PRIDEi | Q9H2L4 |
ProteomicsDBi | 80561 |
Expressioni
Gene expression databases
Bgeei | ENSG00000135211, Expressed in secondary oocyte and 213 other tissues |
Genevisiblei | Q9H2L4, HS |
Organism-specific databases
HPAi | ENSG00000135211, Low tissue specificity |
Interactioni
Binary interactionsi
Q9H2L4
Protein-protein interaction databases
BioGRIDi | 124434, 89 interactors |
IntActi | Q9H2L4, 96 interactors |
STRINGi | 9606.ENSP00000257663 |
Miscellaneous databases
RNActi | Q9H2L4, protein |
Structurei
3D structure databases
AlphaFoldDBi | Q9H2L4 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3879, Eukaryota |
GeneTreei | ENSGT00390000007283 |
HOGENOMi | CLU_152149_0_0_1 |
InParanoidi | Q9H2L4 |
OMAi | FIPLWLY |
OrthoDBi | 1512798at2759 |
PhylomeDBi | Q9H2L4 |
TreeFami | TF325897 |
Family and domain databases
InterProi | View protein in InterPro IPR019396, TM_Fragile-X-F-assoc |
PANTHERi | PTHR13568, PTHR13568, 1 hit |
Pfami | View protein in Pfam PF10269, Tmemb_185A, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9H2L4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRMSLAQRVL LTWLFTLLFL IMLVLKLDEK APWNWFLIFI PVWIFDTILL
60 70 80 90 100
VLLIVKMAGR CKSGFDPRHG SHNIKKKAWY LIAMLLKLAF CLALCAKLEQ
110 120 130
FTTMNLSYVF IPLWALLAGA LTELGYNVFF VRD
Sequence cautioni
The sequence AAH65930 differs from that shown. Reason: Erroneous initiation.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051449 | 42 | V → G. Corresponds to variant dbSNP:rs34580932Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF260336 mRNA Translation: AAG44667.1 AC004955 Genomic DNA Translation: AAP21882.1 AC004955 Genomic DNA Translation: AAP21883.1 CH236949 Genomic DNA Translation: EAL24196.1 CH471091 Genomic DNA Translation: EAW77032.1 BC065930 mRNA Translation: AAH65930.1 Different initiation. |
CCDSi | CCDS5593.1 |
RefSeqi | NP_116325.1, NM_032936.3 |
Genome annotation databases
Ensembli | ENST00000257663.4; ENSP00000257663.3; ENSG00000135211.6 |
GeneIDi | 85025 |
KEGGi | hsa:85025 |
MANE-Selecti | ENST00000257663.4; ENSP00000257663.3; NM_032936.4; NP_116325.1 |
UCSCi | uc003ugn.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF260336 mRNA Translation: AAG44667.1 AC004955 Genomic DNA Translation: AAP21882.1 AC004955 Genomic DNA Translation: AAP21883.1 CH236949 Genomic DNA Translation: EAL24196.1 CH471091 Genomic DNA Translation: EAW77032.1 BC065930 mRNA Translation: AAH65930.1 Different initiation. |
CCDSi | CCDS5593.1 |
RefSeqi | NP_116325.1, NM_032936.3 |
3D structure databases
AlphaFoldDBi | Q9H2L4 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 124434, 89 interactors |
IntActi | Q9H2L4, 96 interactors |
STRINGi | 9606.ENSP00000257663 |
Protein family/group databases
TCDBi | 8.A.76.1.2, the tmem203 or pf14967 (tmem203) family |
Genetic variation databases
BioMutai | TMEM60 |
DMDMi | 47605551 |
Proteomic databases
PaxDbi | Q9H2L4 |
PRIDEi | Q9H2L4 |
ProteomicsDBi | 80561 |
Protocols and materials databases
Antibodypediai | 71000, 4 antibodies from 4 providers |
DNASUi | 85025 |
Genome annotation databases
Ensembli | ENST00000257663.4; ENSP00000257663.3; ENSG00000135211.6 |
GeneIDi | 85025 |
KEGGi | hsa:85025 |
MANE-Selecti | ENST00000257663.4; ENSP00000257663.3; NM_032936.4; NP_116325.1 |
UCSCi | uc003ugn.4, human |
Organism-specific databases
CTDi | 85025 |
DisGeNETi | 85025 |
GeneCardsi | TMEM60 |
HGNCi | HGNC:21754, TMEM60 |
HPAi | ENSG00000135211, Low tissue specificity |
neXtProti | NX_Q9H2L4 |
OpenTargetsi | ENSG00000135211 |
PharmGKBi | PA134910139 |
VEuPathDBi | HostDB:ENSG00000135211 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3879, Eukaryota |
GeneTreei | ENSGT00390000007283 |
HOGENOMi | CLU_152149_0_0_1 |
InParanoidi | Q9H2L4 |
OMAi | FIPLWLY |
OrthoDBi | 1512798at2759 |
PhylomeDBi | Q9H2L4 |
TreeFami | TF325897 |
Enzyme and pathway databases
PathwayCommonsi | Q9H2L4 |
SignaLinki | Q9H2L4 |
Miscellaneous databases
BioGRID-ORCSi | 85025, 14 hits in 1082 CRISPR screens |
ChiTaRSi | TMEM60, human |
GenomeRNAii | 85025 |
Pharosi | Q9H2L4, Tdark |
PROi | PR:Q9H2L4 |
RNActi | Q9H2L4, protein |
Gene expression databases
Bgeei | ENSG00000135211, Expressed in secondary oocyte and 213 other tissues |
Genevisiblei | Q9H2L4, HS |
Family and domain databases
InterProi | View protein in InterPro IPR019396, TM_Fragile-X-F-assoc |
PANTHERi | PTHR13568, PTHR13568, 1 hit |
Pfami | View protein in Pfam PF10269, Tmemb_185A, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TMM60_HUMAN | |
Accessioni | Q9H2L4Primary (citable) accession number: Q9H2L4 Secondary accession number(s): A4D1C3, Q86UM0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 24, 2004 |
Last sequence update: | March 1, 2001 | |
Last modified: | May 25, 2022 | |
This is version 122 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports