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Protein

Tankyrase-2

Gene

TNKS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. Stimulates 26S proteasome activity.5 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Specifically inhibited by XAV939, a small molecule, leading to inhibit the Wnt signaling pathway by stabilizing AXIN1 and AXIN2.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1081ZincBy similarity1
Metal bindingi1084ZincBy similarity1
Metal bindingi1089ZincBy similarity1
Metal bindingi1092ZincBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • NAD+ ADP-ribosyltransferase activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processWnt signaling pathway
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-201681 TCF dependent signaling in response to WNT
R-HSA-4641257 Degradation of AXIN
R-HSA-5545619 XAV939 inhibits tankyrase, stabilizing AXIN
R-HSA-5689880 Ub-specific processing proteases
R-HSA-8948751 Regulation of PTEN stability and activity

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9H2K2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tankyrase-2 (EC:2.4.2.30)
Short name:
TANK2
Alternative name(s):
ADP-ribosyltransferase diphtheria toxin-like 6
Short name:
ARTD6
Poly [ADP-ribose] polymerase 5B
TNKS-2
TRF1-interacting ankyrin-related ADP-ribose polymerase 2
Tankyrase II
Tankyrase-like protein
Tankyrase-related protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TNKS2
Synonyms:PARP5B, TANK2, TNKL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000107854.5

Human Gene Nomenclature Database

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HGNCi
HGNC:15677 TNKS2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
607128 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q9H2K2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Cytoplasm, Golgi apparatus, Membrane, Nucleus, Telomere

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi553H → D: Enhanced hydroxylation by HIF1AN. 1 Publication1
Mutagenesisi553H → N: Enhanced hydroxylation by HIF1AN. 1 Publication1
Mutagenesisi1054M → V: Loss of activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
80351

Open Targets

More...
OpenTargetsi
ENSG00000107854

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38019

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL6154

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
TNKS2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20140805

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002113341 – 1166Tankyrase-2Add BLAST1166

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei203(3S)-3-hydroxyasparagine; by HIF1AN; partial1 Publication1
Modified residuei238(3S)-3-hydroxyhistidine; by HIF1AN; partial1 Publication1
Modified residuei271(3S)-3-hydroxyasparagine; by HIF1AN; partial1 Publication1
Modified residuei427(3S)-3-hydroxyasparagine; by HIF1AN; partial1 Publication1
Modified residuei518(3S)-3-hydroxyasparagine; by HIF1AN; partial1 Publication1
Modified residuei553(3S)-3-hydroxyhistidine; by HIF1AN; partial1 Publication1
Modified residuei586(3S)-3-hydroxyasparagine; by HIF1AN; partial1 Publication1
Modified residuei671(3S)-3-hydroxyasparagine; by HIF1AN; partial1 Publication1
Modified residuei706(3S)-3-hydroxyasparagine; by HIF1AN; partial1 Publication1
Modified residuei739(3S)-3-hydroxyasparagine; by HIF1AN; partial1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated at 'Lys-48' and 'Lys-63' by RNF146 when auto-poly-ADP-ribosylated; this leads to degradation.
ADP-ribosylated (-auto). Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination.
The crystallographic evidence suggests that the 3-hydroxyhistidine may be the (3S) stereoisomer.

Keywords - PTMi

ADP-ribosylation, Hydroxylation, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9H2K2

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9H2K2

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9H2K2

PeptideAtlas

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PeptideAtlasi
Q9H2K2

PRoteomics IDEntifications database

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PRIDEi
Q9H2K2

ProteomicsDB human proteome resource

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ProteomicsDBi
80559

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H2K2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H2K2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in placenta, skeletal muscle, liver, brain, kidney, heart, thymus, spinal cord, lung, peripheral blood leukocytes, pancreas, lymph nodes, spleen, prostate, testis, ovary, small intestine, colon, mammary gland, breast and breast carcinoma, and in common-type meningioma. Highly expressed in fetal liver, heart and brain.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000107854 Expressed in 233 organ(s), highest expression level in skeletal muscle tissue of rectus abdominis

CleanEx database of gene expression profiles

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CleanExi
HS_TNKS2

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9H2K2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA036606

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Oligomerizes and associates with TNKS. Interacts with the cytoplasmic domain of LNPEP/Otase in SLC2A4/GLUT4-vesicles (PubMed:11802774). Binds to the N-terminus of Grb14 and TRF1 with its ankyrin repeat region (PubMed:11802774). Interacts with HIF1AN (PubMed:18936059, PubMed:21251231). Interacts with RNF146; this interaction leads to ubiquitination and proteasomal degradation (PubMed:21799911). Interacts with NUMA1 (PubMed:12080061).7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
123257, 31 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q9H2K2

Database of interacting proteins

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DIPi
DIP-42098N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q9H2K2

Protein interaction database and analysis system

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IntActi
Q9H2K2, 34 interactors

Molecular INTeraction database

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MINTi
Q9H2K2

STRING: functional protein association networks

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STRINGi
9606.ENSP00000360689

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
Q9H2K2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11166
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9H2K2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9H2K2

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q9H2K2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati57 – 89ANK 1Add BLAST33
Repeati90 – 122ANK 2Add BLAST33
Repeati123 – 155ANK 3Add BLAST33
Repeati210 – 242ANK 4Add BLAST33
Repeati243 – 275ANK 5Add BLAST33
Repeati276 – 308ANK 6Add BLAST33
Repeati363 – 398ANK 7Add BLAST36
Repeati399 – 431ANK 8Add BLAST33
Repeati432 – 464ANK 9Add BLAST33
Repeati525 – 557ANK 10Add BLAST33
Repeati558 – 590ANK 11Add BLAST33
Repeati591 – 623ANK 12Add BLAST33
Repeati678 – 710ANK 13Add BLAST33
Repeati711 – 743ANK 14Add BLAST33
Repeati744 – 776ANK 15Add BLAST33
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini873 – 936SAMPROSITE-ProRule annotationAdd BLAST64
Domaini959 – 1164PARP catalyticPROSITE-ProRule annotationAdd BLAST206

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni545 – 553HIF1AN-binding9

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4177 Eukaryota
COG0666 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000159911

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000246964

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG059472

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9H2K2

KEGG Orthology (KO)

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KOi
K10799

Identification of Orthologs from Complete Genome Data

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OMAi
SWHGRPD

Database of Orthologous Groups

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OrthoDBi
EOG091G00W8

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9H2K2

TreeFam database of animal gene trees

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TreeFami
TF326036

Family and domain databases

Conserved Domains Database

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CDDi
cd00204 ANK, 5 hits

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.25.40.20, 5 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR012317 Poly(ADP-ribose)pol_cat_dom
IPR001660 SAM
IPR013761 SAM/pointed_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00023 Ank, 2 hits
PF12796 Ank_2, 5 hits
PF00644 PARP, 1 hit
PF07647 SAM_2, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01415 ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00248 ANK, 15 hits
SM00454 SAM, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47769 SSF47769, 1 hit
SSF48403 SSF48403, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 15 hits
PS51059 PARP_CATALYTIC, 1 hit
PS50105 SAM_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9H2K2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGRRCAGGG AACASAAAEA VEPAARELFE ACRNGDVERV KRLVTPEKVN
60 70 80 90 100
SRDTAGRKST PLHFAAGFGR KDVVEYLLQN GANVQARDDG GLIPLHNACS
110 120 130 140 150
FGHAEVVNLL LRHGADPNAR DNWNYTPLHE AAIKGKIDVC IVLLQHGAEP
160 170 180 190 200
TIRNTDGRTA LDLADPSAKA VLTGEYKKDE LLESARSGNE EKMMALLTPL
210 220 230 240 250
NVNCHASDGR KSTPLHLAAG YNRVKIVQLL LQHGADVHAK DKGDLVPLHN
260 270 280 290 300
ACSYGHYEVT ELLVKHGACV NAMDLWQFTP LHEAASKNRV EVCSLLLSYG
310 320 330 340 350
ADPTLLNCHN KSAIDLAPTP QLKERLAYEF KGHSLLQAAR EADVTRIKKH
360 370 380 390 400
LSLEMVNFKH PQTHETALHC AAASPYPKRK QICELLLRKG ANINEKTKEF
410 420 430 440 450
LTPLHVASEK AHNDVVEVVV KHEAKVNALD NLGQTSLHRA AYCGHLQTCR
460 470 480 490 500
LLLSYGCDPN IISLQGFTAL QMGNENVQQL LQEGISLGNS EADRQLLEAA
510 520 530 540 550
KAGDVETVKK LCTVQSVNCR DIEGRQSTPL HFAAGYNRVS VVEYLLQHGA
560 570 580 590 600
DVHAKDKGGL VPLHNACSYG HYEVAELLVK HGAVVNVADL WKFTPLHEAA
610 620 630 640 650
AKGKYEICKL LLQHGADPTK KNRDGNTPLD LVKDGDTDIQ DLLRGDAALL
660 670 680 690 700
DAAKKGCLAR VKKLSSPDNV NCRDTQGRHS TPLHLAAGYN NLEVAEYLLQ
710 720 730 740 750
HGADVNAQDK GGLIPLHNAA SYGHVDVAAL LIKYNACVNA TDKWAFTPLH
760 770 780 790 800
EAAQKGRTQL CALLLAHGAD PTLKNQEGQT PLDLVSADDV SALLTAAMPP
810 820 830 840 850
SALPSCYKPQ VLNGVRSPGA TADALSSGPS SPSSLSAASS LDNLSGSFSE
860 870 880 890 900
LSSVVSSSGT EGASSLEKKE VPGVDFSITQ FVRNLGLEHL MDIFEREQIT
910 920 930 940 950
LDVLVEMGHK ELKEIGINAY GHRHKLIKGV ERLISGQQGL NPYLTLNTSG
960 970 980 990 1000
SGTILIDLSP DDKEFQSVEE EMQSTVREHR DGGHAGGIFN RYNILKIQKV
1010 1020 1030 1040 1050
CNKKLWERYT HRRKEVSEEN HNHANERMLF HGSPFVNAII HKGFDERHAY
1060 1070 1080 1090 1100
IGGMFGAGIY FAENSSKSNQ YVYGIGGGTG CPVHKDRSCY ICHRQLLFCR
1110 1120 1130 1140 1150
VTLGKSFLQF SAMKMAHSPP GHHSVTGRPS VNGLALAEYV IYRGEQAYPE
1160
YLITYQIMRP EGMVDG
Length:1,166
Mass (Da):126,918
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4C8B3B8D97CEF704
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG25674 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB14665 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti115A → T in BAG37180 (PubMed:14702039).Curated1
Sequence conflicti331 – 337KGHSLLQ → QRPLVAA in AAG25674 (PubMed:11205898).Curated7
Sequence conflicti357 – 361NFKHP → IQAS in AAG25674 (PubMed:11205898).Curated5
Sequence conflicti966Q → P in BAB14665 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF305081 mRNA Translation: AAG25674.1 Different initiation.
AF264912 mRNA Translation: AAG44694.1
AF329696 mRNA Translation: AAK13463.1
AF342982 mRNA Translation: AAK25811.1
AF309033 mRNA Translation: AAK82330.1
AF438201 mRNA Translation: AAL40795.1
AK023746 mRNA Translation: BAB14665.1 Different initiation.
AK314612 mRNA Translation: BAG37180.1
AL359707 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7417.1

NCBI Reference Sequences

More...
RefSeqi
NP_079511.1, NM_025235.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.329327

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000371627; ENSP00000360689; ENSG00000107854

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
80351

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:80351

UCSC genome browser

More...
UCSCi
uc001khp.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF305081 mRNA Translation: AAG25674.1 Different initiation.
AF264912 mRNA Translation: AAG44694.1
AF329696 mRNA Translation: AAK13463.1
AF342982 mRNA Translation: AAK25811.1
AF309033 mRNA Translation: AAK82330.1
AF438201 mRNA Translation: AAL40795.1
AK023746 mRNA Translation: BAB14665.1 Different initiation.
AK314612 mRNA Translation: BAG37180.1
AL359707 Genomic DNA No translation available.
CCDSiCCDS7417.1
RefSeqiNP_079511.1, NM_025235.3
UniGeneiHs.329327

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Y0IX-ray2.28S538-558[»]
3KR7X-ray1.95A946-1162[»]
3KR8X-ray2.10A/C946-1162[»]
3MHJX-ray1.80A/B946-1162[»]
3MHKX-ray2.30A952-1166[»]
3P0NX-ray1.90A/C946-1162[»]
3P0PX-ray2.49A/C946-1162[»]
3P0QX-ray1.90A/C946-1162[»]
3TWQX-ray2.15A/B484-655[»]
3TWRX-ray1.55A/B/C/D488-649[»]
3TWSX-ray1.70A/B/C/D488-649[»]
3TWTX-ray1.85A/B/C/D488-649[»]
3TWUX-ray1.80A488-649[»]
3TWVX-ray2.30A/B/C/D488-649[»]
3TWWX-ray2.00A/B488-649[»]
3TWXX-ray1.80A/B488-649[»]
3U9HX-ray1.75A/B946-1162[»]
3U9YX-ray2.30A946-1162[»]
3UA9X-ray2.15A/B946-1162[»]
3W51X-ray2.00A/B952-1161[»]
4AVUX-ray2.40A/B946-1162[»]
4AVWX-ray2.15A/B946-1162[»]
4BFPX-ray2.40A/B946-1162[»]
4BJ9X-ray2.05A/B946-1162[»]
4BJBX-ray2.30A946-1162[»]
4BJCX-ray2.20A946-1162[»]
4BS4X-ray1.89A/B946-1162[»]
4BU3X-ray2.15A/B946-1162[»]
4BU5X-ray1.80A/B946-1162[»]
4BU6X-ray1.80A/B946-1162[»]
4BU7X-ray2.05A/C946-1162[»]
4BU8X-ray1.85A/C946-1162[»]
4BU9X-ray1.65A/B946-1162[»]
4BUAX-ray1.85A/C946-1162[»]
4BUDX-ray2.50A/C946-1162[»]
4BUEX-ray1.60A/B946-1162[»]
4BUFX-ray2.50A/B946-1162[»]
4BUIX-ray1.95A/C946-1162[»]
4BUSX-ray1.90A/B946-1162[»]
4BUTX-ray1.90A/B946-1162[»]
4BUUX-ray1.60A/B946-1162[»]
4BUVX-ray1.80A/C946-1162[»]
4BUWX-ray1.85A/B946-1162[»]
4BUXX-ray1.95A/C946-1162[»]
4BUYX-ray1.90A/B946-1162[»]
4HKIX-ray2.15A/H946-1113[»]
C/D1114-1162[»]
4HKKX-ray1.95A/C946-1113[»]
B/D1114-1162[»]
4HKNX-ray2.05A946-1113[»]
C1114-1162[»]
4HL5X-ray2.20A946-1113[»]
C1114-1162[»]
4HLFX-ray2.15A/B946-1113[»]
C/D1114-1162[»]
4HLGX-ray2.00A/B946-1113[»]
C/D1114-1162[»]
4HLHX-ray1.75A/B946-1113[»]
C/D1114-1162[»]
4HLKX-ray2.00A/B946-1113[»]
C/D1114-1162[»]
4HLMX-ray1.95A/B946-1113[»]
C/D1114-1162[»]
4HMHX-ray2.30A946-1113[»]
C1114-1162[»]
4HYFX-ray2.80A/B/C946-1162[»]
4IUEX-ray2.38A952-1161[»]
4J1ZX-ray2.00A/B952-1161[»]
4J21X-ray1.93A952-1161[»]
4J22X-ray2.12A/B952-1161[»]
4J3LX-ray2.09A952-1161[»]
4J3MX-ray1.90A/B952-1161[»]
4KZLX-ray2.00A/B946-1113[»]
C/D1114-1162[»]
4KZQX-ray2.25A/B946-1113[»]
C/D1114-1162[»]
4KZUX-ray2.10A/B946-1113[»]
C/D1114-1162[»]
4L09X-ray2.05A/B946-1113[»]
C/D1114-1162[»]
4L0BX-ray1.80A/B946-1113[»]
C/D1114-1162[»]
4L0IX-ray2.30A/B946-1113[»]
C/D1114-1162[»]
4L0SX-ray1.90A/B946-1113[»]
C/D1114-1162[»]
4L0TX-ray2.10A/B946-1113[»]
C/D1114-1162[»]
4L0VX-ray1.70A/B946-1113[»]
C/D1114-1162[»]
4L10X-ray1.70A/B946-1113[»]
C/D1114-1162[»]
4L2FX-ray2.05A/B946-1113[»]
C/D1114-1162[»]
4L2GX-ray2.05A/B946-1113[»]
C/D1114-1162[»]
4L2KX-ray2.10A/B946-1113[»]
C/D1114-1162[»]
4L31X-ray2.00A/B946-1113[»]
C/D1114-1162[»]
4L32X-ray1.85A/B946-1113[»]
C/D1114-1162[»]
4L33X-ray2.10A/B946-1113[»]
C/D1114-1162[»]
4L34X-ray1.80A/B946-1113[»]
C/D1114-1162[»]
4M7BX-ray1.95A/C946-1162[»]
4PMLX-ray1.87A/B/C/D959-1164[»]
4PNLX-ray1.50A/B/C/D959-1164[»]
4PNMX-ray2.19A/B/C/D959-1164[»]
4PNNX-ray1.65A/B/C/D959-1164[»]
4PNQX-ray1.85A/B/C/D959-1164[»]
4PNRX-ray1.71A/B/C/D959-1164[»]
4PNSX-ray1.65A/B/C/D959-1164[»]
4PNTX-ray1.60A/B/C/D959-1164[»]
4TJUX-ray1.57A/B/C/D959-1164[»]
4TJWX-ray1.70A/B/C/D959-1164[»]
4TJYX-ray1.90A/B/C/D959-1164[»]
4TK0X-ray1.65A/B/C/D959-1164[»]
4TK5X-ray2.02A/B/C/D959-1164[»]
4TKFX-ray2.60A/B/C/D959-1164[»]
4TKGX-ray1.95A/B/C/D959-1164[»]
4TKIX-ray2.15A/B/C/D959-1164[»]
4UFUX-ray2.10A/B946-1162[»]
4UFYX-ray1.70A/B946-1162[»]
4UHGX-ray1.70A/B946-1162[»]
4UI3X-ray2.00A/B946-1113[»]
C/D1115-1162[»]
4UI4X-ray2.40A/B946-1113[»]
C/D1115-1162[»]
4UI5X-ray1.65A/B946-1113[»]
C/D1115-1162[»]
4UI6X-ray1.80A/B946-1113[»]
C/D1115-1162[»]
4UI7X-ray1.80A/B946-1113[»]
C/D1115-1162[»]
4UI8X-ray2.05A/B946-1113[»]
C/D1115-1162[»]
4UVLX-ray2.00A/C946-1162[»]
4UVNX-ray2.20A/B946-1162[»]
4UVOX-ray1.85A/B946-1162[»]
4UVPX-ray1.75A/C946-1113[»]
B/D1115-1162[»]
4UVSX-ray2.00A/C946-1162[»]
4UVTX-ray1.95A/C946-1162[»]
4UVUX-ray1.95A/B946-1162[»]
4UVVX-ray1.90A/B946-1162[»]
4UVWX-ray2.10A/B946-1162[»]
4UVXX-ray1.95A/B946-1162[»]
4UVYX-ray1.95A/B946-1162[»]
4UVZX-ray1.60A/C946-1162[»]
4UX4X-ray1.80A/B946-1162[»]
4W5IX-ray1.95A/B952-1162[»]
4Z68X-ray1.86A490-644[»]
5ADQX-ray2.10A946-1113[»]
B1115-1162[»]
5ADRX-ray2.10A946-1113[»]
B1115-1162[»]
5ADSX-ray1.80A946-1113[»]
B1115-1162[»]
5ADTX-ray2.15A946-1113[»]
B1115-1162[»]
5AEHX-ray1.85A/B946-1162[»]
5AKUX-ray1.80A/B946-1162[»]
5AKWX-ray2.07A/B946-1162[»]
5AL1X-ray1.75A/B946-1162[»]
5AL2X-ray1.90A/B946-1162[»]
5AL3X-ray1.75A/B946-1162[»]
5AL4X-ray1.90A/B946-1162[»]
5AL5X-ray2.05A/B946-1162[»]
5BXOX-ray1.33A/B488-649[»]
5BXUX-ray1.35A488-649[»]
5C5PX-ray1.75A/B946-1113[»]
C/D1114-1162[»]
5C5QX-ray2.00A/B946-1113[»]
C/D1114-1162[»]
5C5RX-ray1.55A/B946-1113[»]
C/D1114-1162[»]
5DCZX-ray2.23A936-1166[»]
5FPFX-ray2.60A/B946-1113[»]
C/D1115-1162[»]
5FPGX-ray2.75A/B946-1162[»]
5JRTX-ray1.53A867-940[»]
5NOBX-ray1.85A/B946-1162[»]
5NSPX-ray2.30A/B946-1113[»]
C/D1114-1162[»]
5NUTX-ray1.60A/B952-1162[»]
5OWSX-ray1.80A/B946-1162[»]
5OWTX-ray2.20A/B946-1162[»]
ProteinModelPortaliQ9H2K2
SMRiQ9H2K2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123257, 31 interactors
CORUMiQ9H2K2
DIPiDIP-42098N
ELMiQ9H2K2
IntActiQ9H2K2, 34 interactors
MINTiQ9H2K2
STRINGi9606.ENSP00000360689

Chemistry databases

BindingDBiQ9H2K2
ChEMBLiCHEMBL6154

PTM databases

iPTMnetiQ9H2K2
PhosphoSitePlusiQ9H2K2

Polymorphism and mutation databases

BioMutaiTNKS2
DMDMi20140805

Proteomic databases

EPDiQ9H2K2
MaxQBiQ9H2K2
PaxDbiQ9H2K2
PeptideAtlasiQ9H2K2
PRIDEiQ9H2K2
ProteomicsDBi80559

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
80351
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371627; ENSP00000360689; ENSG00000107854
GeneIDi80351
KEGGihsa:80351
UCSCiuc001khp.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
80351
DisGeNETi80351
EuPathDBiHostDB:ENSG00000107854.5

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TNKS2
HGNCiHGNC:15677 TNKS2
HPAiHPA036606
MIMi607128 gene
neXtProtiNX_Q9H2K2
OpenTargetsiENSG00000107854
PharmGKBiPA38019

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4177 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00940000159911
HOGENOMiHOG000246964
HOVERGENiHBG059472
InParanoidiQ9H2K2
KOiK10799
OMAiSWHGRPD
OrthoDBiEOG091G00W8
PhylomeDBiQ9H2K2
TreeFamiTF326036

Enzyme and pathway databases

ReactomeiR-HSA-201681 TCF dependent signaling in response to WNT
R-HSA-4641257 Degradation of AXIN
R-HSA-5545619 XAV939 inhibits tankyrase, stabilizing AXIN
R-HSA-5689880 Ub-specific processing proteases
R-HSA-8948751 Regulation of PTEN stability and activity
SIGNORiQ9H2K2

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TNKS2 human
EvolutionaryTraceiQ9H2K2

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TNKS2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
80351

Protein Ontology

More...
PROi
PR:Q9H2K2

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000107854 Expressed in 233 organ(s), highest expression level in skeletal muscle tissue of rectus abdominis
CleanExiHS_TNKS2
GenevisibleiQ9H2K2 HS

Family and domain databases

CDDicd00204 ANK, 5 hits
Gene3Di1.25.40.20, 5 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR012317 Poly(ADP-ribose)pol_cat_dom
IPR001660 SAM
IPR013761 SAM/pointed_sf
PfamiView protein in Pfam
PF00023 Ank, 2 hits
PF12796 Ank_2, 5 hits
PF00644 PARP, 1 hit
PF07647 SAM_2, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 15 hits
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF48403 SSF48403, 3 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 15 hits
PS51059 PARP_CATALYTIC, 1 hit
PS50105 SAM_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTNKS2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H2K2
Secondary accession number(s): B2RBD3, Q9H8F2, Q9HAS4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 1, 2001
Last modified: December 5, 2018
This is version 183 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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