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Entry version 136 (07 Oct 2020)
Sequence version 4 (11 Jan 2011)
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Protein

Translation initiation factor IF-3, mitochondrial

Gene

MTIF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

IF-3 binds to the 28S ribosomal subunit and shifts the equilibrum between 55S ribosomes and their 39S and 28S subunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesis initiation begins.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q9H2K0

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-5368286, Mitochondrial translation initiation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Translation initiation factor IF-3, mitochondrial
Short name:
IF-3(Mt)
Short name:
IF-3Mt
Short name:
IF3(mt)
Short name:
IF3mt
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MTIF3
ORF Names:DC38
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000122033.14

Human Gene Nomenclature Database

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HGNCi
HGNC:29788, MTIF3

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q9H2K0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
219402

Open Targets

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OpenTargetsi
ENSG00000122033

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA162396264

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9H2K0, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
MTIF3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
317373570

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 31MitochondrionAdd BLAST31
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000028003732 – 278Translation initiation factor IF-3, mitochondrialAdd BLAST247

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9H2K0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9H2K0

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9H2K0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H2K0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H2K0

PeptideAtlas

More...
PeptideAtlasi
Q9H2K0

PRoteomics IDEntifications database

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PRIDEi
Q9H2K0

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
80558

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H2K0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H2K0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000122033, Expressed in right atrium auricular region and 214 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9H2K0, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000122033, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q9H2K0
With#Exp.IntAct
APOD [P05090]3EBI-3923617,EBI-715495
BCL2L1 [Q07817]3EBI-3923617,EBI-78035
BMP10 [O95393]3EBI-3923617,EBI-3922513
BPIFA1 [Q9NP55]3EBI-3923617,EBI-953896
BRICD5 - isoform 2 [Q6PL45-2]3EBI-3923617,EBI-12244618
CABP7 [Q86V35]3EBI-3923617,EBI-23900553
CD47 - isoform OA3-305 [Q08722-3]3EBI-3923617,EBI-17263290
CDIPT [O14735]3EBI-3923617,EBI-358858
CDS2 [O95674]3EBI-3923617,EBI-3913685
CGRRF1 [Q99675]3EBI-3923617,EBI-2130213
CLDND2 [Q8NHS1]3EBI-3923617,EBI-11959453
CLEC7A - isoform 6 [Q9BXN2-6]3EBI-3923617,EBI-11989440
CMTM5 - isoform 2 [Q96DZ9-2]3EBI-3923617,EBI-11522780
COL4A5 - isoform 2 [P29400-2]3EBI-3923617,EBI-12211159
COQ8A [Q8NI60]3EBI-3923617,EBI-745535
CTXN3 [Q4LDR2]3EBI-3923617,EBI-12019274
CXCL9 [Q07325]3EBI-3923617,EBI-3911467
CYBC1 [Q9BQA9]3EBI-3923617,EBI-2680384
CYP4F2 [P78329]3EBI-3923617,EBI-1752413
EPGN - isoform 2 [Q6UW88-2]3EBI-3923617,EBI-17468158
FETUB [Q9UGM5]3EBI-3923617,EBI-13049494
FXYD3 - isoform 3 [Q14802-3]3EBI-3923617,EBI-12175685
HSFX2 [Q9UBD0]3EBI-3923617,EBI-947253
HTATIP2 - isoform 3 [Q9BUP3-3]3EBI-3923617,EBI-12937691
ITGB2 [P05107]3EBI-3923617,EBI-300173
JAGN1 [Q8N5M9]3EBI-3923617,EBI-10266796
LAPTM4B [Q86VI4]3EBI-3923617,EBI-3267258
LAT - isoform 2 [O43561-2]3EBI-3923617,EBI-8070286
LDLR [P01130]3EBI-3923617,EBI-988319
LHFPL5 [Q8TAF8]3EBI-3923617,EBI-2820517
MGST3 [O14880]3EBI-3923617,EBI-724754
MRFAP1 [Q9Y605]3EBI-3923617,EBI-995714
MS4A1 [P11836]3EBI-3923617,EBI-2808234
NAT8 [Q9UHE5]3EBI-3923617,EBI-2863634
NDRG4 - isoform 2 [Q9ULP0-2]3EBI-3923617,EBI-11978907
ORMDL3 [Q8N138]3EBI-3923617,EBI-721750
PLN [P26678]3EBI-3923617,EBI-692836
PLP1 - isoform DM-20 [P60201-2]3EBI-3923617,EBI-12188331
RPRM [Q9NS64]3EBI-3923617,EBI-1052363
SCD [O00767]3EBI-3923617,EBI-2684237
SELENOK [Q9Y6D0]3EBI-3923617,EBI-9679163
SERP1 [Q9Y6X1]3EBI-3923617,EBI-10329948
SERP2 [Q8N6R1]3EBI-3923617,EBI-749270
SERTM1 [A2A2V5]3EBI-3923617,EBI-17284533
SIAH1 [Q8IUQ4]3EBI-3923617,EBI-747107
SNX2 [O60749]3EBI-3923617,EBI-1046690
SPANXN2 [Q5MJ10]3EBI-3923617,EBI-12023934
STARD4 [Q96DR4]3EBI-3923617,EBI-17217258
STATH [P02808]3EBI-3923617,EBI-738687
STRIT1 [P0DN84]3EBI-3923617,EBI-12200293
STX3 [Q13277]3EBI-3923617,EBI-1394295
STX6 [O43752]3EBI-3923617,EBI-2695795
THBD [P07204]3EBI-3923617,EBI-941422
THSD7B [C9JKN6]3EBI-3923617,EBI-17192156
TMED8 [Q6PL24]3EBI-3923617,EBI-11603430
TMEM109 [Q9BVC6]3EBI-3923617,EBI-1057733
TMEM11 [P17152]3EBI-3923617,EBI-723946
TMEM128 - isoform 2 [Q5BJH2-2]3EBI-3923617,EBI-10694905
TMEM147 [Q9BVK8]3EBI-3923617,EBI-348587
TMEM176A [Q96HP8]3EBI-3923617,EBI-2800645
TMEM218 [A2RU14]3EBI-3923617,EBI-10173151
TMEM239 - isoform 2 [Q8WW34-2]3EBI-3923617,EBI-11528917
TMEM242 [Q9NWH2]3EBI-3923617,EBI-10315004
TMEM243 [Q9BU79]3EBI-3923617,EBI-12887458
TMEM254 [Q8TBM7]3EBI-3923617,EBI-11956809
TMEM42 [Q69YG0]3EBI-3923617,EBI-12038591
TMEM97 [Q5BJF2]3EBI-3923617,EBI-12111910
TSPAN33 [Q86UF1]3EBI-3923617,EBI-12045841
TUFM [A0A384ME17]3EBI-3923617,EBI-12261790
TUSC5 [A5PKU2]3EBI-3923617,EBI-11988865
UNC50 [Q53HI1]3EBI-3923617,EBI-7601760
VAMP4 [O75379]3EBI-3923617,EBI-744953
VKORC1L1 [Q8N0U8]3EBI-3923617,EBI-11337915
YIPF6 [Q96EC8]3EBI-3923617,EBI-751210
ZDHHC15 [Q96MV8]3EBI-3923617,EBI-12837904
ZNF202 [O95125]3EBI-3923617,EBI-751960
A0A087WZY13EBI-3923617,EBI-13387614

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
128525, 84 interactors

Protein interaction database and analysis system

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IntActi
Q9H2K0, 79 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000370508

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9H2K0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1278
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9H2K0

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the IF-3 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502SBZS, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00390000014424

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_086230_0_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9H2K0

KEGG Orthology (KO)

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KOi
K02520

Identification of Orthologs from Complete Genome Data

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OMAi
EPPEYQL

Database of Orthologous Groups

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OrthoDBi
970215at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9H2K0

TreeFam database of animal gene trees

More...
TreeFami
TF332326

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.110.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR036788, T_IF-3_C_sf
IPR036787, T_IF-3_N_sf
IPR001288, Translation_initiation_fac_3
IPR019814, Translation_initiation_fac_3_N

The PANTHER Classification System

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PANTHERi
PTHR10938, PTHR10938, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF05198, IF3_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54364, SSF54364, 1 hit
SSF55200, SSF55200, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H2K0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAALFLKRLT LQTVKSENSC IRCFGKHILQ KTAPAQLSPI ASAPRLSFLI
60 70 80 90 100
HAKAFSTAED TQNEGKKTKK NKTAFSNVGR KISQRVIHLF DEKGNDLGNM
110 120 130 140 150
HRANVIRLMD ERDLRLVQRN TSTEPAEYQL MTGLQILQER QRLREMEKAN
160 170 180 190 200
PKTGPTLRKE LILSSNIGQH DLDTKTKQIQ QWIKKKHLVQ ITIKKGKNVD
210 220 230 240 250
VSENEMEEIF HQILQTMPGI ATFSSRPQAV QGGKALMCVL RAFSKNEEKA
260 270
YKETQETQER DTLNKDHGND KESNVLHQ
Length:278
Mass (Da):31,725
Last modified:January 11, 2011 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE0CA6D5F547DD6E3
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH39599 differs from that shown. Reason: Frameshift.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03104568T → I1 PublicationCorresponds to variant dbSNP:rs17857314Ensembl.1
Natural variantiVAR_031046243F → L3 PublicationsCorresponds to variant dbSNP:rs1218825Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF410851 mRNA Translation: AAL04150.1
AF265440 mRNA Translation: AAG44698.1
AL137059 Genomic DNA No translation available.
BC039599 mRNA Translation: AAH39599.1 Frameshift.
BC046166 mRNA Translation: AAH46166.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9322.1

NCBI Reference Sequences

More...
RefSeqi
NP_001159733.1, NM_001166261.1
NP_001159734.1, NM_001166262.1
NP_001159735.1, NM_001166263.1
NP_690876.3, NM_152912.4
XP_006719834.1, XM_006719771.3
XP_006719835.1, XM_006719772.3
XP_011533259.1, XM_011534957.2
XP_011533260.1, XM_011534958.2
XP_011533261.1, XM_011534959.2
XP_011533262.1, XM_011534960.2
XP_011533263.1, XM_011534961.2
XP_011533264.1, XM_011534962.2
XP_011533265.1, XM_011534963.2
XP_016875906.1, XM_017020417.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000381116; ENSP00000370508; ENSG00000122033
ENST00000381120; ENSP00000370512; ENSG00000122033
ENST00000405591; ENSP00000384659; ENSG00000122033

Database of genes from NCBI RefSeq genomes

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GeneIDi
219402

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:219402

UCSC genome browser

More...
UCSCi
uc001urh.4, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF410851 mRNA Translation: AAL04150.1
AF265440 mRNA Translation: AAG44698.1
AL137059 Genomic DNA No translation available.
BC039599 mRNA Translation: AAH39599.1 Frameshift.
BC046166 mRNA Translation: AAH46166.1
CCDSiCCDS9322.1
RefSeqiNP_001159733.1, NM_001166261.1
NP_001159734.1, NM_001166262.1
NP_001159735.1, NM_001166263.1
NP_690876.3, NM_152912.4
XP_006719834.1, XM_006719771.3
XP_006719835.1, XM_006719772.3
XP_011533259.1, XM_011534957.2
XP_011533260.1, XM_011534958.2
XP_011533261.1, XM_011534959.2
XP_011533262.1, XM_011534960.2
XP_011533263.1, XM_011534961.2
XP_011533264.1, XM_011534962.2
XP_011533265.1, XM_011534963.2
XP_016875906.1, XM_017020417.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6NEQelectron microscopy3.32z32-278[»]
6NF8electron microscopy3.48z32-278[»]
6RW4electron microscopy2.9781-278[»]
6RW5electron microscopy3.1481-278[»]
SMRiQ9H2K0
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi128525, 84 interactors
IntActiQ9H2K0, 79 interactors
STRINGi9606.ENSP00000370508

PTM databases

iPTMnetiQ9H2K0
PhosphoSitePlusiQ9H2K0

Polymorphism and mutation databases

BioMutaiMTIF3
DMDMi317373570

Proteomic databases

EPDiQ9H2K0
jPOSTiQ9H2K0
MassIVEiQ9H2K0
MaxQBiQ9H2K0
PaxDbiQ9H2K0
PeptideAtlasiQ9H2K0
PRIDEiQ9H2K0
ProteomicsDBi80558

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
22665, 289 antibodies

The DNASU plasmid repository

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DNASUi
219402

Genome annotation databases

EnsembliENST00000381116; ENSP00000370508; ENSG00000122033
ENST00000381120; ENSP00000370512; ENSG00000122033
ENST00000405591; ENSP00000384659; ENSG00000122033
GeneIDi219402
KEGGihsa:219402
UCSCiuc001urh.4, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
219402
DisGeNETi219402
EuPathDBiHostDB:ENSG00000122033.14

GeneCards: human genes, protein and diseases

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GeneCardsi
MTIF3
HGNCiHGNC:29788, MTIF3
HPAiENSG00000122033, Low tissue specificity
neXtProtiNX_Q9H2K0
OpenTargetsiENSG00000122033
PharmGKBiPA162396264

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502SBZS, Eukaryota
GeneTreeiENSGT00390000014424
HOGENOMiCLU_086230_0_1_1
InParanoidiQ9H2K0
KOiK02520
OMAiEPPEYQL
OrthoDBi970215at2759
PhylomeDBiQ9H2K0
TreeFamiTF332326

Enzyme and pathway databases

PathwayCommonsiQ9H2K0
ReactomeiR-HSA-5368286, Mitochondrial translation initiation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
219402, 7 hits in 851 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MTIF3, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
219402
PharosiQ9H2K0, Tbio

Protein Ontology

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PROi
PR:Q9H2K0
RNActiQ9H2K0, protein

Gene expression databases

BgeeiENSG00000122033, Expressed in right atrium auricular region and 214 other tissues
GenevisibleiQ9H2K0, HS

Family and domain databases

Gene3Di3.30.110.10, 1 hit
InterProiView protein in InterPro
IPR036788, T_IF-3_C_sf
IPR036787, T_IF-3_N_sf
IPR001288, Translation_initiation_fac_3
IPR019814, Translation_initiation_fac_3_N
PANTHERiPTHR10938, PTHR10938, 1 hit
PfamiView protein in Pfam
PF05198, IF3_N, 1 hit
SUPFAMiSSF54364, SSF54364, 1 hit
SSF55200, SSF55200, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIF3M_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H2K0
Secondary accession number(s): Q05BL8, Q5W0V0, Q86X68
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: January 11, 2011
Last modified: October 7, 2020
This is version 136 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. Translation initiation factors
    List of translation initiation factor entries
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