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Protein

STE20-like serine/threonine-protein kinase

Gene

SLK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates apoptosis and actin stress fiber dissolution.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei63ATPPROSITE-ProRule annotation1
Active sitei155Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi40 – 48ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • cadherin binding Source: BHF-UCL
  • identical protein binding Source: IntAct
  • protein homodimerization activity Source: UniProtKB
  • protein serine/threonine kinase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processApoptosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ9H2G2
SIGNORiQ9H2G2

Names & Taxonomyi

Protein namesi
Recommended name:
STE20-like serine/threonine-protein kinase (EC:2.7.11.1)
Short name:
STE20-like kinase
Short name:
hSLK
Alternative name(s):
CTCL tumor antigen se20-9
STE20-related serine/threonine-protein kinase
Short name:
STE20-related kinase
Serine/threonine-protein kinase 2
Gene namesi
Name:SLK
Synonyms:KIAA0204, STK2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000065613.13
HGNCiHGNC:11088 SLK
MIMi616563 gene
neXtProtiNX_Q9H2G2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi63K → R: Loss of activity. 1 Publication1

Organism-specific databases

DisGeNETi9748
OpenTargetsiENSG00000065613
PharmGKBiPA35941

Chemistry databases

ChEMBLiCHEMBL4202
GuidetoPHARMACOLOGYi2200

Polymorphism and mutation databases

BioMutaiSLK
DMDMi74762732

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002332391 – 1235STE20-like serine/threonine-protein kinaseAdd BLAST1235

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineCombined sources1
Modified residuei183PhosphothreonineBy similarity1
Modified residuei189PhosphoserineCombined sources1
Modified residuei330PhosphoserineCombined sources1
Modified residuei340PhosphoserineBy similarity1
Modified residuei341PhosphoserineCombined sources1
Modified residuei344PhosphoserineCombined sources1
Modified residuei347PhosphoserineCombined sources1
Modified residuei348PhosphoserineCombined sources1
Modified residuei354PhosphoserineBy similarity1
Modified residuei372PhosphoserineCombined sources1
Modified residuei518PhosphoserineCombined sources1
Modified residuei565PhosphoserineCombined sources1
Modified residuei569PhosphothreonineCombined sources1
Modified residuei571PhosphoserineCombined sources1
Modified residuei647PhosphoserineBy similarity1
Modified residuei655PhosphoserineCombined sources1
Modified residuei667PhosphoserineBy similarity1
Modified residuei777PhosphoserineCombined sources1
Modified residuei779PhosphoserineCombined sources1
Modified residuei814PhosphothreonineCombined sources1
Modified residuei818PhosphoserineCombined sources1
Modified residuei1097PhosphothreonineCombined sources1

Post-translational modificationi

Proteolytically cleaved by caspase-3.
Autophosphorylated.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei438 – 439Cleavage; by caspase-3By similarity2

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H2G2
MaxQBiQ9H2G2
PaxDbiQ9H2G2
PeptideAtlasiQ9H2G2
PRIDEiQ9H2G2
ProteomicsDBi80544
80545 [Q9H2G2-2]

PTM databases

iPTMnetiQ9H2G2
PhosphoSitePlusiQ9H2G2

Miscellaneous databases

PMAP-CutDBiQ9H2G2

Expressioni

Tissue specificityi

Ubiquitously expressed. Highest expression is found in heart and in skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000065613 Expressed in 238 organ(s), highest expression level in esophagus squamous epithelium
CleanExiHS_SLK
GenevisibleiQ9H2G2 HS

Organism-specific databases

HPAiHPA015757

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-1022272,EBI-1022272

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115096, 26 interactors
IntActiQ9H2G2, 6 interactors
MINTiQ9H2G2
STRINGi9606.ENSP00000358770

Chemistry databases

BindingDBiQ9H2G2

Structurei

Secondary structure

11235
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9H2G2
SMRiQ9H2G2
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H2G2

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 292Protein kinasePROSITE-ProRule annotationAdd BLAST259
Domaini875 – 910UVRPROSITE-ProRule annotationAdd BLAST36

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili826 – 1069Sequence analysisAdd BLAST244
Coiled coili1109 – 1183Sequence analysisAdd BLAST75

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi16 – 19Poly-Lys4
Compositional biasi302 – 652Glu-richAdd BLAST351

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0579 Eukaryota
ENOG410XPQN LUCA
GeneTreeiENSGT00930000150827
HOVERGENiHBG052712
InParanoidiQ9H2G2
KOiK08836
OMAiKNVDSRW
OrthoDBiEOG091G01Y1
PhylomeDBiQ9H2G2
TreeFamiTF351445

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR022165 PKK
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR001943 UVR_dom
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PF12474 PKK, 2 hits
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS50151 UVR, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9H2G2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSFFNFRKIF KLGSEKKKKQ YEHVKRDLNP EDFWEIIGEL GDGAFGKVYK
60 70 80 90 100
AQNKETSVLA AAKVIDTKSE EELEDYMVEI DILASCDHPN IVKLLDAFYY
110 120 130 140 150
ENNLWILIEF CAGGAVDAVM LELERPLTES QIQVVCKQTL DALNYLHDNK
160 170 180 190 200
IIHRDLKAGN ILFTLDGDIK LADFGVSAKN TRTIQRRDSF IGTPYWMAPE
210 220 230 240 250
VVMCETSKDR PYDYKADVWS LGITLIEMAE IEPPHHELNP MRVLLKIAKS
260 270 280 290 300
EPPTLAQPSR WSSNFKDFLK KCLEKNVDAR WTTSQLLQHP FVTVDSNKPI
310 320 330 340 350
RELIAEAKAE VTEEVEDGKE EDEEEETENS LPIPASKRAS SDLSIASSEE
360 370 380 390 400
DKLSQNACIL ESVSEKTERS NSEDKLNSKI LNEKPTTDEP EKAVEDINEH
410 420 430 440 450
ITDAQLEAMT ELHDRTAVIK ENEREKRPKL ENLPDTEDQE TVDINSVSEG
460 470 480 490 500
KENNIMITLE TNIEHNLKSE EEKDQEKQQM FENKLIKSEE IKDTILQTVD
510 520 530 540 550
LVSQETGEKE ANIQAVDSEV GLTKEDTQEK LGEDDKTQKD VISNTSDVIG
560 570 580 590 600
TCEAADVAQK VDEDSAEDTQ SNDGKEVVEV GQKLINKPMV GPEAGGTKEV
610 620 630 640 650
PIKEIVEMNE IEEGKNKEQA INSSENIMDI NEEPGTTEGE EITESSSTEE
660 670 680 690 700
MEVRSVVADT DQKALGSEVQ DASKVTTQID KEKKEIPVSI KKEPEVTVVS
710 720 730 740 750
QPTEPQPVLI PSININSDSG ENKEEIGSLS KTETILPPES ENPKENDNDS
760 770 780 790 800
GTGSTADTSS IDLNLSISSF LSKTKDSGSI SLQETRRQKK TLKKTRKFIV
810 820 830 840 850
DGVEVSVTTS KIVTDSDSKT EELRFLRRQE LRELRFLQKE EQRAQQQLNS
860 870 880 890 900
KLQQQREQIF RRFEQEMMSK KRQYDQEIEN LEKQQKQTIE RLEQEHTNRL
910 920 930 940 950
RDEAKRIKGE QEKELSKFQN MLKNRKKEVI NEVEKAPKEL RKELMKRRKE
960 970 980 990 1000
ELAQSQHAQE QEFVQKQQQE LDGSLKKIIQ QQKAELANIE RECLNNKQQL
1010 1020 1030 1040 1050
MRAREAAIWE LEERHLQEKH QLLKQQLKDQ YFMQRHQLLK RHEKETEQMQ
1060 1070 1080 1090 1100
RYNQRLIEEL KNRQTQERAR LPKIQRSEAK TRMAMFKKSL RINSTATPDQ
1110 1120 1130 1140 1150
DRDKIKQFAA QEEKRQKNER MAQHQKHENQ MRDLQLQCEA NVRELHQLQN
1160 1170 1180 1190 1200
EKCHLLVEHE TQKLKELDEE HSQELKEWRE KLRPRKKTLE EEFARKLQEQ
1210 1220 1230
EVFFKMTGES ECLNPSTQSR ISKFYPIPSL HSTGS
Length:1,235
Mass (Da):142,695
Last modified:March 1, 2001 - v1
Checksum:i53A43E7CA29B0ED3
GO
Isoform 2 (identifier: Q9H2G2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     929-959: Missing.

Show »
Length:1,204
Mass (Da):138,996
Checksum:i2CA08AF0591C9AD6
GO

Sequence cautioni

The sequence AAH47762 differs from that shown. Contaminating sequence. Potential poly-A sequence starting in position 611.Curated
The sequence AAH47885 differs from that shown. Contaminating sequence. Potential poly-A sequence starting in position 422.Curated
The sequence AAH64804 differs from that shown. Contaminating sequence. Potential poly-A sequence starting in position 614.Curated
The sequence BAA13195 differs from that shown. Reason: Frameshift at position 1172.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5N → S in BAA13195 (PubMed:9039502).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_041080405Q → K in a lung adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041081552C → Y1 PublicationCorresponds to variant dbSNP:rs805657Ensembl.1
Natural variantiVAR_041082604E → Q in an ovarian serous carcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs190220654Ensembl.1
Natural variantiVAR_041083658A → G1 PublicationCorresponds to variant dbSNP:rs56400929Ensembl.1
Natural variantiVAR_051666666G → E. Corresponds to variant dbSNP:rs7071400Ensembl.1
Natural variantiVAR_041084679I → T1 PublicationCorresponds to variant dbSNP:rs34326537Ensembl.1
Natural variantiVAR_041085683K → N1 PublicationCorresponds to variant dbSNP:rs35389916Ensembl.1
Natural variantiVAR_041086697T → I1 PublicationCorresponds to variant dbSNP:rs3740469Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_018100929 – 959Missing in isoform 2. 3 PublicationsAdd BLAST31

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002804 mRNA Translation: BAA19655.1
AF273048 mRNA Translation: AAG34908.1
D86959 mRNA Translation: BAA13195.2 Sequence problems.
AL360170 Genomic DNA No translation available.
AL138761 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49615.1
CH471066 Genomic DNA Translation: EAW49616.1
CH471066 Genomic DNA Translation: EAW49617.1
CH471066 Genomic DNA Translation: EAW49618.1
BC047762 mRNA Translation: AAH47762.1 Sequence problems.
BC047885 mRNA Translation: AAH47885.1 Sequence problems.
BC064804 mRNA Translation: AAH64804.1 Sequence problems.
BC111565 mRNA Translation: AAI11566.1
CCDSiCCDS7553.1 [Q9H2G2-1]
CCDS76334.1 [Q9H2G2-2]
RefSeqiNP_001291672.1, NM_001304743.1 [Q9H2G2-2]
NP_055535.2, NM_014720.3 [Q9H2G2-1]
UniGeneiHs.591922

Genome annotation databases

EnsembliENST00000335753; ENSP00000336824; ENSG00000065613 [Q9H2G2-2]
ENST00000369755; ENSP00000358770; ENSG00000065613 [Q9H2G2-1]
GeneIDi9748
KEGGihsa:9748
UCSCiuc001kxo.2 human [Q9H2G2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002804 mRNA Translation: BAA19655.1
AF273048 mRNA Translation: AAG34908.1
D86959 mRNA Translation: BAA13195.2 Sequence problems.
AL360170 Genomic DNA No translation available.
AL138761 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49615.1
CH471066 Genomic DNA Translation: EAW49616.1
CH471066 Genomic DNA Translation: EAW49617.1
CH471066 Genomic DNA Translation: EAW49618.1
BC047762 mRNA Translation: AAH47762.1 Sequence problems.
BC047885 mRNA Translation: AAH47885.1 Sequence problems.
BC064804 mRNA Translation: AAH64804.1 Sequence problems.
BC111565 mRNA Translation: AAI11566.1
CCDSiCCDS7553.1 [Q9H2G2-1]
CCDS76334.1 [Q9H2G2-2]
RefSeqiNP_001291672.1, NM_001304743.1 [Q9H2G2-2]
NP_055535.2, NM_014720.3 [Q9H2G2-1]
UniGeneiHs.591922

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2J51X-ray2.10A19-320[»]
2JFLX-ray2.20A19-320[»]
2JFMX-ray2.85A19-320[»]
2UV2X-ray2.30A19-320[»]
4USFX-ray1.75A/B19-320[»]
ProteinModelPortaliQ9H2G2
SMRiQ9H2G2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115096, 26 interactors
IntActiQ9H2G2, 6 interactors
MINTiQ9H2G2
STRINGi9606.ENSP00000358770

Chemistry databases

BindingDBiQ9H2G2
ChEMBLiCHEMBL4202
GuidetoPHARMACOLOGYi2200

PTM databases

iPTMnetiQ9H2G2
PhosphoSitePlusiQ9H2G2

Polymorphism and mutation databases

BioMutaiSLK
DMDMi74762732

Proteomic databases

EPDiQ9H2G2
MaxQBiQ9H2G2
PaxDbiQ9H2G2
PeptideAtlasiQ9H2G2
PRIDEiQ9H2G2
ProteomicsDBi80544
80545 [Q9H2G2-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335753; ENSP00000336824; ENSG00000065613 [Q9H2G2-2]
ENST00000369755; ENSP00000358770; ENSG00000065613 [Q9H2G2-1]
GeneIDi9748
KEGGihsa:9748
UCSCiuc001kxo.2 human [Q9H2G2-1]

Organism-specific databases

CTDi9748
DisGeNETi9748
EuPathDBiHostDB:ENSG00000065613.13
GeneCardsiSLK
HGNCiHGNC:11088 SLK
HPAiHPA015757
MIMi616563 gene
neXtProtiNX_Q9H2G2
OpenTargetsiENSG00000065613
PharmGKBiPA35941
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0579 Eukaryota
ENOG410XPQN LUCA
GeneTreeiENSGT00930000150827
HOVERGENiHBG052712
InParanoidiQ9H2G2
KOiK08836
OMAiKNVDSRW
OrthoDBiEOG091G01Y1
PhylomeDBiQ9H2G2
TreeFamiTF351445

Enzyme and pathway databases

SignaLinkiQ9H2G2
SIGNORiQ9H2G2

Miscellaneous databases

ChiTaRSiSLK human
EvolutionaryTraceiQ9H2G2
GeneWikiiSLK_(gene)
GenomeRNAii9748
PMAP-CutDBiQ9H2G2
PROiPR:Q9H2G2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000065613 Expressed in 238 organ(s), highest expression level in esophagus squamous epithelium
CleanExiHS_SLK
GenevisibleiQ9H2G2 HS

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR022165 PKK
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR001943 UVR_dom
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PF12474 PKK, 2 hits
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS50151 UVR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSLK_HUMAN
AccessioniPrimary (citable) accession number: Q9H2G2
Secondary accession number(s): D3DRA0
, D3DRA1, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 167 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  7. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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