Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Coiled-coil domain-containing protein 68

Gene

CCDC68

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells (PubMed:28422092). Together with CCDC120, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly (PubMed:28422092).1 Publication

GO - Biological processi

  • microtubule anchoring at centrosome Source: GO_Central
  • protein localization Source: GO_Central

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 68
Alternative name(s):
Cutaneous T-cell lymphoma-associated antigen se57-1
Short name:
CTCL-associated antigen se57-1
Gene namesi
Name:CCDC68
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000166510.13
HGNCiHGNC:24350 CCDC68
MIMi616909 gene
neXtProtiNX_Q9H2F9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi80323
OpenTargetsiENSG00000166510
PharmGKBiPA143485420

Polymorphism and mutation databases

BioMutaiCCDC68
DMDMi74733556

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002646111 – 335Coiled-coil domain-containing protein 68Add BLAST335

Proteomic databases

PaxDbiQ9H2F9
PeptideAtlasiQ9H2F9
PRIDEiQ9H2F9
ProteomicsDBi80543

PTM databases

iPTMnetiQ9H2F9
PhosphoSitePlusiQ9H2F9

Expressioni

Tissue specificityi

Expressed in bone marrow, colon, small intestine, spleen, testis, trachea and cutaneous T-cell lymphoma (CTCL).2 Publications

Gene expression databases

BgeeiENSG00000166510 Expressed in 152 organ(s), highest expression level in intestine
CleanExiHS_CCDC68
ExpressionAtlasiQ9H2F9 baseline and differential
GenevisibleiQ9H2F9 HS

Organism-specific databases

HPAiHPA040865
HPA048197

Interactioni

Subunit structurei

Interacts with CEP170 (PubMed:28422092).

Binary interactionsi

WithEntry#Exp.IntActNotes
TFIP11Q9UBB95EBI-2813327,EBI-1105213

Protein-protein interaction databases

BioGridi123235, 13 interactors
IntActiQ9H2F9, 10 interactors
STRINGi9606.ENSP00000337209

Structurei

3D structure databases

ProteinModelPortaliQ9H2F9
SMRiQ9H2F9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili101 – 305Sequence analysisAdd BLAST205

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGTN Eukaryota
ENOG4111MW9 LUCA
GeneTreeiENSGT00530000063232
HOGENOMiHOG000234846
HOVERGENiHBG079562
InParanoidiQ9H2F9
OMAiEMDPSCC
OrthoDBiEOG091G0CI2
PhylomeDBiQ9H2F9

Family and domain databases

InterProiView protein in InterPro
IPR026735 Ccdc68
PANTHERiPTHR23171:SF3 PTHR23171:SF3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q9H2F9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTVTVTTEI PPRDKMEDNS ALYESTSAHI IEETEYVKKI RTTLQKIRTQ
60 70 80 90 100
MFKDEIRHDS TNHKLDAKHC GNLQQGSDSE MDPSCCSLDL LMKKIKGKDL
110 120 130 140 150
QLLEMNKENE VLKIKLQASR EAGAAALRNV AQRLFENYQT QSEEVRKKQE
160 170 180 190 200
DSKQLLQVNK LEKEQKLKQH VENLNQVAEK LEEKHSQITE LENLVQRMEK
210 220 230 240 250
EKRTLLERKL SLENKLLQLK SSATYGKSCQ DLQREISILQ EQISHLQFVI
260 270 280 290 300
HSQHQNLRSV IQEMEGLKNN LKEQDKRIEN LREKVNILEA QNKELKTQVA
310 320 330
LSSETPRTKV SKAVSTSELK TEGVSPYLML IRLRK
Length:335
Mass (Da):38,869
Last modified:March 1, 2001 - v1
Checksum:i2D7C0DFAC964A815
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EN04K7EN04_HUMAN
Coiled-coil domain-containing prote...
CCDC68
203Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050762249V → A1 PublicationCorresponds to variant dbSNP:rs34751112Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF273051 mRNA Translation: AAG34911.1
AK313793 mRNA Translation: BAG36530.1
BC029508 mRNA Translation: AAH29508.1
CCDSiCCDS11959.1
RefSeqiNP_001137301.1, NM_001143829.1
NP_079490.1, NM_025214.2
XP_006722615.1, XM_006722552.3
XP_011524500.1, XM_011526198.2
XP_011524501.1, XM_011526199.2
XP_011524502.1, XM_011526200.2
XP_011524503.1, XM_011526201.2
UniGeneiHs.120790

Genome annotation databases

EnsembliENST00000337363; ENSP00000337209; ENSG00000166510
ENST00000432185; ENSP00000413406; ENSG00000166510
ENST00000591504; ENSP00000466690; ENSG00000166510
GeneIDi80323
KEGGihsa:80323
UCSCiuc002lfs.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCCD68_HUMAN
AccessioniPrimary (citable) accession number: Q9H2F9
Secondary accession number(s): B2R9I3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: March 1, 2001
Last modified: September 12, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again