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Entry version 178 (17 Jun 2020)
Sequence version 3 (21 Mar 2006)
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Protein

TRIO and F-actin-binding protein

Gene

TRIOBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May regulate actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin. The localized formation of TARA and TRIO complexes coordinates the amount of F-actin present in stress fibers. May also serve as a linker protein to recruit proteins required for F-actin formation and turnover.1 Publication

Miscellaneous

Has been identified in PubMed:9853615 by a selection system for genes encoding nuclear-targeted protein.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin filament binding Source: MGI
  • GTP-Rho binding Source: UniProtKB
  • myosin II binding Source: UniProtKB
  • ubiquitin protein ligase binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding
Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9H2D6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TRIO and F-actin-binding protein
Alternative name(s):
Protein Tara
Trio-associated repeat on actin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRIOBP
Synonyms:KIAA1662, TARA
ORF Names:HRIHFB2122
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000100106.19

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17009 TRIOBP

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609761 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H2D6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Deafness, autosomal recessive, 28 (DFNB28)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0257191019G → R in DFNB28. 1 PublicationCorresponds to variant dbSNP:rs549095193EnsemblClinVar.1

Keywords - Diseasei

Deafness, Disease mutation, Non-syndromic deafness

Organism-specific databases

DisGeNET

More...
DisGeNETi
11078

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
TRIOBP

MalaCards human disease database

More...
MalaCardsi
TRIOBP
MIMi609823 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000100106

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
90636 Autosomal recessive non-syndromic sensorineural deafness type DFNB

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670699

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9H2D6 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TRIOBP

Domain mapping of disease mutations (DMDM)

More...
DMDMi
90110075

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000724331 – 2365TRIO and F-actin-binding proteinAdd BLAST2365

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1796PhosphoserineCombined sources1
Modified residuei1930Omega-N-methylarginineBy similarity1
Modified residuei1949PhosphoserineCombined sources1
Modified residuei1955PhosphoserineCombined sources1
Isoform 1 (identifier: Q9H2D6-5)
Modified residuei457Phosphothreonine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated by HECTD3, leading to its degradation by the proteasome.1 Publication
Phosphorylation at Thr-457 by PLK1 ensures mitotic progression and is essential for accurate chromosome segregation.1 Publication

Keywords - PTMi

Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9H2D6

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9H2D6

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9H2D6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H2D6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H2D6

PeptideAtlas

More...
PeptideAtlasi
Q9H2D6

PRoteomics IDEntifications database

More...
PRIDEi
Q9H2D6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
23821
29844
80531 [Q9H2D6-1]
80532 [Q9H2D6-2]
80533 [Q9H2D6-3]
80534 [Q9H2D6-4]
80535 [Q9H2D6-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H2D6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H2D6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Highly expressed in heart and placenta. Isoform 3 is expressed in fetal brain, retina and cochlea but is not detectable in the other tissues.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000100106 Expressed in upper lobe of lung and 231 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9H2D6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9H2D6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000100106 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to TRIO and F-actin. May also interact with myosin II.

Interacts with HECTD3.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
116261, 55 interactors

Protein interaction database and analysis system

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IntActi
Q9H2D6, 49 interactors

Molecular INTeraction database

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MINTi
Q9H2D6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000384312

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9H2D6 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9H2D6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1778 – 1887PHPROSITE-ProRule annotationAdd BLAST110

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili2062 – 2247Sequence analysisAdd BLAST186
Coiled coili2281 – 2361Sequence analysisAdd BLAST81

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4807 Eukaryota
ENOG410ZA8F LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157340

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_231134_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9H2D6

KEGG Orthology (KO)

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KOi
K23751

Identification of Orthologs from Complete Genome Data

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OMAi
CAQRDDP

Database of Orthologous Groups

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OrthoDBi
428862at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9H2D6

TreeFam database of animal gene trees

More...
TreeFami
TF343361

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13275 PH_M-RIP, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039597 M-RIP_PH
IPR011993 PH-like_dom_sf
IPR001849 PH_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00169 PH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233 PH, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50003 PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 2 (identifier: Q9H2D6-1) [UniParc]FASTAAdd to basket
Also known as: TRIOBP-6

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEEVPGDALC EHFEANILTQ NRCQNCFHPE EAHGARYQEL RSPSGAEVPY
60 70 80 90 100
CDLPRCPPAP EDPLSASTSG CQSVVDPGLR PGPKRGPSPS AGLPEEGPTA
110 120 130 140 150
APRSRSRELE AVPYLEGLTT SLCGSCNEDP GSDPTSSPDS ATPDDTSNSS
160 170 180 190 200
SVDWDTVERQ EEEAPSWDEL AVMIPRRPRE GPRADSSQRA PSLLTRSPVG
210 220 230 240 250
GDAAGQKKED TGGGGRSAGQ HWARLRGESG LSLERHRSTL TQASSMTPHS
260 270 280 290 300
GPRSTTSQAS PAQRDTAQAA STREIPRASS PHRITQRDTS RASSTQQEIS
310 320 330 340 350
RASSTQQETS RASSTQEDTP RASSTQEDTP RASSTQWNTP RASSPSRSTQ
360 370 380 390 400
LDNPRTSSTQ QDNPQTSFPT CTPQRENPRT PCVQQDDPRA SSPNRTTQRE
410 420 430 440 450
NSRTSCAQRD NPKASRTSSP NRATRDNPRT SCAQRDNPRA SSPSRATRDN
460 470 480 490 500
PTTSCAQRDN PRASRTSSPN RATRDNPRTS CAQRDNPRAS SPSRATRDNP
510 520 530 540 550
TTSCAQRDNP RASRTSSPNR ATRDNPRTSC AQRDNPRASS PNRAARDNPT
560 570 580 590 600
TSCAQRDNPR ASRTSSPNRA TRDNPRTSCA QRDNPRASSP NRATRDNPTT
610 620 630 640 650
SCAQRDNPRA SRTSSPNRAT RDNPRTSCAQ RDNPRASSPN RTTQQDSPRT
660 670 680 690 700
SCARRDDPRA SSPNRTIQQE NPRTSCALRD NPRASSPSRT IQQENPRTSC
710 720 730 740 750
AQRDDPRASS PNRTTQQENP RTSCARRDNP RASSRNRTIQ RDNPRTSCAQ
760 770 780 790 800
RDNPRASSPN RTIQQENLRT SCTRQDNPRT SSPNRATRDN PRTSCAQRDN
810 820 830 840 850
LRASSPIRAT QQDNPRTCIQ QNIPRSSSTQ QDNPKTSCTK RDNLRPTCTQ
860 870 880 890 900
RDRTQSFSFQ RDNPGTSSSQ CCTQKENLRP SSPHRSTQWN NPRNSSPHRT
910 920 930 940 950
NKDIPWASFP LRPTQSDGPR TSSPSRSKQS EVPWASIALR PTQGDRPQTS
960 970 980 990 1000
SPSRPAQHDP PQSSFGPTQY NLPSRATSSS HNPGHQSTSR TSSPVYPAAY
1010 1020 1030 1040 1050
GAPLTSPEPS QPPCAVCIGH RDAPRASSPP RYLQHDPFPF FPEPRAPESE
1060 1070 1080 1090 1100
PPHHEPPYIP PAVCIGHRDA PRASSPPRHT QFDPFPFLPD TSDAEHQCQS
1110 1120 1130 1140 1150
PQHEPLQLPA PVCIGYRDAP RASSPPRQAP EPSLLFQDLP RASTESLVPS
1160 1170 1180 1190 1200
MDSLHECPHI PTPVCIGHRD APSFSSPPRQ APEPSLFFQD PPGTSMESLA
1210 1220 1230 1240 1250
PSTDSLHGSP VLIPQVCIGH RDAPRASSPP RHPPSDLAFL APSPSPGSSG
1260 1270 1280 1290 1300
GSRGSAPPGE TRHNLEREEY TVLADLPPPR RLAQRQPGPQ AQCSSGGRTH
1310 1320 1330 1340 1350
SPGRAEVERL FGQERRKSEA AGAFQAQDEG RSQQPSQGQS QLLRRQSSPA
1360 1370 1380 1390 1400
PSRQVTMLPA KQAELTRRSQ AEPPHPWSPE KRPEGDRQLQ GSPLPPRTSA
1410 1420 1430 1440 1450
RTPERELRTQ RPLESGQAGP RQPLGVWQSQ EEPPGSQGPH RHLERSWSSQ
1460 1470 1480 1490 1500
EGGLGPGGWW GCGEPSLGAA KAPEGAWGGT SREYKESWGQ PEAWEEKPTH
1510 1520 1530 1540 1550
ELPRELGKRS PLTSPPENWG GPAESSQSWH SGTPTAVGWG AEGACPYPRG
1560 1570 1580 1590 1600
SERRPELDWR DLLGLLRAPG EGVWARVPSL DWEGLLELLQ ARLPRKDPAG
1610 1620 1630 1640 1650
HRDDLARALG PELGPPGTND VPEQESHSQP EGWAEATPVN GHSPALQSQS
1660 1670 1680 1690 1700
PVQLPSPACT STQWPKIKVT RGPATATLAG LEQTGPLGSR STAKGPSLPE
1710 1720 1730 1740 1750
LQFQPEEPEE SEPSRGQDPL TDQKQADSAD KRPAEGKAGS PLKGRLVTSW
1760 1770 1780 1790 1800
RMPGDRPTLF NPFLLSLGVL RWRRPDLLNF KKGWMSILDE PGEPPSPSLT
1810 1820 1830 1840 1850
TTSTSQWKKH WFVLTDSSLK YYRDSTAEEA DELDGEIDLR SCTDVTEYAV
1860 1870 1880 1890 1900
QRNYGFQIHT KDAVYTLSAM TSGIRRNWIE ALRKTVRPTS APDVTKLSDS
1910 1920 1930 1940 1950
NKENALHSYS TQKGPLKAGE QRAGSEVISR GGPRKADGQR QALDYVELSP
1960 1970 1980 1990 2000
LTQASPQRAR TPARTPDRLA KQEELERDLA QRSEERRKWF EATDSRTPEV
2010 2020 2030 2040 2050
PAGEGPRRGL GAPLTEDQQN RLSEEIEKKW QELEKLPLRE NKRVPLTALL
2060 2070 2080 2090 2100
NQSRGERRGP PSDGHEALEK EVQALRAQLE AWRLQGEAPQ SALRSQEDGH
2110 2120 2130 2140 2150
IPPGYISQEA CERSLAEMES SHQQVMEELQ RHHERELQRL QQEKEWLLAE
2160 2170 2180 2190 2200
ETAATASAIE AMKKAYQEEL SRELSKTRSL QQGPDGLRKQ HQSDVEALKR
2210 2220 2230 2240 2250
ELQVLSEQYS QKCLEIGALM RQAEEREHTL RRCQQEGQEL LRHNQELHGR
2260 2270 2280 2290 2300
LSEEIDQLRG FIASQGMGNG CGRSNERSSC ELEVLLRVKE NELQYLKKEV
2310 2320 2330 2340 2350
QCLRDELQMM QKDKRFTSGK YQDVYVELSH IKTRSEREIE QLKEHLRLAM
2360
AALQEKESMR NSLAE
Length:2,365
Mass (Da):261,376
Last modified:March 21, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB2CF9AD57E930283
GO
Isoform 3 (identifier: Q9H2D6-2) [UniParc]FASTAAdd to basket
Also known as: Long isoform

The sequence of this isoform differs from the canonical sequence as follows:
     1317-1355: Missing.
     1729-1774: Missing.
     1794-1806: Missing.

Show »
Length:2,267
Mass (Da):250,724
Checksum:iA0055359F5C3D655
GO
Isoform 4 (identifier: Q9H2D6-3) [UniParc]FASTAAdd to basket
Also known as: TRIOBP-3

The sequence of this isoform differs from the canonical sequence as follows:
     1-172: Missing.

Show »
Length:2,193
Mass (Da):243,071
Checksum:i2056F789C0E11E01
GO
Isoform 5 (identifier: Q9H2D6-4) [UniParc]FASTAAdd to basket
Also known as: TRIOBP-4

The sequence of this isoform differs from the canonical sequence as follows:
     1-172: Missing.
     1317-2365: Missing.

Show »
Length:1,144
Mass (Da):125,524
Checksum:i90E403C1C0B946FD
GO
Isoform 1 (identifier: Q9H2D6-5) [UniParc]FASTAAdd to basket
Also known as: TRIOBP-1

The sequence of this isoform differs from the canonical sequence as follows:
     1-1772: Missing.
     1773-1774: RR → MT

Show »
Length:593
Mass (Da):68,041
Checksum:i109AA7D9CC10B21A
GO
Isoform 6 (identifier: Q9H2D6-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: MEEVPGDALC...DLPRCPPAPE → MGGWKGPGQR...LPPPWGAAMT
     62-1774: Missing.
     2109-2144: EACERSLAEMESSHQQVMEELQRHHERELQRLQQEK → LVGVITVPVLQTRPLSSERLCDLPKVTPPAGLKGGI
     2145-2365: Missing.

Show »
Length:431
Mass (Da):47,624
Checksum:i499617230FA5DAC3
GO
Isoform 7 (identifier: Q9H2D6-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: MEEVPGDALC...DLPRCPPAPE → MGGWKGPGQR...LPPPWGAAMT
     62-1774: Missing.

Show »
Length:652
Mass (Da):74,048
Checksum:i2B3B90A23A047212
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6TR96F6TR96_HUMAN
TRIO and F-actin-binding protein
TRIOBP
265Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6WYE2F6WYE2_HUMAN
TRIO and F-actin-binding protein
TRIOBP
256Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y5J9H0Y5J9_HUMAN
TRIO and F-actin-binding protein
TRIOBP
311Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6WMF4F6WMF4_HUMAN
TRIO and F-actin-binding protein
TRIOBP
83Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BXW4H7BXW4_HUMAN
TRIO and F-actin-binding protein
TRIOBP
104Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y5T8H0Y5T8_HUMAN
TRIO and F-actin-binding protein
TRIOBP
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA34800 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti713 – 719RTTQQEN → KSTFGCL in BAB33332 (PubMed:11258795).Curated7
Sequence conflicti1421R → S in ABB77204 (PubMed:16385458).Curated1
Sequence conflicti1689S → G in ABB77204 (PubMed:16385458).Curated1
Sequence conflicti1896Missing in ABB77204 (PubMed:16385458).Curated1
Sequence conflicti1904N → D in ABB77204 (PubMed:16385458).Curated1
Sequence conflicti2114S → T in AAG44841 (PubMed:11148140).Curated1
Sequence conflicti2141Q → L in AAH04303 (PubMed:15489334).Curated1
Sequence conflicti2274S → T in AAG44841 (PubMed:11148140).Curated1
Sequence conflicti2283E → EHLYPQ in AAH04303 (PubMed:15489334).Curated1
Sequence conflicti2359M → I in AAG44841 (PubMed:11148140).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059725217S → N. Corresponds to variant dbSNP:rs12628603EnsemblClinVar.1
Natural variantiVAR_059726493S → N. Corresponds to variant dbSNP:rs4821700EnsemblClinVar.1
Natural variantiVAR_061708817T → S. Corresponds to variant dbSNP:rs41302575Ensembl.1
Natural variantiVAR_051412863N → K. Corresponds to variant dbSNP:rs9610841EnsemblClinVar.1
Natural variantiVAR_0257191019G → R in DFNB28. 1 PublicationCorresponds to variant dbSNP:rs549095193EnsemblClinVar.1
Natural variantiVAR_0597271187F → L. Corresponds to variant dbSNP:rs5756795EnsemblClinVar.1
Natural variantiVAR_0597281300H → R. Corresponds to variant dbSNP:rs739138EnsemblClinVar.1
Natural variantiVAR_0514131372E → D. Corresponds to variant dbSNP:rs8140207EnsemblClinVar.1
Natural variantiVAR_0514141377W → R2 PublicationsCorresponds to variant dbSNP:rs8140958EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0177111 – 1772Missing in isoform 1. 2 PublicationsAdd BLAST1772
Alternative sequenceiVSP_0177121 – 172Missing in isoform 4 and isoform 5. 1 PublicationAdd BLAST172
Alternative sequenceiVSP_0474981 – 61MEEVP…PPAPE → MGGWKGPGQRRGKEGPEARR RAAERGGGGGGGGVPAPRSP AREPRPRSCLLLPPPWGAAM T in isoform 6 and isoform 7. 1 PublicationAdd BLAST61
Alternative sequenceiVSP_04749962 – 1774Missing in isoform 6 and isoform 7. 1 PublicationAdd BLAST1713
Alternative sequenceiVSP_0177131317 – 2365Missing in isoform 5. 1 PublicationAdd BLAST1049
Alternative sequenceiVSP_0177141317 – 1355Missing in isoform 3. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_0177151729 – 1774Missing in isoform 3. 1 PublicationAdd BLAST46
Alternative sequenceiVSP_0177161773 – 1774RR → MT in isoform 1. 2 Publications2
Alternative sequenceiVSP_0177171794 – 1806Missing in isoform 3. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_0475002109 – 2144EACER…LQQEK → LVGVITVPVLQTRPLSSERL CDLPKVTPPAGLKGGI in isoform 6. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_0475012145 – 2365Missing in isoform 6. 1 PublicationAdd BLAST221

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF281030 mRNA Translation: AAG44841.1
DQ228003 mRNA Translation: ABB59559.1
DQ228004 mRNA Translation: ABB59560.1
DQ228005 mRNA Translation: ABB59561.1
DQ278603 mRNA Translation: ABB77204.1
Z83844 Genomic DNA No translation available.
BC003618 mRNA Translation: AAH03618.1
BC004303 mRNA Translation: AAH04303.1
BC013278 mRNA Translation: AAH13278.2
BC022200 mRNA No translation available.
AB015343 mRNA Translation: BAA34800.1 Frameshift.
AB051449 mRNA Translation: BAB33332.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33644.1 [Q9H2D6-6]
CCDS43015.1 [Q9H2D6-1]
CCDS43016.1 [Q9H2D6-7]

NCBI Reference Sequences

More...
RefSeqi
NP_001034230.1, NM_001039141.2 [Q9H2D6-1]
NP_008963.3, NM_007032.5 [Q9H2D6-7]
NP_619538.2, NM_138632.2 [Q9H2D6-6]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000403663; ENSP00000386026; ENSG00000100106 [Q9H2D6-7]
ENST00000407319; ENSP00000383913; ENSG00000100106 [Q9H2D6-6]
ENST00000644935; ENSP00000496394; ENSG00000100106 [Q9H2D6-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
11078

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:11078

UCSC genome browser

More...
UCSCi
uc003atr.4 human [Q9H2D6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF281030 mRNA Translation: AAG44841.1
DQ228003 mRNA Translation: ABB59559.1
DQ228004 mRNA Translation: ABB59560.1
DQ228005 mRNA Translation: ABB59561.1
DQ278603 mRNA Translation: ABB77204.1
Z83844 Genomic DNA No translation available.
BC003618 mRNA Translation: AAH03618.1
BC004303 mRNA Translation: AAH04303.1
BC013278 mRNA Translation: AAH13278.2
BC022200 mRNA No translation available.
AB015343 mRNA Translation: BAA34800.1 Frameshift.
AB051449 mRNA Translation: BAB33332.2
CCDSiCCDS33644.1 [Q9H2D6-6]
CCDS43015.1 [Q9H2D6-1]
CCDS43016.1 [Q9H2D6-7]
RefSeqiNP_001034230.1, NM_001039141.2 [Q9H2D6-1]
NP_008963.3, NM_007032.5 [Q9H2D6-7]
NP_619538.2, NM_138632.2 [Q9H2D6-6]

3D structure databases

SMRiQ9H2D6
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116261, 55 interactors
IntActiQ9H2D6, 49 interactors
MINTiQ9H2D6
STRINGi9606.ENSP00000384312

PTM databases

iPTMnetiQ9H2D6
PhosphoSitePlusiQ9H2D6

Polymorphism and mutation databases

BioMutaiTRIOBP
DMDMi90110075

Proteomic databases

EPDiQ9H2D6
jPOSTiQ9H2D6
MassIVEiQ9H2D6
MaxQBiQ9H2D6
PaxDbiQ9H2D6
PeptideAtlasiQ9H2D6
PRIDEiQ9H2D6
ProteomicsDBi23821
29844
80531 [Q9H2D6-1]
80532 [Q9H2D6-2]
80533 [Q9H2D6-3]
80534 [Q9H2D6-4]
80535 [Q9H2D6-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
288 111 antibodies

The DNASU plasmid repository

More...
DNASUi
11078

Genome annotation databases

EnsembliENST00000403663; ENSP00000386026; ENSG00000100106 [Q9H2D6-7]
ENST00000407319; ENSP00000383913; ENSG00000100106 [Q9H2D6-6]
ENST00000644935; ENSP00000496394; ENSG00000100106 [Q9H2D6-1]
GeneIDi11078
KEGGihsa:11078
UCSCiuc003atr.4 human [Q9H2D6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
11078
DisGeNETi11078
EuPathDBiHostDB:ENSG00000100106.19

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TRIOBP
GeneReviewsiTRIOBP
HGNCiHGNC:17009 TRIOBP
HPAiENSG00000100106 Low tissue specificity
MalaCardsiTRIOBP
MIMi609761 gene
609823 phenotype
neXtProtiNX_Q9H2D6
OpenTargetsiENSG00000100106
Orphaneti90636 Autosomal recessive non-syndromic sensorineural deafness type DFNB
PharmGKBiPA142670699

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4807 Eukaryota
ENOG410ZA8F LUCA
GeneTreeiENSGT00940000157340
HOGENOMiCLU_231134_0_0_1
InParanoidiQ9H2D6
KOiK23751
OMAiCAQRDDP
OrthoDBi428862at2759
PhylomeDBiQ9H2D6
TreeFamiTF343361

Enzyme and pathway databases

SIGNORiQ9H2D6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
11078 5 hits in 790 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TRIOBP human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TRIOBP

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
11078
PharosiQ9H2D6 Tbio

Protein Ontology

More...
PROi
PR:Q9H2D6
RNActiQ9H2D6 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000100106 Expressed in upper lobe of lung and 231 other tissues
ExpressionAtlasiQ9H2D6 baseline and differential
GenevisibleiQ9H2D6 HS

Family and domain databases

CDDicd13275 PH_M-RIP, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR039597 M-RIP_PH
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTARA_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H2D6
Secondary accession number(s): B1AHD4
, B1AHD7, F2Z2W0, F8W6V6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: March 21, 2006
Last modified: June 17, 2020
This is version 178 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
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