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UniProtKB - Q9H2D6 (TARA_HUMAN)

Protein

TRIO and F-actin-binding protein

Gene

TRIOBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May regulate actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin. The localized formation of TARA and TRIO complexes coordinates the amount of F-actin present in stress fibers. May also serve as a linker protein to recruit proteins required for F-actin formation and turnover.1 Publication

Miscellaneous

Has been identified in PubMed:9853615 by a selection system for genes encoding nuclear-targeted protein.

GO - Molecular functioni

  • actin filament binding Source: MGI
  • GTP-Rho binding Source: UniProtKB
  • myosin II binding Source: UniProtKB
  • ubiquitin protein ligase binding Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionActin-binding
Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

SIGNORiQ9H2D6

Names & Taxonomyi

Protein namesi
Recommended name:
TRIO and F-actin-binding protein
Alternative name(s):
Protein Tara
Trio-associated repeat on actin
Gene namesi
Name:TRIOBP
Synonyms:KIAA1662, TARA
ORF Names:HRIHFB2122
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000100106.19
HGNCiHGNC:17009 TRIOBP
MIMi609761 gene
neXtProtiNX_Q9H2D6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Involvement in diseasei

Deafness, autosomal recessive, 28 (DFNB28)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
See also OMIM:609823
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0257191019G → R in DFNB28. 1 Publication1

Keywords - Diseasei

Deafness, Disease mutation, Non-syndromic deafness

Organism-specific databases

DisGeNETi11078
GeneReviewsiTRIOBP
MalaCardsiTRIOBP
MIMi609823 phenotype
OpenTargetsiENSG00000100106
Orphaneti90636 Autosomal recessive non-syndromic sensorineural deafness type DFNB
PharmGKBiPA142670699

Polymorphism and mutation databases

BioMutaiTRIOBP
DMDMi90110075

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000724331 – 2365TRIO and F-actin-binding proteinAdd BLAST2365

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1796PhosphoserineCombined sources1
Modified residuei1930Omega-N-methylarginineBy similarity1
Modified residuei1949PhosphoserineCombined sources1
Modified residuei1955PhosphoserineCombined sources1
Isoform 1 (identifier: Q9H2D6-5)
Modified residuei457Phosphothreonine1 Publication1

Post-translational modificationi

Ubiquitinated by HECTD3, leading to its degradation by the proteasome.1 Publication
Isoform 1: Phosphorylation at Thr-457 by PLK1 ensures mitotic progression and is essential for accurate chromosome segregation.1 Publication

Keywords - PTMi

Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9H2D6
MaxQBiQ9H2D6
PaxDbiQ9H2D6
PeptideAtlasiQ9H2D6
PRIDEiQ9H2D6
ProteomicsDBi80531
80532 [Q9H2D6-2]
80533 [Q9H2D6-3]
80534 [Q9H2D6-4]
80535 [Q9H2D6-5]

PTM databases

iPTMnetiQ9H2D6
PhosphoSitePlusiQ9H2D6

Expressioni

Tissue specificityi

Widely expressed. Highly expressed in heart and placenta. Isoform 3 is expressed in fetal brain, retina and cochlea but is not detectable in the other tissues.1 Publication

Gene expression databases

BgeeiENSG00000100106 Expressed in 232 organ(s), highest expression level in upper lobe of lung
ExpressionAtlasiQ9H2D6 baseline and differential
GenevisibleiQ9H2D6 HS

Organism-specific databases

HPAiHPA003747
HPA019769

Interactioni

Subunit structurei

Binds to TRIO and F-actin. May also interact with myosin II. Interacts with HECTD3.1 Publication

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi116261, 41 interactors
IntActiQ9H2D6, 33 interactors
STRINGi9606.ENSP00000384312

Structurei

3D structure databases

ProteinModelPortaliQ9H2D6
SMRiQ9H2D6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1778 – 1887PHPROSITE-ProRule annotationAdd BLAST110

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili2062 – 2247Sequence analysisAdd BLAST186
Coiled coili2281 – 2361Sequence analysisAdd BLAST81

Domaini

Contains at least 2 actin-binding sites per coiled-coil dimer.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4807 Eukaryota
ENOG410ZA8F LUCA
GeneTreeiENSGT00530000063678
HOVERGENiHBG094025
InParanoidiQ9H2D6
OMAiPDDTSNS
OrthoDBiEOG091G02PB
PhylomeDBiQ9H2D6
TreeFamiTF343361

Family and domain databases

CDDicd13275 PH_M-RIP, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR039597 M-RIP_PH
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR029908 Tara
PANTHERiPTHR17271:SF10 PTHR17271:SF10, 6 hits
PfamiView protein in Pfam
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit

Sequences (7+)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 2 (identifier: Q9H2D6-1) [UniParc]FASTAAdd to basket
Also known as: TRIOBP-6

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEEVPGDALC EHFEANILTQ NRCQNCFHPE EAHGARYQEL RSPSGAEVPY 
        60         70         80         90        100
CDLPRCPPAP EDPLSASTSG CQSVVDPGLR PGPKRGPSPS AGLPEEGPTA 
       110        120        130        140        150
APRSRSRELE AVPYLEGLTT SLCGSCNEDP GSDPTSSPDS ATPDDTSNSS 
       160        170        180        190        200
SVDWDTVERQ EEEAPSWDEL AVMIPRRPRE GPRADSSQRA PSLLTRSPVG 
       210        220        230        240        250
GDAAGQKKED TGGGGRSAGQ HWARLRGESG LSLERHRSTL TQASSMTPHS 
       260        270        280        290        300
GPRSTTSQAS PAQRDTAQAA STREIPRASS PHRITQRDTS RASSTQQEIS 
       310        320        330        340        350
RASSTQQETS RASSTQEDTP RASSTQEDTP RASSTQWNTP RASSPSRSTQ 
       360        370        380        390        400
LDNPRTSSTQ QDNPQTSFPT CTPQRENPRT PCVQQDDPRA SSPNRTTQRE 
       410        420        430        440        450
NSRTSCAQRD NPKASRTSSP NRATRDNPRT SCAQRDNPRA SSPSRATRDN 
       460        470        480        490        500
PTTSCAQRDN PRASRTSSPN RATRDNPRTS CAQRDNPRAS SPSRATRDNP 
       510        520        530        540        550
TTSCAQRDNP RASRTSSPNR ATRDNPRTSC AQRDNPRASS PNRAARDNPT 
       560        570        580        590        600
TSCAQRDNPR ASRTSSPNRA TRDNPRTSCA QRDNPRASSP NRATRDNPTT 
       610        620        630        640        650
SCAQRDNPRA SRTSSPNRAT RDNPRTSCAQ RDNPRASSPN RTTQQDSPRT 
       660        670        680        690        700
SCARRDDPRA SSPNRTIQQE NPRTSCALRD NPRASSPSRT IQQENPRTSC 
       710        720        730        740        750
AQRDDPRASS PNRTTQQENP RTSCARRDNP RASSRNRTIQ RDNPRTSCAQ 
       760        770        780        790        800
RDNPRASSPN RTIQQENLRT SCTRQDNPRT SSPNRATRDN PRTSCAQRDN 
       810        820        830        840        850
LRASSPIRAT QQDNPRTCIQ QNIPRSSSTQ QDNPKTSCTK RDNLRPTCTQ 
       860        870        880        890        900
RDRTQSFSFQ RDNPGTSSSQ CCTQKENLRP SSPHRSTQWN NPRNSSPHRT 
       910        920        930        940        950
NKDIPWASFP LRPTQSDGPR TSSPSRSKQS EVPWASIALR PTQGDRPQTS 
       960        970        980        990       1000
SPSRPAQHDP PQSSFGPTQY NLPSRATSSS HNPGHQSTSR TSSPVYPAAY 
      1010       1020       1030       1040       1050
GAPLTSPEPS QPPCAVCIGH RDAPRASSPP RYLQHDPFPF FPEPRAPESE 
      1060       1070       1080       1090       1100
PPHHEPPYIP PAVCIGHRDA PRASSPPRHT QFDPFPFLPD TSDAEHQCQS 
      1110       1120       1130       1140       1150
PQHEPLQLPA PVCIGYRDAP RASSPPRQAP EPSLLFQDLP RASTESLVPS 
      1160       1170       1180       1190       1200
MDSLHECPHI PTPVCIGHRD APSFSSPPRQ APEPSLFFQD PPGTSMESLA 
      1210       1220       1230       1240       1250
PSTDSLHGSP VLIPQVCIGH RDAPRASSPP RHPPSDLAFL APSPSPGSSG 
      1260       1270       1280       1290       1300
GSRGSAPPGE TRHNLEREEY TVLADLPPPR RLAQRQPGPQ AQCSSGGRTH 
      1310       1320       1330       1340       1350
SPGRAEVERL FGQERRKSEA AGAFQAQDEG RSQQPSQGQS QLLRRQSSPA 
      1360       1370       1380       1390       1400
PSRQVTMLPA KQAELTRRSQ AEPPHPWSPE KRPEGDRQLQ GSPLPPRTSA 
      1410       1420       1430       1440       1450
RTPERELRTQ RPLESGQAGP RQPLGVWQSQ EEPPGSQGPH RHLERSWSSQ 
      1460       1470       1480       1490       1500
EGGLGPGGWW GCGEPSLGAA KAPEGAWGGT SREYKESWGQ PEAWEEKPTH 
      1510       1520       1530       1540       1550
ELPRELGKRS PLTSPPENWG GPAESSQSWH SGTPTAVGWG AEGACPYPRG 
      1560       1570       1580       1590       1600
SERRPELDWR DLLGLLRAPG EGVWARVPSL DWEGLLELLQ ARLPRKDPAG 
      1610       1620       1630       1640       1650
HRDDLARALG PELGPPGTND VPEQESHSQP EGWAEATPVN GHSPALQSQS 
      1660       1670       1680       1690       1700
PVQLPSPACT STQWPKIKVT RGPATATLAG LEQTGPLGSR STAKGPSLPE 
      1710       1720       1730       1740       1750
LQFQPEEPEE SEPSRGQDPL TDQKQADSAD KRPAEGKAGS PLKGRLVTSW 
      1760       1770       1780       1790       1800
RMPGDRPTLF NPFLLSLGVL RWRRPDLLNF KKGWMSILDE PGEPPSPSLT 
      1810       1820       1830       1840       1850
TTSTSQWKKH WFVLTDSSLK YYRDSTAEEA DELDGEIDLR SCTDVTEYAV 
      1860       1870       1880       1890       1900
QRNYGFQIHT KDAVYTLSAM TSGIRRNWIE ALRKTVRPTS APDVTKLSDS 
      1910       1920       1930       1940       1950
NKENALHSYS TQKGPLKAGE QRAGSEVISR GGPRKADGQR QALDYVELSP 
      1960       1970       1980       1990       2000
LTQASPQRAR TPARTPDRLA KQEELERDLA QRSEERRKWF EATDSRTPEV 
      2010       2020       2030       2040       2050
PAGEGPRRGL GAPLTEDQQN RLSEEIEKKW QELEKLPLRE NKRVPLTALL 
      2060       2070       2080       2090       2100
NQSRGERRGP PSDGHEALEK EVQALRAQLE AWRLQGEAPQ SALRSQEDGH 
      2110       2120       2130       2140       2150
IPPGYISQEA CERSLAEMES SHQQVMEELQ RHHERELQRL QQEKEWLLAE 
      2160       2170       2180       2190       2200
ETAATASAIE AMKKAYQEEL SRELSKTRSL QQGPDGLRKQ HQSDVEALKR 
      2210       2220       2230       2240       2250
ELQVLSEQYS QKCLEIGALM RQAEEREHTL RRCQQEGQEL LRHNQELHGR 
      2260       2270       2280       2290       2300
LSEEIDQLRG FIASQGMGNG CGRSNERSSC ELEVLLRVKE NELQYLKKEV 
      2310       2320       2330       2340       2350
QCLRDELQMM QKDKRFTSGK YQDVYVELSH IKTRSEREIE QLKEHLRLAM 
      2360 
AALQEKESMR NSLAE
Length:2,365
Mass (Da):261,376
Last modified:March 21, 2006 - v3
Checksum:iB2CF9AD57E930283
GO
Isoform 3 (identifier: Q9H2D6-2) [UniParc]FASTAAdd to basket
Also known as: Long isoform

The sequence of this isoform differs from the canonical sequence as follows:
     1317-1355: Missing.
     1729-1774: Missing.
     1794-1806: Missing.

Show »
Length:2,267
Mass (Da):250,724
Checksum:iA0055359F5C3D655
GO
Isoform 4 (identifier: Q9H2D6-3) [UniParc]FASTAAdd to basket
Also known as: TRIOBP-3

The sequence of this isoform differs from the canonical sequence as follows:
     1-172: Missing.

Show »
Length:2,193
Mass (Da):243,071
Checksum:i2056F789C0E11E01
GO
Isoform 5 (identifier: Q9H2D6-4) [UniParc]FASTAAdd to basket
Also known as: TRIOBP-4

The sequence of this isoform differs from the canonical sequence as follows:
     1-172: Missing.
     1317-2365: Missing.

Show »
Length:1,144
Mass (Da):125,524
Checksum:i90E403C1C0B946FD
GO
Isoform 1 (identifier: Q9H2D6-5) [UniParc]FASTAAdd to basket
Also known as: TRIOBP-1

The sequence of this isoform differs from the canonical sequence as follows:
     1-1772: Missing.
     1773-1774: RR → MT

Show »
Length:593
Mass (Da):68,041
Checksum:i109AA7D9CC10B21A
GO
Isoform 6 (identifier: Q9H2D6-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: MEEVPGDALC...DLPRCPPAPE → MGGWKGPGQR...LPPPWGAAMT
     62-1774: Missing.
     2109-2144: EACERSLAEMESSHQQVMEELQRHHERELQRLQQEK → LVGVITVPVLQTRPLSSERLCDLPKVTPPAGLKGGI
     2145-2365: Missing.

Note: No experimental confirmation available.
Show »
Length:431
Mass (Da):47,624
Checksum:i499617230FA5DAC3
GO
Isoform 7 (identifier: Q9H2D6-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: MEEVPGDALC...DLPRCPPAPE → MGGWKGPGQR...LPPPWGAAMT
     62-1774: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:652
Mass (Da):74,048
Checksum:i2B3B90A23A047212
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6TR96F6TR96_HUMAN
TRIO and F-actin-binding protein
TRIOBP
265Annotation score:
F6WYE2F6WYE2_HUMAN
TRIO and F-actin-binding protein
TRIOBP
256Annotation score:
F6WMF4F6WMF4_HUMAN
TRIO and F-actin-binding protein
TRIOBP
83Annotation score:
H0Y5J9H0Y5J9_HUMAN
TRIO and F-actin-binding protein
TRIOBP
311Annotation score:
H7BXW4H7BXW4_HUMAN
TRIO and F-actin-binding protein
TRIOBP
104Annotation score:
H0Y5T8H0Y5T8_HUMAN
TRIO and F-actin-binding protein
TRIOBP
102Annotation score:

Sequence cautioni

The sequence BAA34800 differs from that shown. Reason: Frameshift at position 478.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti713 – 719RTTQQEN → KSTFGCL in BAB33332 (PubMed:11258795).Curated7
Sequence conflicti1421R → S in ABB77204 (PubMed:16385458).Curated1
Sequence conflicti1689S → G in ABB77204 (PubMed:16385458).Curated1
Sequence conflicti1896Missing in ABB77204 (PubMed:16385458).Curated1
Sequence conflicti1904N → D in ABB77204 (PubMed:16385458).Curated1
Sequence conflicti2114S → T in AAG44841 (PubMed:11148140).Curated1
Sequence conflicti2141Q → L in AAH04303 (PubMed:15489334).Curated1
Sequence conflicti2274S → T in AAG44841 (PubMed:11148140).Curated1
Sequence conflicti2283E → EHLYPQ in AAH04303 (PubMed:15489334).Curated1
Sequence conflicti2359M → I in AAG44841 (PubMed:11148140).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059725217S → N. Corresponds to variant dbSNP:rs12628603EnsemblClinVar.1
Natural variantiVAR_059726493S → N. Corresponds to variant dbSNP:rs4821700EnsemblClinVar.1
Natural variantiVAR_061708817T → S. Corresponds to variant dbSNP:rs41302575Ensembl.1
Natural variantiVAR_051412863N → K. Corresponds to variant dbSNP:rs9610841EnsemblClinVar.1
Natural variantiVAR_0257191019G → R in DFNB28. 1 Publication1
Natural variantiVAR_0597271187F → L. Corresponds to variant dbSNP:rs5756795EnsemblClinVar.1
Natural variantiVAR_0597281300H → R. Corresponds to variant dbSNP:rs739138EnsemblClinVar.1
Natural variantiVAR_0514131372E → D. Corresponds to variant dbSNP:rs8140207EnsemblClinVar.1
Natural variantiVAR_0514141377W → R2 PublicationsCorresponds to variant dbSNP:rs8140958EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0177111 – 1772Missing in isoform 1. 2 PublicationsAdd BLAST1772
Alternative sequenceiVSP_0177121 – 172Missing in isoform 4 and isoform 5. 1 PublicationAdd BLAST172
Alternative sequenceiVSP_0474981 – 61MEEVP…PPAPE → MGGWKGPGQRRGKEGPEARR RAAERGGGGGGGGVPAPRSP AREPRPRSCLLLPPPWGAAM T in isoform 6 and isoform 7. 1 PublicationAdd BLAST61
Alternative sequenceiVSP_04749962 – 1774Missing in isoform 6 and isoform 7. 1 PublicationAdd BLAST1713
Alternative sequenceiVSP_0177131317 – 2365Missing in isoform 5. 1 PublicationAdd BLAST1049
Alternative sequenceiVSP_0177141317 – 1355Missing in isoform 3. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_0177151729 – 1774Missing in isoform 3. 1 PublicationAdd BLAST46
Alternative sequenceiVSP_0177161773 – 1774RR → MT in isoform 1. 2 Publications2
Alternative sequenceiVSP_0177171794 – 1806Missing in isoform 3. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_0475002109 – 2144EACER…LQQEK → LVGVITVPVLQTRPLSSERL CDLPKVTPPAGLKGGI in isoform 6. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_0475012145 – 2365Missing in isoform 6. 1 PublicationAdd BLAST221

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF281030 mRNA Translation: AAG44841.1
DQ228003 mRNA Translation: ABB59559.1
DQ228004 mRNA Translation: ABB59560.1
DQ228005 mRNA Translation: ABB59561.1
DQ278603 mRNA Translation: ABB77204.1
Z83844 Genomic DNA No translation available.
BC003618 mRNA Translation: AAH03618.1
BC004303 mRNA Translation: AAH04303.1
BC013278 mRNA Translation: AAH13278.2
BC022200 mRNA No translation available.
AB015343 mRNA Translation: BAA34800.1 Frameshift.
AB051449 mRNA Translation: BAB33332.2
CCDSiCCDS33644.1 [Q9H2D6-6]
CCDS43015.1 [Q9H2D6-1]
CCDS43016.1 [Q9H2D6-7]
RefSeqiNP_001034230.1, NM_001039141.2 [Q9H2D6-1]
NP_008963.3, NM_007032.5 [Q9H2D6-7]
NP_619538.2, NM_138632.2 [Q9H2D6-6]
UniGeneiHs.533030

Genome annotation databases

EnsembliENST00000403663; ENSP00000386026; ENSG00000100106 [Q9H2D6-7]
ENST00000406386; ENSP00000384312; ENSG00000100106 [Q9H2D6-1]
ENST00000407319; ENSP00000383913; ENSG00000100106 [Q9H2D6-6]
ENST00000644935; ENSP00000496394; ENSG00000100106 [Q9H2D6-1]
ENST00000646328; ENSP00000495322; ENSG00000100106 [Q9H2D6-6]
GeneIDi11078
KEGGihsa:11078
UCSCiuc003atr.4 human [Q9H2D6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF281030 mRNA Translation: AAG44841.1
DQ228003 mRNA Translation: ABB59559.1
DQ228004 mRNA Translation: ABB59560.1
DQ228005 mRNA Translation: ABB59561.1
DQ278603 mRNA Translation: ABB77204.1
Z83844 Genomic DNA No translation available.
BC003618 mRNA Translation: AAH03618.1
BC004303 mRNA Translation: AAH04303.1
BC013278 mRNA Translation: AAH13278.2
BC022200 mRNA No translation available.
AB015343 mRNA Translation: BAA34800.1 Frameshift.
AB051449 mRNA Translation: BAB33332.2
CCDSiCCDS33644.1 [Q9H2D6-6]
CCDS43015.1 [Q9H2D6-1]
CCDS43016.1 [Q9H2D6-7]
RefSeqiNP_001034230.1, NM_001039141.2 [Q9H2D6-1]
NP_008963.3, NM_007032.5 [Q9H2D6-7]
NP_619538.2, NM_138632.2 [Q9H2D6-6]
UniGeneiHs.533030

3D structure databases

ProteinModelPortaliQ9H2D6
SMRiQ9H2D6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116261, 41 interactors
IntActiQ9H2D6, 33 interactors
STRINGi9606.ENSP00000384312

PTM databases

iPTMnetiQ9H2D6
PhosphoSitePlusiQ9H2D6

Polymorphism and mutation databases

BioMutaiTRIOBP
DMDMi90110075

Proteomic databases

EPDiQ9H2D6
MaxQBiQ9H2D6
PaxDbiQ9H2D6
PeptideAtlasiQ9H2D6
PRIDEiQ9H2D6
ProteomicsDBi80531
80532 [Q9H2D6-2]
80533 [Q9H2D6-3]
80534 [Q9H2D6-4]
80535 [Q9H2D6-5]

Protocols and materials databases

DNASUi11078
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000403663; ENSP00000386026; ENSG00000100106 [Q9H2D6-7]
ENST00000406386; ENSP00000384312; ENSG00000100106 [Q9H2D6-1]
ENST00000407319; ENSP00000383913; ENSG00000100106 [Q9H2D6-6]
ENST00000644935; ENSP00000496394; ENSG00000100106 [Q9H2D6-1]
ENST00000646328; ENSP00000495322; ENSG00000100106 [Q9H2D6-6]
GeneIDi11078
KEGGihsa:11078
UCSCiuc003atr.4 human [Q9H2D6-1]

Organism-specific databases

CTDi11078
DisGeNETi11078
EuPathDBiHostDB:ENSG00000100106.19
GeneCardsiTRIOBP
GeneReviewsiTRIOBP
HGNCiHGNC:17009 TRIOBP
HPAiHPA003747
HPA019769
MalaCardsiTRIOBP
MIMi609761 gene
609823 phenotype
neXtProtiNX_Q9H2D6
OpenTargetsiENSG00000100106
Orphaneti90636 Autosomal recessive non-syndromic sensorineural deafness type DFNB
PharmGKBiPA142670699
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4807 Eukaryota
ENOG410ZA8F LUCA
GeneTreeiENSGT00530000063678
HOVERGENiHBG094025
InParanoidiQ9H2D6
OMAiPDDTSNS
OrthoDBiEOG091G02PB
PhylomeDBiQ9H2D6
TreeFamiTF343361

Enzyme and pathway databases

SIGNORiQ9H2D6

Miscellaneous databases

ChiTaRSiTRIOBP human
GeneWikiiTRIOBP
GenomeRNAii11078
PROiPR:Q9H2D6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100106 Expressed in 232 organ(s), highest expression level in upper lobe of lung
ExpressionAtlasiQ9H2D6 baseline and differential
GenevisibleiQ9H2D6 HS

Family and domain databases

CDDicd13275 PH_M-RIP, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR039597 M-RIP_PH
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR029908 Tara
PANTHERiPTHR17271:SF10 PTHR17271:SF10, 6 hits
PfamiView protein in Pfam
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTARA_HUMAN
AccessioniPrimary (citable) accession number: Q9H2D6
Secondary accession number(s): B1AHD4
, B1AHD7, F2Z2W0, F8W6V6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: March 21, 2006
Last modified: November 7, 2018
This is version 166 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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