UniProtKB - Q9H2D6 (TARA_HUMAN)
TRIO and F-actin-binding protein
TRIOBP
Functioni
May regulate actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin. The localized formation of TARA and TRIO complexes coordinates the amount of F-actin present in stress fibers. May also serve as a linker protein to recruit proteins required for F-actin formation and turnover.
1 PublicationMiscellaneous
GO - Molecular functioni
- actin filament binding Source: MGI
- myosin II binding Source: UniProtKB
- small GTPase binding Source: UniProtKB
- ubiquitin protein ligase binding Source: UniProtKB
GO - Biological processi
- actin filament organization Source: GO_Central
- actin modification Source: UniProtKB
- auditory receptor cell stereocilium organization Source: Ensembl
- barbed-end actin filament capping Source: UniProtKB
- cell cycle Source: UniProtKB-KW
- cell division Source: UniProtKB-KW
- positive regulation of substrate adhesion-dependent cell spreading Source: MGI
- sensory perception of sound Source: Ensembl
Keywordsi
Molecular function | Actin-binding |
Biological process | Cell cycle, Cell division, Mitosis |
Enzyme and pathway databases
PathwayCommonsi | Q9H2D6 |
Reactomei | R-HSA-9662360, Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662361, Sensory processing of sound by outer hair cells of the cochlea |
SignaLinki | Q9H2D6 |
SIGNORi | Q9H2D6 |
Names & Taxonomyi
Protein namesi | Recommended name: TRIO and F-actin-binding proteinAlternative name(s): Protein Tara Trio-associated repeat on actin |
Gene namesi | Name:TRIOBP Synonyms:KIAA1662, TARA ORF Names:HRIHFB2122 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17009, TRIOBP |
MIMi | 609761, gene |
neXtProti | NX_Q9H2D6 |
VEuPathDBi | HostDB:ENSG00000100106 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Cytoskeleton
- cytoskeleton 1 Publication
Note: Localized to F-actin in a periodic pattern.1 Publication
Nucleus
- Nucleus 1 Publication
Cytoskeleton
- centrosome 1 Publication
Other locations
- Midbody 1 Publication
Note: Centrosomal localization occurs upon phosphorylation by PLK1 at Thr-457 and lasts from prophase to anaphase. At telophase, relocalizes to midbody.1 Publication
Cytoskeleton
- actin cytoskeleton Source: MGI
- microtubule organizing center Source: UniProtKB-SubCell
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: UniProtKB-KW
- focal adhesion Source: UniProtKB
- midbody Source: UniProtKB-SubCell
- stereocilium base Source: Ensembl
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, NucleusPathology & Biotechi
Involvement in diseasei
Deafness, autosomal recessive, 28 (DFNB28)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_025719 | 1019 | G → R in DFNB28. 1 PublicationCorresponds to variant dbSNP:rs549095193EnsemblClinVar. | 1 |
Keywords - Diseasei
Deafness, Disease variant, Non-syndromic deafnessOrganism-specific databases
DisGeNETi | 11078 |
GeneReviewsi | TRIOBP |
MalaCardsi | TRIOBP |
MIMi | 609823, phenotype |
OpenTargetsi | ENSG00000100106 |
Orphaneti | 90636, Autosomal recessive non-syndromic sensorineural deafness type DFNB |
PharmGKBi | PA142670699 |
Miscellaneous databases
Pharosi | Q9H2D6, Tbio |
Genetic variation databases
BioMutai | TRIOBP |
DMDMi | 90110075 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000072433 | 1 – 2365 | TRIO and F-actin-binding proteinAdd BLAST | 2365 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 1796 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1930 | Omega-N-methylarginineBy similarity | 1 | ||
Modified residuei | 1949 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1955 | PhosphoserineCombined sources | 1 | ||
Isoform 1 (identifier: Q9H2D6-5) | |||||
Modified residuei | 457 | Phosphothreonine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9H2D6 |
jPOSTi | Q9H2D6 |
MassIVEi | Q9H2D6 |
MaxQBi | Q9H2D6 |
PaxDbi | Q9H2D6 |
PeptideAtlasi | Q9H2D6 |
PRIDEi | Q9H2D6 |
ProteomicsDBi | 23821 29844 80531 [Q9H2D6-1] 80532 [Q9H2D6-2] 80533 [Q9H2D6-3] 80534 [Q9H2D6-4] 80535 [Q9H2D6-5] |
PTM databases
iPTMneti | Q9H2D6 |
PhosphoSitePlusi | Q9H2D6 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000100106, Expressed in upper lobe of lung and 245 other tissues |
ExpressionAtlasi | Q9H2D6, baseline and differential |
Genevisiblei | Q9H2D6, HS |
Organism-specific databases
HPAi | ENSG00000100106, Low tissue specificity |
Interactioni
Subunit structurei
GO - Molecular functioni
- actin filament binding Source: MGI
- myosin II binding Source: UniProtKB
- small GTPase binding Source: UniProtKB
- ubiquitin protein ligase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 116261, 107 interactors |
IntActi | Q9H2D6, 56 interactors |
MINTi | Q9H2D6 |
STRINGi | 9606.ENSP00000384312 |
Miscellaneous databases
RNActi | Q9H2D6, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1778 – 1887 | PHPROSITE-ProRule annotationAdd BLAST | 110 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 48 – 1106 | DisorderedSequence analysisAdd BLAST | 1059 | |
Regioni | 1168 – 1554 | DisorderedSequence analysisAdd BLAST | 387 | |
Regioni | 1593 – 1667 | DisorderedSequence analysisAdd BLAST | 75 | |
Regioni | 1679 – 1751 | DisorderedSequence analysisAdd BLAST | 73 | |
Regioni | 1889 – 2017 | DisorderedSequence analysisAdd BLAST | 129 | |
Regioni | 2174 – 2194 | DisorderedSequence analysisAdd BLAST | 21 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 2062 – 2247 | Sequence analysisAdd BLAST | 186 | |
Coiled coili | 2281 – 2361 | Sequence analysisAdd BLAST | 81 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 120 – 154 | Polar residuesSequence analysisAdd BLAST | 35 | |
Compositional biasi | 234 – 649 | Polar residuesSequence analysisAdd BLAST | 416 | |
Compositional biasi | 662 – 723 | Polar residuesSequence analysisAdd BLAST | 62 | |
Compositional biasi | 736 – 902 | Polar residuesSequence analysisAdd BLAST | 167 | |
Compositional biasi | 914 – 932 | Polar residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 942 – 995 | Polar residuesSequence analysisAdd BLAST | 54 | |
Compositional biasi | 1191 – 1209 | Polar residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 1260 – 1274 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1302 – 1316 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1327 – 1355 | Polar residuesSequence analysisAdd BLAST | 29 | |
Compositional biasi | 1488 – 1507 | Basic and acidic residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 1519 – 1534 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 1594 – 1608 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1641 – 1667 | Polar residuesSequence analysisAdd BLAST | 27 | |
Compositional biasi | 1682 – 1698 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 1724 – 1738 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1891 – 1915 | Polar residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 1946 – 1960 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1964 – 1994 | Basic and acidic residuesSequence analysisAdd BLAST | 31 |
Domaini
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG4807, Eukaryota |
GeneTreei | ENSGT00940000157340 |
HOGENOMi | CLU_231134_0_0_1 |
InParanoidi | Q9H2D6 |
OMAi | QRDNPGT |
OrthoDBi | 428862at2759 |
PhylomeDBi | Q9H2D6 |
TreeFami | TF343361 |
Family and domain databases
CDDi | cd13275, PH_M-RIP, 1 hit |
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR039597, M-RIP_PH IPR011993, PH-like_dom_sf IPR001849, PH_domain |
Pfami | View protein in Pfam PF00169, PH, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit |
PROSITEi | View protein in PROSITE PS50003, PH_DOMAIN, 1 hit |
s (7+)i Sequence
Sequence statusi: Complete.
This entry describes 7 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 7 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEEVPGDALC EHFEANILTQ NRCQNCFHPE EAHGARYQEL RSPSGAEVPY
60 70 80 90 100
CDLPRCPPAP EDPLSASTSG CQSVVDPGLR PGPKRGPSPS AGLPEEGPTA
110 120 130 140 150
APRSRSRELE AVPYLEGLTT SLCGSCNEDP GSDPTSSPDS ATPDDTSNSS
160 170 180 190 200
SVDWDTVERQ EEEAPSWDEL AVMIPRRPRE GPRADSSQRA PSLLTRSPVG
210 220 230 240 250
GDAAGQKKED TGGGGRSAGQ HWARLRGESG LSLERHRSTL TQASSMTPHS
260 270 280 290 300
GPRSTTSQAS PAQRDTAQAA STREIPRASS PHRITQRDTS RASSTQQEIS
310 320 330 340 350
RASSTQQETS RASSTQEDTP RASSTQEDTP RASSTQWNTP RASSPSRSTQ
360 370 380 390 400
LDNPRTSSTQ QDNPQTSFPT CTPQRENPRT PCVQQDDPRA SSPNRTTQRE
410 420 430 440 450
NSRTSCAQRD NPKASRTSSP NRATRDNPRT SCAQRDNPRA SSPSRATRDN
460 470 480 490 500
PTTSCAQRDN PRASRTSSPN RATRDNPRTS CAQRDNPRAS SPSRATRDNP
510 520 530 540 550
TTSCAQRDNP RASRTSSPNR ATRDNPRTSC AQRDNPRASS PNRAARDNPT
560 570 580 590 600
TSCAQRDNPR ASRTSSPNRA TRDNPRTSCA QRDNPRASSP NRATRDNPTT
610 620 630 640 650
SCAQRDNPRA SRTSSPNRAT RDNPRTSCAQ RDNPRASSPN RTTQQDSPRT
660 670 680 690 700
SCARRDDPRA SSPNRTIQQE NPRTSCALRD NPRASSPSRT IQQENPRTSC
710 720 730 740 750
AQRDDPRASS PNRTTQQENP RTSCARRDNP RASSRNRTIQ RDNPRTSCAQ
760 770 780 790 800
RDNPRASSPN RTIQQENLRT SCTRQDNPRT SSPNRATRDN PRTSCAQRDN
810 820 830 840 850
LRASSPIRAT QQDNPRTCIQ QNIPRSSSTQ QDNPKTSCTK RDNLRPTCTQ
860 870 880 890 900
RDRTQSFSFQ RDNPGTSSSQ CCTQKENLRP SSPHRSTQWN NPRNSSPHRT
910 920 930 940 950
NKDIPWASFP LRPTQSDGPR TSSPSRSKQS EVPWASIALR PTQGDRPQTS
960 970 980 990 1000
SPSRPAQHDP PQSSFGPTQY NLPSRATSSS HNPGHQSTSR TSSPVYPAAY
1010 1020 1030 1040 1050
GAPLTSPEPS QPPCAVCIGH RDAPRASSPP RYLQHDPFPF FPEPRAPESE
1060 1070 1080 1090 1100
PPHHEPPYIP PAVCIGHRDA PRASSPPRHT QFDPFPFLPD TSDAEHQCQS
1110 1120 1130 1140 1150
PQHEPLQLPA PVCIGYRDAP RASSPPRQAP EPSLLFQDLP RASTESLVPS
1160 1170 1180 1190 1200
MDSLHECPHI PTPVCIGHRD APSFSSPPRQ APEPSLFFQD PPGTSMESLA
1210 1220 1230 1240 1250
PSTDSLHGSP VLIPQVCIGH RDAPRASSPP RHPPSDLAFL APSPSPGSSG
1260 1270 1280 1290 1300
GSRGSAPPGE TRHNLEREEY TVLADLPPPR RLAQRQPGPQ AQCSSGGRTH
1310 1320 1330 1340 1350
SPGRAEVERL FGQERRKSEA AGAFQAQDEG RSQQPSQGQS QLLRRQSSPA
1360 1370 1380 1390 1400
PSRQVTMLPA KQAELTRRSQ AEPPHPWSPE KRPEGDRQLQ GSPLPPRTSA
1410 1420 1430 1440 1450
RTPERELRTQ RPLESGQAGP RQPLGVWQSQ EEPPGSQGPH RHLERSWSSQ
1460 1470 1480 1490 1500
EGGLGPGGWW GCGEPSLGAA KAPEGAWGGT SREYKESWGQ PEAWEEKPTH
1510 1520 1530 1540 1550
ELPRELGKRS PLTSPPENWG GPAESSQSWH SGTPTAVGWG AEGACPYPRG
1560 1570 1580 1590 1600
SERRPELDWR DLLGLLRAPG EGVWARVPSL DWEGLLELLQ ARLPRKDPAG
1610 1620 1630 1640 1650
HRDDLARALG PELGPPGTND VPEQESHSQP EGWAEATPVN GHSPALQSQS
1660 1670 1680 1690 1700
PVQLPSPACT STQWPKIKVT RGPATATLAG LEQTGPLGSR STAKGPSLPE
1710 1720 1730 1740 1750
LQFQPEEPEE SEPSRGQDPL TDQKQADSAD KRPAEGKAGS PLKGRLVTSW
1760 1770 1780 1790 1800
RMPGDRPTLF NPFLLSLGVL RWRRPDLLNF KKGWMSILDE PGEPPSPSLT
1810 1820 1830 1840 1850
TTSTSQWKKH WFVLTDSSLK YYRDSTAEEA DELDGEIDLR SCTDVTEYAV
1860 1870 1880 1890 1900
QRNYGFQIHT KDAVYTLSAM TSGIRRNWIE ALRKTVRPTS APDVTKLSDS
1910 1920 1930 1940 1950
NKENALHSYS TQKGPLKAGE QRAGSEVISR GGPRKADGQR QALDYVELSP
1960 1970 1980 1990 2000
LTQASPQRAR TPARTPDRLA KQEELERDLA QRSEERRKWF EATDSRTPEV
2010 2020 2030 2040 2050
PAGEGPRRGL GAPLTEDQQN RLSEEIEKKW QELEKLPLRE NKRVPLTALL
2060 2070 2080 2090 2100
NQSRGERRGP PSDGHEALEK EVQALRAQLE AWRLQGEAPQ SALRSQEDGH
2110 2120 2130 2140 2150
IPPGYISQEA CERSLAEMES SHQQVMEELQ RHHERELQRL QQEKEWLLAE
2160 2170 2180 2190 2200
ETAATASAIE AMKKAYQEEL SRELSKTRSL QQGPDGLRKQ HQSDVEALKR
2210 2220 2230 2240 2250
ELQVLSEQYS QKCLEIGALM RQAEEREHTL RRCQQEGQEL LRHNQELHGR
2260 2270 2280 2290 2300
LSEEIDQLRG FIASQGMGNG CGRSNERSSC ELEVLLRVKE NELQYLKKEV
2310 2320 2330 2340 2350
QCLRDELQMM QKDKRFTSGK YQDVYVELSH IKTRSEREIE QLKEHLRLAM
2360
AALQEKESMR NSLAE
The sequence of this isoform differs from the canonical sequence as follows:
1-61: MEEVPGDALC...DLPRCPPAPE → MGGWKGPGQR...LPPPWGAAMT
62-1774: Missing.
2109-2144: EACERSLAEMESSHQQVMEELQRHHERELQRLQQEK → LVGVITVPVLQTRPLSSERLCDLPKVTPPAGLKGGI
2145-2365: Missing.
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF6TR96 | F6TR96_HUMAN | TRIO and F-actin-binding protein | TRIOBP | 265 | Annotation score: | ||
F6WYE2 | F6WYE2_HUMAN | TRIO and F-actin-binding protein | TRIOBP | 256 | Annotation score: | ||
H0Y5J9 | H0Y5J9_HUMAN | TRIO and F-actin-binding protein | TRIOBP | 311 | Annotation score: | ||
F6WMF4 | F6WMF4_HUMAN | TRIO and F-actin-binding protein | TRIOBP | 83 | Annotation score: | ||
H0Y5T8 | H0Y5T8_HUMAN | TRIO and F-actin-binding protein | TRIOBP | 102 | Annotation score: | ||
H7BXW4 | H7BXW4_HUMAN | TRIO and F-actin-binding protein | TRIOBP | 104 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 713 – 719 | RTTQQEN → KSTFGCL in BAB33332 (PubMed:11258795).Curated | 7 | |
Sequence conflicti | 1421 | R → S in ABB77204 (PubMed:16385458).Curated | 1 | |
Sequence conflicti | 1689 | S → G in ABB77204 (PubMed:16385458).Curated | 1 | |
Sequence conflicti | 1896 | Missing in ABB77204 (PubMed:16385458).Curated | 1 | |
Sequence conflicti | 1904 | N → D in ABB77204 (PubMed:16385458).Curated | 1 | |
Sequence conflicti | 2114 | S → T in AAG44841 (PubMed:11148140).Curated | 1 | |
Sequence conflicti | 2141 | Q → L in AAH04303 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 2274 | S → T in AAG44841 (PubMed:11148140).Curated | 1 | |
Sequence conflicti | 2283 | E → EHLYPQ in AAH04303 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 2359 | M → I in AAG44841 (PubMed:11148140).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_059725 | 217 | S → N. Corresponds to variant dbSNP:rs12628603EnsemblClinVar. | 1 | |
Natural variantiVAR_059726 | 493 | S → N. Corresponds to variant dbSNP:rs4821700EnsemblClinVar. | 1 | |
Natural variantiVAR_061708 | 817 | T → S. Corresponds to variant dbSNP:rs41302575Ensembl. | 1 | |
Natural variantiVAR_051412 | 863 | N → K. Corresponds to variant dbSNP:rs9610841EnsemblClinVar. | 1 | |
Natural variantiVAR_025719 | 1019 | G → R in DFNB28. 1 PublicationCorresponds to variant dbSNP:rs549095193EnsemblClinVar. | 1 | |
Natural variantiVAR_059727 | 1187 | F → L. Corresponds to variant dbSNP:rs5756795EnsemblClinVar. | 1 | |
Natural variantiVAR_059728 | 1300 | H → R. Corresponds to variant dbSNP:rs739138EnsemblClinVar. | 1 | |
Natural variantiVAR_051413 | 1372 | E → D. Corresponds to variant dbSNP:rs8140207EnsemblClinVar. | 1 | |
Natural variantiVAR_051414 | 1377 | W → R2 PublicationsCorresponds to variant dbSNP:rs8140958EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_017711 | 1 – 1772 | Missing in isoform 1. 2 PublicationsAdd BLAST | 1772 | |
Alternative sequenceiVSP_017712 | 1 – 172 | Missing in isoform 4 and isoform 5. 1 PublicationAdd BLAST | 172 | |
Alternative sequenceiVSP_047498 | 1 – 61 | MEEVP…PPAPE → MGGWKGPGQRRGKEGPEARR RAAERGGGGGGGGVPAPRSP AREPRPRSCLLLPPPWGAAM T in isoform 6 and isoform 7. 1 PublicationAdd BLAST | 61 | |
Alternative sequenceiVSP_047499 | 62 – 1774 | Missing in isoform 6 and isoform 7. 1 PublicationAdd BLAST | 1713 | |
Alternative sequenceiVSP_017713 | 1317 – 2365 | Missing in isoform 5. 1 PublicationAdd BLAST | 1049 | |
Alternative sequenceiVSP_017714 | 1317 – 1355 | Missing in isoform 3. 1 PublicationAdd BLAST | 39 | |
Alternative sequenceiVSP_017715 | 1729 – 1774 | Missing in isoform 3. 1 PublicationAdd BLAST | 46 | |
Alternative sequenceiVSP_017716 | 1773 – 1774 | RR → MT in isoform 1. 2 Publications | 2 | |
Alternative sequenceiVSP_017717 | 1794 – 1806 | Missing in isoform 3. 1 PublicationAdd BLAST | 13 | |
Alternative sequenceiVSP_047500 | 2109 – 2144 | EACER…LQQEK → LVGVITVPVLQTRPLSSERL CDLPKVTPPAGLKGGI in isoform 6. 1 PublicationAdd BLAST | 36 | |
Alternative sequenceiVSP_047501 | 2145 – 2365 | Missing in isoform 6. 1 PublicationAdd BLAST | 221 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF281030 mRNA Translation: AAG44841.1 DQ228003 mRNA Translation: ABB59559.1 DQ228004 mRNA Translation: ABB59560.1 DQ228005 mRNA Translation: ABB59561.1 DQ278603 mRNA Translation: ABB77204.1 Z83844 Genomic DNA No translation available. BC003618 mRNA Translation: AAH03618.1 BC004303 mRNA Translation: AAH04303.1 BC013278 mRNA Translation: AAH13278.2 BC022200 mRNA No translation available. AB015343 mRNA Translation: BAA34800.1 Frameshift. AB051449 mRNA Translation: BAB33332.2 |
CCDSi | CCDS33644.1 [Q9H2D6-6] CCDS43015.1 [Q9H2D6-1] CCDS43016.1 [Q9H2D6-7] |
RefSeqi | NP_001034230.1, NM_001039141.2 [Q9H2D6-1] NP_008963.3, NM_007032.5 [Q9H2D6-7] NP_619538.2, NM_138632.2 [Q9H2D6-6] |
Genome annotation databases
Ensembli | ENST00000403663.6; ENSP00000386026.2; ENSG00000100106.22 [Q9H2D6-7] ENST00000407319.7; ENSP00000383913.2; ENSG00000100106.22 [Q9H2D6-6] ENST00000644935.1; ENSP00000496394.1; ENSG00000100106.22 |
GeneIDi | 11078 |
KEGGi | hsa:11078 |
MANE-Selecti | ENST00000644935.1; ENSP00000496394.1; NM_001039141.3; NP_001034230.1 |
UCSCi | uc003atr.4, human [Q9H2D6-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF281030 mRNA Translation: AAG44841.1 DQ228003 mRNA Translation: ABB59559.1 DQ228004 mRNA Translation: ABB59560.1 DQ228005 mRNA Translation: ABB59561.1 DQ278603 mRNA Translation: ABB77204.1 Z83844 Genomic DNA No translation available. BC003618 mRNA Translation: AAH03618.1 BC004303 mRNA Translation: AAH04303.1 BC013278 mRNA Translation: AAH13278.2 BC022200 mRNA No translation available. AB015343 mRNA Translation: BAA34800.1 Frameshift. AB051449 mRNA Translation: BAB33332.2 |
CCDSi | CCDS33644.1 [Q9H2D6-6] CCDS43015.1 [Q9H2D6-1] CCDS43016.1 [Q9H2D6-7] |
RefSeqi | NP_001034230.1, NM_001039141.2 [Q9H2D6-1] NP_008963.3, NM_007032.5 [Q9H2D6-7] NP_619538.2, NM_138632.2 [Q9H2D6-6] |
3D structure databases
AlphaFoldDBi | Q9H2D6 |
SMRi | Q9H2D6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 116261, 107 interactors |
IntActi | Q9H2D6, 56 interactors |
MINTi | Q9H2D6 |
STRINGi | 9606.ENSP00000384312 |
PTM databases
iPTMneti | Q9H2D6 |
PhosphoSitePlusi | Q9H2D6 |
Genetic variation databases
BioMutai | TRIOBP |
DMDMi | 90110075 |
Proteomic databases
EPDi | Q9H2D6 |
jPOSTi | Q9H2D6 |
MassIVEi | Q9H2D6 |
MaxQBi | Q9H2D6 |
PaxDbi | Q9H2D6 |
PeptideAtlasi | Q9H2D6 |
PRIDEi | Q9H2D6 |
ProteomicsDBi | 23821 29844 80531 [Q9H2D6-1] 80532 [Q9H2D6-2] 80533 [Q9H2D6-3] 80534 [Q9H2D6-4] 80535 [Q9H2D6-5] |
Protocols and materials databases
Antibodypediai | 288, 118 antibodies from 25 providers |
DNASUi | 11078 |
Genome annotation databases
Ensembli | ENST00000403663.6; ENSP00000386026.2; ENSG00000100106.22 [Q9H2D6-7] ENST00000407319.7; ENSP00000383913.2; ENSG00000100106.22 [Q9H2D6-6] ENST00000644935.1; ENSP00000496394.1; ENSG00000100106.22 |
GeneIDi | 11078 |
KEGGi | hsa:11078 |
MANE-Selecti | ENST00000644935.1; ENSP00000496394.1; NM_001039141.3; NP_001034230.1 |
UCSCi | uc003atr.4, human [Q9H2D6-1] |
Organism-specific databases
CTDi | 11078 |
DisGeNETi | 11078 |
GeneCardsi | TRIOBP |
GeneReviewsi | TRIOBP |
HGNCi | HGNC:17009, TRIOBP |
HPAi | ENSG00000100106, Low tissue specificity |
MalaCardsi | TRIOBP |
MIMi | 609761, gene 609823, phenotype |
neXtProti | NX_Q9H2D6 |
OpenTargetsi | ENSG00000100106 |
Orphaneti | 90636, Autosomal recessive non-syndromic sensorineural deafness type DFNB |
PharmGKBi | PA142670699 |
VEuPathDBi | HostDB:ENSG00000100106 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4807, Eukaryota |
GeneTreei | ENSGT00940000157340 |
HOGENOMi | CLU_231134_0_0_1 |
InParanoidi | Q9H2D6 |
OMAi | QRDNPGT |
OrthoDBi | 428862at2759 |
PhylomeDBi | Q9H2D6 |
TreeFami | TF343361 |
Enzyme and pathway databases
PathwayCommonsi | Q9H2D6 |
Reactomei | R-HSA-9662360, Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662361, Sensory processing of sound by outer hair cells of the cochlea |
SignaLinki | Q9H2D6 |
SIGNORi | Q9H2D6 |
Miscellaneous databases
BioGRID-ORCSi | 11078, 16 hits in 1082 CRISPR screens |
ChiTaRSi | TRIOBP, human |
GeneWikii | TRIOBP |
GenomeRNAii | 11078 |
Pharosi | Q9H2D6, Tbio |
PROi | PR:Q9H2D6 |
RNActi | Q9H2D6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000100106, Expressed in upper lobe of lung and 245 other tissues |
ExpressionAtlasi | Q9H2D6, baseline and differential |
Genevisiblei | Q9H2D6, HS |
Family and domain databases
CDDi | cd13275, PH_M-RIP, 1 hit |
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR039597, M-RIP_PH IPR011993, PH-like_dom_sf IPR001849, PH_domain |
Pfami | View protein in Pfam PF00169, PH, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit |
PROSITEi | View protein in PROSITE PS50003, PH_DOMAIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TARA_HUMAN | |
Accessioni | Q9H2D6Primary (citable) accession number: Q9H2D6 Secondary accession number(s): B1AHD4 Q9Y3L4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 2, 2002 |
Last sequence update: | March 21, 2006 | |
Last modified: | May 25, 2022 | |
This is version 187 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot