OR52A5

Functionⁱ

Odorant receptor.Curated

GO - Molecular functionⁱ

G protein-coupled receptor activity Source: UniProtKB-KW
olfactory receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

sensory perception of smell
Source: UniProtKB
Non-traceable author statementⁱ
- 11121057

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer
Biological process	Olfaction, Sensory transduction

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381753 Olfactory Signaling Pathway

Reactomeⁱ

R-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Olfactory receptor 52A5 Alternative name(s): Odorant receptor HOR3'beta5 Olfactory receptor OR11-33
Gene namesⁱ	Name:OR52A5
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000171944.1
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:19580 OR52A5
neXtProtⁱ	NX_Q9H2C5

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 27	ExtracellularSequence analysisAdd BLAST	27
Transmembraneⁱ	28 – 48	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	49 – 56	CytoplasmicSequence analysis	8
Transmembraneⁱ	57 – 77	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	78 – 101	ExtracellularSequence analysisAdd BLAST	24
Transmembraneⁱ	102 – 122	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	123 – 141	CytoplasmicSequence analysisAdd BLAST	19
Transmembraneⁱ	142 – 162	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	163 – 199	ExtracellularSequence analysisAdd BLAST	37
Transmembraneⁱ	200 – 220	Helical; Name=5Sequence analysisAdd BLAST	21
Topological domainⁱ	221 – 240	CytoplasmicSequence analysisAdd BLAST	20
Transmembraneⁱ	241 – 261	Helical; Name=6Sequence analysisAdd BLAST	21
Topological domainⁱ	262 – 276	ExtracellularSequence analysisAdd BLAST	15
Transmembraneⁱ	277 – 297	Helical; Name=7Sequence analysisAdd BLAST	21
Topological domainⁱ	298 – 316	CytoplasmicSequence analysisAdd BLAST	19

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA134991603

PharmGKBⁱ

PA134991603

Polymorphism and mutation databases

BioMutaⁱ	OR52A5
DMDMⁱ	74762730

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000150766	1 – 316	Olfactory receptor 52A5Add BLAST		316

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	5	N-linked (GlcNAc...) asparagineSequence analysis		1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

PaxDbⁱ	Q9H2C5
PRIDEⁱ	Q9H2C5
ProteomicsDBⁱ	80528

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000171944 Expressed in 2 organ(s), highest expression level in dorsolateral prefrontal cortex
CleanExⁱ	HS_OR52A5
ExpressionAtlasⁱ	Q9H2C5 baseline and differential

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000303469

STRINGⁱ

9606.ENSP00000303469

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9H2C5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IVT7 Eukaryota ENOG4111EGC LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00840000129788
HOGENOMⁱ	HOG000041363
HOVERGENⁱ	HBG017625
InParanoidⁱ	Q9H2C5
KEGG Orthology (KO) More...KOⁱ	K04257
OMAⁱ	FSAMYLI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0AZH
PhylomeDBⁱ	Q9H2C5
TreeFamⁱ	TF352744

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13853 7tm_4, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR00245 OLFACTORYR
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9H2C5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPTFNGSVFM PSAFILIGIP GLESVQCWIG IPFSAMYLIG VIGNSLILVI 
        60         70         80         90        100
IKYENSLHIP MYIFLAMLAA TDIALNTCIL PKMLGIFWFH LPEISFDACL 
       110        120        130        140        150
FQMWLIHSFQ AIESGILLAM ALDRYVAICI PLRHATIFSQ QFLTHIGLGV 
       160        170        180        190        200
TLRAAILIIP SLGLIKCCLK HYRTTVISHS YCEHMAIVKL ATEDIRVNKI 
       210        220        230        240        250
YGLFVAFAIL GFDIIFITLS YVQIFITVFQ LPQKEARFKA FNTCIAHICV 
       260        270        280        290        300
FLQFYLLAFF SFFTHRFGSH IPPYIHILLS NLYLLVPPFL NPIVYGVKTK 
       310 
QIRDHIVKVF FFKKVT

Length:316

Mass (Da):35,955

Last modified:March 1, 2001 - v1

Checksum:ⁱ0B0820B4BE747623

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF289204 Genomic DNA Translation: AAG42368.1 BK004433 Genomic DNA Translation: DAA04831.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31373.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001005160.1, NM_001005160.2
UniGeneⁱ	Hs.546593

Genome annotation databases

Ensemblⁱ	ENST00000307388; ENSP00000303469; ENSG00000171944 ENST00000642125; ENSP00000493298; ENSG00000171944
GeneIDⁱ	390054
KEGGⁱ	hsa:390054
UCSC genome browser More...UCSCⁱ	uc010qyx.2 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9H2C5	Olfactory receptor		HUMAN		316	UniRef100_Q9H2C5

Protein	Similar proteins		Species	Score	Length	Source
Q9H2C5	Olfactory receptor		HUMAN		316	UniRef90_Q9H2C5
Olfactory receptor		PAPAN		316
Olfactory receptor		PANTR		316
Olfactory receptor		PONAB		316
Olfactory receptor		CALJA		316
+20

Protein	Similar proteins		Species	Score	Length	Source
Q9H2C5	Olfactory receptor 52J3		HUMAN		311	UniRef50_Q8NH60
Olfactory receptor		GORGO		311
Olfactory receptor		PANTR		311
Olfactory receptor		RHIRO		311
Olfactory receptor		PONAB		314
+2011

Cross-referencesⁱ

Web resourcesⁱ

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF289204 Genomic DNA Translation: AAG42368.1 BK004433 Genomic DNA Translation: DAA04831.1
CCDSⁱ	CCDS31373.1
RefSeqⁱ	NP_001005160.1, NM_001005160.2
UniGeneⁱ	Hs.546593

3D structure databases

ProteinModelPortalⁱ	Q9H2C5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000303469

STRINGⁱ

9606.ENSP00000303469

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

Polymorphism and mutation databases

BioMutaⁱ	OR52A5
DMDMⁱ	74762730

Proteomic databases

PaxDbⁱ	Q9H2C5
PRIDEⁱ	Q9H2C5
ProteomicsDBⁱ	80528

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	390054
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000307388; ENSP00000303469; ENSG00000171944 ENST00000642125; ENSP00000493298; ENSG00000171944
GeneIDⁱ	390054
KEGGⁱ	hsa:390054
UCSCⁱ	uc010qyx.2 human

Organism-specific databases

CTDⁱ	390054
EuPathDBⁱ	HostDB:ENSG00000171944.1
GeneCardsⁱ	OR52A5
HGNCⁱ	HGNC:19580 OR52A5
neXtProtⁱ	NX_Q9H2C5
PharmGKBⁱ	PA134991603
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IVT7 Eukaryota ENOG4111EGC LUCA
GeneTreeⁱ	ENSGT00840000129788
HOGENOMⁱ	HOG000041363
HOVERGENⁱ	HBG017625
InParanoidⁱ	Q9H2C5
KOⁱ	K04257
OMAⁱ	FSAMYLI
OrthoDBⁱ	EOG091G0AZH
PhylomeDBⁱ	Q9H2C5
TreeFamⁱ	TF352744

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381753 Olfactory Signaling Pathway

Reactomeⁱ

R-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiⁱ	OR52A5
GenomeRNAiⁱ	390054
Protein Ontology More...PROⁱ	PR:Q9H2C5

Gene expression databases

Bgeeⁱ	ENSG00000171944 Expressed in 2 organ(s), highest expression level in dorsolateral prefrontal cortex
CleanExⁱ	HS_OR52A5
ExpressionAtlasⁱ	Q9H2C5 baseline and differential

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt
Pfamⁱ	View protein in Pfam PF13853 7tm_4, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR00245 OLFACTORYR
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	O52A5_HUMAN
Accessionⁱ	Q9H2C5Primary (citable) accession number: Q9H2C5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
	Last sequence update:	March 1, 2001
	Last modified:	November 7, 2018
	This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries

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UniProtKB - Q9H2C5 (O52A5_HUMAN)

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Olfactory receptor 52A5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ