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Protein

Olfactory receptor 52A5

Gene

OR52A5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G protein-coupled receptor activity Source: UniProtKB-KW
  • olfactory receptor activity Source: GO_Central

GO - Biological processi

  • sensory perception of smell Source: UniProtKB

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 52A5
Alternative name(s):
Odorant receptor HOR3'beta5
Olfactory receptor OR11-33
Gene namesi
Name:OR52A5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000171944.1
HGNCiHGNC:19580 OR52A5
neXtProtiNX_Q9H2C5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
Transmembranei28 – 48Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini49 – 56CytoplasmicSequence analysis8
Transmembranei57 – 77Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini78 – 101ExtracellularSequence analysisAdd BLAST24
Transmembranei102 – 122Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini123 – 141CytoplasmicSequence analysisAdd BLAST19
Transmembranei142 – 162Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini163 – 199ExtracellularSequence analysisAdd BLAST37
Transmembranei200 – 220Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini221 – 240CytoplasmicSequence analysisAdd BLAST20
Transmembranei241 – 261Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini262 – 276ExtracellularSequence analysisAdd BLAST15
Transmembranei277 – 297Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini298 – 316CytoplasmicSequence analysisAdd BLAST19

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134991603

Polymorphism and mutation databases

BioMutaiOR52A5
DMDMi74762730

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507661 – 316Olfactory receptor 52A5Add BLAST316

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9H2C5
PRIDEiQ9H2C5
ProteomicsDBi80528

Expressioni

Gene expression databases

BgeeiENSG00000171944 Expressed in 2 organ(s), highest expression level in dorsolateral prefrontal cortex
CleanExiHS_OR52A5
ExpressionAtlasiQ9H2C5 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000303469

Structurei

3D structure databases

ProteinModelPortaliQ9H2C5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVT7 Eukaryota
ENOG4111EGC LUCA
GeneTreeiENSGT00840000129788
HOGENOMiHOG000041363
HOVERGENiHBG017625
InParanoidiQ9H2C5
KOiK04257
OMAiFSAMYLI
OrthoDBiEOG091G0AZH
PhylomeDBiQ9H2C5
TreeFamiTF352744

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9H2C5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPTFNGSVFM PSAFILIGIP GLESVQCWIG IPFSAMYLIG VIGNSLILVI
60 70 80 90 100
IKYENSLHIP MYIFLAMLAA TDIALNTCIL PKMLGIFWFH LPEISFDACL
110 120 130 140 150
FQMWLIHSFQ AIESGILLAM ALDRYVAICI PLRHATIFSQ QFLTHIGLGV
160 170 180 190 200
TLRAAILIIP SLGLIKCCLK HYRTTVISHS YCEHMAIVKL ATEDIRVNKI
210 220 230 240 250
YGLFVAFAIL GFDIIFITLS YVQIFITVFQ LPQKEARFKA FNTCIAHICV
260 270 280 290 300
FLQFYLLAFF SFFTHRFGSH IPPYIHILLS NLYLLVPPFL NPIVYGVKTK
310
QIRDHIVKVF FFKKVT
Length:316
Mass (Da):35,955
Last modified:March 1, 2001 - v1
Checksum:i0B0820B4BE747623
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF289204 Genomic DNA Translation: AAG42368.1
BK004433 Genomic DNA Translation: DAA04831.1
CCDSiCCDS31373.1
RefSeqiNP_001005160.1, NM_001005160.2
UniGeneiHs.546593

Genome annotation databases

EnsembliENST00000307388; ENSP00000303469; ENSG00000171944
ENST00000642125; ENSP00000493298; ENSG00000171944
GeneIDi390054
KEGGihsa:390054
UCSCiuc010qyx.2 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF289204 Genomic DNA Translation: AAG42368.1
BK004433 Genomic DNA Translation: DAA04831.1
CCDSiCCDS31373.1
RefSeqiNP_001005160.1, NM_001005160.2
UniGeneiHs.546593

3D structure databases

ProteinModelPortaliQ9H2C5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000303469

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR52A5
DMDMi74762730

Proteomic databases

PaxDbiQ9H2C5
PRIDEiQ9H2C5
ProteomicsDBi80528

Protocols and materials databases

DNASUi390054
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307388; ENSP00000303469; ENSG00000171944
ENST00000642125; ENSP00000493298; ENSG00000171944
GeneIDi390054
KEGGihsa:390054
UCSCiuc010qyx.2 human

Organism-specific databases

CTDi390054
EuPathDBiHostDB:ENSG00000171944.1
GeneCardsiOR52A5
HGNCiHGNC:19580 OR52A5
neXtProtiNX_Q9H2C5
PharmGKBiPA134991603
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVT7 Eukaryota
ENOG4111EGC LUCA
GeneTreeiENSGT00840000129788
HOGENOMiHOG000041363
HOVERGENiHBG017625
InParanoidiQ9H2C5
KOiK04257
OMAiFSAMYLI
OrthoDBiEOG091G0AZH
PhylomeDBiQ9H2C5
TreeFamiTF352744

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR52A5
GenomeRNAii390054
PROiPR:Q9H2C5

Gene expression databases

BgeeiENSG00000171944 Expressed in 2 organ(s), highest expression level in dorsolateral prefrontal cortex
CleanExiHS_OR52A5
ExpressionAtlasiQ9H2C5 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO52A5_HUMAN
AccessioniPrimary (citable) accession number: Q9H2C5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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