UniProtKB - Q9H2C5 (O52A5_HUMAN)
Protein
Olfactory receptor 52A5
Gene
OR52A5
Organism
Homo sapiens (Human)
Status
Functioni
Odorant receptor.Curated
GO - Molecular functioni
- G protein-coupled receptor activity Source: UniProtKB-KW
- olfactory receptor activity Source: UniProtKB
GO - Biological processi
- sensory perception of smell Source: UniProtKB
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Olfaction, Sensory transduction |
Enzyme and pathway databases
PathwayCommonsi | Q9H2C5 |
Reactomei | R-HSA-381753, Olfactory Signaling Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Olfactory receptor 52A5Alternative name(s): Odorant receptor HOR3'beta5 Olfactory receptor OR11-33 |
Gene namesi | Name:OR52A5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19580, OR52A5 |
neXtProti | NX_Q9H2C5 |
VEuPathDBi | HostDB:ENSG00000171944.1 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 27 | ExtracellularSequence analysisAdd BLAST | 27 | |
Transmembranei | 28 – 48 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 49 – 56 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 57 – 77 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 78 – 101 | ExtracellularSequence analysisAdd BLAST | 24 | |
Transmembranei | 102 – 122 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 123 – 141 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 142 – 162 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 163 – 199 | ExtracellularSequence analysisAdd BLAST | 37 | |
Transmembranei | 200 – 220 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 221 – 240 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 241 – 261 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 262 – 276 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 277 – 297 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 298 – 316 | CytoplasmicSequence analysisAdd BLAST | 19 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
PharmGKBi | PA134991603 |
Miscellaneous databases
Pharosi | Q9H2C5, Tdark |
Genetic variation databases
BioMutai | OR52A5 |
DMDMi | 74762730 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000150766 | 1 – 316 | Olfactory receptor 52A5Add BLAST | 316 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 5 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | Q9H2C5 |
PeptideAtlasi | Q9H2C5 |
PRIDEi | Q9H2C5 |
ProteomicsDBi | 80528 |
PTM databases
GlyGeni | Q9H2C5, 1 site |
Expressioni
Gene expression databases
Bgeei | ENSG00000171944, Expressed in bone marrow and 5 other tissues |
ExpressionAtlasi | Q9H2C5, baseline and differential |
Organism-specific databases
HPAi | ENSG00000171944, Tissue enhanced (bone) |
Interactioni
Protein-protein interaction databases
STRINGi | 9606.ENSP00000303469 |
Miscellaneous databases
RNActi | Q9H2C5, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502SITM, Eukaryota |
GeneTreei | ENSGT01010000222449 |
HOGENOMi | CLU_012526_0_0_1 |
InParanoidi | Q9H2C5 |
OMAi | FSAMYLI |
OrthoDBi | 889142at2759 |
PhylomeDBi | Q9H2C5 |
TreeFami | TF352744 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000725, Olfact_rcpt |
Pfami | View protein in Pfam PF13853, 7tm_4, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00245, OLFACTORYR |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9H2C5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPTFNGSVFM PSAFILIGIP GLESVQCWIG IPFSAMYLIG VIGNSLILVI
60 70 80 90 100
IKYENSLHIP MYIFLAMLAA TDIALNTCIL PKMLGIFWFH LPEISFDACL
110 120 130 140 150
FQMWLIHSFQ AIESGILLAM ALDRYVAICI PLRHATIFSQ QFLTHIGLGV
160 170 180 190 200
TLRAAILIIP SLGLIKCCLK HYRTTVISHS YCEHMAIVKL ATEDIRVNKI
210 220 230 240 250
YGLFVAFAIL GFDIIFITLS YVQIFITVFQ LPQKEARFKA FNTCIAHICV
260 270 280 290 300
FLQFYLLAFF SFFTHRFGSH IPPYIHILLS NLYLLVPPFL NPIVYGVKTK
310
QIRDHIVKVF FFKKVT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF289204 Genomic DNA Translation: AAG42368.1 BK004433 Genomic DNA Translation: DAA04831.1 |
CCDSi | CCDS31373.1 |
RefSeqi | NP_001005160.1, NM_001005160.2 |
Genome annotation databases
Ensembli | ENST00000307388; ENSP00000303469; ENSG00000171944 ENST00000642125; ENSP00000493298; ENSG00000171944 |
GeneIDi | 390054 |
KEGGi | hsa:390054 |
UCSCi | uc010qyx.2, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Human Olfactory Receptor Data Exploratorium (HORDE) |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF289204 Genomic DNA Translation: AAG42368.1 BK004433 Genomic DNA Translation: DAA04831.1 |
CCDSi | CCDS31373.1 |
RefSeqi | NP_001005160.1, NM_001005160.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000303469 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q9H2C5, 1 site |
Genetic variation databases
BioMutai | OR52A5 |
DMDMi | 74762730 |
Proteomic databases
PaxDbi | Q9H2C5 |
PeptideAtlasi | Q9H2C5 |
PRIDEi | Q9H2C5 |
ProteomicsDBi | 80528 |
Protocols and materials databases
Antibodypediai | 23571, 113 antibodies |
DNASUi | 390054 |
Genome annotation databases
Ensembli | ENST00000307388; ENSP00000303469; ENSG00000171944 ENST00000642125; ENSP00000493298; ENSG00000171944 |
GeneIDi | 390054 |
KEGGi | hsa:390054 |
UCSCi | uc010qyx.2, human |
Organism-specific databases
CTDi | 390054 |
GeneCardsi | OR52A5 |
HGNCi | HGNC:19580, OR52A5 |
HPAi | ENSG00000171944, Tissue enhanced (bone) |
neXtProti | NX_Q9H2C5 |
PharmGKBi | PA134991603 |
VEuPathDBi | HostDB:ENSG00000171944.1 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SITM, Eukaryota |
GeneTreei | ENSGT01010000222449 |
HOGENOMi | CLU_012526_0_0_1 |
InParanoidi | Q9H2C5 |
OMAi | FSAMYLI |
OrthoDBi | 889142at2759 |
PhylomeDBi | Q9H2C5 |
TreeFami | TF352744 |
Enzyme and pathway databases
PathwayCommonsi | Q9H2C5 |
Reactomei | R-HSA-381753, Olfactory Signaling Pathway |
Miscellaneous databases
BioGRID-ORCSi | 390054, 4 hits in 503 CRISPR screens |
GeneWikii | OR52A5 |
GenomeRNAii | 390054 |
Pharosi | Q9H2C5, Tdark |
PROi | PR:Q9H2C5 |
RNActi | Q9H2C5, protein |
Gene expression databases
Bgeei | ENSG00000171944, Expressed in bone marrow and 5 other tissues |
ExpressionAtlasi | Q9H2C5, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000725, Olfact_rcpt |
Pfami | View protein in Pfam PF13853, 7tm_4, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00245, OLFACTORYR |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | O52A5_HUMAN | |
Accessioni | Q9H2C5Primary (citable) accession number: Q9H2C5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 20, 2005 |
Last sequence update: | March 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 140 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families