UniProtKB - Q9H2B4 (S26A1_HUMAN)
Protein
Sulfate anion transporter 1
Gene
SLC26A1
Organism
Homo sapiens (Human)
Status
Functioni
Mediates sulfate transport with high affinity (PubMed:12713736). Mediates oxalate transport (PubMed:12713736). Mediates bicarbonate transport (By similarity). Does not accept succinate as cosubstrate (By similarity).By similarity1 Publication
GO - Molecular functioni
- anion:anion antiporter activity Source: UniProtKB
- bicarbonate transmembrane transporter activity Source: GO_Central
- chloride transmembrane transporter activity Source: UniProtKB
- oxalate transmembrane transporter activity Source: UniProtKB
- secondary active sulfate transmembrane transporter activity Source: InterPro
- sulfate transmembrane transporter activity Source: UniProtKB
GO - Biological processi
- 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process Source: Reactome
- chloride transport Source: UniProtKB
- ion transport Source: Reactome
- oxalate transport Source: UniProtKB
- sulfate transport Source: UniProtKB
Keywordsi
Molecular function | Ion channel |
Biological process | Anion exchange, Antiport, Ion transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q9H2B4 |
Reactomei | R-HSA-174362, Transport and synthesis of PAPS R-HSA-427601, Multifunctional anion exchangers |
Protein family/group databases
TCDBi | 2.A.53.2.16, the sulfate permease (sulp) family |
Names & Taxonomyi
Protein namesi | Recommended name: Sulfate anion transporter 1Short name: SAT-1 Alternative name(s): Solute carrier family 26 member 1 |
Gene namesi | Name:SLC26A1 Synonyms:SAT1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000145217.13 |
HGNCi | HGNC:10993, SLC26A1 |
MIMi | 610130, gene |
neXtProti | NX_Q9H2B4 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein Sequence analysis
- Basolateral cell membrane By similarity
Plasma Membrane
- basolateral plasma membrane Source: UniProtKB-SubCell
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 68 – 90 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 94 – 116 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 176 – 198 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 255 – 277 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 290 – 309 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 342 – 364 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 377 – 399 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 412 – 434 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 472 – 494 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Involvement in diseasei
Nephrolithiasis, calcium oxalate (CAON)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of nephrolithiasis, a condition in which urinary supersaturation leads to stone formation in the urinary system. Patients manifest acute renal colic with severe pain originating in the flank. Patients with small, non-obstructing stones or those with staghorn calculi may be asymptomatic. The majority of renal calculi contain calcium. CAON is characterized by calcium oxalate kidney stones.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_077134 | 56 | A → T in CAON; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs142573758EnsemblClinVar. | 1 | |
Natural variantiVAR_077135 | 185 | T → M in CAON. 1 PublicationCorresponds to variant dbSNP:rs139024319EnsemblClinVar. | 1 | |
Natural variantiVAR_077136 | 358 | S → L in CAON. 1 PublicationCorresponds to variant dbSNP:rs148832260EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease mutationOrganism-specific databases
DisGeNETi | 10861 |
MalaCardsi | SLC26A1 |
MIMi | 167030, phenotype |
OpenTargetsi | ENSG00000145217 |
PharmGKBi | PA400 |
Miscellaneous databases
Pharosi | Q9H2B4, Tbio |
Polymorphism and mutation databases
BioMutai | SLC26A1 |
DMDMi | 209572674 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000080155 | 1 – 701 | Sulfate anion transporter 1Add BLAST | 701 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 158 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 163 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
jPOSTi | Q9H2B4 |
MassIVEi | Q9H2B4 |
MaxQBi | Q9H2B4 |
PaxDbi | Q9H2B4 |
PeptideAtlasi | Q9H2B4 |
PRIDEi | Q9H2B4 |
ProteomicsDBi | 80523 [Q9H2B4-1] 80524 [Q9H2B4-2] |
PTM databases
GlyGeni | Q9H2B4, 2 sites |
iPTMneti | Q9H2B4 |
PhosphoSitePlusi | Q9H2B4 |
Expressioni
Tissue specificityi
Expressed most abundantly in the kidney and liver, with lower levels in the pancreas, testis, brain, small intestine, colon, and lung.1 Publication
Gene expression databases
Bgeei | ENSG00000145217, Expressed in fundus of stomach and 114 other tissues |
Genevisiblei | Q9H2B4, HS |
Organism-specific databases
HPAi | ENSG00000145217, Tissue enhanced (kidney, liver) |
Interactioni
Binary interactionsi
Protein-protein interaction databases
BioGRIDi | 116071, 3 interactors |
IntActi | Q9H2B4, 1 interactor |
STRINGi | 9606.ENSP00000354721 |
Miscellaneous databases
RNActi | Q9H2B4, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 527 – 687 | STASPROSITE-ProRule annotationAdd BLAST | 161 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0236, Eukaryota |
GeneTreei | ENSGT01010000222494 |
HOGENOMi | CLU_1234655_0_0_1 |
InParanoidi | Q9H2B4 |
OMAi | QMVVGPE |
OrthoDBi | 690428at2759 |
PhylomeDBi | Q9H2B4 |
TreeFami | TF313784 |
Family and domain databases
InterProi | View protein in InterPro IPR018045, S04_transporter_CS IPR011547, SLC26A/SulP_dom IPR001902, SLC26A/SulP_fam IPR030331, SLC26A1 IPR002645, STAS_dom IPR036513, STAS_dom_sf |
PANTHERi | PTHR11814, PTHR11814, 1 hit PTHR11814:SF31, PTHR11814:SF31, 1 hit |
Pfami | View protein in Pfam PF01740, STAS, 1 hit PF00916, Sulfate_transp, 1 hit |
SUPFAMi | SSF52091, SSF52091, 1 hit |
TIGRFAMsi | TIGR00815, sulP, 1 hit |
PROSITEi | View protein in PROSITE PS01130, SLC26A, 1 hit PS50801, STAS, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q9H2B4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDESPEPLQQ GRGPVPVRRQ RPAPRGLREM LKARLWCSCS CSVLCVRALV
60 70 80 90 100
QDLLPATRWL RQYRPREYLA GDVMSGLVIG IILVPQAIAY SLLAGLQPIY
110 120 130 140 150
SLYTSFFANL IYFLMGTSRH VSVGIFSLLC LMVGQVVDRE LQLAGFDPSQ
160 170 180 190 200
DGLQPGANSS TLNGSAAMLD CGRDCYAIRV ATALTLMTGL YQVLMGVLRL
210 220 230 240 250
GFVSAYLSQP LLDGFAMGAS VTILTSQLKH LLGVRIPRHQ GPGMVVLTWL
260 270 280 290 300
SLLRGAGQAN VCDVVTSTVC LAVLLAAKEL SDRYRHRLRV PLPTELLVIV
310 320 330 340 350
VATLVSHFGQ LHKRFGSSVA GDIPTGFMPP QVPEPRLMQR VALDAVALAL
360 370 380 390 400
VAAAFSISLA EMFARSHGYS VRANQELLAV GCCNVLPAFL HCFATSAALA
410 420 430 440 450
KSLVKTATGC RTQLSSVVSA TVVLLVLLAL APLFHDLQRS VLACVIVVSL
460 470 480 490 500
RGALRKVWDL PRLWRMSPAD ALVWAGTAAT CMLVSTEAGL LAGVILSLLS
510 520 530 540 550
LAGRTQRPRT ALLARIGDTA FYEDATEFEG LVPEPGVRVF RFGGPLYYAN
560 570 580 590 600
KDFFLQSLYS LTGLDAGCMA ARRKEGGSET GVGEGGPAQG EDLGPVSTRA
610 620 630 640 650
ALVPAAAGFH TVVIDCAPLL FLDAAGVSTL QDLRRDYGAL GISLLLACCS
660 670 680 690 700
PPVRDILSRG GFLGEGPGDT AEEEQLFLSV HDAVQTARAR HRELEATDAH
L
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 459 – 460 | DL → GF in AAG22075 (PubMed:11087667).Curated | 2 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_077134 | 56 | A → T in CAON; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs142573758EnsemblClinVar. | 1 | |
Natural variantiVAR_077135 | 185 | T → M in CAON. 1 PublicationCorresponds to variant dbSNP:rs139024319EnsemblClinVar. | 1 | |
Natural variantiVAR_077136 | 358 | S → L in CAON. 1 PublicationCorresponds to variant dbSNP:rs148832260EnsemblClinVar. | 1 | |
Natural variantiVAR_046727 | 556 | Q → R2 PublicationsCorresponds to variant dbSNP:rs3796622Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043671 | 193 – 224 | VLMGV…SVTIL → TSWGRNSFQQHPWQLTQRSD SQELLEEEERSC in isoform 2. 1 PublicationAdd BLAST | 32 | |
Alternative sequenceiVSP_043672 | 225 – 701 | Missing in isoform 2. 1 PublicationAdd BLAST | 477 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF297659 mRNA Translation: AAG22075.1 AY124771 mRNA Translation: AAM94171.1 AK292747 mRNA Translation: BAF85436.1 AC019103 Genomic DNA No translation available. CH471131 Genomic DNA Translation: EAW82628.1 CH471131 Genomic DNA Translation: EAW82629.1 BC015517 mRNA Translation: AAH15517.1 |
CCDSi | CCDS33933.1 [Q9H2B4-2] CCDS33934.1 [Q9H2B4-1] |
RefSeqi | NP_071325.2, NM_022042.3 [Q9H2B4-1] NP_602297.1, NM_134425.2 [Q9H2B4-2] NP_998778.1, NM_213613.3 [Q9H2B4-1] |
Genome annotation databases
Ensembli | ENST00000361661; ENSP00000354721; ENSG00000145217 [Q9H2B4-1] ENST00000398516; ENSP00000381528; ENSG00000145217 [Q9H2B4-1] ENST00000398520; ENSP00000381532; ENSG00000145217 [Q9H2B4-2] ENST00000622731; ENSP00000483506; ENSG00000145217 [Q9H2B4-2] |
GeneIDi | 10861 |
KEGGi | hsa:10861 |
UCSCi | uc003gbx.5, human [Q9H2B4-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF297659 mRNA Translation: AAG22075.1 AY124771 mRNA Translation: AAM94171.1 AK292747 mRNA Translation: BAF85436.1 AC019103 Genomic DNA No translation available. CH471131 Genomic DNA Translation: EAW82628.1 CH471131 Genomic DNA Translation: EAW82629.1 BC015517 mRNA Translation: AAH15517.1 |
CCDSi | CCDS33933.1 [Q9H2B4-2] CCDS33934.1 [Q9H2B4-1] |
RefSeqi | NP_071325.2, NM_022042.3 [Q9H2B4-1] NP_602297.1, NM_134425.2 [Q9H2B4-2] NP_998778.1, NM_213613.3 [Q9H2B4-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 116071, 3 interactors |
IntActi | Q9H2B4, 1 interactor |
STRINGi | 9606.ENSP00000354721 |
Protein family/group databases
TCDBi | 2.A.53.2.16, the sulfate permease (sulp) family |
PTM databases
GlyGeni | Q9H2B4, 2 sites |
iPTMneti | Q9H2B4 |
PhosphoSitePlusi | Q9H2B4 |
Polymorphism and mutation databases
BioMutai | SLC26A1 |
DMDMi | 209572674 |
Proteomic databases
jPOSTi | Q9H2B4 |
MassIVEi | Q9H2B4 |
MaxQBi | Q9H2B4 |
PaxDbi | Q9H2B4 |
PeptideAtlasi | Q9H2B4 |
PRIDEi | Q9H2B4 |
ProteomicsDBi | 80523 [Q9H2B4-1] 80524 [Q9H2B4-2] |
Protocols and materials databases
Antibodypediai | 8230, 97 antibodies |
CPTCi | Q9H2B4, 3 antibodies |
DNASUi | 10861 |
Genome annotation databases
Ensembli | ENST00000361661; ENSP00000354721; ENSG00000145217 [Q9H2B4-1] ENST00000398516; ENSP00000381528; ENSG00000145217 [Q9H2B4-1] ENST00000398520; ENSP00000381532; ENSG00000145217 [Q9H2B4-2] ENST00000622731; ENSP00000483506; ENSG00000145217 [Q9H2B4-2] |
GeneIDi | 10861 |
KEGGi | hsa:10861 |
UCSCi | uc003gbx.5, human [Q9H2B4-1] |
Organism-specific databases
CTDi | 10861 |
DisGeNETi | 10861 |
EuPathDBi | HostDB:ENSG00000145217.13 |
GeneCardsi | SLC26A1 |
HGNCi | HGNC:10993, SLC26A1 |
HPAi | ENSG00000145217, Tissue enhanced (kidney, liver) |
MalaCardsi | SLC26A1 |
MIMi | 167030, phenotype 610130, gene |
neXtProti | NX_Q9H2B4 |
OpenTargetsi | ENSG00000145217 |
PharmGKBi | PA400 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0236, Eukaryota |
GeneTreei | ENSGT01010000222494 |
HOGENOMi | CLU_1234655_0_0_1 |
InParanoidi | Q9H2B4 |
OMAi | QMVVGPE |
OrthoDBi | 690428at2759 |
PhylomeDBi | Q9H2B4 |
TreeFami | TF313784 |
Enzyme and pathway databases
PathwayCommonsi | Q9H2B4 |
Reactomei | R-HSA-174362, Transport and synthesis of PAPS R-HSA-427601, Multifunctional anion exchangers |
Miscellaneous databases
BioGRID-ORCSi | 10861, 4 hits in 843 CRISPR screens |
ChiTaRSi | SLC26A1, human |
GenomeRNAii | 10861 |
Pharosi | Q9H2B4, Tbio |
PROi | PR:Q9H2B4 |
RNActi | Q9H2B4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000145217, Expressed in fundus of stomach and 114 other tissues |
Genevisiblei | Q9H2B4, HS |
Family and domain databases
InterProi | View protein in InterPro IPR018045, S04_transporter_CS IPR011547, SLC26A/SulP_dom IPR001902, SLC26A/SulP_fam IPR030331, SLC26A1 IPR002645, STAS_dom IPR036513, STAS_dom_sf |
PANTHERi | PTHR11814, PTHR11814, 1 hit PTHR11814:SF31, PTHR11814:SF31, 1 hit |
Pfami | View protein in Pfam PF01740, STAS, 1 hit PF00916, Sulfate_transp, 1 hit |
SUPFAMi | SSF52091, SSF52091, 1 hit |
TIGRFAMsi | TIGR00815, sulP, 1 hit |
PROSITEi | View protein in PROSITE PS01130, SLC26A, 1 hit PS50801, STAS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | S26A1_HUMAN | |
Accessioni | Q9H2B4Primary (citable) accession number: Q9H2B4 Secondary accession number(s): A8K9N2, Q7Z5R3, Q96BK0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 5, 2002 |
Last sequence update: | October 14, 2008 | |
Last modified: | December 2, 2020 | |
This is version 161 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations