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Protein

Synaptotagmin-4

Gene

SYT4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).By similarity1 Publication

Cofactori

Ca2+By similarityNote: Binds 3 Ca2+ ions per subunit. The ions are bound to the C2 domains.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi184Calcium 1By similarity1
Metal bindingi184Calcium 2By similarity1
Metal bindingi191Calcium 1By similarity1
Metal bindingi245Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi246Calcium 1By similarity1
Metal bindingi246Calcium 2By similarity1
Metal bindingi246Calcium 3By similarity1
Metal bindingi249Calcium 3By similarity1
Metal bindingi252Calcium 2By similarity1
Metal bindingi252Calcium 3By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDifferentiation
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-4
Alternative name(s):
Synaptotagmin IV
Short name:
SytIV
Gene namesi
Name:SYT4
Synonyms:KIAA1342
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000132872.11
HGNCiHGNC:11512 SYT4
MIMi600103 gene
neXtProtiNX_Q9H2B2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16VesicularSequence analysisAdd BLAST16
Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Topological domaini38 – 425CytoplasmicSequence analysisAdd BLAST388

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi6860
OpenTargetsiENSG00000132872
PharmGKBiPA36293

Polymorphism and mutation databases

BioMutaiSYT4
DMDMi18202937

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001839481 – 425Synaptotagmin-4Add BLAST425

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei135PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9H2B2
PeptideAtlasiQ9H2B2
PRIDEiQ9H2B2
ProteomicsDBi80522

PTM databases

iPTMnetiQ9H2B2
PhosphoSitePlusiQ9H2B2

Expressioni

Tissue specificityi

Expressed in melanocytes (PubMed:23999003). Expressed in brain. Within brain, expression is highest in hippocampus, with substantial levels also detected in amygdala and thalamus (PubMed:23999003).1 Publication

Gene expression databases

BgeeiENSG00000132872 Expressed in 124 organ(s), highest expression level in cerebellum
CleanExiHS_SYT4
ExpressionAtlasiQ9H2B2 baseline and differential
GenevisibleiQ9H2B2 HS

Organism-specific databases

HPAiHPA010574

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112724, 4 interactors
ELMiQ9H2B2
IntActiQ9H2B2, 4 interactors
STRINGi9606.ENSP00000255224

Structurei

Secondary structure

1425
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9H2B2
SMRiQ9H2B2
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H2B2

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini155 – 258C2 1PROSITE-ProRule annotationAdd BLAST104
Domaini289 – 392C2 2PROSITE-ProRule annotationAdd BLAST104

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni147 – 297Phospholipid bindingCuratedAdd BLAST151

Sequence similaritiesi

Belongs to the synaptotagmin family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1028 Eukaryota
ENOG410XRME LUCA
GeneTreeiENSGT00760000118973
HOGENOMiHOG000232126
HOVERGENiHBG005010
InParanoidiQ9H2B2
KOiK19904
OMAiQIAKWHM
OrthoDBiEOG091G09ZN
PhylomeDBiQ9H2B2
TreeFamiTF315600

Family and domain databases

Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR001565 Synaptotagmin
IPR028683 SYT4
PANTHERiPTHR10024:SF114 PTHR10024:SF114, 1 hit
PfamiView protein in Pfam
PF00168 C2, 2 hits
PRINTSiPR00399 SYNAPTOTAGMN
SMARTiView protein in SMART
SM00239 C2, 2 hits
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q9H2B2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPITTSREE FDEIPTVVGI FSAFGLVFTV SLFAWICCQR KSSKSNKTPP
60 70 80 90 100
YKFVHVLKGV DIYPENLNSK KKFGADDKNE VKNKPAVPKN SLHLDLEKRD
110 120 130 140 150
LNGNFPKTNL KPGSPSDLEN ATPKLFLEGE KESVSPESLK SSTSLTSEEK
160 170 180 190 200
QEKLGTLFFS LEYNFERKAF VVNIKEARGL PAMDEQSMTS DPYIKMTILP
210 220 230 240 250
EKKHKVKTRV LRKTLDPAFD ETFTFYGIPY TQIQELALHF TILSFDRFSR
260 270 280 290 300
DDIIGEVLIP LSGIELSEGK MLMNREIIKR NVRKSSGRGE LLISLCYQST
310 320 330 340 350
TNTLTVVVLK ARHLPKSDVS GLSDPYVKVN LYHAKKRISK KKTHVKKCTP
360 370 380 390 400
NAVFNELFVF DIPCEGLEDI SVEFLVLDSE RGSRNEVIGQ LVLGAAAEGT
410 420
GGEHWKEICD YPRRQIAKWH VLCDG
Length:425
Mass (Da):47,958
Last modified:March 1, 2001 - v1
Checksum:iDA3D4CB175CB528D
GO
Isoform 2 (identifier: Q9H2B2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-29: Missing.

Note: No experimental confirmation available.
Show »
Length:407
Mass (Da):46,064
Checksum:iCE234AC75CBDEB5C
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QZF3M0QZF3_HUMAN
Synaptotagmin-4
SYT4
103Annotation score:
M0R2I0M0R2I0_HUMAN
Synaptotagmin-4
SYT4
143Annotation score:

Sequence cautioni

The sequence BAA92580 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052239142S → N. Corresponds to variant dbSNP:rs16977447Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05664312 – 29Missing in isoform 2. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF299075 mRNA Translation: AAG37229.1
AB037763 mRNA Translation: BAA92580.1 Different initiation.
AK293791 mRNA Translation: BAG57204.1
AC091039 Genomic DNA No translation available.
BC036538 mRNA Translation: AAH36538.1
CCDSiCCDS11922.1 [Q9H2B2-1]
RefSeqiNP_065834.1, NM_020783.3 [Q9H2B2-1]
UniGeneiHs.8059

Genome annotation databases

EnsembliENST00000255224; ENSP00000255224; ENSG00000132872 [Q9H2B2-1]
ENST00000590752; ENSP00000466930; ENSG00000132872 [Q9H2B2-2]
GeneIDi6860
KEGGihsa:6860
UCSCiuc002law.4 human [Q9H2B2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSYT4_HUMAN
AccessioniPrimary (citable) accession number: Q9H2B2
Secondary accession number(s): B4DEU3, Q9P2K4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: March 1, 2001
Last modified: September 12, 2018
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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