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Entry version 128 (16 Oct 2019)
Sequence version 2 (15 Mar 2005)
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Protein

Carbohydrate sulfotransferase 8

Gene

CHST8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Required for biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Only active against terminal GalNAcbeta1,GalNAcbeta. Not active toward chondroitin.2 Publications

Caution

PubMed:10988300 reports the possible existence of a secreted isoform starting at Met-119. However, they do not provide any experimental evidence.Curated

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=10 µM for carbonic anhydrase VI1 Publication

    pH dependencei

    Optimum pH is 7.2.1 Publication

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi198 – 204PAPSBy similarity7
    Nucleotide bindingi258 – 266PAPSBy similarity9

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionTransferase
    Biological processCarbohydrate metabolism

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-975578 Reactions specific to the complex N-glycan synthesis pathway

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    Q9H2A9

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Carbohydrate sulfotransferase 8 (EC:2.8.2.-)
    Alternative name(s):
    GalNAc-4-O-sulfotransferase 1
    Short name:
    GalNAc-4-ST1
    Short name:
    GalNAc4ST-1
    N-acetylgalactosamine-4-O-sulfotransferase 1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:CHST8
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:15993 CHST8

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    610190 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q9H2A9

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 10CytoplasmicSequence analysis10
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei11 – 31Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
    Topological domaini32 – 424LumenalSequence analysisAdd BLAST393

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

    Peeling skin syndrome 3 (PSS3)1 Publication
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionA form of peeling skin syndrome, a genodermatosis characterized by generalized, continuous shedding of the outer layers of the epidermis. Two main PSS subtypes have been suggested. Patients with non-inflammatory PSS (type A) manifest white scaling, with painless and easy removal of the skin, irritation when in contact with water, dust and sand, and no history of erythema, pruritis or atopy. Inflammatory PSS (type B) is associated with generalized erythema, pruritus and atopy. It is an ichthyosiform erythroderma characterized by lifelong patchy peeling of the entire skin with onset at birth or shortly after. Several patients have been reported with high IgE levels. PSS3 is characterized by generalized white scaling occurring over the upper and lower extremities. Symptoms start during the second half of the first decade of life.
    Related information in OMIM
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06772377R → W in PSS3; results in decreased enzyme activity; the mutant protein shows reduced glycosylation. 1 PublicationCorresponds to variant dbSNP:rs149660944EnsemblClinVar.1

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    64377

    MalaCards human disease database

    More...
    MalaCardsi
    CHST8
    MIMi616265 phenotype

    Open Targets

    More...
    OpenTargetsi
    ENSG00000124302

    Orphanet; a database dedicated to information on rare diseases and orphan drugs

    More...
    Orphaneti
    263548 Peeling skin syndrome type A

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA26508

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    Q9H2A9

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    CHST8

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    61212124

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001896531 – 424Carbohydrate sulfotransferase 8Add BLAST424

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi128N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi294N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi367N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi415N-linked (GlcNAc...) asparagineSequence analysis1

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q9H2A9

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q9H2A9

    PeptideAtlas

    More...
    PeptideAtlasi
    Q9H2A9

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q9H2A9

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    80521

    Consortium for Top Down Proteomics

    More...
    TopDownProteomicsi
    Q9H2A9

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q9H2A9

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q9H2A9

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Predominantly expressed in pituitary gland. In brain, it is expressed in pituitary gland, cerebellum, medulla oblongata, pons, thalamus and spinal cord. Expressed in the epidermis. Expressed at lower level in lung, spleen, adrenal gland, placenta, prostate, testis, mammary gland and trachea.4 Publications

    <p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    Down-regulated (17-fold) in prion-infected cells.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000124302 Expressed in 133 organ(s), highest expression level in adenohypophysis

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q9H2A9 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q9H2A9 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA016004

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    122148, 36 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q9H2A9, 25 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000262622

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the sulfotransferase 2 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG4651 Eukaryota
    ENOG4111GJR LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000159100

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000231801

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q9H2A9

    KEGG Orthology (KO)

    More...
    KOi
    K09672

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    MCAKYKS

    Database of Orthologous Groups

    More...
    OrthoDBi
    1330889at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q9H2A9

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF325581

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR018011 Carb_sulfotrans_8-10
    IPR005331 Sulfotransferase

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR12137 PTHR12137, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF03567 Sulfotransfer_2, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

    Q9H2A9-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MTLRPGTMRL ACMFSSILLF GAAGLLLFIS LQDPTELAPQ QVPGIKFNIR
    60 70 80 90 100
    PRQPHHDLPP GGSQDGDLKE PTERVTRDLS SGAPRGRNLP APDQPQPPLQ
    110 120 130 140 150
    RGTRLRLRQR RRRLLIKKMP AAATIPANSS DAPFIRPGPG TLDGRWVSLH
    160 170 180 190 200
    RSQQERKRVM QEACAKYRAS SSRRAVTPRH VSRIFVEDRH RVLYCEVPKA
    210 220 230 240 250
    GCSNWKRVLM VLAGLASSTA DIQHNTVHYG SALKRLDTFD RQGILHRLST
    260 270 280 290 300
    YTKMLFVREP FERLVSAFRD KFEHPNSYYH PVFGKAILAR YRANASREAL
    310 320 330 340 350
    RTGSGVRFPE FVQYLLDVHR PVGMDIHWDH VSRLCSPCLI DYDFVGKFES
    360 370 380 390 400
    MEDDANFFLS LIRAPRNLTF PRFKDRHSQE ARTTARIAHQ YFAQLSALQR
    410 420
    QRTYDFYYMD YLMFNYSKPF ADLY
    Length:424
    Mass (Da):48,834
    Last modified:March 15, 2005 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD4CEF1E7287D6102
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    K7ENM3K7ENM3_HUMAN
    Carbohydrate sulfotransferase
    CHST8
    178Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti326I → T in AAG39444 (PubMed:10988300).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_06772377R → W in PSS3; results in decreased enzyme activity; the mutant protein shows reduced glycosylation. 1 PublicationCorresponds to variant dbSNP:rs149660944EnsemblClinVar.1
    Natural variantiVAR_036538247R → H in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1261984908Ensembl.1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF300612 mRNA Translation: AAG39444.1
    AB047801 mRNA Translation: BAB19806.1
    AF305781 mRNA Translation: AAL09373.1
    BC011380 mRNA Translation: AAH11380.1
    BC014250 mRNA Translation: AAH14250.1
    BC018723 mRNA Translation: AAH18723.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS12433.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001121367.1, NM_001127895.1
    NP_001121368.1, NM_001127896.1
    NP_071912.2, NM_022467.3
    XP_011525524.1, XM_011527222.1
    XP_011525526.1, XM_011527224.1
    XP_016882632.1, XM_017027143.1

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000262622; ENSP00000262622; ENSG00000124302
    ENST00000434302; ENSP00000392604; ENSG00000124302
    ENST00000438847; ENSP00000393879; ENSG00000124302
    ENST00000650847; ENSP00000499084; ENSG00000124302

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    64377

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:64377

    UCSC genome browser

    More...
    UCSCi
    uc002nus.5 human

    Keywords - Coding sequence diversityi

    Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF300612 mRNA Translation: AAG39444.1
    AB047801 mRNA Translation: BAB19806.1
    AF305781 mRNA Translation: AAL09373.1
    BC011380 mRNA Translation: AAH11380.1
    BC014250 mRNA Translation: AAH14250.1
    BC018723 mRNA Translation: AAH18723.1
    CCDSiCCDS12433.1
    RefSeqiNP_001121367.1, NM_001127895.1
    NP_001121368.1, NM_001127896.1
    NP_071912.2, NM_022467.3
    XP_011525524.1, XM_011527222.1
    XP_011525526.1, XM_011527224.1
    XP_016882632.1, XM_017027143.1

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Protein-protein interaction databases

    BioGridi122148, 36 interactors
    IntActiQ9H2A9, 25 interactors
    STRINGi9606.ENSP00000262622

    PTM databases

    iPTMnetiQ9H2A9
    PhosphoSitePlusiQ9H2A9

    Polymorphism and mutation databases

    BioMutaiCHST8
    DMDMi61212124

    Proteomic databases

    MassIVEiQ9H2A9
    PaxDbiQ9H2A9
    PeptideAtlasiQ9H2A9
    PRIDEiQ9H2A9
    ProteomicsDBi80521
    TopDownProteomicsiQ9H2A9

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    64377

    Genome annotation databases

    EnsembliENST00000262622; ENSP00000262622; ENSG00000124302
    ENST00000434302; ENSP00000392604; ENSG00000124302
    ENST00000438847; ENSP00000393879; ENSG00000124302
    ENST00000650847; ENSP00000499084; ENSG00000124302
    GeneIDi64377
    KEGGihsa:64377
    UCSCiuc002nus.5 human

    Organism-specific databases

    Comparative Toxicogenomics Database

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    CTDi
    64377
    DisGeNETi64377

    GeneCards: human genes, protein and diseases

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    GeneCardsi
    CHST8
    HGNCiHGNC:15993 CHST8
    HPAiHPA016004
    MalaCardsiCHST8
    MIMi610190 gene
    616265 phenotype
    neXtProtiNX_Q9H2A9
    OpenTargetsiENSG00000124302
    Orphaneti263548 Peeling skin syndrome type A
    PharmGKBiPA26508

    GenAtlas: human gene database

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    GenAtlasi
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    Phylogenomic databases

    eggNOGiKOG4651 Eukaryota
    ENOG4111GJR LUCA
    GeneTreeiENSGT00940000159100
    HOGENOMiHOG000231801
    InParanoidiQ9H2A9
    KOiK09672
    OMAiMCAKYKS
    OrthoDBi1330889at2759
    PhylomeDBiQ9H2A9
    TreeFamiTF325581

    Enzyme and pathway databases

    ReactomeiR-HSA-975578 Reactions specific to the complex N-glycan synthesis pathway
    SABIO-RKiQ9H2A9

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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    ChiTaRSi
    CHST8 human

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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    GenomeRNAii
    64377
    PharosiQ9H2A9

    Protein Ontology

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    PROi
    PR:Q9H2A9

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000124302 Expressed in 133 organ(s), highest expression level in adenohypophysis
    ExpressionAtlasiQ9H2A9 baseline and differential
    GenevisibleiQ9H2A9 HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR018011 Carb_sulfotrans_8-10
    IPR005331 Sulfotransferase
    PANTHERiPTHR12137 PTHR12137, 1 hit
    PfamiView protein in Pfam
    PF03567 Sulfotransfer_2, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

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    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

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    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCHST8_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H2A9
    Secondary accession number(s): Q9H3N2
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: March 15, 2005
    Last modified: October 16, 2019
    This is version 128 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    5. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
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