CXCL16

Functionⁱ

Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo.By similarity

GO - Molecular functionⁱ

chemokine activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 18373975
low-density lipoprotein particle receptor activity Source: UniProtKB
scavenger receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

chemotaxis
Source: UniProtKB
Non-traceable author statementⁱ
- 11290797
G protein-coupled receptor signaling pathway Source: Reactome
positive regulation of cell growth
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18373975
positive regulation of cell migration
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18373975
receptor-mediated endocytosis
Source: UniProtKB
Non-traceable author statementⁱ
- 11060282
response to cytokine
Source: BHF-UCL
Inferred from direct assayⁱ
- 18373975
response to interferon-gamma
Source: BHF-UCL
Inferred from direct assayⁱ
- 18373975
response to tumor necrosis factor
Source: BHF-UCL
Inferred from direct assayⁱ
- 18373975
T cell chemotaxis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Cytokine
Biological process	Chemotaxis

Enzyme and pathway databases

Reactomeⁱ	R-HSA-380108 Chemokine receptors bind chemokines R-HSA-418594 G alpha (i) signalling events

Reactomeⁱ

R-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events

Protein family/group databases

TCDBⁱ	9.B.173.1.1 the chemokine, cxcl16 (cxcl16) family

TCDBⁱ

9.B.173.1.1 the chemokine, cxcl16 (cxcl16) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: C-X-C motif chemokine 16 Alternative name(s): Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein Short name: SR-PSOX Small-inducible cytokine B16 Transmembrane chemokine CXCL16
Gene namesⁱ	Name:CXCL16 Synonyms:SCYB16, SRPSOX ORF Names:UNQ2759/PRO6714
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000161921.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16642 CXCL16
MIMⁱ	605398 gene
neXtProtⁱ	NX_Q9H2A7

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	30 – 205	ExtracellularSequence analysisAdd BLAST	176
Transmembraneⁱ	206 – 226	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	227 – 254	CytoplasmicSequence analysisAdd BLAST	28

Keywords - Cellular componentⁱ

Cell membrane, Membrane, Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	58191
PharmGKBⁱ	PA27057

Polymorphism and mutation databases

BioMutaⁱ	CXCL16
DMDMⁱ	209572770

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 29	Sequence analysisAdd BLAST		29
ChainⁱPRO_0000005118	30 – 254	C-X-C motif chemokine 16Add BLAST		225

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	38 ↔ 68	By similarity
Disulfide bondⁱ	40 ↔ 82	By similarity
Glycosylationⁱ	168	N-linked (GlcNAc...) asparagineSequence analysis	1

Post-translational modificationⁱ

Glycosylated.

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

EPDⁱ	Q9H2A7
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9H2A7
PaxDbⁱ	Q9H2A7
PeptideAtlas More...PeptideAtlasⁱ	Q9H2A7
PRIDEⁱ	Q9H2A7
ProteomicsDBⁱ	80520

PTM databases

iPTMnetⁱ	Q9H2A7
PhosphoSitePlusⁱ	Q9H2A7

Expressionⁱ

Tissue specificityⁱ

Expressed in T-cell areas. Expressed in spleen, lymph nodes, lung, kidney, small intestine and thymus. Weak expression in heart and liver and no expression in brain and bone marrow.

Gene expression databases

Bgeeⁱ	ENSG00000161921 Expressed in 173 organ(s), highest expression level in right testis
CleanExⁱ	HS_CXCL16
ExpressionAtlasⁱ	Q9H2A7 baseline and differential
Genevisibleⁱ	Q9H2A7 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA053253 HPA066315

HPAⁱ

HPA053253
HPA066315

Interactionⁱ

GO - Molecular functionⁱ

chemokine activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 18373975

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	121805, 31 interactors
STRINGⁱ	9606.ENSP00000293778

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	32 – 107	ChemokineAdd BLAST		76

Sequence similaritiesⁱ

Belongs to the intercrine alpha (chemokine CxC) family.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410J8A5 Eukaryota ENOG4111D6H LUCA
HOVERGENⁱ	HBG107790
InParanoidⁱ	Q9H2A7
KEGG Orthology (KO) More...KOⁱ	K10035
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0P40
PhylomeDBⁱ	Q9H2A7
TreeFamⁱ	TF337941

Family and domain databases

InterProⁱ	View protein in InterPro IPR026296 CXCL16
PANTHERⁱ	PTHR14385 PTHR14385, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q9H2A7-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGRDLRPGSR VLLLLLLLLL VYLTQPGNGN EGSVTGSCYC GKRISSDSPP 
        60         70         80         90        100
SVQFMNRLRK HLRAYHRCLY YTRFQLLSWS VCGGNKDPWV QELMSCLDLK 
       110        120        130        140        150
ECGHAYSGIV AHQKHLLPTS PPISQASEGA SSDIHTPAQM LLSTLQSTQR 
       160        170        180        190        200
PTLPVGSLSS DKELTRPNET TIHTAGHSLA AGPEAGENQK QPEKNAGPTA 
       210        220        230        240        250
RTSATVPVLC LLAIIFILTA ALSYVLCKRR RGQSPQSSPD LPVHYIPVAP 

DSNT

Length:254

Mass (Da):27,579

Last modified:October 14, 2008 - v4

Checksum:ⁱEA627A87958B83B6

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	I3L333	I3L333_HUMAN		C-X-C motif chemokine 16 C-X-C motif chemokine 16	CXCL16	93	Annotation score:

Sequence cautionⁱ

The sequence AAG34365 differs from that shown. Reason: Erroneous initiation.Curated

The sequence AAH17588 differs from that shown. Reason: Erroneous initiation.Curated

The sequence AAH44930 differs from that shown. Reason: Erroneous initiation.Curated

The sequence ABK41925 differs from that shown. Reason: Erroneous initiation.Curated

The sequence BAB55078 differs from that shown. Reason: Erroneous initiation.Curated

The sequence BAF84803 differs from that shown. Reason: Erroneous initiation.Curated

The sequence BAG37507 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	67	R → W in BAG37507 (PubMed:14702039).Curated	1
Sequence conflictⁱ	135	H → L in BAB55078 (PubMed:14702039).Curated	1
Sequence conflictⁱ	143	S → P in BAG37507 (PubMed:14702039).Curated	1
Sequence conflictⁱ	222	L → P in AAK38275 (PubMed:11290797).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_015424	123	I → T3 Publications		1
Natural variantⁱVAR_015425	181	A → V4 PublicationsCorresponds to variant dbSNP:rs2277680Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF301016 mRNA Translation: AAG34365.1 Different initiation. AF337812 mRNA Translation: AAK38275.1 AF275260 mRNA Translation: AAG31750.1 EF064742 Genomic DNA Translation: ABK41925.1 Different initiation. AY358909 mRNA Translation: AAQ89268.1 AK027389 mRNA Translation: BAB55078.1 Different initiation. AK292114 mRNA Translation: BAF84803.1 Different initiation. AK315017 mRNA Translation: BAG37507.1 Different initiation. BC017588 mRNA Translation: AAH17588.1 Different initiation. BC044930 mRNA Translation: AAH44930.1 Different initiation.
NCBI Reference Sequences More...RefSeqⁱ	NP_001094282.1, NM_001100812.1 NP_071342.2, NM_022059.3
UniGeneⁱ	Hs.745037

Genome annotation databases

Ensemblⁱ	ENST00000293778; ENSP00000293778; ENSG00000161921 ENST00000574412; ENSP00000459592; ENSG00000161921
GeneIDⁱ	58191
KEGGⁱ	hsa:58191
UCSC genome browser More...UCSCⁱ	uc002fyr.6 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9H2A7	C-X-C motif chemokine 16 (Fragment)		HUMAN		93	UniRef100_Q9H2A7
UPI000013E11E		HUMAN		273

Protein	Similar proteins		Species	Score	Length	Source
Q9H2A7	C-X-C motif chemokine 16 (Fragment)		HUMAN		93	UniRef90_Q9H2A7
C-X-C motif chemokine ligand 16		PANTR		273
Uncharacterized protein		PANPA		273
C-X-C motif chemokine ligand 16		GORGO		273
Uncharacterized protein		PONAB		250
+6

Protein	Similar proteins		Species	Score	Length	Source
Q9H2A7	C-X-C motif chemokine 16 (Fragment)		HUMAN		93	UniRef50_Q9H2A7
C-X-C motif chemokine ligand 16		PANTR		273
Uncharacterized protein		PANPA		273
C-X-C motif chemokine ligand 16		GORGO		273
Uncharacterized protein		PONAB		250
+24

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

CXCL16 entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF301016 mRNA Translation: AAG34365.1 Different initiation. AF337812 mRNA Translation: AAK38275.1 AF275260 mRNA Translation: AAG31750.1 EF064742 Genomic DNA Translation: ABK41925.1 Different initiation. AY358909 mRNA Translation: AAQ89268.1 AK027389 mRNA Translation: BAB55078.1 Different initiation. AK292114 mRNA Translation: BAF84803.1 Different initiation. AK315017 mRNA Translation: BAG37507.1 Different initiation. BC017588 mRNA Translation: AAH17588.1 Different initiation. BC044930 mRNA Translation: AAH44930.1 Different initiation.
RefSeqⁱ	NP_001094282.1, NM_001100812.1 NP_071342.2, NM_022059.3
UniGeneⁱ	Hs.745037

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	121805, 31 interactors
STRINGⁱ	9606.ENSP00000293778

Protein family/group databases

TCDBⁱ	9.B.173.1.1 the chemokine, cxcl16 (cxcl16) family

TCDBⁱ

9.B.173.1.1 the chemokine, cxcl16 (cxcl16) family

PTM databases

iPTMnetⁱ	Q9H2A7
PhosphoSitePlusⁱ	Q9H2A7

Polymorphism and mutation databases

BioMutaⁱ	CXCL16
DMDMⁱ	209572770

Proteomic databases

EPDⁱ	Q9H2A7
MaxQBⁱ	Q9H2A7
PaxDbⁱ	Q9H2A7
PeptideAtlasⁱ	Q9H2A7
PRIDEⁱ	Q9H2A7
ProteomicsDBⁱ	80520

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	58191
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000293778; ENSP00000293778; ENSG00000161921 ENST00000574412; ENSP00000459592; ENSG00000161921
GeneIDⁱ	58191
KEGGⁱ	hsa:58191
UCSCⁱ	uc002fyr.6 human

Organism-specific databases

CTDⁱ	58191
DisGeNETⁱ	58191
EuPathDBⁱ	HostDB:ENSG00000161921.14
GeneCardsⁱ	CXCL16
H-InvDBⁱ	HIX0013447
HGNCⁱ	HGNC:16642 CXCL16
HPAⁱ	HPA053253 HPA066315
MIMⁱ	605398 gene
neXtProtⁱ	NX_Q9H2A7
PharmGKBⁱ	PA27057
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J8A5 Eukaryota ENOG4111D6H LUCA
HOVERGENⁱ	HBG107790
InParanoidⁱ	Q9H2A7
KOⁱ	K10035
OrthoDBⁱ	EOG091G0P40
PhylomeDBⁱ	Q9H2A7
TreeFamⁱ	TF337941

Enzyme and pathway databases

Reactomeⁱ	R-HSA-380108 Chemokine receptors bind chemokines R-HSA-418594 G alpha (i) signalling events

Reactomeⁱ

R-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events

Miscellaneous databases

ChiTaRSⁱ	CXCL16 human
GenomeRNAiⁱ	58191
Protein Ontology More...PROⁱ	PR:Q9H2A7
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000161921 Expressed in 173 organ(s), highest expression level in right testis
CleanExⁱ	HS_CXCL16
ExpressionAtlasⁱ	Q9H2A7 baseline and differential
Genevisibleⁱ	Q9H2A7 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR026296 CXCL16
PANTHERⁱ	PTHR14385 PTHR14385, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CXL16_HUMAN
Accessionⁱ	Q9H2A7Primary (citable) accession number: Q9H2A7 Secondary accession number(s): A0N0N4 Q9H2F6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 5, 2001
	Last sequence update:	October 14, 2008
	Last modified:	November 7, 2018
	This is version 151 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM

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UniParc

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UniRef

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Supporting data

UniProtKB - Q9H2A7 (CXL16_HUMAN)

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C-X-C motif chemokine 16

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Plasma membrane

Extracellular region or secreted

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ