Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
We will be switching to the new UniProt website soon. Please explore and share your feedback. Take me to the new website.

UniProtKB - Q9H2A7 (CXL16_HUMAN)

Entry version 168 (23 Feb 2022)
Sequence version 4 (14 Oct 2008)
Previous versions | rss
Add a publicationFeedback
Protein

C-X-C motif chemokine 16

Gene

CXCL16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity).

Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine
Biological processChemotaxis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9H2A7

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-380108, Chemokine receptors bind chemokines
R-HSA-418594, G alpha (i) signalling events

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9H2A7

Protein family/group databases

Transport Classification Database

More...TCDBi		9.B.173.1.1, the chemokine, cxcl16 (cxcl16) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
C-X-C motif chemokine 16
Alternative name(s):
Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein
Short name:
SR-PSOX
Small-inducible cytokine B16
Transmembrane chemokine CXCL16
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CXCL16
Synonyms:SCYB16, SRPSOX
ORF Names:UNQ2759/PRO6714
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:16642, CXCL16

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605398, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9H2A7

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000161921

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini30 – 205ExtracellularSequence analysisAdd BLAST176
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei206 – 226HelicalSequence analysisAdd BLAST21
Topological domaini227 – 254CytoplasmicSequence analysisAdd BLAST28

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		58191

Open Targets

More...OpenTargetsi		ENSG00000161921

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27057

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9H2A7, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CXCL16

Domain mapping of disease mutations (DMDM)

More...DMDMi		209572770

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 29Sequence analysisAdd BLAST29
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000511830 – 254C-X-C motif chemokine 16Add BLAST225

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi38 ↔ 68By similarity
Disulfide bondi40 ↔ 82By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi168N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9H2A7

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9H2A7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9H2A7

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9H2A7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9H2A7

PeptideAtlas

More...PeptideAtlasi		Q9H2A7

PRoteomics IDEntifications database

More...PRIDEi		Q9H2A7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		80520

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9H2A7, 3 sites, 2 O-linked glycans (2 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9H2A7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9H2A7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in T-cell areas. Expressed in spleen, lymph nodes, lung, kidney, small intestine and thymus. Weak expression in heart and liver and no expression in brain and bone marrow.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000161921, Expressed in right testis and 190 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9H2A7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9H2A7, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000161921, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121805, 84 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000293778

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9H2A7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9H2A7

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni32 – 107ChemokineAdd BLAST76
Regioni146 – 165DisorderedSequence analysisAdd BLAST20
Regioni178 – 200DisorderedSequence analysisAdd BLAST23
Regioni231 – 254DisorderedSequence analysisAdd BLAST24

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the intercrine alpha (chemokine CxC) family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502T0B7, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000002148

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_049889_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9H2A7

Identification of Orthologs from Complete Genome Data

More...OMAi		CFDSGEC

Database of Orthologous Groups

More...OrthoDBi		1450357at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9H2A7

TreeFam database of animal gene trees

More...TreeFami		TF337941

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026296, CXCL16

The PANTHER Classification System

More...PANTHERi		PTHR14385, PTHR14385, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9H2A7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRDLRPGSR VLLLLLLLLL VYLTQPGNGN EGSVTGSCYC GKRISSDSPP 
        60         70         80         90        100
SVQFMNRLRK HLRAYHRCLY YTRFQLLSWS VCGGNKDPWV QELMSCLDLK 
       110        120        130        140        150
ECGHAYSGIV AHQKHLLPTS PPISQASEGA SSDIHTPAQM LLSTLQSTQR 
       160        170        180        190        200
PTLPVGSLSS DKELTRPNET TIHTAGHSLA AGPEAGENQK QPEKNAGPTA 
       210        220        230        240        250
RTSATVPVLC LLAIIFILTA ALSYVLCKRR RGQSPQSSPD LPVHYIPVAP 

DSNT
Length:254
Mass (Da):27,579
Last modified:October 14, 2008 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEA627A87958B83B6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A6I8PIU7A0A6I8PIU7_HUMAN
C-X-C motif chemokine 16
CXCL16
115Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L333I3L333_HUMAN
C-X-C motif chemokine 16
CXCL16
93Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG34365 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH17588 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH44930 differs from that shown. Reason: Erroneous initiation.Curated
The sequence ABK41925 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB55078 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAF84803 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAG37507 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti67R → W in BAG37507 (PubMed:14702039).Curated1
Sequence conflicti135H → L in BAB55078 (PubMed:14702039).Curated1
Sequence conflicti143S → P in BAG37507 (PubMed:14702039).Curated1
Sequence conflicti222L → P in AAK38275 (PubMed:11290797).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_015424123I → T3 Publications1
Natural variantiVAR_015425181A → V4 PublicationsCorresponds to variant dbSNP:rs2277680Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF301016 mRNA Translation: AAG34365.1 Different initiation.
AF337812 mRNA Translation: AAK38275.1
AF275260 mRNA Translation: AAG31750.1
EF064742 Genomic DNA Translation: ABK41925.1 Different initiation.
AY358909 mRNA Translation: AAQ89268.1
AK027389 mRNA Translation: BAB55078.1 Different initiation.
AK292114 mRNA Translation: BAF84803.1 Different initiation.
AK315017 mRNA Translation: BAG37507.1 Different initiation.
BC017588 mRNA Translation: AAH17588.1 Different initiation.
BC044930 mRNA Translation: AAH44930.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11052.1

NCBI Reference Sequences

More...RefSeqi		NP_001094282.1, NM_001100812.1
NP_071342.2, NM_022059.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000293778; ENSP00000293778; ENSG00000161921
ENST00000574412; ENSP00000459592; ENSG00000161921

Database of genes from NCBI RefSeq genomes

More...GeneIDi		58191

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:58191

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000293778.12; ENSP00000293778.7; NM_001386809.1; NP_001373738.1

UCSC genome browser

More...UCSCi		uc002fyr.6, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

CXCL16 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF301016 mRNA Translation: AAG34365.1 Different initiation.
AF337812 mRNA Translation: AAK38275.1
AF275260 mRNA Translation: AAG31750.1
EF064742 Genomic DNA Translation: ABK41925.1 Different initiation.
AY358909 mRNA Translation: AAQ89268.1
AK027389 mRNA Translation: BAB55078.1 Different initiation.
AK292114 mRNA Translation: BAF84803.1 Different initiation.
AK315017 mRNA Translation: BAG37507.1 Different initiation.
BC017588 mRNA Translation: AAH17588.1 Different initiation.
BC044930 mRNA Translation: AAH44930.1 Different initiation.
CCDSiCCDS11052.1
RefSeqiNP_001094282.1, NM_001100812.1
NP_071342.2, NM_022059.3

3D structure databases

SMRiQ9H2A7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi121805, 84 interactors
STRINGi9606.ENSP00000293778

Protein family/group databases

TCDBi9.B.173.1.1, the chemokine, cxcl16 (cxcl16) family

PTM databases

GlyGeniQ9H2A7, 3 sites, 2 O-linked glycans (2 sites)
iPTMnetiQ9H2A7
PhosphoSitePlusiQ9H2A7

Genetic variation databases

BioMutaiCXCL16
DMDMi209572770

Proteomic databases

EPDiQ9H2A7
jPOSTiQ9H2A7
MassIVEiQ9H2A7
MaxQBiQ9H2A7
PaxDbiQ9H2A7
PeptideAtlasiQ9H2A7
PRIDEiQ9H2A7
ProteomicsDBi80520

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		11299, 483 antibodies from 34 providers

The DNASU plasmid repository

More...DNASUi		58191

Genome annotation databases

EnsembliENST00000293778; ENSP00000293778; ENSG00000161921
ENST00000574412; ENSP00000459592; ENSG00000161921
GeneIDi58191
KEGGihsa:58191
MANE-SelectiENST00000293778.12; ENSP00000293778.7; NM_001386809.1; NP_001373738.1
UCSCiuc002fyr.6, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		58191
DisGeNETi58191

GeneCards: human genes, protein and diseases

More...GeneCardsi		CXCL16
HGNCiHGNC:16642, CXCL16
HPAiENSG00000161921, Low tissue specificity
MIMi605398, gene
neXtProtiNX_Q9H2A7
OpenTargetsiENSG00000161921
PharmGKBiPA27057
VEuPathDBiHostDB:ENSG00000161921

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502T0B7, Eukaryota
GeneTreeiENSGT00390000002148
HOGENOMiCLU_049889_0_0_1
InParanoidiQ9H2A7
OMAiCFDSGEC
OrthoDBi1450357at2759
PhylomeDBiQ9H2A7
TreeFamiTF337941

Enzyme and pathway databases

PathwayCommonsiQ9H2A7
ReactomeiR-HSA-380108, Chemokine receptors bind chemokines
R-HSA-418594, G alpha (i) signalling events
SignaLinkiQ9H2A7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		58191, 6 hits in 1039 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CXCL16, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		58191
PharosiQ9H2A7, Tbio

Protein Ontology

More...PROi		PR:Q9H2A7
RNActiQ9H2A7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000161921, Expressed in right testis and 190 other tissues
ExpressionAtlasiQ9H2A7, baseline and differential
GenevisibleiQ9H2A7, HS

Family and domain databases

InterProiView protein in InterPro
IPR026296, CXCL16
PANTHERiPTHR14385, PTHR14385, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCXL16_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H2A7
Secondary accession number(s): A0N0N4
, A8K7U9, B2RCB0, Q8TC80, Q96K63, Q9BXD6, Q9H2F6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: October 14, 2008
Last modified: February 23, 2022
This is version 168 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again