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UniProtKB - Q9H2A7 (CXL16_HUMAN)
Protein
C-X-C motif chemokine 16
Gene
CXCL16
Organism
Homo sapiens (Human)
Status
Functioni
Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity).
Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo.
By similarityGO - Molecular functioni
- chemokine activity Source: BHF-UCL
- low-density lipoprotein particle receptor activity Source: UniProtKB
- scavenger receptor activity Source: GO_Central
GO - Biological processi
- chemotaxis Source: UniProtKB
- positive regulation of cell growth Source: BHF-UCL
- positive regulation of cell migration Source: BHF-UCL
- receptor-mediated endocytosis Source: UniProtKB
- response to cytokine Source: BHF-UCL
- response to interferon-gamma Source: BHF-UCL
- response to tumor necrosis factor Source: BHF-UCL
- T cell chemotaxis Source: GO_Central
Keywordsi
Molecular function | Cytokine |
Biological process | Chemotaxis |
Enzyme and pathway databases
PathwayCommonsi | Q9H2A7 |
Reactomei | R-HSA-380108, Chemokine receptors bind chemokines R-HSA-418594, G alpha (i) signalling events |
SignaLinki | Q9H2A7 |
Protein family/group databases
TCDBi | 9.B.173.1.1, the chemokine, cxcl16 (cxcl16) family |
Names & Taxonomyi
Protein namesi | Recommended name: C-X-C motif chemokine 16Alternative name(s): Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein Short name: SR-PSOX Small-inducible cytokine B16 Transmembrane chemokine CXCL16 |
Gene namesi | Name:CXCL16 Synonyms:SCYB16, SRPSOX ORF Names:UNQ2759/PRO6714 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16642, CXCL16 |
MIMi | 605398, gene |
neXtProti | NX_Q9H2A7 |
VEuPathDBi | HostDB:ENSG00000161921 |
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Single-pass type I membrane protein Curated
Extracellular region or secreted
Note: Also exists as a soluble form.
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: BHF-UCL
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB
- membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 30 – 205 | ExtracellularSequence analysisAdd BLAST | 176 | |
Transmembranei | 206 – 226 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 227 – 254 | CytoplasmicSequence analysisAdd BLAST | 28 |
Keywords - Cellular componenti
Cell membrane, Membrane, SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 58191 |
OpenTargetsi | ENSG00000161921 |
PharmGKBi | PA27057 |
Miscellaneous databases
Pharosi | Q9H2A7, Tbio |
Genetic variation databases
BioMutai | CXCL16 |
DMDMi | 209572770 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 29 | Sequence analysisAdd BLAST | 29 | |
ChainiPRO_0000005118 | 30 – 254 | C-X-C motif chemokine 16Add BLAST | 225 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 38 ↔ 68 | By similarity | ||
Disulfide bondi | 40 ↔ 82 | By similarity | ||
Glycosylationi | 168 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Glycosylated.
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | Q9H2A7 |
jPOSTi | Q9H2A7 |
MassIVEi | Q9H2A7 |
MaxQBi | Q9H2A7 |
PaxDbi | Q9H2A7 |
PeptideAtlasi | Q9H2A7 |
PRIDEi | Q9H2A7 |
ProteomicsDBi | 80520 |
PTM databases
GlyGeni | Q9H2A7, 3 sites, 2 O-linked glycans (2 sites) |
iPTMneti | Q9H2A7 |
PhosphoSitePlusi | Q9H2A7 |
Expressioni
Tissue specificityi
Expressed in T-cell areas. Expressed in spleen, lymph nodes, lung, kidney, small intestine and thymus. Weak expression in heart and liver and no expression in brain and bone marrow.
Gene expression databases
Bgeei | ENSG00000161921, Expressed in right testis and 190 other tissues |
ExpressionAtlasi | Q9H2A7, baseline and differential |
Genevisiblei | Q9H2A7, HS |
Organism-specific databases
HPAi | ENSG00000161921, Low tissue specificity |
Interactioni
GO - Molecular functioni
- chemokine activity Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 121805, 84 interactors |
STRINGi | 9606.ENSP00000293778 |
Miscellaneous databases
RNActi | Q9H2A7, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 32 – 107 | ChemokineAdd BLAST | 76 | |
Regioni | 146 – 165 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 178 – 200 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 231 – 254 | DisorderedSequence analysisAdd BLAST | 24 |
Sequence similaritiesi
Belongs to the intercrine alpha (chemokine CxC) family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502T0B7, Eukaryota |
GeneTreei | ENSGT00390000002148 |
HOGENOMi | CLU_049889_0_0_1 |
InParanoidi | Q9H2A7 |
OMAi | CFDSGEC |
OrthoDBi | 1450357at2759 |
PhylomeDBi | Q9H2A7 |
TreeFami | TF337941 |
Family and domain databases
InterProi | View protein in InterPro IPR026296, CXCL16 |
PANTHERi | PTHR14385, PTHR14385, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q9H2A7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGRDLRPGSR VLLLLLLLLL VYLTQPGNGN EGSVTGSCYC GKRISSDSPP
60 70 80 90 100
SVQFMNRLRK HLRAYHRCLY YTRFQLLSWS VCGGNKDPWV QELMSCLDLK
110 120 130 140 150
ECGHAYSGIV AHQKHLLPTS PPISQASEGA SSDIHTPAQM LLSTLQSTQR
160 170 180 190 200
PTLPVGSLSS DKELTRPNET TIHTAGHSLA AGPEAGENQK QPEKNAGPTA
210 220 230 240 250
RTSATVPVLC LLAIIFILTA ALSYVLCKRR RGQSPQSSPD LPVHYIPVAP
DSNT
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A6I8PIU7 | A0A6I8PIU7_HUMAN | C-X-C motif chemokine 16 | CXCL16 | 115 | Annotation score: | ||
I3L333 | I3L333_HUMAN | C-X-C motif chemokine 16 | CXCL16 | 93 | Annotation score: |
Sequence cautioni
The sequence AAG34365 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH17588 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH44930 differs from that shown. Reason: Erroneous initiation.Curated
The sequence ABK41925 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB55078 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAF84803 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAG37507 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 67 | R → W in BAG37507 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 135 | H → L in BAB55078 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 143 | S → P in BAG37507 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 222 | L → P in AAK38275 (PubMed:11290797).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_015424 | 123 | I → T3 Publications | 1 | |
Natural variantiVAR_015425 | 181 | A → V4 PublicationsCorresponds to variant dbSNP:rs2277680Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF301016 mRNA Translation: AAG34365.1 Different initiation. AF337812 mRNA Translation: AAK38275.1 AF275260 mRNA Translation: AAG31750.1 EF064742 Genomic DNA Translation: ABK41925.1 Different initiation. AY358909 mRNA Translation: AAQ89268.1 AK027389 mRNA Translation: BAB55078.1 Different initiation. AK292114 mRNA Translation: BAF84803.1 Different initiation. AK315017 mRNA Translation: BAG37507.1 Different initiation. BC017588 mRNA Translation: AAH17588.1 Different initiation. BC044930 mRNA Translation: AAH44930.1 Different initiation. |
CCDSi | CCDS11052.1 |
RefSeqi | NP_001094282.1, NM_001100812.1 NP_071342.2, NM_022059.3 |
Genome annotation databases
Ensembli | ENST00000293778; ENSP00000293778; ENSG00000161921 ENST00000574412; ENSP00000459592; ENSG00000161921 |
GeneIDi | 58191 |
KEGGi | hsa:58191 |
MANE-Selecti | ENST00000293778.12; ENSP00000293778.7; NM_001386809.1; NP_001373738.1 |
UCSCi | uc002fyr.6, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia CXCL16 entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF301016 mRNA Translation: AAG34365.1 Different initiation. AF337812 mRNA Translation: AAK38275.1 AF275260 mRNA Translation: AAG31750.1 EF064742 Genomic DNA Translation: ABK41925.1 Different initiation. AY358909 mRNA Translation: AAQ89268.1 AK027389 mRNA Translation: BAB55078.1 Different initiation. AK292114 mRNA Translation: BAF84803.1 Different initiation. AK315017 mRNA Translation: BAG37507.1 Different initiation. BC017588 mRNA Translation: AAH17588.1 Different initiation. BC044930 mRNA Translation: AAH44930.1 Different initiation. |
CCDSi | CCDS11052.1 |
RefSeqi | NP_001094282.1, NM_001100812.1 NP_071342.2, NM_022059.3 |
3D structure databases
SMRi | Q9H2A7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 121805, 84 interactors |
STRINGi | 9606.ENSP00000293778 |
Protein family/group databases
TCDBi | 9.B.173.1.1, the chemokine, cxcl16 (cxcl16) family |
PTM databases
GlyGeni | Q9H2A7, 3 sites, 2 O-linked glycans (2 sites) |
iPTMneti | Q9H2A7 |
PhosphoSitePlusi | Q9H2A7 |
Genetic variation databases
BioMutai | CXCL16 |
DMDMi | 209572770 |
Proteomic databases
EPDi | Q9H2A7 |
jPOSTi | Q9H2A7 |
MassIVEi | Q9H2A7 |
MaxQBi | Q9H2A7 |
PaxDbi | Q9H2A7 |
PeptideAtlasi | Q9H2A7 |
PRIDEi | Q9H2A7 |
ProteomicsDBi | 80520 |
Protocols and materials databases
Antibodypediai | 11299, 483 antibodies from 34 providers |
DNASUi | 58191 |
Genome annotation databases
Ensembli | ENST00000293778; ENSP00000293778; ENSG00000161921 ENST00000574412; ENSP00000459592; ENSG00000161921 |
GeneIDi | 58191 |
KEGGi | hsa:58191 |
MANE-Selecti | ENST00000293778.12; ENSP00000293778.7; NM_001386809.1; NP_001373738.1 |
UCSCi | uc002fyr.6, human |
Organism-specific databases
CTDi | 58191 |
DisGeNETi | 58191 |
GeneCardsi | CXCL16 |
HGNCi | HGNC:16642, CXCL16 |
HPAi | ENSG00000161921, Low tissue specificity |
MIMi | 605398, gene |
neXtProti | NX_Q9H2A7 |
OpenTargetsi | ENSG00000161921 |
PharmGKBi | PA27057 |
VEuPathDBi | HostDB:ENSG00000161921 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502T0B7, Eukaryota |
GeneTreei | ENSGT00390000002148 |
HOGENOMi | CLU_049889_0_0_1 |
InParanoidi | Q9H2A7 |
OMAi | CFDSGEC |
OrthoDBi | 1450357at2759 |
PhylomeDBi | Q9H2A7 |
TreeFami | TF337941 |
Enzyme and pathway databases
PathwayCommonsi | Q9H2A7 |
Reactomei | R-HSA-380108, Chemokine receptors bind chemokines R-HSA-418594, G alpha (i) signalling events |
SignaLinki | Q9H2A7 |
Miscellaneous databases
BioGRID-ORCSi | 58191, 6 hits in 1039 CRISPR screens |
ChiTaRSi | CXCL16, human |
GenomeRNAii | 58191 |
Pharosi | Q9H2A7, Tbio |
PROi | PR:Q9H2A7 |
RNActi | Q9H2A7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000161921, Expressed in right testis and 190 other tissues |
ExpressionAtlasi | Q9H2A7, baseline and differential |
Genevisiblei | Q9H2A7, HS |
Family and domain databases
InterProi | View protein in InterPro IPR026296, CXCL16 |
PANTHERi | PTHR14385, PTHR14385, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CXL16_HUMAN | |
Accessioni | Q9H2A7Primary (citable) accession number: Q9H2A7 Secondary accession number(s): A0N0N4 Q9H2F6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 5, 2001 |
Last sequence update: | October 14, 2008 | |
Last modified: | February 23, 2022 | |
This is version 168 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families