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Protein

C-X-C motif chemokine 16

Gene

CXCL16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo.By similarity

GO - Molecular functioni

  • chemokine activity Source: BHF-UCL
  • low-density lipoprotein particle receptor activity Source: UniProtKB
  • scavenger receptor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis

Enzyme and pathway databases

ReactomeiR-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events

Protein family/group databases

TCDBi9.B.173.1.1 the chemokine, cxcl16 (cxcl16) family

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 16
Alternative name(s):
Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein
Short name:
SR-PSOX
Small-inducible cytokine B16
Transmembrane chemokine CXCL16
Gene namesi
Name:CXCL16
Synonyms:SCYB16, SRPSOX
ORF Names:UNQ2759/PRO6714
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000161921.14
HGNCiHGNC:16642 CXCL16
MIMi605398 gene
neXtProtiNX_Q9H2A7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 205ExtracellularSequence analysisAdd BLAST176
Transmembranei206 – 226HelicalSequence analysisAdd BLAST21
Topological domaini227 – 254CytoplasmicSequence analysisAdd BLAST28

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi58191
PharmGKBiPA27057

Polymorphism and mutation databases

BioMutaiCXCL16
DMDMi209572770

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000000511830 – 254C-X-C motif chemokine 16Add BLAST225

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi38 ↔ 68By similarity
Disulfide bondi40 ↔ 82By similarity
Glycosylationi168N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9H2A7
MaxQBiQ9H2A7
PaxDbiQ9H2A7
PeptideAtlasiQ9H2A7
PRIDEiQ9H2A7
ProteomicsDBi80520

PTM databases

iPTMnetiQ9H2A7
PhosphoSitePlusiQ9H2A7

Expressioni

Tissue specificityi

Expressed in T-cell areas. Expressed in spleen, lymph nodes, lung, kidney, small intestine and thymus. Weak expression in heart and liver and no expression in brain and bone marrow.

Gene expression databases

BgeeiENSG00000161921 Expressed in 173 organ(s), highest expression level in right testis
CleanExiHS_CXCL16
ExpressionAtlasiQ9H2A7 baseline and differential
GenevisibleiQ9H2A7 HS

Organism-specific databases

HPAiHPA053253
HPA066315

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121805, 31 interactors
STRINGi9606.ENSP00000293778

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni32 – 107ChemokineAdd BLAST76

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J8A5 Eukaryota
ENOG4111D6H LUCA
HOVERGENiHBG107790
InParanoidiQ9H2A7
KOiK10035
OrthoDBiEOG091G0P40
PhylomeDBiQ9H2A7
TreeFamiTF337941

Family and domain databases

InterProiView protein in InterPro
IPR026296 CXCL16
PANTHERiPTHR14385 PTHR14385, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9H2A7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRDLRPGSR VLLLLLLLLL VYLTQPGNGN EGSVTGSCYC GKRISSDSPP
60 70 80 90 100
SVQFMNRLRK HLRAYHRCLY YTRFQLLSWS VCGGNKDPWV QELMSCLDLK
110 120 130 140 150
ECGHAYSGIV AHQKHLLPTS PPISQASEGA SSDIHTPAQM LLSTLQSTQR
160 170 180 190 200
PTLPVGSLSS DKELTRPNET TIHTAGHSLA AGPEAGENQK QPEKNAGPTA
210 220 230 240 250
RTSATVPVLC LLAIIFILTA ALSYVLCKRR RGQSPQSSPD LPVHYIPVAP

DSNT
Length:254
Mass (Da):27,579
Last modified:October 14, 2008 - v4
Checksum:iEA627A87958B83B6
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L333I3L333_HUMAN
C-X-C motif chemokine 16
CXCL16
93Annotation score:

Sequence cautioni

The sequence AAG34365 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH17588 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH44930 differs from that shown. Reason: Erroneous initiation.Curated
The sequence ABK41925 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB55078 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAF84803 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAG37507 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti67R → W in BAG37507 (PubMed:14702039).Curated1
Sequence conflicti135H → L in BAB55078 (PubMed:14702039).Curated1
Sequence conflicti143S → P in BAG37507 (PubMed:14702039).Curated1
Sequence conflicti222L → P in AAK38275 (PubMed:11290797).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_015424123I → T3 Publications1
Natural variantiVAR_015425181A → V4 PublicationsCorresponds to variant dbSNP:rs2277680Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF301016 mRNA Translation: AAG34365.1 Different initiation.
AF337812 mRNA Translation: AAK38275.1
AF275260 mRNA Translation: AAG31750.1
EF064742 Genomic DNA Translation: ABK41925.1 Different initiation.
AY358909 mRNA Translation: AAQ89268.1
AK027389 mRNA Translation: BAB55078.1 Different initiation.
AK292114 mRNA Translation: BAF84803.1 Different initiation.
AK315017 mRNA Translation: BAG37507.1 Different initiation.
BC017588 mRNA Translation: AAH17588.1 Different initiation.
BC044930 mRNA Translation: AAH44930.1 Different initiation.
RefSeqiNP_001094282.1, NM_001100812.1
NP_071342.2, NM_022059.3
UniGeneiHs.745037

Genome annotation databases

EnsembliENST00000293778; ENSP00000293778; ENSG00000161921
ENST00000574412; ENSP00000459592; ENSG00000161921
GeneIDi58191
KEGGihsa:58191
UCSCiuc002fyr.6 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

CXCL16 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF301016 mRNA Translation: AAG34365.1 Different initiation.
AF337812 mRNA Translation: AAK38275.1
AF275260 mRNA Translation: AAG31750.1
EF064742 Genomic DNA Translation: ABK41925.1 Different initiation.
AY358909 mRNA Translation: AAQ89268.1
AK027389 mRNA Translation: BAB55078.1 Different initiation.
AK292114 mRNA Translation: BAF84803.1 Different initiation.
AK315017 mRNA Translation: BAG37507.1 Different initiation.
BC017588 mRNA Translation: AAH17588.1 Different initiation.
BC044930 mRNA Translation: AAH44930.1 Different initiation.
RefSeqiNP_001094282.1, NM_001100812.1
NP_071342.2, NM_022059.3
UniGeneiHs.745037

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121805, 31 interactors
STRINGi9606.ENSP00000293778

Protein family/group databases

TCDBi9.B.173.1.1 the chemokine, cxcl16 (cxcl16) family

PTM databases

iPTMnetiQ9H2A7
PhosphoSitePlusiQ9H2A7

Polymorphism and mutation databases

BioMutaiCXCL16
DMDMi209572770

Proteomic databases

EPDiQ9H2A7
MaxQBiQ9H2A7
PaxDbiQ9H2A7
PeptideAtlasiQ9H2A7
PRIDEiQ9H2A7
ProteomicsDBi80520

Protocols and materials databases

DNASUi58191
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000293778; ENSP00000293778; ENSG00000161921
ENST00000574412; ENSP00000459592; ENSG00000161921
GeneIDi58191
KEGGihsa:58191
UCSCiuc002fyr.6 human

Organism-specific databases

CTDi58191
DisGeNETi58191
EuPathDBiHostDB:ENSG00000161921.14
GeneCardsiCXCL16
H-InvDBiHIX0013447
HGNCiHGNC:16642 CXCL16
HPAiHPA053253
HPA066315
MIMi605398 gene
neXtProtiNX_Q9H2A7
PharmGKBiPA27057
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J8A5 Eukaryota
ENOG4111D6H LUCA
HOVERGENiHBG107790
InParanoidiQ9H2A7
KOiK10035
OrthoDBiEOG091G0P40
PhylomeDBiQ9H2A7
TreeFamiTF337941

Enzyme and pathway databases

ReactomeiR-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events

Miscellaneous databases

ChiTaRSiCXCL16 human
GenomeRNAii58191
PROiPR:Q9H2A7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000161921 Expressed in 173 organ(s), highest expression level in right testis
CleanExiHS_CXCL16
ExpressionAtlasiQ9H2A7 baseline and differential
GenevisibleiQ9H2A7 HS

Family and domain databases

InterProiView protein in InterPro
IPR026296 CXCL16
PANTHERiPTHR14385 PTHR14385, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCXL16_HUMAN
AccessioniPrimary (citable) accession number: Q9H2A7
Secondary accession number(s): A0N0N4
, A8K7U9, B2RCB0, Q8TC80, Q96K63, Q9BXD6, Q9H2F6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: October 14, 2008
Last modified: November 7, 2018
This is version 151 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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