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Protein

Interleukin-25

Gene

IL25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8. Proinflammatory cytokine favoring Th2-type immune responses.

GO - Molecular functioni

  • cytokine activity Source: UniProtKB-KW
  • interleukin-17E receptor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

ReactomeiR-HSA-448424 Interleukin-17 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-25
Short name:
IL-25
Alternative name(s):
Interleukin-17E
Short name:
IL-17E
Gene namesi
Name:IL25
Synonyms:IL17E
ORF Names:UNQ3120/PRO10272
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000166090.8
HGNCiHGNC:13765 IL25
MIMi605658 gene
neXtProtiNX_Q9H293

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi64806
OpenTargetsiENSG00000166090
PharmGKBiPA29799

Polymorphism and mutation databases

BioMutaiIL25
DMDMi20138730

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 321 PublicationAdd BLAST32
ChainiPRO_000001543133 – 177Interleukin-25Add BLAST145

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi110 ↔ 168By similarity
Disulfide bondi115 ↔ 170By similarity
Glycosylationi136N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9H293
PeptideAtlasiQ9H293
PRIDEiQ9H293
ProteomicsDBi80511
80512 [Q9H293-2]
TopDownProteomicsiQ9H293-2 [Q9H293-2]

PTM databases

iPTMnetiQ9H293
PhosphoSitePlusiQ9H293

Expressioni

Tissue specificityi

Expressed at low levels in several tissues, including brain, kidney, lung, prostate, testis, spinal cord, adrenal gland, and trachea.

Gene expression databases

BgeeiENSG00000166090
CleanExiHS_IL25
GenevisibleiQ9H293 HS

Organism-specific databases

HPAiCAB024864

Interactioni

GO - Molecular functioni

  • cytokine activity Source: UniProtKB-KW
  • interleukin-17E receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi122310, 16 interactors
IntActiQ9H293, 1 interactor
STRINGi9606.ENSP00000328111

Structurei

3D structure databases

ProteinModelPortaliQ9H293
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-17 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHJ5 Eukaryota
ENOG4111VTD LUCA
GeneTreeiENSGT00920000149115
HOGENOMiHOG000113041
HOVERGENiHBG052097
InParanoidiQ9H293
KOiK05493
OMAiFYRRPCP
OrthoDBiEOG091G17O0
PhylomeDBiQ9H293
TreeFamiTF314701

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR010345 IL-17_fam
PfamiView protein in Pfam
PF06083 IL17, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H293-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRERPRLGED SSLISLFLQV VAFLAMVMGT HTYSHWPSCC PSKGQDTSEE
60 70 80 90 100
LLRWSTVPVP PLEPARPNRH PESCRASEDG PLNSRAISPW RYELDRDLNR
110 120 130 140 150
LPQDLYHARC LCPHCVSLQT GSHMDPRGNS ELLYHNQTVF YRRPCHGEKG
160 170
THKGYCLERR LYRVSLACVC VRPRVMG
Length:177
Mass (Da):20,330
Last modified:March 1, 2001 - v1
Checksum:i52D895710CD59871
GO
Isoform 2 (identifier: Q9H293-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MRERPRLGEDSSLISLFL → MY

Show »
Length:161
Mass (Da):18,523
Checksum:i37685913FCFE151D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti177G → A in AAL57622 (PubMed:11754819).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0101591 – 18MRERP…ISLFL → MY in isoform 2. 3 PublicationsAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF305200 mRNA Translation: AAG40848.1
AF458059 mRNA Translation: AAL57622.1
AF461739 mRNA Translation: AAN39038.1
AY359127 mRNA Translation: AAQ89484.1
CH471078 Genomic DNA Translation: EAW66162.1
BC069565 mRNA Translation: AAH69565.1
BC104929 mRNA Translation: AAI04930.1
BC104931 mRNA Translation: AAI04932.1
CCDSiCCDS45086.1 [Q9H293-2]
CCDS9597.1 [Q9H293-1]
RefSeqiNP_073626.1, NM_022789.3 [Q9H293-1]
NP_758525.1, NM_172314.1 [Q9H293-2]
UniGeneiHs.302036

Genome annotation databases

EnsembliENST00000329715; ENSP00000328111; ENSG00000166090 [Q9H293-1]
ENST00000397242; ENSP00000380417; ENSG00000166090 [Q9H293-2]
GeneIDi64806
KEGGihsa:64806
UCSCiuc001wjq.4 human [Q9H293-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiIL25_HUMAN
AccessioniPrimary (citable) accession number: Q9H293
Secondary accession number(s): Q2M3F0, Q8IZV3, Q8WXB0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: March 1, 2001
Last modified: June 20, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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