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Entry version 160 (08 May 2019)
Sequence version 2 (03 Apr 2007)
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Protein

Caspase recruitment domain-containing protein 9

Gene

CARD9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter protein that plays a key role in innate immune response to a number of intracellular pathogens, such as C.albicans and L.monocytogenes. Is at the crossroads of ITAM-tyrosine kinase and the Toll-like receptors (TLR) and NOD2 signaling pathways. Probably controls various innate immune response pathways depending on the intracellular pathogen. In response to L.monocytogenes infection, acts by connecting NOD2 recognition of peptidoglycan to downstream activation of MAP kinases (MAPK) without activating NF-kappa-B. Also involved in activation of myeloid cells via classical ITAM-associated receptors and TLR: required for TLR-mediated activation of MAPK, while it is not required for TLR-induced activation of NF-kappa-B (By similarity). Controls CLEC7A (dectin-1)-mediated myeloid cell activation induced by the yeast cell wall component zymosan, leading to cytokine production and innate anti-fungal immunity: acts by regulating BCL10-MALT1-mediated NF-kappa-B activation pathway. Activates NF-kappa-B via BCL10. In response to the hyphal form of C.albicans, mediates CLEC6A (dectin-2)-induced I-kappa-B kinase ubiquitination, leading to NF-kappa-B activation via interaction with BCL10. In response to fungal infection, may be required for the development and subsequent differentiation of interleukin 17-producing T helper (TH-17) cells.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processImmunity, Innate immunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-168638 NOD1/2 Signaling Pathway
R-HSA-5607764 CLEC7A (Dectin-1) signaling

SIGNOR Signaling Network Open Resource

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SIGNORi
Q9H257

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Caspase recruitment domain-containing protein 9
Short name:
hCARD9
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CARD9
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:16391 CARD9

Online Mendelian Inheritance in Man (OMIM)

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MIMi
607212 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q9H257

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Candidiasis, familial, 2 (CANDF2)3 Publications
The disease is caused by mutations affecting the gene represented in this entry. Defects induce reduced numbers of CD4(+) Th17 lymphocytes as well as a lack of monocyte-derived cytokines in response to Candida strains. Neutrophils show a selective Candida albicans killing defect with abnormal ultrastructural phagolysosomes and outgrowth of hyphae (PubMed:23335372).1 Publication
Disease descriptionA primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.
See also OMIM:212050
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07082872G → S in CANDF2; found in a compound heterozygote also carrying P-373; patient neutrophils do not express CARD9. 1 PublicationCorresponds to variant dbSNP:rs398122362EnsemblClinVar.1
Natural variantiVAR_070829101R → C in CANDF2. 1 PublicationCorresponds to variant dbSNP:rs398122364EnsemblClinVar.1
Natural variantiVAR_070830373R → P in CANDF2; found in a compound heterozygote also carrying S-72; patient neutrophils do not express CARD9. 1 PublicationCorresponds to variant dbSNP:rs149712114EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
64170

MalaCards human disease database

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MalaCardsi
CARD9
MIMi212050 phenotype

Open Targets

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OpenTargetsi
ENSG00000187796

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
457088 Predisposition to invasive fungal disease due to CARD9 deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA26077

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
CARD9

Domain mapping of disease mutations (DMDM)

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DMDMi
143811370

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001440821 – 536Caspase recruitment domain-containing protein 9Add BLAST536

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2PhosphoserineBy similarity1
Modified residuei277PhosphoserineCombined sources1
Modified residuei424PhosphoserineBy similarity1
Modified residuei425PhosphoserineCombined sources1
Modified residuei431PhosphoserineBy similarity1
Modified residuei450PhosphoserineBy similarity1
Modified residuei460PhosphoserineCombined sources1
Modified residuei483PhosphoserineCombined sources1
Modified residuei498PhosphoserineCombined sources1
Modified residuei531Phosphothreonine; by CK2By similarity1
Modified residuei533Phosphothreonine; by CK2By similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated at Thr-531 and Thr-533 by CK2 following interaction with VHL, leading to inhibit the ability to activate NF-kappa-B.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9H257

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9H257

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9H257

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9H257

PeptideAtlas

More...
PeptideAtlasi
Q9H257

PRoteomics IDEntifications database

More...
PRIDEi
Q9H257

ProteomicsDB human proteome resource

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ProteomicsDBi
80503
80504 [Q9H257-2]
80505 [Q9H257-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9H257

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9H257

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in spleen. Also detected in liver, placenta, lung, peripheral blood leukocytes and in brain.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000187796 Expressed in 112 organ(s), highest expression level in blood

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9H257 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9H257 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA059502

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with NOD2 (via NACHT domain) (PubMed:24960071). Interacts with RIPK2 (By similarity). Interacts with VHL; without leading to protein degradation (By similarity). Self-associates. Interacts (via CARD domain) with BCL10 (via CARD domain) (PubMed:11053425).By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
A8K9323EBI-751319,EBI-10174671
ABLIM1O146393EBI-751319,EBI-487024
AESQ081173EBI-751319,EBI-717810
AMOTL2Q9Y2J4-45EBI-751319,EBI-10187270
AXIN1A0A0S2Z4M13EBI-16431743,EBI-16429430
AXIN1O151693EBI-11530605,EBI-710484
BCL10O959996EBI-751319,EBI-958922
BLZF1Q9H2G93EBI-751319,EBI-2548012
C1orf94Q6P1W53EBI-751319,EBI-946029
C2CD6Q53TS83EBI-751319,EBI-739879
CARD10Q9BWT74EBI-11530605,EBI-3866279
CCDC36Q8IYA83EBI-751319,EBI-8638439
CCHCR1Q8TD31-33EBI-751319,EBI-10175300
CDCA7LQ96GN53EBI-751319,EBI-5278764
CEP57L1Q8IYX8-23EBI-751319,EBI-10181988
CEP70Q8NHQ13EBI-751319,EBI-739624
CWF19L2Q2TBE03EBI-751319,EBI-5453285
DAXXQ9UER73EBI-751319,EBI-77321
DUSP13Q9UII64EBI-11530605,EBI-749800
EIF4E2O605733EBI-751319,EBI-398610
FAM124BQ9H5Z63EBI-751319,EBI-741626
FAM161AQ3B8204EBI-11530605,EBI-719941
FAM208BQ5VWN6-23EBI-751319,EBI-10172380
FAM50BQ9Y2473EBI-751319,EBI-742802
HMBOX1Q6NT763EBI-751319,EBI-2549423
KCTD9Q7L2733EBI-751319,EBI-4397613
KIFC3Q9BVG8-54EBI-11530605,EBI-14069005
KRT19P087273EBI-751319,EBI-742756
KRT31Q153233EBI-751319,EBI-948001
KRT40Q6A1623EBI-751319,EBI-10171697
KRTAP10-5P603703EBI-751319,EBI-10172150
LENG1Q96BZ83EBI-751319,EBI-726510
LMO1P258003EBI-751319,EBI-8639312
LZTS2Q9BRK43EBI-751319,EBI-741037
MEOX2P502223EBI-751319,EBI-748397
MFAP1P550813EBI-751319,EBI-1048159
MID2Q9UJV3-24EBI-11530605,EBI-10172526
NECAB2Q7Z6G3-23EBI-751319,EBI-10172876
PAK5Q9P2863EBI-751319,EBI-741896
PBX2P404253EBI-751319,EBI-348489
PHC2Q8IXK03EBI-751319,EBI-713786
PNMA5Q96PV43EBI-751319,EBI-10171633
PPP1R18Q6NYC83EBI-751319,EBI-2557469
RTP5Q14D333EBI-751319,EBI-10217913
SSX2IPQ9Y2D83EBI-751319,EBI-2212028
STX11O755583EBI-751319,EBI-714135
SUMO1P631653EBI-751319,EBI-80140
TCEANCQ8N8B73EBI-751319,EBI-954696
TCL1AP562793EBI-751319,EBI-749995
TFIP11Q9UBB93EBI-751319,EBI-1105213
TNFAIP1Q138293EBI-751319,EBI-2505861
TRIM23P364063EBI-751319,EBI-740098
TRIM29Q141343EBI-751319,EBI-702370
TRIM42Q8IWZ53EBI-751319,EBI-5235829
TRIM54Q9BYV23EBI-751319,EBI-2130429
TSGA10IPQ3SY004EBI-11530605,EBI-10241197
TSNAXQ995985EBI-751319,EBI-742638
USP15Q9Y4E83EBI-751319,EBI-1043104
VPS28Q548N13EBI-751319,EBI-10243107
VPS28Q9UK414EBI-11530605,EBI-727424
ZCCHC7Q8N3Z63EBI-751319,EBI-7265024
ZNF250P15622-33EBI-751319,EBI-10177272
ZNF417Q8TAU33EBI-751319,EBI-740727
ZNF572Q7Z3I76EBI-751319,EBI-10172590
ZNF587Q96SQ53EBI-751319,EBI-6427977
ZNF655Q8N7203EBI-751319,EBI-625509
ZNF688A0A0S2Z5X43EBI-16431743,EBI-16429014

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
122094, 81 interactors

Protein interaction database and analysis system

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IntActi
Q9H257, 138 interactors

Molecular INTeraction database

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MINTi
Q9H257

STRING: functional protein association networks

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STRINGi
9606.ENSP00000360797

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1536
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6E25NMR-A1-97[»]
6E26NMR-A1-97[»]
6E27X-ray1.81C/D2-97[»]
6E28X-ray1.36C/D2-97[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9H257

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 98CARDPROSITE-ProRule annotationAdd BLAST93

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili117 – 277Sequence analysisAdd BLAST161
Coiled coili332 – 419Sequence analysisAdd BLAST88

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IE3N Eukaryota
ENOG410Y2EE LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000160570

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231538

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9H257

KEGG Orthology (KO)

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KOi
K12794

Identification of Orthologs from Complete Genome Data

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OMAi
PYLRQCQ

Database of Orthologous Groups

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OrthoDBi
115953at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9H257

TreeFam database of animal gene trees

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TreeFami
TF351139

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001315 CARD
IPR011029 DEATH-like_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00619 CARD, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47986 SSF47986, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50209 CARD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H257-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSDYENDDEC WSVLEGFRVT LTSVIDPSRI TPYLRQCKVL NPDDEEQVLS
60 70 80 90 100
DPNLVIRKRK VGVLLDILQR TGHKGYVAFL ESLELYYPQL YKKVTGKEPA
110 120 130 140 150
RVFSMIIDAS GESGLTQLLM TEVMKLQKKV QDLTALLSSK DDFIKELRVK
160 170 180 190 200
DSLLRKHQER VQRLKEECEA GSRELKRCKE ENYDLAMRLA HQSEEKGAAL
210 220 230 240 250
MRNRDLQLEI DQLKHSLMKA EDDCKVERKH TLKLRHAMEQ RPSQELLWEL
260 270 280 290 300
QQEKALLQAR VQELEASVQE GKLDRSSPYI QVLEEDWRQA LRDHQEQANT
310 320 330 340 350
IFSLRKDLRQ GEARRLRCME EKEMFELQCL ALRKDSKMYK DRIEAILLQM
360 370 380 390 400
EEVAIERDQA IATREELHAQ HARGLQEKDA LRKQVRELGE KADELQLQVF
410 420 430 440 450
QCEAQLLAVE GRLRRQQLET LVLSSDLEDG SPRRSQELSL PQDLEDTQLS
460 470 480 490 500
DKGCLAGGGS PKQPFAALHQ EQVLRNPHDA GLSSGEPPEK ERRRLKESFE
510 520 530
NYRRKRALRK MQKGWRQGEE DRENTTGSDN TDTEGS
Length:536
Mass (Da):62,241
Last modified:April 3, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6EB18353112F2BAC
GO
Isoform 2 (identifier: Q9H257-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     482-492: LSSGEPPEKER → PAGLPGIGAVC
     493-536: Missing.

Note: No experimental confirmation available.
Show »
Length:492
Mass (Da):56,667
Checksum:iAADBCF6A5E81125F
GO
Isoform 3 (identifier: Q9H257-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     360-366: AIATREE → STQMEGL
     367-536: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:366
Mass (Da):42,953
Checksum:iEC1CB0ABCF6C7CF4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A286YFD5A0A286YFD5_HUMAN
Caspase recruitment domain-containi...
CARD9
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04860712S → N2 PublicationsCorresponds to variant dbSNP:rs4077515EnsemblClinVar.1
Natural variantiVAR_07082872G → S in CANDF2; found in a compound heterozygote also carrying P-373; patient neutrophils do not express CARD9. 1 PublicationCorresponds to variant dbSNP:rs398122362EnsemblClinVar.1
Natural variantiVAR_070829101R → C in CANDF2. 1 PublicationCorresponds to variant dbSNP:rs398122364EnsemblClinVar.1
Natural variantiVAR_070830373R → P in CANDF2; found in a compound heterozygote also carrying S-72; patient neutrophils do not express CARD9. 1 PublicationCorresponds to variant dbSNP:rs149712114EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_024390360 – 366AIATREE → STQMEGL in isoform 3. 1 Publication7
Alternative sequenceiVSP_024391367 – 536Missing in isoform 3. 1 PublicationAdd BLAST170
Alternative sequenceiVSP_024392482 – 492LSSGEPPEKER → PAGLPGIGAVC in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_024393493 – 536Missing in isoform 2. 1 PublicationAdd BLAST44

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF311287 mRNA Translation: AAG28790.1
AK024001 mRNA Translation: BAB14766.1
AK292081 mRNA Translation: BAF84770.1
AL592301 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW88220.1
BC008877 mRNA Translation: AAH08877.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS48057.1 [Q9H257-2]
CCDS6997.1 [Q9H257-1]

NCBI Reference Sequences

More...
RefSeqi
NP_434700.2, NM_052813.4 [Q9H257-1]
NP_434701.1, NM_052814.3 [Q9H257-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000371732; ENSP00000360797; ENSG00000187796 [Q9H257-1]
ENST00000371734; ENSP00000360799; ENSG00000187796 [Q9H257-2]
ENST00000489932; ENSP00000451368; ENSG00000187796 [Q9H257-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
64170

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:64170

UCSC genome browser

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UCSCi
uc004chg.4 human [Q9H257-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF311287 mRNA Translation: AAG28790.1
AK024001 mRNA Translation: BAB14766.1
AK292081 mRNA Translation: BAF84770.1
AL592301 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW88220.1
BC008877 mRNA Translation: AAH08877.1
CCDSiCCDS48057.1 [Q9H257-2]
CCDS6997.1 [Q9H257-1]
RefSeqiNP_434700.2, NM_052813.4 [Q9H257-1]
NP_434701.1, NM_052814.3 [Q9H257-2]

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6E25NMR-A1-97[»]
6E26NMR-A1-97[»]
6E27X-ray1.81C/D2-97[»]
6E28X-ray1.36C/D2-97[»]
SMRiQ9H257
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122094, 81 interactors
IntActiQ9H257, 138 interactors
MINTiQ9H257
STRINGi9606.ENSP00000360797

PTM databases

iPTMnetiQ9H257
PhosphoSitePlusiQ9H257

Polymorphism and mutation databases

BioMutaiCARD9
DMDMi143811370

Proteomic databases

EPDiQ9H257
jPOSTiQ9H257
MaxQBiQ9H257
PaxDbiQ9H257
PeptideAtlasiQ9H257
PRIDEiQ9H257
ProteomicsDBi80503
80504 [Q9H257-2]
80505 [Q9H257-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
64170
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371732; ENSP00000360797; ENSG00000187796 [Q9H257-1]
ENST00000371734; ENSP00000360799; ENSG00000187796 [Q9H257-2]
ENST00000489932; ENSP00000451368; ENSG00000187796 [Q9H257-3]
GeneIDi64170
KEGGihsa:64170
UCSCiuc004chg.4 human [Q9H257-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
64170
DisGeNETi64170

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CARD9
HGNCiHGNC:16391 CARD9
HPAiHPA059502
MalaCardsiCARD9
MIMi212050 phenotype
607212 gene
neXtProtiNX_Q9H257
OpenTargetsiENSG00000187796
Orphaneti457088 Predisposition to invasive fungal disease due to CARD9 deficiency
PharmGKBiPA26077

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IE3N Eukaryota
ENOG410Y2EE LUCA
GeneTreeiENSGT00940000160570
HOGENOMiHOG000231538
InParanoidiQ9H257
KOiK12794
OMAiPYLRQCQ
OrthoDBi115953at2759
PhylomeDBiQ9H257
TreeFamiTF351139

Enzyme and pathway databases

ReactomeiR-HSA-168638 NOD1/2 Signaling Pathway
R-HSA-5607764 CLEC7A (Dectin-1) signaling
SIGNORiQ9H257

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CARD9

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
64170

Protein Ontology

More...
PROi
PR:Q9H257

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000187796 Expressed in 112 organ(s), highest expression level in blood
ExpressionAtlasiQ9H257 baseline and differential
GenevisibleiQ9H257 HS

Family and domain databases

InterProiView protein in InterPro
IPR001315 CARD
IPR011029 DEATH-like_dom_sf
PfamiView protein in Pfam
PF00619 CARD, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50209 CARD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCARD9_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H257
Secondary accession number(s): Q5SXM5, Q5SXM6, Q9H854
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: April 3, 2007
Last modified: May 8, 2019
This is version 160 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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