Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Olfactory receptor 51E2

Gene

OR51E2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable G protein-coupled receptor that is activated by the short chain fatty acids (SCFA) acetate and propionate. In response to SCFA, may positively regulate renin secretion and increase blood pressure (PubMed:23401498). May also be activated by steroid hormones and regulate cell proliferation (PubMed:19389702). May also function as an olfactory receptor being activated by beta-ionone (PubMed:19389702).2 Publications

GO - Molecular functioni

  • G-protein coupled receptor activity Source: UniProtKB-KW
  • olfactory receptor activity Source: UniProtKB
  • signaling receptor activity Source: UniProtKB
  • steroid hormone receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 51E2
Alternative name(s):
HPRAJ
Olfactory receptor OR11-16
Prostate-specific G-protein coupled receptor
Gene namesi
Name:OR51E2
Synonyms:PSGR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000167332.7
HGNCiHGNC:15195 OR51E2
MIMi611268 gene
neXtProtiNX_Q9H255

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24ExtracellularSequence analysisAdd BLAST24
Transmembranei25 – 45Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini46 – 53CytoplasmicSequence analysis8
Transmembranei54 – 74Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini75 – 98ExtracellularSequence analysisAdd BLAST24
Transmembranei99 – 119Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini120 – 138CytoplasmicSequence analysisAdd BLAST19
Transmembranei139 – 159Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini160 – 195ExtracellularSequence analysisAdd BLAST36
Transmembranei196 – 216Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini217 – 236CytoplasmicSequence analysisAdd BLAST20
Transmembranei237 – 257Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini258 – 272ExtracellularSequence analysisAdd BLAST15
Transmembranei273 – 293Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini294 – 320CytoplasmicSequence analysisAdd BLAST27

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi81285
OpenTargetsiENSG00000167332
PharmGKBiPA32372

Polymorphism and mutation databases

BioMutaiOR51E2
DMDMi18202936

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507511 – 320Olfactory receptor 51E2Add BLAST320

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi96 ↔ 178PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9H255
PeptideAtlasiQ9H255
PRIDEiQ9H255
ProteomicsDBi80502

Expressioni

Tissue specificityi

Mainly expressed in the prostate. Also expressed in spleen, liver, olfactory epithelium and medulla oblongata.2 Publications

Gene expression databases

BgeeiENSG00000167332
CleanExiHS_OR51E2
ExpressionAtlasiQ9H255 baseline and differential
GenevisibleiQ9H255 HS

Interactioni

Protein-protein interaction databases

BioGridi123434, 9 interactors
STRINGi9606.ENSP00000380153

Structurei

3D structure databases

ProteinModelPortaliQ9H255
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGD6 Eukaryota
ENOG41120HT LUCA
GeneTreeiENSGT00900000141042
HOGENOMiHOG000041363
HOVERGENiHBG017625
InParanoidiQ9H255
KOiK04257
OMAiPLLSMYA
OrthoDBiEOG091G0AZH
PhylomeDBiQ9H255
TreeFamiTF342735

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9H255-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSCNFTHAT FVLIGIPGLE KAHFWVGFPL LSMYVVAMFG NCIVVFIVRT
60 70 80 90 100
ERSLHAPMYL FLCMLAAIDL ALSTSTMPKI LALFWFDSRE ISFEACLTQM
110 120 130 140 150
FFIHALSAIE STILLAMAFD RYVAICHPLR HAAVLNNTVT AQIGIVAVVR
160 170 180 190 200
GSLFFFPLPL LIKRLAFCHS NVLSHSYCVH QDVMKLAYAD TLPNVVYGLT
210 220 230 240 250
AILLVMGVDV MFISLSYFLI IRTVLQLPSK SERAKAFGTC VSHIGVVLAF
260 270 280 290 300
YVPLIGLSVV HRFGNSLHPI VRVVMGDIYL LLPPVINPII YGAKTKQIRT
310 320
RVLAMFKISC DKDLQAVGGK
Length:320
Mass (Da):35,493
Last modified:March 1, 2001 - v1
Checksum:i03582CC2AAB6E2C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF311306 Genomic DNA Translation: AAG40776.1
AF369708 mRNA Translation: AAK38728.1
AY033942 mRNA Translation: AAK57550.1
AK314051 mRNA Translation: BAG36760.1
CH471064 Genomic DNA Translation: EAW68829.1
BC020768 mRNA Translation: AAH20768.1
BK004368 Genomic DNA Translation: DAA04766.1
CCDSiCCDS7751.1
RefSeqiNP_110401.1, NM_030774.3
UniGeneiHs.501758
Hs.606330

Genome annotation databases

EnsembliENST00000396950; ENSP00000380153; ENSG00000167332
ENST00000641638; ENSP00000493442; ENSG00000167332
GeneIDi81285
KEGGihsa:81285
UCSCiuc001lzk.3 human

Similar proteinsi

Entry informationi

Entry nameiO51E2_HUMAN
AccessioniPrimary (citable) accession number: Q9H255
Secondary accession number(s): B2RA63, Q6IF94
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: March 1, 2001
Last modified: June 20, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health