Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sphingosine 1-phosphate receptor 5

Gene

S1PR5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-418594 G alpha (i) signalling events
R-HSA-419408 Lysosphingolipid and LPA receptors

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sphingosine 1-phosphate receptor 5
Short name:
S1P receptor 5
Short name:
S1P5
Alternative name(s):
Endothelial differentiation G-protein-coupled receptor 8
Sphingosine 1-phosphate receptor Edg-8
Short name:
S1P receptor Edg-8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:S1PR5
Synonyms:EDG8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000180739.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14299 S1PR5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605146 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H228

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 40ExtracellularBy similarityAdd BLAST40
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei41 – 61Helical; Name=1By similarityAdd BLAST21
Topological domaini62 – 70CytoplasmicBy similarity9
Transmembranei71 – 91Helical; Name=2By similarityAdd BLAST21
Topological domaini92 – 111ExtracellularBy similarityAdd BLAST20
Transmembranei112 – 132Helical; Name=3By similarityAdd BLAST21
Topological domaini133 – 151CytoplasmicBy similarityAdd BLAST19
Transmembranei152 – 172Helical; Name=4By similarityAdd BLAST21
Topological domaini173 – 192ExtracellularBy similarityAdd BLAST20
Transmembranei193 – 213Helical; Name=5By similarityAdd BLAST21
Topological domaini214 – 252CytoplasmicBy similarityAdd BLAST39
Transmembranei253 – 273Helical; Name=6By similarityAdd BLAST21
Topological domaini274 – 287ExtracellularBy similarityAdd BLAST14
Transmembranei288 – 308Helical; Name=7By similarityAdd BLAST21
Topological domaini309 – 398CytoplasmicBy similarityAdd BLAST90

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
53637

Open Targets

More...
OpenTargetsi
ENSG00000180739

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162402378

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2274

Drug and drug target database

More...
DrugBanki
DB08868 Fingolimod

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
279

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
S1PR5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
62510663

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000694361 – 398Sphingosine 1-phosphate receptor 5Add BLAST398

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi20N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi323S-palmitoyl cysteineBy similarity1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei381PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H228

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H228

PeptideAtlas

More...
PeptideAtlasi
Q9H228

PRoteomics IDEntifications database

More...
PRIDEi
Q9H228

ProteomicsDB human proteome resource

More...
ProteomicsDBi
80479
80480 [Q9H228-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H228

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H228

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed in the brain, most prominently in the corpus callosum, which is predominantly white matter. Detected in spleen, peripheral blood leukocytes, placenta, lung, aorta and fetal spleen. Low-level signal detected in many tissue extracts. Overexpressed in leukemic large granular lymphocytes. Isoform 1 is predominantly expressed in peripheral tissues. Isoform 2 is expressed in brain, spleen and peripheral blood leukocytes.3 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

At 24 weeks of gestation, fragments of radial glial fibers are positive within the cortical plate and subplate of allocortical areas. These positive fragments often appear enlarged as varicosities and some of them terminate at blood vessels. Between 28 and 30 weeks of gestation, all iso- and allocortical areas contain immunolabeled radial glial fibers revealing curvature next to sulci. After 32 weeks of gestation, radial glial fibers gradually disappear; instead positive transitional stages between radial glia and astrocytes were found.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000180739 Expressed in 131 organ(s), highest expression level in C1 segment of cervical spinal cord

CleanEx database of gene expression profiles

More...
CleanExi
HS_S1PR5

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9H228 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H228 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA029683

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119793, 6 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9H228

Protein interaction database and analysis system

More...
IntActi
Q9H228, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000328472

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9H228

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9H228

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9H228

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IIK8 Eukaryota
ENOG4111FBV LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153354

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000233501

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG103071

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H228

KEGG Orthology (KO)

More...
KOi
K04295

Identification of Orthologs from Complete Genome Data

More...
OMAi
LCCGRRP

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0DD4

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H228

TreeFam database of animal gene trees

More...
TreeFami
TF330052

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005386 EDG8_S1P_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR004061 S1P_rcpt

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01561 EDG8RECEPTOR
PR00237 GPCRRHODOPSN
PR01523 S1PRECEPTOR

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H228-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MESGLLRPAP VSEVIVLHYN YTGKLRGARY QPGAGLRADA VVCLAVCAFI
60 70 80 90 100
VLENLAVLLV LGRHPRFHAP MFLLLGSLTL SDLLAGAAYA ANILLSGPLT
110 120 130 140 150
LKLSPALWFA REGGVFVALT ASVLSLLAIA LERSLTMARR GPAPVSSRGR
160 170 180 190 200
TLAMAAAAWG VSLLLGLLPA LGWNCLGRLD ACSTVLPLYA KAYVLFCVLA
210 220 230 240 250
FVGILAAICA LYARIYCQVR ANARRLPARP GTAGTTSTRA RRKPRSLALL
260 270 280 290 300
RTLSVVLLAF VACWGPLFLL LLLDVACPAR TCPVLLQADP FLGLAMANSL
310 320 330 340 350
LNPIIYTLTN RDLRHALLRL VCCGRHSCGR DPSGSQQSAS AAEASGGLRR
360 370 380 390
CLPPGLDGSF SGSERSSPQR DGLDTSGSTG SPGAPTAART LVSEPAAD
Length:398
Mass (Da):41,775
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i34ADC6C40D8250BF
GO
Isoform 2 (identifier: Q9H228-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     214-310: RIYCQVRANA...LNPIIYTLTN → LAGLAAHAQR...EWLPAVGERG
     311-398: Missing.

Show »
Length:310
Mass (Da):32,279
Checksum:i906D2B43EC85A8AB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WXR8A0A087WXR8_HUMAN
Sphingosine 1-phosphate receptor 5
S1PR5
254Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EIT5K7EIT5_HUMAN
Sphingosine 1-phosphate receptor 5
S1PR5
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_033466318L → Q. Corresponds to variant dbSNP:rs35483143Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_013369214 – 310RIYCQ…YTLTN → LAGLAAHAQRGAPGLCGMLG PPHPAAVARRGVPGAHLSCT PAGRSLPGTGHGQLTSEPHH LHAHQPRPAPRAPAPGLLRT PLLRQRPEWLPAVGERG in isoform 2. 1 PublicationAdd BLAST97
Alternative sequenceiVSP_013370311 – 398Missing in isoform 2. 1 PublicationAdd BLAST88

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF331840 mRNA Translation: AAL57041.1
AK074661 mRNA Translation: BAC11119.1
AF317676 Genomic DNA Translation: AAG38113.1
AY262689 Genomic DNA Translation: AAP20653.1
AB083602 Genomic DNA Translation: BAB89315.1
AC011461 Genomic DNA No translation available.
BC034703 mRNA Translation: AAH34703.1
BC067781 mRNA Translation: AAH67781.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12240.1 [Q9H228-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001159687.1, NM_001166215.1 [Q9H228-1]
NP_110387.1, NM_030760.4 [Q9H228-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.501561

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000333430; ENSP00000328472; ENSG00000180739 [Q9H228-1]
ENST00000439028; ENSP00000416915; ENSG00000180739 [Q9H228-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
53637

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:53637

UCSC genome browser

More...
UCSCi
uc002mot.2 human [Q9H228-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF331840 mRNA Translation: AAL57041.1
AK074661 mRNA Translation: BAC11119.1
AF317676 Genomic DNA Translation: AAG38113.1
AY262689 Genomic DNA Translation: AAP20653.1
AB083602 Genomic DNA Translation: BAB89315.1
AC011461 Genomic DNA No translation available.
BC034703 mRNA Translation: AAH34703.1
BC067781 mRNA Translation: AAH67781.1
CCDSiCCDS12240.1 [Q9H228-1]
RefSeqiNP_001159687.1, NM_001166215.1 [Q9H228-1]
NP_110387.1, NM_030760.4 [Q9H228-1]
UniGeneiHs.501561

3D structure databases

ProteinModelPortaliQ9H228
SMRiQ9H228
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119793, 6 interactors
CORUMiQ9H228
IntActiQ9H228, 2 interactors
STRINGi9606.ENSP00000328472

Chemistry databases

BindingDBiQ9H228
ChEMBLiCHEMBL2274
DrugBankiDB08868 Fingolimod
GuidetoPHARMACOLOGYi279

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

PTM databases

iPTMnetiQ9H228
PhosphoSitePlusiQ9H228

Polymorphism and mutation databases

BioMutaiS1PR5
DMDMi62510663

Proteomic databases

MaxQBiQ9H228
PaxDbiQ9H228
PeptideAtlasiQ9H228
PRIDEiQ9H228
ProteomicsDBi80479
80480 [Q9H228-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
53637
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333430; ENSP00000328472; ENSG00000180739 [Q9H228-1]
ENST00000439028; ENSP00000416915; ENSG00000180739 [Q9H228-1]
GeneIDi53637
KEGGihsa:53637
UCSCiuc002mot.2 human [Q9H228-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
53637
DisGeNETi53637
EuPathDBiHostDB:ENSG00000180739.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
S1PR5

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0174397
HGNCiHGNC:14299 S1PR5
HPAiHPA029683
MIMi605146 gene
neXtProtiNX_Q9H228
OpenTargetsiENSG00000180739
PharmGKBiPA162402378

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IIK8 Eukaryota
ENOG4111FBV LUCA
GeneTreeiENSGT00940000153354
HOGENOMiHOG000233501
HOVERGENiHBG103071
InParanoidiQ9H228
KOiK04295
OMAiLCCGRRP
OrthoDBiEOG091G0DD4
PhylomeDBiQ9H228
TreeFamiTF330052

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
R-HSA-419408 Lysosphingolipid and LPA receptors

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
S1PR5 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
S1PR5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
53637

Protein Ontology

More...
PROi
PR:Q9H228

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000180739 Expressed in 131 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_S1PR5
ExpressionAtlasiQ9H228 baseline and differential
GenevisibleiQ9H228 HS

Family and domain databases

InterProiView protein in InterPro
IPR005386 EDG8_S1P_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR004061 S1P_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01561 EDG8RECEPTOR
PR00237 GPCRRHODOPSN
PR01523 S1PRECEPTOR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS1PR5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H228
Secondary accession number(s): Q6NW11
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: March 1, 2001
Last modified: December 5, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again