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Protein

Olfactory receptor 10A4

Gene

OR10A4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor (Potential). May be involved in taste perception.Curated

GO - Molecular functioni

  • G protein-coupled receptor activity Source: UniProtKB-KW
  • olfactory receptor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10A4
Alternative name(s):
HP2
Olfactory receptor-like protein JCG5
Gene namesi
Name:OR10A4
Synonyms:OR10A4P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000170782.3
HGNCiHGNC:15130 OR10A4
neXtProtiNX_Q9H209

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26ExtracellularSequence analysisAdd BLAST26
Transmembranei27 – 47Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini48 – 55CytoplasmicSequence analysis8
Transmembranei56 – 76Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini77 – 100ExtracellularSequence analysisAdd BLAST24
Transmembranei101 – 121Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini122 – 140CytoplasmicSequence analysisAdd BLAST19
Transmembranei141 – 161Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini162 – 198ExtracellularSequence analysisAdd BLAST37
Transmembranei199 – 218Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini219 – 238CytoplasmicSequence analysisAdd BLAST20
Transmembranei239 – 259Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini260 – 272ExtracellularSequence analysisAdd BLAST13
Transmembranei273 – 293Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini294 – 315CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi283297
OpenTargetsiENSG00000170782
PharmGKBiPA31952

Polymorphism and mutation databases

BioMutaiOR10A4
DMDMi296439244

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506861 – 315Olfactory receptor 10A4Add BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi98 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9H209
PRIDEiQ9H209
ProteomicsDBi80469

Expressioni

Tissue specificityi

Expressed in the tongue.

Gene expression databases

BgeeiENSG00000170782 Expressed in 4 organ(s), highest expression level in corpus callosum
GenevisibleiQ9H209 HS

Interactioni

Protein-protein interaction databases

BioGridi129519, 4 interactors
STRINGi9606.ENSP00000369157

Structurei

3D structure databases

ProteinModelPortaliQ9H209
SMRiQ9H209
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKK8 Eukaryota
ENOG410YDA3 LUCA
GeneTreeiENSGT00760000119002
HOVERGENiHBG017625
InParanoidiQ9H209
KOiK04257
OMAiWIFSFPF
OrthoDBiEOG091G0FFM
PhylomeDBiQ9H209
TreeFamiTF337350

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9H209-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMWENWTIVS EFVLVSFSAL STELQALLFL LFLTIYLVTL MGNVLIILVT
60 70 80 90 100
IADSALQSPM YFFLRNLSFL EIGFNLVIVP KMLGTLIIQD TTISFLGCAT
110 120 130 140 150
QMYFFFFFGA AECCLLATMA YDRYVAICDP LHYPVIMGHI SCAQLAAASW
160 170 180 190 200
FSGFSVATVQ TTWIFSFPFC GPNRVNHFFC DSPPVIALVC ADTSVFELEA
210 220 230 240 250
LTATVLFILF PFLLILGSYV RILSTIFRMP SAEGKHQAFS TCSAHLLVVS
260 270 280 290 300
LFYSTAILTY FRPQSSASSE SKKLLSLSST VVTPMLNPII YSSRNKEVKA
310
ALKRLIHRTL GSQKL
Length:315
Mass (Da):35,117
Last modified:May 18, 2010 - v2
Checksum:iC8DF67959FDACBFC
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060023206L → P3 PublicationsCorresponds to variant dbSNP:rs2595453Ensembl.1
Natural variantiVAR_034280221R → H. Corresponds to variant dbSNP:rs7938371Ensembl.1
Natural variantiVAR_034281246L → F. Corresponds to variant dbSNP:rs16919049Ensembl.1
Natural variantiVAR_024124262R → Q1 PublicationCorresponds to variant dbSNP:rs10839635Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF321237 Genomic DNA Translation: AAG45205.1
AF209506 mRNA Translation: AAL32993.1
AC087280 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68674.1
BC137024 mRNA Translation: AAI37025.1
BC137027 mRNA Translation: AAI37028.1
AF399625 Genomic DNA Translation: AAK95110.1
CCDSiCCDS7774.1
RefSeqiNP_997069.2, NM_207186.2
UniGeneiHs.448685

Genome annotation databases

EnsembliENST00000379829; ENSP00000369157; ENSG00000170782
GeneIDi283297
KEGGihsa:283297
UCSCiuc010rat.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF321237 Genomic DNA Translation: AAG45205.1
AF209506 mRNA Translation: AAL32993.1
AC087280 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68674.1
BC137024 mRNA Translation: AAI37025.1
BC137027 mRNA Translation: AAI37028.1
AF399625 Genomic DNA Translation: AAK95110.1
CCDSiCCDS7774.1
RefSeqiNP_997069.2, NM_207186.2
UniGeneiHs.448685

3D structure databases

ProteinModelPortaliQ9H209
SMRiQ9H209
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129519, 4 interactors
STRINGi9606.ENSP00000369157

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR10A4
DMDMi296439244

Proteomic databases

PaxDbiQ9H209
PRIDEiQ9H209
ProteomicsDBi80469

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379829; ENSP00000369157; ENSG00000170782
GeneIDi283297
KEGGihsa:283297
UCSCiuc010rat.2 human

Organism-specific databases

CTDi283297
DisGeNETi283297
EuPathDBiHostDB:ENSG00000170782.3
GeneCardsiOR10A4
HGNCiHGNC:15130 OR10A4
neXtProtiNX_Q9H209
OpenTargetsiENSG00000170782
PharmGKBiPA31952
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKK8 Eukaryota
ENOG410YDA3 LUCA
GeneTreeiENSGT00760000119002
HOVERGENiHBG017625
InParanoidiQ9H209
KOiK04257
OMAiWIFSFPF
OrthoDBiEOG091G0FFM
PhylomeDBiQ9H209
TreeFamiTF337350

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR10A4
GenomeRNAii283297
PROiPR:Q9H209

Gene expression databases

BgeeiENSG00000170782 Expressed in 4 organ(s), highest expression level in corpus callosum
GenevisibleiQ9H209 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO10A4_HUMAN
AccessioniPrimary (citable) accession number: Q9H209
Secondary accession number(s): B2RNP5, B9EH36, Q96R20
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  5. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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