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Protein

Epsin-3

Gene

EPN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei8Phosphatidylinositol lipid headgroupBy similarity1
Binding sitei11Phosphatidylinositol lipid headgroupBy similarity1
Binding sitei25Phosphatidylinositol lipid headgroupBy similarity1
Binding sitei30Phosphatidylinositol lipid headgroupBy similarity1
Binding sitei63Phosphatidylinositol lipid headgroupBy similarity1
Binding sitei73Phosphatidylinositol lipid headgroupBy similarity1

GO - Molecular functioni

Keywordsi

LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Epsin-3
Alternative name(s):
EPS-15-interacting protein 3
Gene namesi
Name:EPN3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000049283.17
HGNCiHGNC:18235 EPN3
MIMi607264 gene
neXtProtiNX_Q9H201

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55040
OpenTargetsiENSG00000049283
PharmGKBiPA38513

Polymorphism and mutation databases

BioMutaiEPN3
DMDMi41017054

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000745191 – 632Epsin-3Add BLAST632

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei191PhosphoserineBy similarity1
Modified residuei192PhosphoserineBy similarity1
Modified residuei264PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H201
MaxQBiQ9H201
PaxDbiQ9H201
PeptideAtlasiQ9H201
PRIDEiQ9H201
ProteomicsDBi80463
80464 [Q9H201-2]

PTM databases

iPTMnetiQ9H201
PhosphoSitePlusiQ9H201

Expressioni

Tissue specificityi

Detected in migrating keratinocytes from wounded skin, but not in differentiating keratinocytes or in normal skin. Detected in chronic wounds, basal cell carcinoma and ulcerative colitis.1 Publication

Inductioni

In keratinocytes, by wounding or contact with collagen.1 Publication

Gene expression databases

BgeeiENSG00000049283 Expressed in 85 organ(s), highest expression level in fundus of stomach
CleanExiHS_EPN3
ExpressionAtlasiQ9H201 baseline and differential
GenevisibleiQ9H201 HS

Organism-specific databases

HPAiHPA055546
HPA063224

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi120369, 31 interactors
ELMiQ9H201
IntActiQ9H201, 3 interactors
MINTiQ9H201
STRINGi9606.ENSP00000268933

Structurei

3D structure databases

ProteinModelPortaliQ9H201
SMRiQ9H201
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 144ENTHPROSITE-ProRule annotationAdd BLAST133
Domaini209 – 228UIM 1PROSITE-ProRule annotationAdd BLAST20
Domaini236 – 255UIM 2PROSITE-ProRule annotationAdd BLAST20
Repeati321 – 32313
Repeati344 – 34623
Repeati371 – 37333
Repeati387 – 38943
Repeati404 – 40653
Repeati524 – 52613
Repeati537 – 53923
Repeati629 – 63133

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni321 – 4065 X 3 AA repeats of [DE]-P-WAdd BLAST86
Regioni524 – 6313 X 3 AA repeats of N-P-FAdd BLAST108

Sequence similaritiesi

Belongs to the epsin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2056 Eukaryota
ENOG410XSM0 LUCA
GeneTreeiENSGT00550000074611
HOGENOMiHOG000008298
HOVERGENiHBG006690
InParanoidiQ9H201
KOiK12471
OMAiADPWSPI
OrthoDBiEOG091G0L45
PhylomeDBiQ9H201
TreeFamiTF313361

Family and domain databases

CDDicd03571 ENTH_epsin, 1 hit
Gene3Di1.25.40.90, 1 hit
InterProiView protein in InterPro
IPR013809 ENTH
IPR008942 ENTH_VHS
IPR027318 Epsin-3_metazoa
IPR039416 Epsin_ENTH
IPR003903 UIM_dom
PANTHERiPTHR12276:SF16 PTHR12276:SF16, 1 hit
PfamiView protein in Pfam
PF01417 ENTH, 1 hit
PF02809 UIM, 2 hits
SMARTiView protein in SMART
SM00273 ENTH, 1 hit
SM00726 UIM, 2 hits
SUPFAMiSSF48464 SSF48464, 1 hit
PROSITEiView protein in PROSITE
PS50942 ENTH, 1 hit
PS50330 UIM, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H201-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTTSALRRQV KNIVHNYSEA EIKVREATSN DPWGPPSSLM SEIADLTFNT
60 70 80 90 100
VAFTEVMGML WRRLNDSGKN WRHVYKALTL LDYLLKTGSE RVAHQCRENL
110 120 130 140 150
YTIQTLKDFQ YIDRDGKDQG VNVREKVKQV MALLKDEERL RQERTHALKT
160 170 180 190 200
KERMALEGIG IGSGQLGFSR RYGEDYSRSR GSPSSYNSSS SSPRYTSDLE
210 220 230 240 250
QARPQTSGEE ELQLQLALAM SREEAEKPVP PASHRDEDLQ LQLALRLSRQ
260 270 280 290 300
EHEKEVRSWQ GDGSPMANGA GAVVHHQRDR EPEREERKEE EKLKTSQSSI
310 320 330 340 350
LDLADIFVPA LAPPSTHCSA DPWDIPGFRP NTEASGSSWG PSADPWSPIP
360 370 380 390 400
SGTVLSRSQP WDLTPMLSSS EPWGRTPVLP AGPPTTDPWA LNSPHHKLPS
410 420 430 440 450
TGADPWGASL ETSDTPGGAS TFDPFAKPPE STETKEGLEQ ALPSGKPSSP
460 470 480 490 500
VELDLFGDPS PSSKQNGTKE PDALDLGILG EALTQPSKEA RACRTPESFL
510 520 530 540 550
GPSASSLVNL DSLVKAPQVA KTRNPFLTGL SAPSPTNPFG AGEPGRPTLN
560 570 580 590 600
QMRTGSPALG LAGGPVGAPL GSMTYSASLP LPLSSVPAGL TLPASVSVFP
610 620 630
QAGAFAPQPL LPTPSSAGPR PPPPQTGTNP FL
Length:632
Mass (Da):68,222
Last modified:March 1, 2001 - v1
Checksum:i13940F2FBD6215D0
GO
Isoform 2 (identifier: Q9H201-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     188-208: SSSSSPRYTSDLEQARPQTSG → CPASDVRGRGTAAAAGPRHEP
     209-632: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:208
Mass (Da):23,608
Checksum:i4B45EB0984ED8081
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RBR6D6RBR6_HUMAN
Epsin-3
EPN3
108Annotation score:
D6RFG3D6RFG3_HUMAN
Epsin-3
EPN3
136Annotation score:
D6REL6D6REL6_HUMAN
Epsin-3
EPN3
168Annotation score:
D6RBI9D6RBI9_HUMAN
Epsin-3
EPN3
51Annotation score:
I6L9I8I6L9I8_HUMAN
EPN3 protein
EPN3
318Annotation score:
D6R907D6R907_HUMAN
Epsin-3
EPN3
50Annotation score:
D6RBA4D6RBA4_HUMAN
Epsin-3
EPN3
11Annotation score:
D6RF39D6RF39_HUMAN
Epsin-3
EPN3
17Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti375R → K in BAF85666 (PubMed:14702039).Curated1
Sequence conflicti396H → Y in BAA91378 (PubMed:14702039).Curated1
Sequence conflicti417G → S in BAF85666 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059973544P → T1 PublicationCorresponds to variant dbSNP:rs4794159Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_009158188 – 208SSSSS…PQTSG → CPASDVRGRGTAAAAGPRHE P in isoform 2. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_009159209 – 632Missing in isoform 2. 1 PublicationAdd BLAST424

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF324241 mRNA Translation: AAG45223.1
AK000785 mRNA Translation: BAA91378.1
AK291658 mRNA Translation: BAF84347.1
AK292977 mRNA Translation: BAF85666.1
CH471109 Genomic DNA Translation: EAW94607.1
BC001038 mRNA No translation available.
BC051365 mRNA No translation available.
BC077722 mRNA No translation available.
CCDSiCCDS11570.1 [Q9H201-1]
RefSeqiNP_060427.2, NM_017957.2 [Q9H201-1]
UniGeneiHs.670090

Genome annotation databases

EnsembliENST00000268933; ENSP00000268933; ENSG00000049283 [Q9H201-1]
ENST00000510045; ENSP00000421933; ENSG00000049283 [Q9H201-2]
GeneIDi55040
KEGGihsa:55040
UCSCiuc002ira.5 human [Q9H201-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF324241 mRNA Translation: AAG45223.1
AK000785 mRNA Translation: BAA91378.1
AK291658 mRNA Translation: BAF84347.1
AK292977 mRNA Translation: BAF85666.1
CH471109 Genomic DNA Translation: EAW94607.1
BC001038 mRNA No translation available.
BC051365 mRNA No translation available.
BC077722 mRNA No translation available.
CCDSiCCDS11570.1 [Q9H201-1]
RefSeqiNP_060427.2, NM_017957.2 [Q9H201-1]
UniGeneiHs.670090

3D structure databases

ProteinModelPortaliQ9H201
SMRiQ9H201
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120369, 31 interactors
ELMiQ9H201
IntActiQ9H201, 3 interactors
MINTiQ9H201
STRINGi9606.ENSP00000268933

PTM databases

iPTMnetiQ9H201
PhosphoSitePlusiQ9H201

Polymorphism and mutation databases

BioMutaiEPN3
DMDMi41017054

Proteomic databases

EPDiQ9H201
MaxQBiQ9H201
PaxDbiQ9H201
PeptideAtlasiQ9H201
PRIDEiQ9H201
ProteomicsDBi80463
80464 [Q9H201-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000268933; ENSP00000268933; ENSG00000049283 [Q9H201-1]
ENST00000510045; ENSP00000421933; ENSG00000049283 [Q9H201-2]
GeneIDi55040
KEGGihsa:55040
UCSCiuc002ira.5 human [Q9H201-1]

Organism-specific databases

CTDi55040
DisGeNETi55040
EuPathDBiHostDB:ENSG00000049283.17
GeneCardsiEPN3
HGNCiHGNC:18235 EPN3
HPAiHPA055546
HPA063224
MIMi607264 gene
neXtProtiNX_Q9H201
OpenTargetsiENSG00000049283
PharmGKBiPA38513
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2056 Eukaryota
ENOG410XSM0 LUCA
GeneTreeiENSGT00550000074611
HOGENOMiHOG000008298
HOVERGENiHBG006690
InParanoidiQ9H201
KOiK12471
OMAiADPWSPI
OrthoDBiEOG091G0L45
PhylomeDBiQ9H201
TreeFamiTF313361

Miscellaneous databases

GenomeRNAii55040
PROiPR:Q9H201
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000049283 Expressed in 85 organ(s), highest expression level in fundus of stomach
CleanExiHS_EPN3
ExpressionAtlasiQ9H201 baseline and differential
GenevisibleiQ9H201 HS

Family and domain databases

CDDicd03571 ENTH_epsin, 1 hit
Gene3Di1.25.40.90, 1 hit
InterProiView protein in InterPro
IPR013809 ENTH
IPR008942 ENTH_VHS
IPR027318 Epsin-3_metazoa
IPR039416 Epsin_ENTH
IPR003903 UIM_dom
PANTHERiPTHR12276:SF16 PTHR12276:SF16, 1 hit
PfamiView protein in Pfam
PF01417 ENTH, 1 hit
PF02809 UIM, 2 hits
SMARTiView protein in SMART
SM00273 ENTH, 1 hit
SM00726 UIM, 2 hits
SUPFAMiSSF48464 SSF48464, 1 hit
PROSITEiView protein in PROSITE
PS50942 ENTH, 1 hit
PS50330 UIM, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiEPN3_HUMAN
AccessioniPrimary (citable) accession number: Q9H201
Secondary accession number(s): A8K6J3
, A8KAB2, Q9BVN6, Q9NWK2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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