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Protein

Opsin-3

Gene

OPN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in encephalic photoreception.

GO - Molecular functioni

  • G-protein coupled photoreceptor activity Source: GO_Central
  • G-protein coupled receptor activity Source: ProtInc
  • photoreceptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer
Biological process
LigandChromophore

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
R-HSA-419771 Opsins

Names & Taxonomyi

Protein namesi
Recommended name:
Opsin-3
Alternative name(s):
Encephalopsin
Panopsin
Gene namesi
Name:OPN3
Synonyms:ECPN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000054277.12
HGNCiHGNC:14007 OPN3
MIMi606695 gene
neXtProtiNX_Q9H1Y3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 40ExtracellularSequence analysisAdd BLAST40
Transmembranei41 – 65Helical; Name=1Sequence analysisAdd BLAST25
Topological domaini66 – 77CytoplasmicSequence analysisAdd BLAST12
Transmembranei78 – 102Helical; Name=2Sequence analysisAdd BLAST25
Topological domaini103 – 117ExtracellularSequence analysisAdd BLAST15
Transmembranei118 – 137Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini138 – 153CytoplasmicSequence analysisAdd BLAST16
Transmembranei154 – 177Helical; Name=4Sequence analysisAdd BLAST24
Topological domaini178 – 201ExtracellularSequence analysisAdd BLAST24
Transmembranei202 – 229Helical; Name=5Sequence analysisAdd BLAST28
Topological domaini230 – 255CytoplasmicSequence analysisAdd BLAST26
Transmembranei256 – 279Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini280 – 287ExtracellularSequence analysis8
Transmembranei288 – 312Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini313 – 402CytoplasmicSequence analysisAdd BLAST90

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi23596
OpenTargetsiENSG00000054277
PharmGKBiPA31939

Polymorphism and mutation databases

BioMutaiOPN3
DMDMi17380172

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001978131 – 402Opsin-3Add BLAST402

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi114 ↔ 188PROSITE-ProRule annotation
Glycosylationi198N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei299N6-(retinylidene)lysine1
Lipidationi325S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

MaxQBiQ9H1Y3
PaxDbiQ9H1Y3
PeptideAtlasiQ9H1Y3
PRIDEiQ9H1Y3
ProteomicsDBi80458
80459 [Q9H1Y3-2]

PTM databases

iPTMnetiQ9H1Y3
PhosphoSitePlusiQ9H1Y3

Expressioni

Tissue specificityi

Strongly expressed in brain. Highly expressed in the preoptic area and paraventricular nucleus of the hypothalamus. Shows highly patterned expression in other regions of the brain, being enriched in selected regions of the cerebral cortex, cerebellar Purkinje cells, a subset of striatal neurons, selected thalamic nuclei, and a subset of interneurons in the ventral horn of the spinal cord.

Gene expression databases

BgeeiENSG00000054277 Expressed in 216 organ(s), highest expression level in testis
CleanExiHS_OPN3
ExpressionAtlasiQ9H1Y3 baseline and differential
GenevisibleiQ9H1Y3 HS

Organism-specific databases

HPAiCAB013682
HPA064443

Interactioni

Protein-protein interaction databases

BioGridi117131, 5 interactors
STRINGi9606.ENSP00000355512

Structurei

3D structure databases

ProteinModelPortaliQ9H1Y3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118977
HOGENOMiHOG000029042
HOVERGENiHBG100337
InParanoidiQ9H1Y3
KOiK04256
OMAiIMAYCYG
OrthoDBiEOG091G0ALC
PhylomeDBiQ9H1Y3
TreeFamiTF324998

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR027430 Retinal_BS
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
PS00238 OPSIN, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q9H1Y3-1) [UniParc]FASTAAdd to basket
Also known as: 1-4b-5-6

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYSGNRSGGH GYWDGGGAAG AEGPAPAGTL SPAPLFSPGT YERLALLLGS
60 70 80 90 100
IGLLGVGNNL LVLVLYYKFQ RLRTPTHLLL VNISLSDLLV SLFGVTFTFV
110 120 130 140 150
SCLRNGWVWD TVGCVWDGFS GSLFGIVSIA TLTVLAYERY IRVVHARVIN
160 170 180 190 200
FSWAWRAITY IWLYSLAWAG APLLGWNRYI LDVHGLGCTV DWKSKDANDS
210 220 230 240 250
SFVLFLFLGC LVVPLGVIAH CYGHILYSIR MLRCVEDLQT IQVIKILKYE
260 270 280 290 300
KKLAKMCFLM IFTFLVCWMP YIVICFLVVN GHGHLVTPTI SIVSYLFAKS
310 320 330 340 350
NTVYNPVIYV FMIRKFRRSL LQLLCLRLLR CQRPAKDLPA AGSEMQIRPI
360 370 380 390 400
VMSQKDGDRP KKKVTFNSSS IIFIITSDES LSVDDSDKTN GSKVDVIQVR

PL
Length:402
Mass (Da):44,873
Last modified:March 1, 2001 - v1
Checksum:i370F64C19F834A71
GO
Isoform 2 (identifier: Q9H1Y3-2) [UniParc]FASTAAdd to basket
Also known as: 1-2-5-6

The sequence of this isoform differs from the canonical sequence as follows:
     126-231: IVSIATLTVL...YGHILYSIRM → WISQLQAATREARASMGPVQQGTICMQ

Show »
Length:323
Mass (Da):35,730
Checksum:iBA9734383981FF2F
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6P5W7Q6P5W7_HUMAN
Opsin 3 (Encephalopsin, panopsin), ...
OPN3 hCG_1989351
189Annotation score:
Q6GMT1Q6GMT1_HUMAN
Opsin 3 (Encephalopsin, panopsin), ...
OPN3 hCG_1989351
142Annotation score:
A0A1B0GUF8A0A1B0GUF8_HUMAN
Opsin-3
OPN3
155Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti390 – 396NGSKVDV → IGVQSLML in AAD32671 (PubMed:10234000).Curated7

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050613167A → V. Corresponds to variant dbSNP:rs12072790Ensembl.1
Natural variantiVAR_050614183V → I. Corresponds to variant dbSNP:rs2273712Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010209126 – 231IVSIA…YSIRM → WISQLQAATREARASMGPVQ QGTICMQ in isoform 2. CuratedAdd BLAST106

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF140242 mRNA Translation: AAD32671.1
AF303588 mRNA Translation: AAK37447.1
AF482426 Genomic DNA Translation: AAO15715.1
AF482426 Genomic DNA Translation: AAO15717.1
AL133390 Genomic DNA No translation available.
BC036773 mRNA Translation: AAH36773.1
CCDSiCCDS31072.1 [Q9H1Y3-1]
RefSeqiNP_055137.2, NM_014322.2 [Q9H1Y3-1]
UniGeneiHs.409081

Genome annotation databases

EnsembliENST00000366554; ENSP00000355512; ENSG00000054277 [Q9H1Y3-1]
GeneIDi23596
KEGGihsa:23596
UCSCiuc001hza.4 human [Q9H1Y3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF140242 mRNA Translation: AAD32671.1
AF303588 mRNA Translation: AAK37447.1
AF482426 Genomic DNA Translation: AAO15715.1
AF482426 Genomic DNA Translation: AAO15717.1
AL133390 Genomic DNA No translation available.
BC036773 mRNA Translation: AAH36773.1
CCDSiCCDS31072.1 [Q9H1Y3-1]
RefSeqiNP_055137.2, NM_014322.2 [Q9H1Y3-1]
UniGeneiHs.409081

3D structure databases

ProteinModelPortaliQ9H1Y3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117131, 5 interactors
STRINGi9606.ENSP00000355512

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9H1Y3
PhosphoSitePlusiQ9H1Y3

Polymorphism and mutation databases

BioMutaiOPN3
DMDMi17380172

Proteomic databases

MaxQBiQ9H1Y3
PaxDbiQ9H1Y3
PeptideAtlasiQ9H1Y3
PRIDEiQ9H1Y3
ProteomicsDBi80458
80459 [Q9H1Y3-2]

Protocols and materials databases

DNASUi23596
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366554; ENSP00000355512; ENSG00000054277 [Q9H1Y3-1]
GeneIDi23596
KEGGihsa:23596
UCSCiuc001hza.4 human [Q9H1Y3-1]

Organism-specific databases

CTDi23596
DisGeNETi23596
EuPathDBiHostDB:ENSG00000054277.12
GeneCardsiOPN3
HGNCiHGNC:14007 OPN3
HPAiCAB013682
HPA064443
MIMi606695 gene
neXtProtiNX_Q9H1Y3
OpenTargetsiENSG00000054277
PharmGKBiPA31939
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118977
HOGENOMiHOG000029042
HOVERGENiHBG100337
InParanoidiQ9H1Y3
KOiK04256
OMAiIMAYCYG
OrthoDBiEOG091G0ALC
PhylomeDBiQ9H1Y3
TreeFamiTF324998

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
R-HSA-419771 Opsins

Miscellaneous databases

GeneWikiiOPN3
GenomeRNAii23596
PROiPR:Q9H1Y3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000054277 Expressed in 216 organ(s), highest expression level in testis
CleanExiHS_OPN3
ExpressionAtlasiQ9H1Y3 baseline and differential
GenevisibleiQ9H1Y3 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR027430 Retinal_BS
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
PS00238 OPSIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOPN3_HUMAN
AccessioniPrimary (citable) accession number: Q9H1Y3
Secondary accession number(s): Q8IX08, Q9Y344
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: March 1, 2001
Last modified: September 12, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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