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Protein

Autophagy protein 5

Gene

ATG5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.By similarity4 Publications
May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.2 Publications
(Microbial infection) May act as a proviral factor. In association with ATG12, negatively regulates the innate antiviral immune response by impairing the type I IFN production pathway upon vesicular stomatitis virus (VSV) infection (PubMed:17709747). Required for the translation of incoming hepatitis C virus (HCV) RNA and, thereby, for initiation of HCV replication, but not required once infection is established (PubMed:19666601).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis, Autophagy, Immunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-1632852 Macroautophagy
R-HSA-5205685 Pink/Parkin Mediated Mitophagy
R-HSA-8934903 Receptor Mediated Mitophagy
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling

SIGNOR Signaling Network Open Resource

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SIGNORi
Q9H1Y0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Autophagy protein 5
Alternative name(s):
APG5-like
Apoptosis-specific protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATG5
Synonyms:APG5L, ASP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000057663.12

Human Gene Nomenclature Database

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HGNCi
HGNC:589 ATG5

Online Mendelian Inheritance in Man (OMIM)

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MIMi
604261 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H1Y0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Spinocerebellar ataxia, autosomal recessive, 25 (SCAR25)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR25 patients manifest delayed psychomotor development with delayed walking, truncal ataxia, dysmetria, and nystagmus, Cerebellar hypoplasia is seen on brain imaging.
See also OMIM:617584
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_079274122E → D in SCAR25; reduced conjugation to ATG12; decrease in autophagy activity. 1 PublicationCorresponds to variant dbSNP:rs1131692265Ensembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi130K → R: Loss of conjugaction with ATG12. Does affect interaction with DHX58, nor with MAVS. 2 Publications1

Keywords - Diseasei

Disease mutation, Neurodegeneration

Organism-specific databases

DisGeNET

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DisGeNETi
9474

MalaCards human disease database

More...
MalaCardsi
ATG5
MIMi617584 phenotype

Open Targets

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OpenTargetsi
ENSG00000057663

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA24880

Polymorphism and mutation databases

Domain mapping of disease mutations (DMDM)

More...
DMDMi
17366828

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002189941 – 275Autophagy protein 5Add BLAST275

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki130Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ATG12)Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Conjugated to ATG12; which is essential for autophagy, but is not required for association with isolation membrane.
Acetylated by EP300.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9H1Y0

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9H1Y0

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9H1Y0

PeptideAtlas

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PeptideAtlasi
Q9H1Y0

PRoteomics IDEntifications database

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PRIDEi
Q9H1Y0

ProteomicsDB human proteome resource

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ProteomicsDBi
80456
80457 [Q9H1Y0-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9H1Y0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9H1Y0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. The mRNA is present at similar levels in viable and apoptotic cells, whereas the protein is dramatically highly expressed in apoptotic cells.

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By apoptotic stimuli.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000057663 Expressed in 225 organ(s), highest expression level in colonic mucosa

CleanEx database of gene expression profiles

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CleanExi
HS_ATG5

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9H1Y0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9H1Y0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB034432
CAB037309
HPA042973

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a conjugate with ATG12 (PubMed:12207896, PubMed:11825910, PubMed:17709747, PubMed:26812546). The ATG5-ATG12 conjugate forms a complex with several units of ATG16L. Interacts with TECPR1; the interaction is direct and does not take place when ATG16L is associated with the ATG5-ATG12 conjugate (PubMed:21575909, PubMed:22342342). Interacts with DHX58/RIG-1, IFIH1/MDA5 and MAVS/IPS-1 in monomeric form as well as in ATG12-ATG5 conjugate form. The interaction with MAVS is further enhanced upon vesicular stomatitis virus (VSV) infection (PubMed:17709747). Interacts with ATG3 (PubMed:12207896, PubMed:11825910). Interacts with ATG7 and ATG10 (By similarity). Interacts with FADD (PubMed:15778222).By similarity7 Publications
(Microbial infection) Interacts transiently interacts with hepatitis C virus (HCV) protein NS5B during HCV infection.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
114859, 41 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-200 ATG12-ATG5-ATG16L1 complex
CPX-354 ATG12-ATG5-ATG16L2 complex
CPX-356 ATG5-ATG12 complex
CPX-358 ATG5-ATG12-TECPR1 complex

Database of interacting proteins

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DIPi
DIP-29758N

Protein interaction database and analysis system

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IntActi
Q9H1Y0, 52 interactors

Molecular INTeraction database

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MINTi
Q9H1Y0

STRING: functional protein association networks

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STRINGi
9606.ENSP00000343313

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1275
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9H1Y0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9H1Y0

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ATG5 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2976 Eukaryota
ENOG410XQ71 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000004766

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000007893

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG018731

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9H1Y0

KEGG Orthology (KO)

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KOi
K08339

Identification of Orthologs from Complete Genome Data

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OMAi
MVPRLSY

Database of Orthologous Groups

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OrthoDBi
EOG091G0JU7

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9H1Y0

TreeFam database of animal gene trees

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TreeFami
TF314415

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR007239 Atg5

The PANTHER Classification System

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PANTHERi
PTHR13040 PTHR13040, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF04106 APG5, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform Long (identifier: Q9H1Y0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTDDKDVLRD VWFGRIPTCF TLYQDEITER EAEPYYLLLP RVSYLTLVTD
60 70 80 90 100
KVKKHFQKVM RQEDISEIWF EYEGTPLKWH YPIGLLFDLL ASSSALPWNI
110 120 130 140 150
TVHFKSFPEK DLLHCPSKDA IEAHFMSCMK EADALKHKSQ VINEMQKKDH
160 170 180 190 200
KQLWMGLQND RFDQFWAINR KLMEYPAEEN GFRYIPFRIY QTTTERPFIQ
210 220 230 240 250
KLFRPVAADG QLHTLGDLLK EVCPSAIDPE DGEKKNQVMI HGIEPMLETP
260 270
LQWLSEHLSY PDNFLHISII PQPTD
Length:275
Mass (Da):32,447
Last modified:November 16, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC33A1E0B3C1DBE5C
GO
Isoform Short (identifier: Q9H1Y0-2) [UniParc]FASTAAdd to basket
Also known as: APG5beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: MTDDKDVLRD...FEYEGTPLKW → M

Show »
Length:197
Mass (Da):22,931
Checksum:i05FC581F6EABB753
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GV54A0A1B0GV54_HUMAN
Autophagy protein 5
ATG5
153Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GUS1A0A1B0GUS1_HUMAN
Autophagy protein 5
ATG5
159Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
L7UQJ2L7UQJ2_HUMAN
Autophagy protein 5
ATG5
162Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y718A0A2R8Y718_HUMAN
Autophagy protein 5
ATG5
233Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q7Z3H3Q7Z3H3_HUMAN
Autophagy protein 5
ATG5 DKFZp686F0183
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
L7UMD8L7UMD8_HUMAN
ATG5 variant 3
ATG5
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti79W → M in CAC19459 (PubMed:14574404).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03624358K → M in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_079274122E → D in SCAR25; reduced conjugation to ATG12; decrease in autophagy activity. 1 PublicationCorresponds to variant dbSNP:rs1131692265Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0037911 – 79MTDDK…TPLKW → M in isoform Short. 2 PublicationsAdd BLAST79

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
Y11588 mRNA Translation: CAA72327.1
AF293841 mRNA Translation: AAG44955.1
CR749386 mRNA Translation: CAH18236.1
AL022067, AL133509, AL138917 Genomic DNA Translation: CAI42297.1
AL022067, AL133509, AL138917 Genomic DNA Translation: CAI42298.1
AL133509, AL022067, AL138917 Genomic DNA Translation: CAC19459.2
AL133509, AL022067, AL138917 Genomic DNA Translation: CAI42831.1
AL138917, AL133509, AL022067 Genomic DNA Translation: CAI20313.1
AL138917, AL022067, AL133509 Genomic DNA Translation: CAI20314.1
BC002699 mRNA Translation: AAH02699.1
BC093011 mRNA Translation: AAH93011.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS5055.1 [Q9H1Y0-1]
CCDS69159.1 [Q9H1Y0-2]

NCBI Reference Sequences

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RefSeqi
NP_001273035.1, NM_001286106.1 [Q9H1Y0-1]
NP_001273036.1, NM_001286107.1 [Q9H1Y0-2]
NP_001273037.1, NM_001286108.1
NP_001273040.1, NM_001286111.1
NP_004840.1, NM_004849.3 [Q9H1Y0-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.486063

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000343245; ENSP00000343313; ENSG00000057663 [Q9H1Y0-1]
ENST00000369076; ENSP00000358072; ENSG00000057663 [Q9H1Y0-1]
ENST00000635758; ENSP00000490493; ENSG00000057663 [Q9H1Y0-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9474

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9474

UCSC genome browser

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UCSCi
uc003prf.4 human [Q9H1Y0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11588 mRNA Translation: CAA72327.1
AF293841 mRNA Translation: AAG44955.1
CR749386 mRNA Translation: CAH18236.1
AL022067, AL133509, AL138917 Genomic DNA Translation: CAI42297.1
AL022067, AL133509, AL138917 Genomic DNA Translation: CAI42298.1
AL133509, AL022067, AL138917 Genomic DNA Translation: CAC19459.2
AL133509, AL022067, AL138917 Genomic DNA Translation: CAI42831.1
AL138917, AL133509, AL022067 Genomic DNA Translation: CAI20313.1
AL138917, AL022067, AL133509 Genomic DNA Translation: CAI20314.1
BC002699 mRNA Translation: AAH02699.1
BC093011 mRNA Translation: AAH93011.1
CCDSiCCDS5055.1 [Q9H1Y0-1]
CCDS69159.1 [Q9H1Y0-2]
RefSeqiNP_001273035.1, NM_001286106.1 [Q9H1Y0-1]
NP_001273036.1, NM_001286107.1 [Q9H1Y0-2]
NP_001273037.1, NM_001286108.1
NP_001273040.1, NM_001286111.1
NP_004840.1, NM_004849.3 [Q9H1Y0-1]
UniGeneiHs.486063

3D structure databases

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Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4GDKX-ray2.70B/E1-275[»]
4GDLX-ray2.88B1-275[»]
4NAWX-ray2.20B/F/J/N1-275[»]
4TQ0X-ray2.70A/C/E1-275[»]
4TQ1X-ray1.80A1-275[»]
5D7GX-ray3.00A/C/E/G1-275[»]
5NPVX-ray3.10A/C1-275[»]
5NPWX-ray3.10A/C/E/G1-275[»]
ProteinModelPortaliQ9H1Y0
SMRiQ9H1Y0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114859, 41 interactors
ComplexPortaliCPX-200 ATG12-ATG5-ATG16L1 complex
CPX-354 ATG12-ATG5-ATG16L2 complex
CPX-356 ATG5-ATG12 complex
CPX-358 ATG5-ATG12-TECPR1 complex
DIPiDIP-29758N
IntActiQ9H1Y0, 52 interactors
MINTiQ9H1Y0
STRINGi9606.ENSP00000343313

PTM databases

iPTMnetiQ9H1Y0
PhosphoSitePlusiQ9H1Y0

Polymorphism and mutation databases

DMDMi17366828

Proteomic databases

EPDiQ9H1Y0
MaxQBiQ9H1Y0
PaxDbiQ9H1Y0
PeptideAtlasiQ9H1Y0
PRIDEiQ9H1Y0
ProteomicsDBi80456
80457 [Q9H1Y0-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
9474
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343245; ENSP00000343313; ENSG00000057663 [Q9H1Y0-1]
ENST00000369076; ENSP00000358072; ENSG00000057663 [Q9H1Y0-1]
ENST00000635758; ENSP00000490493; ENSG00000057663 [Q9H1Y0-2]
GeneIDi9474
KEGGihsa:9474
UCSCiuc003prf.4 human [Q9H1Y0-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9474
DisGeNETi9474
EuPathDBiHostDB:ENSG00000057663.12

GeneCards: human genes, protein and diseases

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GeneCardsi
ATG5
HGNCiHGNC:589 ATG5
HPAiCAB034432
CAB037309
HPA042973
MalaCardsiATG5
MIMi604261 gene
617584 phenotype
neXtProtiNX_Q9H1Y0
OpenTargetsiENSG00000057663
PharmGKBiPA24880

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2976 Eukaryota
ENOG410XQ71 LUCA
GeneTreeiENSGT00390000004766
HOGENOMiHOG000007893
HOVERGENiHBG018731
InParanoidiQ9H1Y0
KOiK08339
OMAiMVPRLSY
OrthoDBiEOG091G0JU7
PhylomeDBiQ9H1Y0
TreeFamiTF314415

Enzyme and pathway databases

ReactomeiR-HSA-1632852 Macroautophagy
R-HSA-5205685 Pink/Parkin Mediated Mitophagy
R-HSA-8934903 Receptor Mediated Mitophagy
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling
SIGNORiQ9H1Y0

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ATG5 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ATG5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9474

Protein Ontology

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PROi
PR:Q9H1Y0

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000057663 Expressed in 225 organ(s), highest expression level in colonic mucosa
CleanExiHS_ATG5
ExpressionAtlasiQ9H1Y0 baseline and differential
GenevisibleiQ9H1Y0 HS

Family and domain databases

InterProiView protein in InterPro
IPR007239 Atg5
PANTHERiPTHR13040 PTHR13040, 1 hit
PfamiView protein in Pfam
PF04106 APG5, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATG5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H1Y0
Secondary accession number(s): O60875
, Q5JVR2, Q68DI4, Q9H2B8, Q9HCZ7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: November 16, 2001
Last modified: December 5, 2018
This is version 165 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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