ATG5

Functionⁱ

Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.By similarity4 Publications

May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.2 Publications

(Microbial infection) May act as a proviral factor. In association with ATG12, negatively regulates the innate antiviral immune response by impairing the type I IFN production pathway upon vesicular stomatitis virus (VSV) infection (PubMed:17709747). Required for the translation of incoming hepatitis C virus (HCV) RNA and, thereby, for initiation of HCV replication, but not required once infection is established (PubMed:19666601).2 Publications

GO - Biological processⁱ

aggrephagy
Source: ParkinsonsUK-UCL
Inferred from mutant phenotypeⁱ
- 22982048
antigen processing and presentation of endogenous antigen Source: Ensembl
apoptotic process Source: UniProtKB-KW
autophagosome assembly Source: UniProtKB
autophagy
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 26812546
autophagy of host cells involved in interaction with symbiont
Source: UniProtKB
Inferred from genetic interactionⁱ
- 28389568
autophagy of mitochondrion Source: GO_Central
autophagy of nucleus Source: GO_Central
blood vessel remodeling Source: Ensembl
cellular homeostasis Source: Ensembl
cellular response to nitrogen starvation Source: GO_Central
cellular response to nitrosative stress Source: Ensembl
C-terminal protein lipidation Source: GO_Central
heart contraction Source: Ensembl
macroautophagy Source: Reactome
negative regulation of apoptotic process Source: Ensembl
negative regulation of cell death
Source: MGI
Inferred from mutant phenotypeⁱ
- 19273585
negative regulation of histone H4-K16 acetylation Source: Ensembl
negative regulation of phagocytosis Source: Ensembl
negative regulation of protein ubiquitination Source: Ensembl
negative regulation of reactive oxygen species metabolic process Source: Ensembl
negative stranded viral RNA replication Source: Ensembl
negative thymic T cell selection Source: Ensembl
otolith development Source: Ensembl
positive regulation of mucus secretion Source: Ensembl
post-translational protein modification Source: UniProtKB
protein lipidation involved in autophagosome assembly Source: Ensembl
regulation of cilium assembly Source: UniProtKB
regulation of cytokine secretion involved in immune response Source: Ensembl
regulation of release of sequestered calcium ion into cytosol Source: Ensembl
response to drug Source: Ensembl
response to fungus Source: Ensembl
vasodilation Source: Ensembl
ventricular cardiac muscle cell development Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Apoptosis, Autophagy, Immunity

Biological process

Apoptosis, Autophagy, Immunity

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1632852 Macroautophagy R-HSA-5205685 Pink/Parkin Mediated Mitophagy R-HSA-8934903 Receptor Mediated Mitophagy R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling
SIGNORⁱ	Q9H1Y0

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Autophagy protein 5 Alternative name(s): APG5-like Apoptosis-specific protein
Gene namesⁱ	Name:ATG5 Synonyms:APG5L, ASP
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000057663.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:589 ATG5
MIMⁱ	604261 gene
neXtProtⁱ	NX_Q9H1Y0

Keywords - Cellular componentⁱ

Cytoplasm, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Spinocerebellar ataxia, autosomal recessive, 25 (SCAR25)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR25 patients manifest delayed psychomotor development with delayed walking, truncal ataxia, dysmetria, and nystagmus, Cerebellar hypoplasia is seen on brain imaging.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_079274	122	E → D in SCAR25; reduced conjugation to ATG12; decrease in autophagy activity. 1 PublicationCorresponds to variant dbSNP:rs1131692265Ensembl.		1

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	130	K → R: Loss of conjugaction with ATG12. Does affect interaction with DHX58, nor with MAVS. 2 Publications		1

Keywords - Diseaseⁱ

Disease mutation, Neurodegeneration

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9474
MalaCards human disease database More...MalaCardsⁱ	ATG5
MIMⁱ	617584 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000057663
PharmGKBⁱ	PA24880

Polymorphism and mutation databases

DMDMⁱ	17366828

DMDMⁱ

17366828

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000218994	1 – 275	Autophagy protein 5Add BLAST		275

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources		1
Cross-linkⁱ	130	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ATG12)Curated

Post-translational modificationⁱ

Conjugated to ATG12; which is essential for autophagy, but is not required for association with isolation membrane.

Acetylated by EP300.1 Publication

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDⁱ	Q9H1Y0
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9H1Y0
PaxDbⁱ	Q9H1Y0
PeptideAtlas More...PeptideAtlasⁱ	Q9H1Y0
PRIDEⁱ	Q9H1Y0
ProteomicsDBⁱ	80456 80457 [Q9H1Y0-2]

PTM databases

iPTMnetⁱ	Q9H1Y0
PhosphoSitePlusⁱ	Q9H1Y0

Expressionⁱ

Tissue specificityⁱ

Ubiquitous. The mRNA is present at similar levels in viable and apoptotic cells, whereas the protein is dramatically highly expressed in apoptotic cells.

Inductionⁱ

By apoptotic stimuli.

Gene expression databases

Bgeeⁱ	ENSG00000057663 Expressed in 225 organ(s), highest expression level in colonic mucosa
CleanExⁱ	HS_ATG5
ExpressionAtlasⁱ	Q9H1Y0 baseline and differential
Genevisibleⁱ	Q9H1Y0 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB034432 CAB037309 HPA042973

HPAⁱ

CAB034432
CAB037309
HPA042973

Interactionⁱ

Subunit structureⁱ

Forms a conjugate with ATG12 (PubMed:12207896, PubMed:11825910, PubMed:17709747, PubMed:26812546). The ATG5-ATG12 conjugate forms a complex with several units of ATG16L. Interacts with TECPR1; the interaction is direct and does not take place when ATG16L is associated with the ATG5-ATG12 conjugate (PubMed:21575909, PubMed:22342342). Interacts with DHX58/RIG-1, IFIH1/MDA5 and MAVS/IPS-1 in monomeric form as well as in ATG12-ATG5 conjugate form. The interaction with MAVS is further enhanced upon vesicular stomatitis virus (VSV) infection (PubMed:17709747). Interacts with ATG3 (PubMed:12207896, PubMed:11825910). Interacts with ATG7 and ATG10 (By similarity). Interacts with FADD (PubMed:15778222).By similarity7 Publications

(Microbial infection) Interacts transiently interacts with hepatitis C virus (HCV) protein NS5B during HCV infection.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
ATG16L1	Q676U5	7	EBI-1047414,EBI-535909
Atg16l1	Q8C0J2-3	2	EBI-1047414,EBI-16029274	From a different organism.
CCDC12	Q8WUD4	3	EBI-1047414,EBI-2557572
DDX58	O95786-1	4	EBI-1047414,EBI-15577823
GABARAP	O95166	2	EBI-1047414,EBI-712001
MAP1LC3B	Q9GZQ8	2	EBI-1047414,EBI-373144
MAVS	Q7Z434-1	4	EBI-1047414,EBI-15577799
RB1CC1	Q8TDY2	3	EBI-1047414,EBI-1047793
TECPR1	Q7Z6L1	8	EBI-1047414,EBI-2946676
WDFY3	Q8IZQ1	7	EBI-1047414,EBI-1569256

Protein-protein interaction databases

BioGridⁱ	114859, 41 interactors
ComplexPortalⁱ	CPX-200 ATG12-ATG5-ATG16L1 complex CPX-354 ATG12-ATG5-ATG16L2 complex CPX-356 ATG5-ATG12 complex CPX-358 ATG5-ATG12-TECPR1 complex
Database of interacting proteins More...DIPⁱ	DIP-29758N
IntActⁱ	Q9H1Y0, 52 interactors
Molecular INTeraction database More...MINTⁱ	Q9H1Y0
STRINGⁱ	9606.ENSP00000343313

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	4 – 12	Combined sources	9
Beta strandⁱ	15 – 22	Combined sources	8
Beta strandⁱ	24 – 26	Combined sources	3
Beta strandⁱ	28 – 30	Combined sources	3
Beta strandⁱ	35 – 40	Combined sources	6
Helixⁱ	45 – 48	Combined sources	4
Helixⁱ	50 – 57	Combined sources	8
Helixⁱ	62 – 64	Combined sources	3
Beta strandⁱ	69 – 72	Combined sources	4
Helixⁱ	83 – 91	Combined sources	9
Beta strandⁱ	92 – 94	Combined sources	3
Beta strandⁱ	96 – 103	Combined sources	8
Turnⁱ	109 – 111	Combined sources	3
Beta strandⁱ	113 – 115	Combined sources	3
Helixⁱ	118 – 137	Combined sources	20
Helixⁱ	140 – 144	Combined sources	5
Helixⁱ	147 – 158	Combined sources	12
Helixⁱ	162 – 172	Combined sources	11
Helixⁱ	177 – 179	Combined sources	3
Beta strandⁱ	187 – 192	Combined sources	6
Beta strandⁱ	194 – 196	Combined sources	3
Beta strandⁱ	208 – 210	Combined sources	3
Helixⁱ	215 – 222	Combined sources	8
Helixⁱ	224 – 226	Combined sources	3
Turnⁱ	229 – 231	Combined sources	3
Beta strandⁱ	232 – 240	Combined sources	9
Helixⁱ	251 – 257	Combined sources	7
Beta strandⁱ	265 – 270	Combined sources	6

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9H1Y0
SMRⁱ	Q9H1Y0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the ATG5 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2976 Eukaryota ENOG410XQ71 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000004766
HOGENOMⁱ	HOG000007893
HOVERGENⁱ	HBG018731
InParanoidⁱ	Q9H1Y0
KEGG Orthology (KO) More...KOⁱ	K08339
OMAⁱ	WHYPIGV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0JU7
PhylomeDBⁱ	Q9H1Y0
TreeFamⁱ	TF314415

Family and domain databases

InterProⁱ	View protein in InterPro IPR007239 Atg5
PANTHERⁱ	PTHR13040 PTHR13040, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04106 APG5, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show all Align All

Isoform Long (identifier: Q9H1Y0-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTDDKDVLRD VWFGRIPTCF TLYQDEITER EAEPYYLLLP RVSYLTLVTD 
        60         70         80         90        100
KVKKHFQKVM RQEDISEIWF EYEGTPLKWH YPIGLLFDLL ASSSALPWNI 
       110        120        130        140        150
TVHFKSFPEK DLLHCPSKDA IEAHFMSCMK EADALKHKSQ VINEMQKKDH 
       160        170        180        190        200
KQLWMGLQND RFDQFWAINR KLMEYPAEEN GFRYIPFRIY QTTTERPFIQ 
       210        220        230        240        250
KLFRPVAADG QLHTLGDLLK EVCPSAIDPE DGEKKNQVMI HGIEPMLETP 
       260        270 
LQWLSEHLSY PDNFLHISII PQPTD

Length:275

Mass (Da):32,447

Last modified:November 16, 2001 - v2

Checksum:ⁱC33A1E0B3C1DBE5C

GO

Isoform Short (identifier: Q9H1Y0-2) [UniParc]FASTA Add to basket

Also known as: APG5beta

The sequence of this isoform differs from the canonical sequence as follows:
1-79: MTDDKDVLRD...FEYEGTPLKW → M

« Hide

        10         20         30         40         50
MHYPIGLLFD LLASSSALPW NITVHFKSFP EKDLLHCPSK DAIEAHFMSC 
        60         70         80         90        100
MKEADALKHK SQVINEMQKK DHKQLWMGLQ NDRFDQFWAI NRKLMEYPAE 
       110        120        130        140        150
ENGFRYIPFR IYQTTTERPF IQKLFRPVAA DGQLHTLGDL LKEVCPSAID 
       160        170        180        190 
PEDGEKKNQV MIHGIEPMLE TPLQWLSEHL SYPDNFLHIS IIPQPTD

Show »

Length:197

Mass (Da):22,931

Checksum:ⁱ05FC581F6EABB753

GO

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A1B0GV54	A0A1B0GV54_HUMAN	Autophagy protein 5 Autophagy protein 5	ATG5	153	Annotation score:
A0A1B0GUS1	A0A1B0GUS1_HUMAN	Autophagy protein 5 Autophagy protein 5	ATG5	159	Annotation score:
L7UQJ2	L7UQJ2_HUMAN	Autophagy protein 5 Autophagy protein 5	ATG5	162	Annotation score:
A0A2R8Y718	A0A2R8Y718_HUMAN	Autophagy protein 5 Autophagy protein 5	ATG5	233	Annotation score:
Q7Z3H3	Q7Z3H3_HUMAN	Autophagy protein 5 Autophagy protein 5	ATG5 DKFZp686F0183	91	Annotation score:
L7UMD8	L7UMD8_HUMAN	ATG5 variant 3 ATG5 variant 3 (Autophagy protein 5)	ATG5	44	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	79	W → M in CAC19459 (PubMed:14574404).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_036243	58	K → M in a colorectal cancer sample; somatic mutation. 1 Publication		1
Natural variantⁱVAR_079274	122	E → D in SCAR25; reduced conjugation to ATG12; decrease in autophagy activity. 1 PublicationCorresponds to variant dbSNP:rs1131692265Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_003791	1 – 79	MTDDK…TPLKW → M in isoform Short. 2 PublicationsAdd BLAST		79

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y11588 mRNA Translation: CAA72327.1 AF293841 mRNA Translation: AAG44955.1 CR749386 mRNA Translation: CAH18236.1 AL022067, AL133509, AL138917 Genomic DNA Translation: CAI42297.1 AL022067, AL133509, AL138917 Genomic DNA Translation: CAI42298.1 AL133509, AL022067, AL138917 Genomic DNA Translation: CAC19459.2 AL133509, AL022067, AL138917 Genomic DNA Translation: CAI42831.1 AL138917, AL133509, AL022067 Genomic DNA Translation: CAI20313.1 AL138917, AL022067, AL133509 Genomic DNA Translation: CAI20314.1 BC002699 mRNA Translation: AAH02699.1 BC093011 mRNA Translation: AAH93011.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5055.1 [Q9H1Y0-1] CCDS69159.1 [Q9H1Y0-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001273035.1, NM_001286106.1 [Q9H1Y0-1] NP_001273036.1, NM_001286107.1 [Q9H1Y0-2] NP_001273037.1, NM_001286108.1 NP_001273040.1, NM_001286111.1 NP_004840.1, NM_004849.3 [Q9H1Y0-1]
UniGeneⁱ	Hs.486063

Genome annotation databases

Ensemblⁱ	ENST00000343245; ENSP00000343313; ENSG00000057663 [Q9H1Y0-1] ENST00000369076; ENSP00000358072; ENSG00000057663 [Q9H1Y0-1] ENST00000635758; ENSP00000490493; ENSG00000057663 [Q9H1Y0-2]
GeneIDⁱ	9474
KEGGⁱ	hsa:9474
UCSC genome browser More...UCSCⁱ	uc003prf.4 human [Q9H1Y0-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9H1Y0	Autophagy protein 5		HUMAN		275	UniRef100_Q9H1Y0
Autophagy protein 5		MACMU		275
Autophagy protein 5		PANTR		275
Autophagy protein 5		PANPA		275
UPI0005CF9268		HUMAN		289
Q9H1Y0-2	Autophagy protein 5		PANTR		197	UniRef100_Q9H1Y0-2
Autophagy protein 5		PANPA		197
Autophagy protein 5		HUMAN		153
Autophagy protein 5		PANTR		153

Protein	Similar proteins		Species	Score	Length	Source
Q9H1Y0	Autophagy protein 5		MOUSE		275	UniRef90_Q99J83
Autophagy protein 5		PIG		275
Autophagy protein 5		PONAB		275
Autophagy protein 5		RAT		275
Autophagy protein 5 (Fragment)		MUSPF		284
+74
Q9H1Y0-2	Autophagy protein 5		PANTR		197	UniRef90_Q9H1Y0-2
Autophagy protein 5		PANPA		197
Autophagy protein 5		HUMAN		153
Autophagy protein 5		ODORO		197
Autophagy protein 5		GORGO		197
+66

Protein	Similar proteins		Species	Score	Length	Source
Q9H1Y0	Autophagy protein 5		MOUSE		275	UniRef50_Q99J83
Autophagy protein 5		PONAB		275
Autophagy protein 5		PIG		275
Autophagy protein 5		RAT		275
Autophagy protein 5		BOVIN		275
+361
Q9H1Y0-2	Autophagy protein 5		PANTR		197	UniRef50_Q9H1Y0-2
Autophagy protein 5		PANPA		197
Autophagy protein 5		HUMAN		153
Uncharacterized protein		FELCA		197
Autophagy protein 5		DELLE		197
+121

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y11588 mRNA Translation: CAA72327.1 AF293841 mRNA Translation: AAG44955.1 CR749386 mRNA Translation: CAH18236.1 AL022067, AL133509, AL138917 Genomic DNA Translation: CAI42297.1 AL022067, AL133509, AL138917 Genomic DNA Translation: CAI42298.1 AL133509, AL022067, AL138917 Genomic DNA Translation: CAC19459.2 AL133509, AL022067, AL138917 Genomic DNA Translation: CAI42831.1 AL138917, AL133509, AL022067 Genomic DNA Translation: CAI20313.1 AL138917, AL022067, AL133509 Genomic DNA Translation: CAI20314.1 BC002699 mRNA Translation: AAH02699.1 BC093011 mRNA Translation: AAH93011.1
CCDSⁱ	CCDS5055.1 [Q9H1Y0-1] CCDS69159.1 [Q9H1Y0-2]
RefSeqⁱ	NP_001273035.1, NM_001286106.1 [Q9H1Y0-1] NP_001273036.1, NM_001286107.1 [Q9H1Y0-2] NP_001273037.1, NM_001286108.1 NP_001273040.1, NM_001286111.1 NP_004840.1, NM_004849.3 [Q9H1Y0-1]
UniGeneⁱ	Hs.486063

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4GDK	X-ray	2.70	B/E	1-275	[»]
	4GDL	X-ray	2.88	B	1-275	[»]
	4NAW	X-ray	2.20	B/F/J/N	1-275	[»]
	4TQ0	X-ray	2.70	A/C/E	1-275	[»]
	4TQ1	X-ray	1.80	A	1-275	[»]
	5D7G	X-ray	3.00	A/C/E/G	1-275	[»]
	5NPV	X-ray	3.10	A/C	1-275	[»]
	5NPW	X-ray	3.10	A/C/E/G	1-275	[»]
ProteinModelPortalⁱ	Q9H1Y0
SMRⁱ	Q9H1Y0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114859, 41 interactors
ComplexPortalⁱ	CPX-200 ATG12-ATG5-ATG16L1 complex CPX-354 ATG12-ATG5-ATG16L2 complex CPX-356 ATG5-ATG12 complex CPX-358 ATG5-ATG12-TECPR1 complex
DIPⁱ	DIP-29758N
IntActⁱ	Q9H1Y0, 52 interactors
MINTⁱ	Q9H1Y0
STRINGⁱ	9606.ENSP00000343313

PTM databases

iPTMnetⁱ	Q9H1Y0
PhosphoSitePlusⁱ	Q9H1Y0

Polymorphism and mutation databases

DMDMⁱ	17366828

DMDMⁱ

17366828

Proteomic databases

EPDⁱ	Q9H1Y0
MaxQBⁱ	Q9H1Y0
PaxDbⁱ	Q9H1Y0
PeptideAtlasⁱ	Q9H1Y0
PRIDEⁱ	Q9H1Y0
ProteomicsDBⁱ	80456 80457 [Q9H1Y0-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	9474
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000343245; ENSP00000343313; ENSG00000057663 [Q9H1Y0-1] ENST00000369076; ENSP00000358072; ENSG00000057663 [Q9H1Y0-1] ENST00000635758; ENSP00000490493; ENSG00000057663 [Q9H1Y0-2]
GeneIDⁱ	9474
KEGGⁱ	hsa:9474
UCSCⁱ	uc003prf.4 human [Q9H1Y0-1]

Organism-specific databases

CTDⁱ	9474
DisGeNETⁱ	9474
EuPathDBⁱ	HostDB:ENSG00000057663.12
GeneCardsⁱ	ATG5
HGNCⁱ	HGNC:589 ATG5
HPAⁱ	CAB034432 CAB037309 HPA042973
MalaCardsⁱ	ATG5
MIMⁱ	604261 gene 617584 phenotype
neXtProtⁱ	NX_Q9H1Y0
OpenTargetsⁱ	ENSG00000057663
PharmGKBⁱ	PA24880
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2976 Eukaryota ENOG410XQ71 LUCA
GeneTreeⁱ	ENSGT00390000004766
HOGENOMⁱ	HOG000007893
HOVERGENⁱ	HBG018731
InParanoidⁱ	Q9H1Y0
KOⁱ	K08339
OMAⁱ	WHYPIGV
OrthoDBⁱ	EOG091G0JU7
PhylomeDBⁱ	Q9H1Y0
TreeFamⁱ	TF314415

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1632852 Macroautophagy R-HSA-5205685 Pink/Parkin Mediated Mitophagy R-HSA-8934903 Receptor Mediated Mitophagy R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling
SIGNORⁱ	Q9H1Y0

Miscellaneous databases

ChiTaRSⁱ	ATG5 human
GeneWikiⁱ	ATG5
GenomeRNAiⁱ	9474
Protein Ontology More...PROⁱ	PR:Q9H1Y0
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000057663 Expressed in 225 organ(s), highest expression level in colonic mucosa
CleanExⁱ	HS_ATG5
ExpressionAtlasⁱ	Q9H1Y0 baseline and differential
Genevisibleⁱ	Q9H1Y0 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR007239 Atg5
PANTHERⁱ	PTHR13040 PTHR13040, 1 hit
Pfamⁱ	View protein in Pfam PF04106 APG5, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ATG5_HUMAN
Accessionⁱ	Q9H1Y0Primary (citable) accession number: Q9H1Y0 Secondary accession number(s): O60875 , Q5JVR2, Q68DI4, Q9H2B8, Q9HCZ7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 16, 2001
	Last sequence update:	November 16, 2001
	Last modified:	September 12, 2018
	This is version 163 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q9H1Y0 (ATG5_HUMAN)

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Autophagy protein 5

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

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<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

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Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

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Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

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Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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Sequence databases

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PTM databases

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Genome annotation databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ