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Entry version 142 (13 Feb 2019)
Sequence version 1 (01 Mar 2001)
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Protein

Solute carrier family 25 member 51

Gene

SLC25A51

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.29.2.14 the mitochondrial carrier (mc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier family 25 member 51
Alternative name(s):
Mitochondrial carrier triple repeat protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC25A51
Synonyms:MCART1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000122696.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23323 SLC25A51

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H1U9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei36 – 56Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei85 – 105Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei116 – 135Helical; Name=3Sequence analysisAdd BLAST20
Transmembranei179 – 199Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei215 – 235Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei268 – 289Helical; Name=6Sequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000122696

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134888553

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC25A51

Domain mapping of disease mutations (DMDM)

More...
DMDMi
38605048

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000907111 – 297Solute carrier family 25 member 51Add BLAST297

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9H1U9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9H1U9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H1U9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H1U9

PeptideAtlas

More...
PeptideAtlasi
Q9H1U9

PRoteomics IDEntifications database

More...
PRIDEi
Q9H1U9

ProteomicsDB human proteome resource

More...
ProteomicsDBi
80448

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H1U9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H1U9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000122696 Expressed in 145 organ(s), highest expression level in heart

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H1U9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA046388
HPA058261

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124902, 15 interactors

Protein interaction database and analysis system

More...
IntActi
Q9H1U9, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000242275

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9H1U9

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati28 – 108Solcar 1Add BLAST81
Repeati116 – 200Solcar 2Add BLAST85
Repeati213 – 296Solcar 3Add BLAST84

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1519 Eukaryota
ENOG410XNWT LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155622

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000233158

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052423

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H1U9

Identification of Orthologs from Complete Genome Data

More...
OMAi
GFLYRGM

Database of Orthologous Groups

More...
OrthoDBi
966424at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H1U9

TreeFam database of animal gene trees

More...
TreeFami
TF314192

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.50.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR040062 Mitochondrial_carrier_protein
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR24089 PTHR24089, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00153 Mito_carr, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103506 SSF103506, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50920 SOLCAR, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9H1U9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMDSEAHEKR PPILTSSKQD ISPHITNVGE MKHYLCGCCA AFNNVAITFP
60 70 80 90 100
IQKVLFRQQL YGIKTRDAIL QLRRDGFRNL YRGILPPLMQ KTTTLALMFG
110 120 130 140 150
LYEDLSCLLH KHVSAPEFAT SGVAAVLAGT TEAIFTPLER VQTLLQDHKH
160 170 180 190 200
HDKFTNTYQA FKALKCHGIG EYYRGLVPIL FRNGLSNVLF FGLRGPIKEH
210 220 230 240 250
LPTATTHSAH LVNDFICGGL LGAMLGFLFF PINVVKTRIQ SQIGGEFQSF
260 270 280 290
PKVFQKIWLE RDRKLINLFR GAHLNYHRSL ISWGIINATY EFLLKVI
Length:297
Mass (Da):33,672
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2AE13422BEDC5F1E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036333205T → M in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs780199922Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL138752 Genomic DNA No translation available.
BC008500 mRNA Translation: AAH08500.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6614.1

NCBI Reference Sequences

More...
RefSeqi
NP_219480.1, NM_033412.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.634120

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000242275; ENSP00000242275; ENSG00000122696
ENST00000377716; ENSP00000366945; ENSG00000122696

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
92014

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:92014

UCSC genome browser

More...
UCSCi
uc004aav.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL138752 Genomic DNA No translation available.
BC008500 mRNA Translation: AAH08500.1
CCDSiCCDS6614.1
RefSeqiNP_219480.1, NM_033412.3
UniGeneiHs.634120

3D structure databases

ProteinModelPortaliQ9H1U9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124902, 15 interactors
IntActiQ9H1U9, 2 interactors
STRINGi9606.ENSP00000242275

Protein family/group databases

TCDBi2.A.29.2.14 the mitochondrial carrier (mc) family

PTM databases

iPTMnetiQ9H1U9
PhosphoSitePlusiQ9H1U9

Polymorphism and mutation databases

BioMutaiSLC25A51
DMDMi38605048

Proteomic databases

EPDiQ9H1U9
jPOSTiQ9H1U9
MaxQBiQ9H1U9
PaxDbiQ9H1U9
PeptideAtlasiQ9H1U9
PRIDEiQ9H1U9
ProteomicsDBi80448

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
92014
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000242275; ENSP00000242275; ENSG00000122696
ENST00000377716; ENSP00000366945; ENSG00000122696
GeneIDi92014
KEGGihsa:92014
UCSCiuc004aav.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
92014
EuPathDBiHostDB:ENSG00000122696.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SLC25A51

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0026170
HIX0033169
HGNCiHGNC:23323 SLC25A51
HPAiHPA046388
HPA058261
neXtProtiNX_Q9H1U9
OpenTargetsiENSG00000122696
PharmGKBiPA134888553

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1519 Eukaryota
ENOG410XNWT LUCA
GeneTreeiENSGT00940000155622
HOGENOMiHOG000233158
HOVERGENiHBG052423
InParanoidiQ9H1U9
OMAiGFLYRGM
OrthoDBi966424at2759
PhylomeDBiQ9H1U9
TreeFamiTF314192

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SLC25A51 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
92014

Protein Ontology

More...
PROi
PR:Q9H1U9

Gene expression databases

BgeeiENSG00000122696 Expressed in 145 organ(s), highest expression level in heart
GenevisibleiQ9H1U9 HS

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR040062 Mitochondrial_carrier_protein
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PANTHERiPTHR24089 PTHR24089, 1 hit
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS2551_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H1U9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: March 1, 2001
Last modified: February 13, 2019
This is version 142 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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