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Protein

Solute carrier family 25 member 51

Gene

SLC25A51

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Protein family/group databases

TCDBi2.A.29.2.14 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 51
Alternative name(s):
Mitochondrial carrier triple repeat protein 1
Gene namesi
Name:SLC25A51
Synonyms:MCART1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000122696.12
HGNCiHGNC:23323 SLC25A51
neXtProtiNX_Q9H1U9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei36 – 56Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei85 – 105Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei116 – 135Helical; Name=3Sequence analysisAdd BLAST20
Transmembranei179 – 199Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei215 – 235Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei268 – 289Helical; Name=6Sequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000122696
PharmGKBiPA134888553

Polymorphism and mutation databases

BioMutaiSLC25A51
DMDMi38605048

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000907111 – 297Solute carrier family 25 member 51Add BLAST297

Proteomic databases

EPDiQ9H1U9
MaxQBiQ9H1U9
PaxDbiQ9H1U9
PeptideAtlasiQ9H1U9
PRIDEiQ9H1U9
ProteomicsDBi80448

PTM databases

iPTMnetiQ9H1U9
PhosphoSitePlusiQ9H1U9

Expressioni

Gene expression databases

BgeeiENSG00000122696 Expressed in 145 organ(s), highest expression level in heart
CleanExiHS_MCART1
GenevisibleiQ9H1U9 HS

Organism-specific databases

HPAiHPA046388
HPA058261

Interactioni

Protein-protein interaction databases

BioGridi124902, 15 interactors
IntActiQ9H1U9, 2 interactors
STRINGi9606.ENSP00000242275

Structurei

3D structure databases

ProteinModelPortaliQ9H1U9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati28 – 108Solcar 1Add BLAST81
Repeati116 – 200Solcar 2Add BLAST85
Repeati213 – 296Solcar 3Add BLAST84

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1519 Eukaryota
ENOG410XNWT LUCA
GeneTreeiENSGT00730000110930
HOGENOMiHOG000233158
HOVERGENiHBG052423
InParanoidiQ9H1U9
OMAiGFLYRGM
OrthoDBiEOG091G0L68
PhylomeDBiQ9H1U9
TreeFamiTF314192

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q9H1U9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMDSEAHEKR PPILTSSKQD ISPHITNVGE MKHYLCGCCA AFNNVAITFP
60 70 80 90 100
IQKVLFRQQL YGIKTRDAIL QLRRDGFRNL YRGILPPLMQ KTTTLALMFG
110 120 130 140 150
LYEDLSCLLH KHVSAPEFAT SGVAAVLAGT TEAIFTPLER VQTLLQDHKH
160 170 180 190 200
HDKFTNTYQA FKALKCHGIG EYYRGLVPIL FRNGLSNVLF FGLRGPIKEH
210 220 230 240 250
LPTATTHSAH LVNDFICGGL LGAMLGFLFF PINVVKTRIQ SQIGGEFQSF
260 270 280 290
PKVFQKIWLE RDRKLINLFR GAHLNYHRSL ISWGIINATY EFLLKVI
Length:297
Mass (Da):33,672
Last modified:March 1, 2001 - v1
Checksum:i2AE13422BEDC5F1E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036333205T → M in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs780199922Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL138752 Genomic DNA No translation available.
BC008500 mRNA Translation: AAH08500.1
CCDSiCCDS6614.1
RefSeqiNP_219480.1, NM_033412.3
UniGeneiHs.634120

Genome annotation databases

EnsembliENST00000242275; ENSP00000242275; ENSG00000122696
ENST00000377716; ENSP00000366945; ENSG00000122696
GeneIDi92014
KEGGihsa:92014
UCSCiuc004aav.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL138752 Genomic DNA No translation available.
BC008500 mRNA Translation: AAH08500.1
CCDSiCCDS6614.1
RefSeqiNP_219480.1, NM_033412.3
UniGeneiHs.634120

3D structure databases

ProteinModelPortaliQ9H1U9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124902, 15 interactors
IntActiQ9H1U9, 2 interactors
STRINGi9606.ENSP00000242275

Protein family/group databases

TCDBi2.A.29.2.14 the mitochondrial carrier (mc) family

PTM databases

iPTMnetiQ9H1U9
PhosphoSitePlusiQ9H1U9

Polymorphism and mutation databases

BioMutaiSLC25A51
DMDMi38605048

Proteomic databases

EPDiQ9H1U9
MaxQBiQ9H1U9
PaxDbiQ9H1U9
PeptideAtlasiQ9H1U9
PRIDEiQ9H1U9
ProteomicsDBi80448

Protocols and materials databases

DNASUi92014
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000242275; ENSP00000242275; ENSG00000122696
ENST00000377716; ENSP00000366945; ENSG00000122696
GeneIDi92014
KEGGihsa:92014
UCSCiuc004aav.3 human

Organism-specific databases

CTDi92014
EuPathDBiHostDB:ENSG00000122696.12
GeneCardsiSLC25A51
H-InvDBiHIX0026170
HIX0033169
HGNCiHGNC:23323 SLC25A51
HPAiHPA046388
HPA058261
neXtProtiNX_Q9H1U9
OpenTargetsiENSG00000122696
PharmGKBiPA134888553
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1519 Eukaryota
ENOG410XNWT LUCA
GeneTreeiENSGT00730000110930
HOGENOMiHOG000233158
HOVERGENiHBG052423
InParanoidiQ9H1U9
OMAiGFLYRGM
OrthoDBiEOG091G0L68
PhylomeDBiQ9H1U9
TreeFamiTF314192

Miscellaneous databases

ChiTaRSiSLC25A51 human
GenomeRNAii92014
PROiPR:Q9H1U9

Gene expression databases

BgeeiENSG00000122696 Expressed in 145 organ(s), highest expression level in heart
CleanExiHS_MCART1
GenevisibleiQ9H1U9 HS

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiS2551_HUMAN
AccessioniPrimary (citable) accession number: Q9H1U9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: March 1, 2001
Last modified: October 10, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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Main funding by: National Institutes of Health

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