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Entry version 162 (29 Sep 2021)
Sequence version 1 (01 Mar 2001)
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Protein

Oxysterol-binding protein-related protein 2

Gene

OSBPL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Intracellular transport protein that binds sterols and phospholipids and mediates lipid transport between intracellular compartments. Increases plasma membrane cholesterol levels and decreases phosphatidylinositol-4,5-bisphosphate levels in the cell membrane (PubMed:30581148).

Binds phosphoinositides, such as phosphatidylinositol-4,5-bisphosphate (PubMed:30581148).

Exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate (PubMed:11279184).

Binds cholesterol, dehydroergosterol, 22(R)-hydroxycholesterol and 25-hydroxycholesterol (in vitro) (PubMed:17428193, PubMed:19224871, PubMed:30581148).

3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei90Phosphatidylinositol-4,5-bisphosphateCombined sources1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processLipid transport, Transport
LigandLipid-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9H1P3

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-192105, Synthesis of bile acids and bile salts

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001533

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Oxysterol-binding protein-related protein 2
Short name:
ORP-2
Short name:
OSBP-related protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:OSBPL2
Synonyms:KIAA0772, ORP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:15761, OSBPL2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606731, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H1P3

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000130703

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Lipid droplet, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Deafness, autosomal dominant, 67 (DFNA67)3 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Related information in OMIM

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi79I → A: No effect on phosphatidylinositide binding, but impaired tetramerization and decreased cholesterol binding, plus decreased cholesterol and phosphatidylinositide transport. 1 Publication1
Mutagenesisi83C → A: No effect on phosphatidylinositide binding, but impaired tetramerization and decreased cholesterol binding, plus decreased cholesterol and phosphatidylinositide transport. 1 Publication1
Mutagenesisi87 – 90Missing : Loss of the ability to promote cholesterol accumulation at the cell membrane. No effect on phosphatidylinositide levels at the cell membrane. 1 Publication4
Mutagenesisi93M → K: Mildly decreased 25-hydroxycholesterol binding. 1 Publication1
Mutagenesisi103F → W: Mildly decreased 25-hydroxycholesterol binding. 1 Publication1
Mutagenesisi110Y → A: No effect on phosphatidylinositide binding, but decreased cholesterol binding, plus decreased cholesterol and phosphatidylinositide transport. 1 Publication1
Mutagenesisi150K → A: Reduces 25-hydroxycholesterol binding. 1 Publication1
Mutagenesisi152F → D: Does not significantly impair 25-hydroxycholesterol binding. 1 Publication1
Mutagenesisi178 – 179HH → DD: Loss of increased cholesterol and decreased phosphatidylinositide accumulation at the cell membrane. 1 Publication2
Mutagenesisi215P → A: No effect on phosphatidylinositide binding, but decreased cholesterol binding, plus decreased cholesterol and phosphatidylinositide transport. 1 Publication1
Mutagenesisi249I → W: Reduces 25-hydroxycholesterol binding. Loss of 22(R)-hydroxycholesterol binding. 2 Publications1
Mutagenesisi423K → A: Loss of increased cholesterol and decreased phosphatidylinositide accumulation at the cell membrane. 1 Publication1

Keywords - Diseasei

Deafness, Non-syndromic deafness

Organism-specific databases

DisGeNET

More...
DisGeNETi
9885

MalaCards human disease database

More...
MalaCardsi
OSBPL2
MIMi616340, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000130703

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
90635, Autosomal dominant non-syndromic sensorineural deafness type DFNA

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA32827

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9H1P3, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
OSBPL2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20139174

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001003691 – 480Oxysterol-binding protein-related protein 2Add BLAST480

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei19PhosphoserineCombined sources1
Modified residuei20PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9H1P3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9H1P3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9H1P3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H1P3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H1P3

PeptideAtlas

More...
PeptideAtlasi
Q9H1P3

PRoteomics IDEntifications database

More...
PRIDEi
Q9H1P3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
80434 [Q9H1P3-1]
80435 [Q9H1P3-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H1P3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H1P3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000130703, Expressed in skin of abdomen and 238 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9H1P3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H1P3, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000130703, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer. Homotetramer; phosphatidylinositol-4,5-bisphosphate binding promotes formation of stable tetramers (PubMed:30581148).

Interacts with DIAPH1.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
115216, 19 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q9H1P3

Protein interaction database and analysis system

More...
IntActi
Q9H1P3, 14 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000316649

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9H1P3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1480
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9H1P3

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 60DisorderedSequence analysisAdd BLAST60
Regioni178 – 179Phosphatidylinositol-4,5-bisphosphate bindingCombined sources1 Publication2
Regioni427 – 431Phosphatidylinositol-4,5-bisphosphate bindingCombined sources1 Publication5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi13 – 60Polar residuesSequence analysisAdd BLAST48

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the OSBP family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2209, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158762

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007105_6_2_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9H1P3

Identification of Orthologs from Complete Genome Data

More...
OMAi
REAKGHQ

Database of Orthologous Groups

More...
OrthoDBi
863978at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H1P3

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037239, OSBP_sf
IPR000648, Oxysterol-bd
IPR018494, Oxysterol-bd_CS

The PANTHER Classification System

More...
PANTHERi
PTHR10972, PTHR10972, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01237, Oxysterol_BP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF144000, SSF144000, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01013, OSBP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 17 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H1P3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNGEEEFFDA VTGFDSDNSS GEFSEANQKV TGMIDLDTSK NNRIGKTGER
60 70 80 90 100
PSQENGIQKH RTSLPAPMFS RSDFSVWTIL KKCVGLELSK ITMPIAFNEP
110 120 130 140 150
LSFLQRITEY MEHVYLIHRA SCQPQPLERM QSVAAFAVSA VASQWERTGK
160 170 180 190 200
PFNPLLGETY ELIREDLGFR FISEQVSHHP PISAFHSEGL NHDFLFHGSI
210 220 230 240 250
YPKLKFWGKS VEAEPRGTIT LELLKHNEAY TWTNPTCCVH NVIIGKLWIE
260 270 280 290 300
QYGTVEILNH RTGHKCVLHF KPCGLFGKEL HKVEGHIQDK NKKKLFMIYG
310 320 330 340 350
KWTECLWGID PVSYESFKKQ ERRGDHLRKA KLDEDSGKAD SDVADDVPVA
360 370 380 390 400
QETVQVIPGS KLLWRINTRP PNSAQMYNFT SFTVSLNELE TGMEKTLPPT
410 420 430 440 450
DCRLRPDIRG MENGNMDLAS QEKERLEEKQ REARRERAKE EAEWQTRWFY
460 470 480
PGNNPYTGTP DWLYAGDYFE RNFSDCPDIY
Length:480
Mass (Da):55,201
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA93D1B389D0A2740
GO
Isoform 2 (identifier: Q9H1P3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     13-24: Missing.

Show »
Length:468
Mass (Da):53,971
Checksum:i9C51392E0EDF4DF8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 17 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8YD49A0A2R8YD49_HUMAN
Oxysterol-binding protein
OSBPL2
448Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ET92E7ET92_HUMAN
Oxysterol-binding protein
OSBPL2
370Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y5R1A0A2R8Y5R1_HUMAN
Oxysterol-binding protein
OSBPL2
370Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y690A0A2R8Y690_HUMAN
Oxysterol-binding protein
OSBPL2
291Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YFT0A0A2R8YFT0_HUMAN
Oxysterol-binding protein
OSBPL2 hCG_40342
243Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YG95A0A2R8YG95_HUMAN
Oxysterol-binding protein
OSBPL2
225Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YG59A0A2R8YG59_HUMAN
Oxysterol-binding protein
OSBPL2
369Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YDU7A0A2R8YDU7_HUMAN
Oxysterol-binding protein
OSBPL2
388Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YEX0A0A2R8YEX0_HUMAN
Oxysterol-binding protein
OSBPL2
413Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y362A0A2R8Y362_HUMAN
Oxysterol-binding protein
OSBPL2
439Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA34492 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00378113 – 24Missing in isoform 2. 4 PublicationsAdd BLAST12

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY028168 mRNA Translation: AAK18044.1
AF392447 mRNA Translation: AAL40660.1
AB018315 mRNA Translation: BAA34492.2 Different initiation.
AK291851 mRNA Translation: BAF84540.1
CR456722 mRNA Translation: CAG33003.1
AL354836 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75377.1
CH471077 Genomic DNA Translation: EAW75379.1
BC000296 mRNA Translation: AAH00296.1
BC004455 mRNA Translation: AAH04455.1
AF331963 mRNA Translation: AAG53416.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS13494.1 [Q9H1P3-2]
CCDS13495.1 [Q9H1P3-1]

NCBI Reference Sequences

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RefSeqi
NP_055650.1, NM_014835.3 [Q9H1P3-2]
NP_653081.1, NM_144498.2 [Q9H1P3-1]
XP_016883654.1, XM_017028165.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000313733; ENSP00000316649; ENSG00000130703 [Q9H1P3-1]
ENST00000358053; ENSP00000350755; ENSG00000130703 [Q9H1P3-2]
ENST00000643412; ENSP00000494549; ENSG00000130703 [Q9H1P3-1]
ENST00000643981; ENSP00000495379; ENSG00000130703 [Q9H1P3-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9885

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9885

UCSC genome browser

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UCSCi
uc002yck.3, human [Q9H1P3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY028168 mRNA Translation: AAK18044.1
AF392447 mRNA Translation: AAL40660.1
AB018315 mRNA Translation: BAA34492.2 Different initiation.
AK291851 mRNA Translation: BAF84540.1
CR456722 mRNA Translation: CAG33003.1
AL354836 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75377.1
CH471077 Genomic DNA Translation: EAW75379.1
BC000296 mRNA Translation: AAH00296.1
BC004455 mRNA Translation: AAH04455.1
AF331963 mRNA Translation: AAG53416.1
CCDSiCCDS13494.1 [Q9H1P3-2]
CCDS13495.1 [Q9H1P3-1]
RefSeqiNP_055650.1, NM_014835.3 [Q9H1P3-2]
NP_653081.1, NM_144498.2 [Q9H1P3-1]
XP_016883654.1, XM_017028165.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5ZM8X-ray2.70A/B49-480[»]
SMRiQ9H1P3
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi115216, 19 interactors
ELMiQ9H1P3
IntActiQ9H1P3, 14 interactors
STRINGi9606.ENSP00000316649

Chemistry databases

SwissLipidsiSLP:000001533

PTM databases

iPTMnetiQ9H1P3
PhosphoSitePlusiQ9H1P3

Genetic variation databases

BioMutaiOSBPL2
DMDMi20139174

Proteomic databases

EPDiQ9H1P3
jPOSTiQ9H1P3
MassIVEiQ9H1P3
MaxQBiQ9H1P3
PaxDbiQ9H1P3
PeptideAtlasiQ9H1P3
PRIDEiQ9H1P3
ProteomicsDBi80434 [Q9H1P3-1]
80435 [Q9H1P3-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
29467, 188 antibodies

The DNASU plasmid repository

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DNASUi
9885

Genome annotation databases

EnsembliENST00000313733; ENSP00000316649; ENSG00000130703 [Q9H1P3-1]
ENST00000358053; ENSP00000350755; ENSG00000130703 [Q9H1P3-2]
ENST00000643412; ENSP00000494549; ENSG00000130703 [Q9H1P3-1]
ENST00000643981; ENSP00000495379; ENSG00000130703 [Q9H1P3-1]
GeneIDi9885
KEGGihsa:9885
UCSCiuc002yck.3, human [Q9H1P3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9885
DisGeNETi9885

GeneCards: human genes, protein and diseases

More...
GeneCardsi
OSBPL2
HGNCiHGNC:15761, OSBPL2
HPAiENSG00000130703, Low tissue specificity
MalaCardsiOSBPL2
MIMi606731, gene
616340, phenotype
neXtProtiNX_Q9H1P3
OpenTargetsiENSG00000130703
Orphaneti90635, Autosomal dominant non-syndromic sensorineural deafness type DFNA
PharmGKBiPA32827
VEuPathDBiHostDB:ENSG00000130703

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2209, Eukaryota
GeneTreeiENSGT00940000158762
HOGENOMiCLU_007105_6_2_1
InParanoidiQ9H1P3
OMAiREAKGHQ
OrthoDBi863978at2759
PhylomeDBiQ9H1P3

Enzyme and pathway databases

PathwayCommonsiQ9H1P3
ReactomeiR-HSA-192105, Synthesis of bile acids and bile salts

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
9885, 12 hits in 1018 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
OSBPL2, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
OSBPL2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9885
PharosiQ9H1P3, Tbio

Protein Ontology

More...
PROi
PR:Q9H1P3
RNActiQ9H1P3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000130703, Expressed in skin of abdomen and 238 other tissues
ExpressionAtlasiQ9H1P3, baseline and differential
GenevisibleiQ9H1P3, HS

Family and domain databases

InterProiView protein in InterPro
IPR037239, OSBP_sf
IPR000648, Oxysterol-bd
IPR018494, Oxysterol-bd_CS
PANTHERiPTHR10972, PTHR10972, 1 hit
PfamiView protein in Pfam
PF01237, Oxysterol_BP, 1 hit
SUPFAMiSSF144000, SSF144000, 1 hit
PROSITEiView protein in PROSITE
PS01013, OSBP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOSBL2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H1P3
Secondary accession number(s): A8K736
, Q6IBT0, Q9BZB1, Q9Y4B8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: March 1, 2001
Last modified: September 29, 2021
This is version 162 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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