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Protein

Beta-defensin 127

Gene

DEFB127

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has antibacterial activity.Curated

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiR-HSA-1461957 Beta defensins
R-HSA-1461973 Defensins

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 127
Alternative name(s):
Beta-defensin 27
Short name:
DEFB-27
Defensin, beta 127
Gene namesi
Name:DEFB127
Synonyms:C20orf73, DEFB27
ORF Names:UNQ1956/PRO6071
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000088782.4
HGNCiHGNC:16206 DEFB127
neXtProtiNX_Q9H1M4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27247

Polymorphism and mutation databases

DMDMi23813958

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 201 PublicationAdd BLAST20
PeptideiPRO_000000700221 – 63Beta-defensin 127Add BLAST43
PropeptideiPRO_000000700366 – 99Sequence analysisAdd BLAST34

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 53By similarity
Disulfide bondi33 ↔ 47By similarity
Disulfide bondi37 ↔ 54By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiQ9H1M4
PRIDEiQ9H1M4
ProteomicsDBi80430

Expressioni

Gene expression databases

BgeeiENSG00000088782 Expressed in 9 organ(s), highest expression level in caput epididymis
CleanExiHS_DEFB127
GenevisibleiQ9H1M4 HS

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TFECO149483EBI-10305240,EBI-3916574

Protein-protein interaction databases

BioGridi126734, 14 interactors
IntActiQ9H1M4, 8 interactors
STRINGi9606.ENSP00000371825

Structurei

3D structure databases

ProteinModelPortaliQ9H1M4
SMRiQ9H1M4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JEA5 Eukaryota
ENOG41114BX LUCA
GeneTreeiENSGT00530000064502
HOGENOMiHOG000112159
HOVERGENiHBG051310
InParanoidiQ9H1M4
OMAiREVLCEN
OrthoDBiEOG091G0Y45
PhylomeDBiQ9H1M4

Family and domain databases

InterProiView protein in InterPro
IPR025933 Beta_defensin
PANTHERiPTHR15001 PTHR15001, 1 hit
PfamiView protein in Pfam
PF13841 Defensin_beta_2, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD866254 PD866254, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H1M4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLFMIIAIL LFQKPTVTEQ LKKCWNNYVQ GHCRKICRVN EVPEALCENG
60 70 80 90
RYCCLNIKEL EACKKITKPP RPKPATLALT LQDYVTIIEN FPSLKTQST
Length:99
Mass (Da):11,343
Last modified:March 1, 2001 - v1
Checksum:iC9CBDB27D17AF380
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti74 – 77PATL → QHLH in AAM93920 (PubMed:11854508).Curated4

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04886431G → R1 PublicationCorresponds to variant dbSNP:rs12624954Ensembl.1
Natural variantiVAR_04886571R → S1 PublicationCorresponds to variant dbSNP:rs16995685Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF525929 mRNA Translation: AAP47222.1
AY358796 mRNA Translation: AAQ89156.1
AL360078 Genomic DNA No translation available.
BC069486 mRNA Translation: AAH69486.1
BC109395 mRNA Translation: AAI09396.1
AY122479 mRNA Translation: AAM93920.1
CCDSiCCDS12991.1
RefSeqiNP_620713.1, NM_139074.3
UniGeneiHs.99362

Genome annotation databases

EnsembliENST00000382388; ENSP00000371825; ENSG00000088782
GeneIDi140850
KEGGihsa:140850
UCSCiuc002wcy.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF525929 mRNA Translation: AAP47222.1
AY358796 mRNA Translation: AAQ89156.1
AL360078 Genomic DNA No translation available.
BC069486 mRNA Translation: AAH69486.1
BC109395 mRNA Translation: AAI09396.1
AY122479 mRNA Translation: AAM93920.1
CCDSiCCDS12991.1
RefSeqiNP_620713.1, NM_139074.3
UniGeneiHs.99362

3D structure databases

ProteinModelPortaliQ9H1M4
SMRiQ9H1M4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126734, 14 interactors
IntActiQ9H1M4, 8 interactors
STRINGi9606.ENSP00000371825

Polymorphism and mutation databases

DMDMi23813958

Proteomic databases

PaxDbiQ9H1M4
PRIDEiQ9H1M4
ProteomicsDBi80430

Protocols and materials databases

DNASUi140850
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382388; ENSP00000371825; ENSG00000088782
GeneIDi140850
KEGGihsa:140850
UCSCiuc002wcy.2 human

Organism-specific databases

CTDi140850
EuPathDBiHostDB:ENSG00000088782.4
GeneCardsiDEFB127
HGNCiHGNC:16206 DEFB127
neXtProtiNX_Q9H1M4
PharmGKBiPA27247
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JEA5 Eukaryota
ENOG41114BX LUCA
GeneTreeiENSGT00530000064502
HOGENOMiHOG000112159
HOVERGENiHBG051310
InParanoidiQ9H1M4
OMAiREVLCEN
OrthoDBiEOG091G0Y45
PhylomeDBiQ9H1M4

Enzyme and pathway databases

ReactomeiR-HSA-1461957 Beta defensins
R-HSA-1461973 Defensins

Miscellaneous databases

GeneWikiiDEFB127
GenomeRNAii140850
PROiPR:Q9H1M4

Gene expression databases

BgeeiENSG00000088782 Expressed in 9 organ(s), highest expression level in caput epididymis
CleanExiHS_DEFB127
GenevisibleiQ9H1M4 HS

Family and domain databases

InterProiView protein in InterPro
IPR025933 Beta_defensin
PANTHERiPTHR15001 PTHR15001, 1 hit
PfamiView protein in Pfam
PF13841 Defensin_beta_2, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD866254 PD866254, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDB127_HUMAN
AccessioniPrimary (citable) accession number: Q9H1M4
Secondary accession number(s): Q14DW7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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