DEFB127

Functionⁱ

Has antibacterial activity.Curated

GO - Biological processⁱ

antimicrobial humoral immune response mediated by antimicrobial peptide
Source: UniProtKB
Inferred from direct assayⁱ
- 19373462
defense response to bacterium
Source: UniProtKB
Traceable author statementⁱ
- 10588992
defense response to Gram-negative bacterium
Source: UniProtKB
Inferred from direct assayⁱ
- 19373462
innate immune response
Source: UniProtKB
Traceable author statementⁱ
- 10588992

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Antibiotic, Antimicrobial, Defensin

Molecular function

Antibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1461957 Beta defensins R-HSA-1461973 Defensins

Reactomeⁱ

R-HSA-1461957 Beta defensins
R-HSA-1461973 Defensins

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Beta-defensin 127 Alternative name(s): Beta-defensin 27 Short name: DEFB-27 Defensin, beta 127
Gene namesⁱ	Name:DEFB127 Synonyms:C20orf73, DEFB27 ORF Names:UNQ1956/PRO6071
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 20

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000088782.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16206 DEFB127
neXtProtⁱ	NX_Q9H1M4

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA27247

PharmGKBⁱ

PA27247

Polymorphism and mutation databases

DMDMⁱ	23813958

DMDMⁱ

23813958

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 20	1 PublicationAdd BLAST	20
PeptideⁱPRO_0000007002	21 – 63	Beta-defensin 127Add BLAST	43
PropeptideⁱPRO_0000007003	66 – 99	Sequence analysisAdd BLAST	34

Amino acid modifications

Feature key	Position(s)	DescriptionActions
Disulfide bondⁱ	24 ↔ 53	By similarity
Disulfide bondⁱ	33 ↔ 47	By similarity
Disulfide bondⁱ	37 ↔ 54	By similarity

Keywords - PTMⁱ

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbⁱ	Q9H1M4
PRIDEⁱ	Q9H1M4
ProteomicsDBⁱ	80430

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000088782 Expressed in 9 organ(s), highest expression level in caput epididymis
CleanExⁱ	HS_DEFB127
Genevisibleⁱ	Q9H1M4 HS

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
TFEC	O14948	3	EBI-10305240,EBI-3916574

With

Entry

#Exp.

IntAct

Notes

TFEC

O14948

3

EBI-10305240,EBI-3916574

Protein-protein interaction databases

BioGridⁱ	126734, 14 interactors
IntActⁱ	Q9H1M4, 8 interactors
STRINGⁱ	9606.ENSP00000371825

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9H1M4
SMRⁱ	Q9H1M4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the beta-defensin family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410JEA5 Eukaryota ENOG41114BX LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000064502
HOGENOMⁱ	HOG000112159
HOVERGENⁱ	HBG051310
InParanoidⁱ	Q9H1M4
OMAⁱ	REVLCEN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0Y45
PhylomeDBⁱ	Q9H1M4

Family and domain databases

InterProⁱ	View protein in InterPro IPR025933 Beta_defensin
PANTHERⁱ	PTHR15001 PTHR15001, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13841 Defensin_beta_2, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD866254 PD866254, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q9H1M4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGLFMIIAIL LFQKPTVTEQ LKKCWNNYVQ GHCRKICRVN EVPEALCENG 
        60         70         80         90 
RYCCLNIKEL EACKKITKPP RPKPATLALT LQDYVTIIEN FPSLKTQST

Length:99

Mass (Da):11,343

Last modified:March 1, 2001 - v1

Checksum:ⁱC9CBDB27D17AF380

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	74 – 77	PATL → QHLH in AAM93920 (PubMed:11854508).Curated		4

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_048864	31	G → R1 PublicationCorresponds to variant dbSNP:rs12624954Ensembl.		1
Natural variantⁱVAR_048865	71	R → S1 PublicationCorresponds to variant dbSNP:rs16995685Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF525929 mRNA Translation: AAP47222.1 AY358796 mRNA Translation: AAQ89156.1 AL360078 Genomic DNA No translation available. BC069486 mRNA Translation: AAH69486.1 BC109395 mRNA Translation: AAI09396.1 AY122479 mRNA Translation: AAM93920.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12991.1
NCBI Reference Sequences More...RefSeqⁱ	NP_620713.1, NM_139074.3
UniGeneⁱ	Hs.99362

Genome annotation databases

Ensemblⁱ	ENST00000382388; ENSP00000371825; ENSG00000088782
GeneIDⁱ	140850
KEGGⁱ	hsa:140850
UCSC genome browser More...UCSCⁱ	uc002wcy.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9H1M4	Beta-defensin 127		PANTR		99	UniRef90_Q9H1M4
Beta-defensin		PONAB		100
Beta-defensin		PANPA		99
Beta-defensin		HUMAN		99
Beta-defensin (Fragment)		PONPY		95
+4

Protein	Similar proteins		Species	Score	Length	Source
Q9H1M4	Beta-defensin 127		PANTR		99	UniRef50_Q9H1M4
Beta-defensin		PONAB		100
Beta-defensin		HUMAN		99
Beta-defensin		PANPA		99
Beta-defensin (Fragment)		PONPY		95
+34

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF525929 mRNA Translation: AAP47222.1 AY358796 mRNA Translation: AAQ89156.1 AL360078 Genomic DNA No translation available. BC069486 mRNA Translation: AAH69486.1 BC109395 mRNA Translation: AAI09396.1 AY122479 mRNA Translation: AAM93920.1
CCDSⁱ	CCDS12991.1
RefSeqⁱ	NP_620713.1, NM_139074.3
UniGeneⁱ	Hs.99362

3D structure databases

ProteinModelPortalⁱ	Q9H1M4
SMRⁱ	Q9H1M4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	126734, 14 interactors
IntActⁱ	Q9H1M4, 8 interactors
STRINGⁱ	9606.ENSP00000371825

Polymorphism and mutation databases

DMDMⁱ	23813958

DMDMⁱ

23813958

Proteomic databases

PaxDbⁱ	Q9H1M4
PRIDEⁱ	Q9H1M4
ProteomicsDBⁱ	80430

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	140850
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000382388; ENSP00000371825; ENSG00000088782
GeneIDⁱ	140850
KEGGⁱ	hsa:140850
UCSCⁱ	uc002wcy.2 human

Organism-specific databases

CTDⁱ	140850
EuPathDBⁱ	HostDB:ENSG00000088782.4
GeneCardsⁱ	DEFB127
HGNCⁱ	HGNC:16206 DEFB127
neXtProtⁱ	NX_Q9H1M4
PharmGKBⁱ	PA27247
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410JEA5 Eukaryota ENOG41114BX LUCA
GeneTreeⁱ	ENSGT00530000064502
HOGENOMⁱ	HOG000112159
HOVERGENⁱ	HBG051310
InParanoidⁱ	Q9H1M4
OMAⁱ	REVLCEN
OrthoDBⁱ	EOG091G0Y45
PhylomeDBⁱ	Q9H1M4

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1461957 Beta defensins R-HSA-1461973 Defensins

Reactomeⁱ

R-HSA-1461957 Beta defensins
R-HSA-1461973 Defensins

Miscellaneous databases

GeneWikiⁱ	DEFB127
GenomeRNAiⁱ	140850
Protein Ontology More...PROⁱ	PR:Q9H1M4

Gene expression databases

Bgeeⁱ	ENSG00000088782 Expressed in 9 organ(s), highest expression level in caput epididymis
CleanExⁱ	HS_DEFB127
Genevisibleⁱ	Q9H1M4 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR025933 Beta_defensin
PANTHERⁱ	PTHR15001 PTHR15001, 1 hit
Pfamⁱ	View protein in Pfam PF13841 Defensin_beta_2, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD866254 PD866254, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DB127_HUMAN
Accessionⁱ	Q9H1M4Primary (citable) accession number: Q9H1M4 Secondary accession number(s): Q14DW7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 10, 2002
	Last sequence update:	March 1, 2001
	Last modified:	November 7, 2018
	This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM

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UniParc

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UniProtKB - Q9H1M4 (DB127_HUMAN)

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Beta-defensin 127

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ