UniProtKB - Q9H1M4 (DB127_HUMAN)
Protein
Beta-defensin 127
Gene
DEFB127
Organism
Homo sapiens (Human)
Status
Functioni
Has antibacterial activity.Curated
GO - Biological processi
- antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
- defense response to bacterium Source: UniProtKB
- defense response to Gram-negative bacterium Source: UniProtKB
- innate immune response Source: UniProtKB
Keywordsi
Molecular function | Antibiotic, Antimicrobial, Defensin |
Enzyme and pathway databases
PathwayCommonsi | Q9H1M4 |
Reactomei | R-HSA-1461957, Beta defensins R-HSA-1461973, Defensins |
Names & Taxonomyi
Protein namesi | Recommended name: Beta-defensin 127Alternative name(s): Beta-defensin 27 Short name: DEFB-27 Defensin, beta 127 |
Gene namesi | Name:DEFB127 Synonyms:C20orf73, DEFB27 ORF Names:UNQ1956/PRO6071 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16206, DEFB127 |
neXtProti | NX_Q9H1M4 |
VEuPathDBi | HostDB:ENSG00000088782.4 |
Subcellular locationi
Extracellular region or secreted
- Secreted Curated
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 140850 |
PharmGKBi | PA27247 |
Miscellaneous databases
Pharosi | Q9H1M4, Tbio |
Genetic variation databases
BioMutai | DEFB127 |
DMDMi | 23813958 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | 1 PublicationAdd BLAST | 20 | |
PeptideiPRO_0000007002 | 21 – 63 | Beta-defensin 127Add BLAST | 43 | |
PropeptideiPRO_0000007003 | 66 – 99 | Sequence analysisAdd BLAST | 34 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 24 ↔ 53 | By similarity | ||
Disulfide bondi | 33 ↔ 47 | By similarity | ||
Disulfide bondi | 37 ↔ 54 | By similarity |
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bondProteomic databases
MassIVEi | Q9H1M4 |
PaxDbi | Q9H1M4 |
PeptideAtlasi | Q9H1M4 |
PRIDEi | Q9H1M4 |
ProteomicsDBi | 80430 |
Expressioni
Gene expression databases
Bgeei | ENSG00000088782, Expressed in caput epididymis and 12 other tissues |
Genevisiblei | Q9H1M4, HS |
Organism-specific databases
HPAi | ENSG00000088782, Tissue enriched (epididymis) |
Interactioni
Binary interactionsi
Hide detailsQ9H1M4
Protein-protein interaction databases
BioGRIDi | 126734, 26 interactors |
IntActi | Q9H1M4, 24 interactors |
STRINGi | 9606.ENSP00000371825 |
Miscellaneous databases
RNActi | Q9H1M4, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the beta-defensin family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502TFAJ, Eukaryota |
GeneTreei | ENSGT00530000064502 |
HOGENOMi | CLU_181906_1_0_1 |
InParanoidi | Q9H1M4 |
OMAi | REVLCEN |
OrthoDBi | 1495393at2759 |
PhylomeDBi | Q9H1M4 |
Family and domain databases
InterProi | View protein in InterPro IPR025933, Beta_defensin |
Pfami | View protein in Pfam PF13841, Defensin_beta_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9H1M4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGLFMIIAIL LFQKPTVTEQ LKKCWNNYVQ GHCRKICRVN EVPEALCENG
60 70 80 90
RYCCLNIKEL EACKKITKPP RPKPATLALT LQDYVTIIEN FPSLKTQST
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 74 – 77 | PATL → QHLH in AAM93920 (PubMed:11854508).Curated | 4 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_048864 | 31 | G → R1 PublicationCorresponds to variant dbSNP:rs12624954Ensembl. | 1 | |
Natural variantiVAR_048865 | 71 | R → S1 PublicationCorresponds to variant dbSNP:rs16995685Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF525929 mRNA Translation: AAP47222.1 AY358796 mRNA Translation: AAQ89156.1 AL360078 Genomic DNA No translation available. BC069486 mRNA Translation: AAH69486.1 BC109395 mRNA Translation: AAI09396.1 AY122479 mRNA Translation: AAM93920.1 |
CCDSi | CCDS12991.1 |
RefSeqi | NP_620713.1, NM_139074.3 |
Genome annotation databases
Ensembli | ENST00000382388; ENSP00000371825; ENSG00000088782 |
GeneIDi | 140850 |
KEGGi | hsa:140850 |
UCSCi | uc002wcy.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF525929 mRNA Translation: AAP47222.1 AY358796 mRNA Translation: AAQ89156.1 AL360078 Genomic DNA No translation available. BC069486 mRNA Translation: AAH69486.1 BC109395 mRNA Translation: AAI09396.1 AY122479 mRNA Translation: AAM93920.1 |
CCDSi | CCDS12991.1 |
RefSeqi | NP_620713.1, NM_139074.3 |
3D structure databases
SMRi | Q9H1M4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 126734, 26 interactors |
IntActi | Q9H1M4, 24 interactors |
STRINGi | 9606.ENSP00000371825 |
Genetic variation databases
BioMutai | DEFB127 |
DMDMi | 23813958 |
Proteomic databases
MassIVEi | Q9H1M4 |
PaxDbi | Q9H1M4 |
PeptideAtlasi | Q9H1M4 |
PRIDEi | Q9H1M4 |
ProteomicsDBi | 80430 |
Protocols and materials databases
Antibodypediai | 54077, 5 antibodies |
DNASUi | 140850 |
Genome annotation databases
Ensembli | ENST00000382388; ENSP00000371825; ENSG00000088782 |
GeneIDi | 140850 |
KEGGi | hsa:140850 |
UCSCi | uc002wcy.2, human |
Organism-specific databases
CTDi | 140850 |
DisGeNETi | 140850 |
GeneCardsi | DEFB127 |
HGNCi | HGNC:16206, DEFB127 |
HPAi | ENSG00000088782, Tissue enriched (epididymis) |
neXtProti | NX_Q9H1M4 |
PharmGKBi | PA27247 |
VEuPathDBi | HostDB:ENSG00000088782.4 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502TFAJ, Eukaryota |
GeneTreei | ENSGT00530000064502 |
HOGENOMi | CLU_181906_1_0_1 |
InParanoidi | Q9H1M4 |
OMAi | REVLCEN |
OrthoDBi | 1495393at2759 |
PhylomeDBi | Q9H1M4 |
Enzyme and pathway databases
PathwayCommonsi | Q9H1M4 |
Reactomei | R-HSA-1461957, Beta defensins R-HSA-1461973, Defensins |
Miscellaneous databases
BioGRID-ORCSi | 140850, 4 hits in 847 CRISPR screens |
GeneWikii | DEFB127 |
GenomeRNAii | 140850 |
Pharosi | Q9H1M4, Tbio |
PROi | PR:Q9H1M4 |
RNActi | Q9H1M4, protein |
Gene expression databases
Bgeei | ENSG00000088782, Expressed in caput epididymis and 12 other tissues |
Genevisiblei | Q9H1M4, HS |
Family and domain databases
InterProi | View protein in InterPro IPR025933, Beta_defensin |
Pfami | View protein in Pfam PF13841, Defensin_beta_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DB127_HUMAN | |
Accessioni | Q9H1M4Primary (citable) accession number: Q9H1M4 Secondary accession number(s): Q14DW7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 10, 2002 |
Last sequence update: | March 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 139 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families