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Protein

Beta-defensin 129

Gene

DEFB129

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Has antibacterial activity.Curated

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiR-HSA-1461957 Beta defensins
R-HSA-1461973 Defensins

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 129
Alternative name(s):
Beta-defensin 29
Short name:
DEFB-29
Defensin, beta 129
Gene namesi
Name:DEFB129
Synonyms:C20orf87, DEFB29
ORF Names:UNQ5794/PRO19599
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000125903.4
HGNCiHGNC:16218 DEFB129
neXtProtiNX_Q9H1M3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000125903
PharmGKBiPA27248

Polymorphism and mutation databases

BioMutaiDEFB129
DMDMi26392781

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000000700520 – 183Beta-defensin 129Add BLAST164

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 53By similarity
Disulfide bondi34 ↔ 48By similarity
Disulfide bondi38 ↔ 54By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9H1M3
PeptideAtlasiQ9H1M3
PRIDEiQ9H1M3
ProteomicsDBi80429

Expressioni

Tissue specificityi

Expressed specifically in testis.1 Publication

Gene expression databases

BgeeiENSG00000125903 Expressed in 9 organ(s), highest expression level in corpus epididymis
CleanExiHS_DEFB129
GenevisibleiQ9H1M3 HS

Organism-specific databases

HPAiHPA014581

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000246105

Structurei

3D structure databases

ProteinModelPortaliQ9H1M3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi160 – 167Poly-Pro8

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J03G Eukaryota
ENOG41119SG LUCA
GeneTreeiENSGT00390000008616
HOGENOMiHOG000112160
HOVERGENiHBG051312
InParanoidiQ9H1M3
OMAiLMGFGRC
OrthoDBiEOG091G0XGR
PhylomeDBiQ9H1M3

Family and domain databases

InterProiView protein in InterPro
IPR020520 Beta-defensin_129
IPR025933 Beta_defensin
PANTHERiPTHR15001 PTHR15001, 1 hit
PTHR15001:SF15 PTHR15001:SF15, 1 hit
PfamiView protein in Pfam
PF13841 Defensin_beta_2, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD307569 Beta-defensin_129, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H1M3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLLFPIFAS LMLQYQVNTE FIGLRRCLMG LGRCRDHCNV DEKEIQKCKM
60 70 80 90 100
KKCCVGPKVV KLIKNYLQYG TPNVLNEDVQ EMLKPAKNSS AVIQRKHILS
110 120 130 140 150
VLPQIKSTSF FANTNFVIIP NATPMNSATI STMTPGQITY TATSTKSNTK
160 170 180
ESRDSATASP PPAPPPPNIL PTPSLELEEA EEQ
Length:183
Mass (Da):20,299
Last modified:March 1, 2001 - v1
Checksum:iA531A68C39F6EFF9
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024327149T → S. Corresponds to variant dbSNP:rs1053783Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF529413 mRNA Translation: AAQ09522.1
AF525931 mRNA Translation: AAP47224.1
AY358186 mRNA Translation: AAQ88553.1
AL360078 Genomic DNA No translation available.
BC070359 mRNA Translation: AAH70359.1
AY122480 mRNA Translation: AAM93921.1
CCDSiCCDS12992.1
RefSeqiNP_543021.1, NM_080831.3
UniGeneiHs.112087

Genome annotation databases

EnsembliENST00000246105; ENSP00000246105; ENSG00000125903
GeneIDi140881
KEGGihsa:140881
UCSCiuc002wda.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF529413 mRNA Translation: AAQ09522.1
AF525931 mRNA Translation: AAP47224.1
AY358186 mRNA Translation: AAQ88553.1
AL360078 Genomic DNA No translation available.
BC070359 mRNA Translation: AAH70359.1
AY122480 mRNA Translation: AAM93921.1
CCDSiCCDS12992.1
RefSeqiNP_543021.1, NM_080831.3
UniGeneiHs.112087

3D structure databases

ProteinModelPortaliQ9H1M3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000246105

Polymorphism and mutation databases

BioMutaiDEFB129
DMDMi26392781

Proteomic databases

PaxDbiQ9H1M3
PeptideAtlasiQ9H1M3
PRIDEiQ9H1M3
ProteomicsDBi80429

Protocols and materials databases

DNASUi140881
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000246105; ENSP00000246105; ENSG00000125903
GeneIDi140881
KEGGihsa:140881
UCSCiuc002wda.3 human

Organism-specific databases

CTDi140881
EuPathDBiHostDB:ENSG00000125903.4
GeneCardsiDEFB129
HGNCiHGNC:16218 DEFB129
HPAiHPA014581
neXtProtiNX_Q9H1M3
OpenTargetsiENSG00000125903
PharmGKBiPA27248
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J03G Eukaryota
ENOG41119SG LUCA
GeneTreeiENSGT00390000008616
HOGENOMiHOG000112160
HOVERGENiHBG051312
InParanoidiQ9H1M3
OMAiLMGFGRC
OrthoDBiEOG091G0XGR
PhylomeDBiQ9H1M3

Enzyme and pathway databases

ReactomeiR-HSA-1461957 Beta defensins
R-HSA-1461973 Defensins

Miscellaneous databases

GeneWikiiDEFB129
GenomeRNAii140881
PROiPR:Q9H1M3

Gene expression databases

BgeeiENSG00000125903 Expressed in 9 organ(s), highest expression level in corpus epididymis
CleanExiHS_DEFB129
GenevisibleiQ9H1M3 HS

Family and domain databases

InterProiView protein in InterPro
IPR020520 Beta-defensin_129
IPR025933 Beta_defensin
PANTHERiPTHR15001 PTHR15001, 1 hit
PTHR15001:SF15 PTHR15001:SF15, 1 hit
PfamiView protein in Pfam
PF13841 Defensin_beta_2, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD307569 Beta-defensin_129, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDB129_HUMAN
AccessioniPrimary (citable) accession number: Q9H1M3
Secondary accession number(s): Q8NES7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: March 1, 2001
Last modified: September 12, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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