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Protein

Nucleoporin-62 C-terminal-like protein

Gene

NUP62CL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoporin-62 C-terminal-like protein
Gene namesi
Name:NUP62CL
Synonyms:NUP62L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000198088.10
HGNCiHGNC:25960 NUP62CL
neXtProtiNX_Q9H1M0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198088
PharmGKBiPA145148360

Polymorphism and mutation databases

BioMutaiNUP62CL
DMDMi317373409

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002578341 – 184Nucleoporin-62 C-terminal-like proteinAdd BLAST184

Proteomic databases

PaxDbiQ9H1M0
PRIDEiQ9H1M0
ProteomicsDBi80427
80428 [Q9H1M0-2]

PTM databases

PhosphoSitePlusiQ9H1M0

Expressioni

Gene expression databases

BgeeiENSG00000198088 Expressed in 126 organ(s), highest expression level in right uterine tube
CleanExiHS_NUP62CL
ExpressionAtlasiQ9H1M0 baseline and differential
GenevisibleiQ9H1M0 HS

Organism-specific databases

HPAiHPA001884

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi120184, 29 interactors
IntActiQ9H1M0, 5 interactors
STRINGi9606.ENSP00000361544

Structurei

3D structure databases

ProteinModelPortaliQ9H1M0
SMRiQ9H1M0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili117 – 151Sequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi11 – 43Thr-richAdd BLAST33

Sequence similaritiesi

Belongs to the nucleoporin NSP1/NUP62 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2196 Eukaryota
ENOG410XT5X LUCA
GeneTreeiENSGT00730000111010
HOGENOMiHOG000171766
HOVERGENiHBG082003
InParanoidiQ9H1M0
PhylomeDBiQ9H1M0

Family and domain databases

InterProiView protein in InterPro
IPR026010 NSP1/NUP62
IPR007758 Nucleoporin_NSP1_C
PANTHERiPTHR12084 PTHR12084, 1 hit
PfamiView protein in Pfam
PF05064 Nsp1_C, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q9H1M0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQFTSISNSL TSTAAIGLSF TTSTTTTATF TTNTTTTITS GFTVNQNQLL
60 70 80 90 100
SRGFENLVPY TSTVSVVATP VMTYGHLEGL INEWNLELED QEKYFLLQAT
110 120 130 140 150
QVNAWDHTLI ENGEMIRILH GEVNKVKLDQ KRLEQELDFI LSQQQELEFL
160 170 180
LTYLEESTRD QSGLHYLQDA DEEHVEISTR SAEF
Length:184
Mass (Da):20,837
Last modified:January 11, 2011 - v3
Checksum:iAF5CA4AC5DCEB344
GO
Isoform 2 (identifier: Q9H1M0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     65-72: SVVATPVM → RFVFYMEK
     73-184: Missing.

Show »
Length:72
Mass (Da):7,880
Checksum:i0B88E1359C41F611
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y6X7H0Y6X7_HUMAN
Nucleoporin-62 C-terminal-like prot...
NUP62CL
198Annotation score:
Q5JSN5Q5JSN5_HUMAN
Nucleoporin-62 C-terminal-like prot...
NUP62CL
136Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05056954F → L. Corresponds to variant dbSNP:rs16987290Ensembl.1
Natural variantiVAR_028920177I → T2 PublicationsCorresponds to variant dbSNP:rs1298577Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02136765 – 72SVVATPVM → RFVFYMEK in isoform 2. 1 Publication8
Alternative sequenceiVSP_02136873 – 184Missing in isoform 2. 1 PublicationAdd BLAST112

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000137 mRNA Translation: BAA90968.1
AL390039 Genomic DNA No translation available.
CH471120 Genomic DNA Translation: EAX02718.1
CH471120 Genomic DNA Translation: EAX02720.1
BC016327 mRNA Translation: AAH16327.1
BC017799 mRNA Translation: AAH17799.1
CCDSiCCDS14527.1 [Q9H1M0-1]
RefSeqiNP_060151.2, NM_017681.2 [Q9H1M0-1]
UniGeneiHs.163629

Genome annotation databases

EnsembliENST00000372466; ENSP00000361544; ENSG00000198088 [Q9H1M0-1]
ENST00000484614; ENSP00000433269; ENSG00000198088 [Q9H1M0-2]
GeneIDi54830
KEGGihsa:54830
UCSCiuc004ena.4 human [Q9H1M0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiN62CL_HUMAN
AccessioniPrimary (citable) accession number: Q9H1M0
Secondary accession number(s): D3DUX4, Q8WVL6, Q9NXP2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: January 11, 2011
Last modified: September 12, 2018
This is version 113 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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